Blood最新文献 - Book学术

B-1 B cells lose self-control in SCD.

IF 20.3 1区医学

Blood Pub Date : 2025-01-16 DOI: 10.1182/blood.2024026549

David R Gibb,Sean R Stowell

引用次数: 0

Combined targeted modality in cHL: a risky bet?

IF 20.3 1区医学

Blood Pub Date : 2025-01-16 DOI: 10.1182/blood.2024027360

Paul J Bröckelmann,Bastian von Tresckow

引用次数: 0

HLA-I aberrations in cutaneous T-cell lymphoma.

IF 20.3 1区医学

Blood Pub Date : 2025-01-16 DOI: 10.1182/blood.2024027135

Ting Zhou,Kojo S J Elenitoba-Johnson

引用次数: 0

Brentuximab vedotin and nivolumab for cHL.

IF 20.3 1区医学

Blood Pub Date : 2025-01-16 DOI: 10.1182/blood.2024027957

引用次数: 0

Is it time to screen for multiple myeloma?

IF 20.3 1区医学

Blood Pub Date : 2025-01-16 DOI: 10.1182/blood.2024027065

Irene M Ghobrial,Floris Chabrun

引用次数: 0

Defining 2 Biologically and Clinically Distinct Groups in Acute Leukemia with a Mixed Phenotype.

IF 20.3 1区医学

Blood Pub Date : 2025-01-15 DOI: 10.1182/blood.2024026273

Pallavi Galera,Deepika Dilip,Andriy Derkach,Alexander Chan,Yanming Zhang,Sonali Persaud,Tanmay Mishra,Kyle Kramer,Mahak Kathpalia,Ying Liu,Christopher A Famulare,Qi Gao,Douglas Alexander Mata,Maria E Arcila,Mark B Geyer,Eytan M Stein,Ahmet Dogan,Mikhail Roshal,Ross L Levine,Jacob L Glass,Wenbin Xiao

{"title":"Defining 2 Biologically and Clinically Distinct Groups in Acute Leukemia with a Mixed Phenotype.","authors":"Pallavi Galera,Deepika Dilip,Andriy Derkach,Alexander Chan,Yanming Zhang,Sonali Persaud,Tanmay Mishra,Kyle Kramer,Mahak Kathpalia,Ying Liu,Christopher A Famulare,Qi Gao,Douglas Alexander Mata,Maria E Arcila,Mark B Geyer,Eytan M Stein,Ahmet Dogan,Mikhail Roshal,Ross L Levine,Jacob L Glass,Wenbin Xiao","doi":"10.1182/blood.2024026273","DOIUrl":"https://doi.org/10.1182/blood.2024026273","url":null,"abstract":"A mixed phenotype is characteristic of de novo Mixed Phenotype Acute Leukemia (MPAL) but can also be seen in other leukemias. It poses substantial classification and management dilemmas. Herein, we report a large cohort of acute leukemia with a mixed phenotype and define Acute Myeloid Leukemia with Mixed Phenotype (AML-MP) and MPAL as two distinct groups by characterizing the clinical, genetic, and transcriptomic features. Clinically, patients with AML-MP and MPAL were both treated with either AML- or acute lymphoblastic leukemia (ALL)-directed induction regimens. AML-MP shows inferior responses (HR, 12.5; 95% CI, 2.72-57.8; p=.001), while MPAL shows better responses to ALL-directed treatment. Genetically, AML-MP harbors more frequent RUNX1 (23/52, 44%) and TP53 (12/52, 23.1%) mutations. In contrast, RUNX1 mutations are less frequent in MPAL (8/35, 23%, p=.01 vs AML-MP) and TP53 mutations as a driver are virtually absent in MPAL. Transcriptionally, AML-MP shows enrichment for stemness signatures, and a relative deficit of transcription factors critical for myeloid and lymphoid differentiation. Furthermore, AML-MP rarely switches to a lymphoid immunophenotype after treatment, in contrast to MPAL (1/40, 2.5%, vs. 10/28, 35.7%, p=.0003). Lastly, a genomic classification framework is proposed for future studies. Together, these data support the designation of AML-MP as a diagnosis distinct from MPAL and provide novel insights into the pathogenesis and therapies of acute leukemia with a mixed phenotype.","PeriodicalId":9102,"journal":{"name":"Blood","volume":"30 1","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A phase 1 trial of prizloncabtagene autoleucel, a CD19/CD20 CAR T-cell therapy for relapsed/refractory B-cell non-Hodgkin lymphoma.

