Blood最新文献

{"title":"STINGing leukemia stem cells through PSTK inhibition.","authors":"Sylvain Garciaz","doi":"10.1182/blood.2024028046","DOIUrl":"https://doi.org/10.1182/blood.2024028046","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"219 1","pages":"1833-1835"},"PeriodicalIF":20.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recycling is \"bad to the bone\" in patients with myeloma.","authors":"Kevin C Miller,Alexander M Lesokhin","doi":"10.1182/blood.2024027940","DOIUrl":"https://doi.org/10.1182/blood.2024027940","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"72 1","pages":"1832-1833"},"PeriodicalIF":20.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"17(R)-Resolvin D1: a novel approach for SCD cardiomyopathy.","authors":"Thilina U Jayawardena,Gavin Y Oudit","doi":"10.1182/blood.2025028490","DOIUrl":"https://doi.org/10.1182/blood.2025028490","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"7 1","pages":"1835-1837"},"PeriodicalIF":20.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeing is believing: a histology textbook's dream case of sarcoidosis.","authors":"Pravin Patel,Olga Pozdnyakova","doi":"10.1182/blood.2025028699","DOIUrl":"https://doi.org/10.1182/blood.2025028699","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"130 1","pages":"1962"},"PeriodicalIF":20.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond conVENtional 7+3 in acute myeloid leukemia.","authors":"Christine M McMahon","doi":"10.1182/blood.2025028442","DOIUrl":"https://doi.org/10.1182/blood.2025028442","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"42 1","pages":"1831-1832"},"PeriodicalIF":20.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate and glucarpidase: the emperor has new clothes.","authors":"Stefan Schwartz,Jesper Heldrup","doi":"10.1182/blood.2024027791","DOIUrl":"https://doi.org/10.1182/blood.2024027791","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"275 1","pages":"1829-1830"},"PeriodicalIF":20.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new variable to study in transplant: APOE variant status.","authors":"Satoshi Kaito,Susan DeWolf","doi":"10.1182/blood.2025028406","DOIUrl":"https://doi.org/10.1182/blood.2025028406","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"20 1","pages":"1839-1840"},"PeriodicalIF":20.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of 'Super' transplantability.","authors":"Fang Dong,Sen Zhang,Caiying Zhu,Zining Yang,Lisha Wang,Yao Ma,Jiayi Lu,Xialin Li,Xiaofang Wang,Nini Wang,Shanshan Zhang,Miner Xie,Jinhong Wang,Xiaobing Zhang,Yawei Zheng,Shihui Ma,Hideo Ema,Hui Cheng,Sha Hao,Toshio Suda,Yu Lan,Bing Liu,Ping Zhu,Junren Chen,Tao Cheng","doi":"10.1182/blood.2024027872","DOIUrl":"https://doi.org/10.1182/blood.2024027872","url":null,"abstract":"Hematopoietic stem cells (HSCs) are heterogeneous, and the quality of HSCs - that is, 'transplantability' - is a key determinant for posttransplant hematopoietic reconstitution. However, molecular modalities of high-potency HSCs with superior transplantability still remain poorly understood. Here, we conducted large-scale single-clone serial-transplant experiments and tracked descendant cells of 288 HSC clones to quantify their intrinsic capability for hematopoietic reconstitution. Using integrated single-cell transcriptional, immunophenotypical, and Bayesian dynamic analyses, we uncovered three classes of HSC clones - 'Super', 'Flash', and 'Trickle' - that had higher output in the 1st generation but exhibited markedly different behavior in later generations. The 'Super'-class HSC clones comprised 4% of the HSCs and manifested persistent superior transplantability and balanced myeloid/lymphoid lineage outputs across generations in serial transplants. The 'Super'-class HSCs had a unique molecular signature, including low expression of CD27, that was distinct from previously known 'Classical HSC' signatures. Validation experiments indicated that CD27- HSCs had superior transplantability compared to CD27+ HSCs. Our study asserted an operational definition for 'Super' transplantability of HSCs, defined its molecular program, and suggested new directions for enriching high-potency HSCs in grafts.","PeriodicalId":9102,"journal":{"name":"Blood","volume":"12 1","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T-ICAHT: Grading and Prognostic Impact of Thrombocytopenia After CAR T-cell Therapy.","authors":"Kai Rejeski,Jaime Sanz,Teng Fei,Monica S Nair,Hamza Hashmi,Abraham Avigdor,Ofrat Beyar-Katz,Veit L Bücklein,Kevin J Curran,Sigrun Einarsdottir,Jonathan H