Blood最新文献

{"title":"T cells targeting immunoglobulin in myeloma: a way forward?","authors":"David E Avigan","doi":"10.1182/blood.2026033711","DOIUrl":"https://doi.org/10.1182/blood.2026033711","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"148 16","pages":"1950-1952"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematopoietic stem cell culture comes of age.","authors":"Adam C Wilkinson, Berthold Göttgens","doi":"10.1182/blood.2026035565","DOIUrl":"https://doi.org/10.1182/blood.2026035565","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"148 16","pages":"1943-1945"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurotoxicity with CAR T cells in myeloma deciphered?","authors":"Monika Engelhardt, Ralph Wäsch","doi":"10.1182/blood.2026035515","DOIUrl":"https://doi.org/10.1182/blood.2026035515","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"148 16","pages":"1947-1948"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone marrow ménage à trois balances neutrophil production.","authors":"Vincent Suerdieck, Oliver Soehnlein","doi":"10.1182/blood.2026035694","DOIUrl":"https://doi.org/10.1182/blood.2026035694","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"148 16","pages":"1956-1958"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin constant domains as targets for T-cell receptor-based treatment of multiple myeloma.","authors":"Miranda H Meeuwsen, Anne K Wouters, Johannes C Wellershoff, Tassilo L A Wachsmann, Dennis F G Remst, Renate S Hagedoorn, Michel G D Kester, Dirk M van der Steen, Arnoud H de Ru, Els P van Hees, Masashi Matsuda, Fumihiko Ishikawa, Peter A van Veelen, J H Frederik Falkenburg, Mirjam H M Heemskerk","doi":"10.1182/blood.2025032234","DOIUrl":"10.1182/blood.2025032234","url":null,"abstract":"<p><strong>Abstract: </strong>Despite major progress with chimeric antigen receptor T-cell therapy, multiple myeloma (MM) remains largely incurable and most patients relapse. To broaden therapeutic options and overcome antigen escape, we explored T-cell receptor (TCR)-based targeting of intracellular antigens derived from immunoglobulin heavy chain constant domains. Using HLA class-I peptidomics, we identified 9 immunoglobulin G (IgG)- or IgA-derived peptides presented by common HLA alleles (HLA-A∗01:01, HLA-A∗02:01, HLA-A∗03:01, and HLA-B∗07:02). High-avidity T-cell clones recognizing 4 of these epitopes were isolated from HLA-mismatched healthy donors. The transfer of these immunoglobulin-specific TCRs into donor T cells conferred potent and selective recognition of IgG- or IgA-expressing MM cell lines, sparing antigen-negative cells. Safety profiling confirmed strict HLA-restricted specificity without cross-reactivity toward other HLA alleles, non-B-lineage tumor cell lines, or healthy tissues, except for the depletion of isotype-matched B cells. Immunoglobulin-TCR T cells efficiently lysed patient-derived MM cells ex vivo and eradicated established IgA- or IgG-expressing MM tumors in murine xenograft models. Mechanistic studies revealed that dendritic cells could cross-present immunoglobulin peptides at high serum concentrations, potentially enhancing T-cell activation in vivo. Importantly, subtype-specific depletion of B cells implies that immunoglobulin-TCR T-cell therapy could partly preserve humoral immunity, reducing the need for antibody replacement compared with pan-B-cell depletion strategies. Collectively, these findings establish immunoglobulin heavy chain constant domains as promising targets for TCR-based cellular immunotherapy in MM and potentially other immunoglobulin-producing malignancies or autoantibody-mediated autoimmune diseases.</p>","PeriodicalId":9102,"journal":{"name":"Blood","volume":" ","pages":"1998-2012"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taking the brakes off cytolytic CD4+ T cells.","authors":"Tobias Wertheimer","doi":"10.1182/blood.2026035655","DOIUrl":"https://doi.org/10.1182/blood.2026035655","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"148 16","pages":"1958-1959"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isaac ST, Bishop DC, Shaikh F, Micklethwaite K, Gottlieb DJ, Blyth E. Human herpesvirus 6 viremia and encephalitis in CAR T-cell recipients. Blood. 2025;146(25):3124-3128.","authors":"","doi":"10.1182/blood.2026036302","DOIUrl":"https://doi.org/10.1182/blood.2026036302","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"148 16","pages":"2084"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cilta-cel CAR T-cell expansion and neurotoxicity.","authors":"","doi":"10.1182/blood.2026036298","DOIUrl":"https://doi.org/10.1182/blood.2026036298","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"148 16","pages":"2085"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myelofibrosis end points and self-evident truths.","authors":"Pankit Vachhani, Raajit K Rampal","doi":"10.1182/blood.2026035301","DOIUrl":"https://doi.org/10.1182/blood.2026035301","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"148 16","pages":"1954-1956"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The enigma of rapid response vs safety in AL amyloidosis.","authors":"Angela Dispenzieri","doi":"10.1182/blood.2026035095","DOIUrl":"https://doi.org/10.1182/blood.2026035095","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"148 16","pages":"1948-1950"},"PeriodicalIF":23.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}