Esensten,Netta Glaubach,Noa Golan-Accav,Marina Gomez-Llobell,Iris Halamis,Orit Itzhaki,Frederick L Locke,Sham Mailankody,Ronit Marcus,Marcela V Maus,M Lia Palomba,Jae H Park,Marcelo C Pasquini,Sandeep S Raj,Sridevi Rajeeve,Gilles A Salles,Michael Scordo,Gunjan L Shah,Avichai Shimoni,Marion Subklewe,Tobias Tix,Saad Z Usmani,Ori Ben Valid,Yannis K Valtis,Tsila Zuckerman,Nirali N Shah,Miguel-Angel Perales,Roni Shouval","doi":"10.1182/blood.2025028833","DOIUrl":"https://doi.org/10.1182/blood.2025028833","url":null,"abstract":"Immune effector cell-associated hematotoxicity (ICAHT) was recently introduced as a distinct toxicity category of CAR-T therapy. While a grading system based solely on neutrophil counts was proposed (hereafter termed N-ICAHT), the prevalence and prognostic impact of thrombocytopenia remains poorly defined. In this multicenter observational study, we systematically examined patterns of thrombocytopenia in 744 patients treated with commercial CD19 CAR-T for B-cell Non-Hodgkin Lymphoma (B-NHL). We developed a grading system termed T-ICAHT with thresholds that closely aligned with N-ICAHT - based on depth, duration and timing of thrombocytopenia. In the core NHL dataset, 43% of patients developed any-grade early T-ICAHT (day 0-30), with 23% developing severe (G3+) manifestations. Late T-ICAHT (day 31-100) was observed in 42% (G3+: 13%). While T-ICAHT and N-ICAHT gradings showed some correlation, considerable discordance was noted. On multivariate analysis, bridging therapy, poor performance status, and high Hematotox scores were associated with increased risk of severe early T-ICAHT. Patients with higher T-ICAHT grades showed increased platelet and red blood cell transfusion burden (p<0.001) and more bleeding events (p=0.01). T-ICAHT grades were inversely associated with overall survival (OS), with landmarked 2-year estimates ranging from 67% (G0), to 48% (G1-2) and 35% (G3+). In multivariable Cox regression analysis, the independent prognostic capacity of T-ICAHT for OS was confirmed. Finally, we validated T-ICAHT's clinical and prognostic utility in 3 external cohorts spanning an additional 599 pediatric and adult patients (NHL, MM, B-ALL), confirming its broad applicability. These findings support integrating T-ICAHT into the ICAHT framework to standardize thrombocytopenia grading in CAR-T recipients.","PeriodicalId":9102,"journal":{"name":"Blood","volume":"19 1","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid ADAMTS13 activity assays for thrombotic thrombocytopenic purpura: a systematic review and meta-analysis.","authors":"Saarang R Deshpande,Hemza Tarawneh,Chloe Cate Deitelzweig,Jiayi Tong,Ting Zhou,Yong Chen,Adam Cuker","doi":"10.1182/blood.2025028416","DOIUrl":"https://doi.org/10.1182/blood.2025028416","url":null,"abstract":"Thrombotic thrombocytopenic purpura (TTP) is a rare, potentially fatal thrombotic microangiopathy caused by severe ADAMTS13 deficiency. Prompt treatment improves survival; however, reference standard ELISA and FRETS-VWF73 ADAMTS13 activity assays have long turnaround times that necessitate empiric treatment of many patients who ultimately are found not to have TTP. Rapid assays with analytical turnaround times within one hour have recently become available. We conducted a systematic review and meta-analysis of the performance characteristics of rapid assays relative to reference standard assays for ADAMTS13 activity for patients with suspected or confirmed TTP. Nineteen studies representing three rapid ADAMTS13 assays and 4,207 patient samples were included. The HemosIL AcuStar CLIA demonstrated high sensitivity (0.98, 95% CI 0.94 - 1.00), specificity (0.99, 0.97 - 1.00), and positive (0.96, 0.90 - 0.98) and negative predictive value (0.99, 0.99 - 1.00). The Technofluor FRET and Technoscreen assays had sensitivity of 0.93 (0.86 - 0.96) and 0.98 (0.42 - 1.00), specificity of 0.98 (0.95 - 0.99) and 0.87 (0.76 - 0.94), PPV of 0.97 (0.85 - 1.00) and 0.71 (0.59 - 0.80), and NPV of 0.96 (0.93 - 0.98) and 0.99 (0.72 - 1.00), respectively. The proportion of discrepant results (relative to reference standard assays) was 0.04 (0.03 - 0.05) for HemosIL AcuStar, 0.04 (0.02 - 0.06) for Technofluor FRET, and 0.11 (0.07 - 0.16) for the Technoscreen assay. With rapid turnaround time and high sensitivity, the HemosIL AcuStar CLIA appears able to reliably avert empiric plasma exchange, corticosteroids, and caplacizumab in patients without TTP.","PeriodicalId":9102,"journal":{"name":"Blood","volume":"17 1","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}