IF 20.3 1区医学

Blood Pub Date : 2025-01-15 DOI: 10.1182/blood.2024026401

Wenjuan Yu,Ping Li,Lili Zhou,Min Yang,Shiguang Ye,Dan Zhu,Jiaqi Huang,Xin Yao,Yan Zhang,Lanfang Li,Jing Zhao,Kevin Zhu,Jing Li,Chengxiao Zheng,Liping Lan,Hui Wan,Yihong Yao,Huilai Zhang,Daobin Zhou,Jie Jin,Aibin Liang

{"title":"A phase 1 trial of prizloncabtagene autoleucel, a CD19/CD20 CAR T-cell therapy for relapsed/refractory B-cell non-Hodgkin lymphoma.","authors":"Wenjuan Yu,Ping Li,Lili Zhou,Min Yang,Shiguang Ye,Dan Zhu,Jiaqi Huang,Xin Yao,Yan Zhang,Lanfang Li,Jing Zhao,Kevin Zhu,Jing Li,Chengxiao Zheng,Liping Lan,Hui Wan,Yihong Yao,Huilai Zhang,Daobin Zhou,Jie Jin,Aibin Liang","doi":"10.1182/blood.2024026401","DOIUrl":"https://doi.org/10.1182/blood.2024026401","url":null,"abstract":"Prizloncabtagene autoleucel (prizlon-cel), a novel bispecific chimeric antigen receptor (CAR) T-cell, targets and eliminates CD19/CD20 positive tumor cells. This phase 1, open-label study investigated the safety and efficacy of prizlon-cel in patients with relapsed/refractory B-cell non-Hodgkin Lymphoma (r/r B-NHL). Patients with CD19 and/or CD20-positive r/r B-NHL received a 3-day lymphodepletion (cyclophosphamide: 300 mg/m2/d; fludarabine: 30 mg/m2/d) followed by an intravenous dose of prizlon-cel. The primary endpoints were dose-limiting toxicity (DLT) and incidence and severity of treatment-emergent adverse events (TEAEs). Secondary endpoints included overall response rate (ORR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Of the 48 patients infused prizlon-cel, 44 had large B-cell lymphoma (LBCL). No patient experienced DLT. Cytokine release syndrome occurred in 93.8% of patients, with only one case of grade 3. Immune effector cell-associated neurotoxicity syndrome occurred in 6.3% of patients, with no grade 3 or higher events. The most common grade 3 or higher TEAEs were neutropenia (83.3%) and leukopenia (50%). The ORR and complete response (CR) rates in all patients were 91.5% and 85.1%, respectively, and in LBCL patients, ORR was 90.7% with 86.0% CR. With median follow up of 30.0 months, median DOR, PFS, and OS were all not reached. The Kaplan-Meier estimate of 2-year DOR, PFS and OS rates were 66.0%, 62.6%, and 76.5%, respectively. Prizlon-cel showed a favorable safety profile and a high and durable response in patients with r/r B-NHL, suggesting a promising treatment option for patients with r/r B-NHL. (ClinicalTrials.gov number: NCT04317885, NCT04655677, NCT04696432, NCT04693676).","PeriodicalId":9102,"journal":{"name":"Blood","volume":"27 1","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common Hereditary Variants of the APOE Gene and Posttransplant Outcome in Acute Myeloid Leukemia.

IF 20.3 1区医学

Blood Pub Date : 2025-01-15 DOI: 10.1182/blood.2024026886

Julian Ronnacker,Michael Grau,Maximilian Klasmeier,Christian Klesse,Henning Baldauf,Stefan Abert,Andrew F Berdel,Friederike T Füsser,Sarah Sandmann,Jorn C Albring,Christian Reicherts,Simon Call,Julia Marx,Matthias Floeth,Eva Esseling,Lina Kolloch,Philipp Berning,Annika Scheller,Klaus Wethmar,Hartmut Schmidt,Bernhard Schlüter,Wolfgang E Berdel,Benjamin N Ostendorf,Sohail F Tavazoie,Jan-Henrik Mikesch,Georg Lenz,Katharina Fleischhauer,Johannes Schetelig,Matthias Stelljes,Christoph Schliemann

{"title":"Common Hereditary Variants of the APOE Gene and Posttransplant Outcome in Acute Myeloid Leukemia.","authors":"Julian Ronnacker,Michael Grau,Maximilian Klasmeier,Christian Klesse,Henning Baldauf,Stefan Abert,Andrew F Berdel,Friederike T Füsser,Sarah Sandmann,Jorn C Albring,Christian Reicherts,Simon Call,Julia Marx,Matthias Floeth,Eva Esseling,Lina Kolloch,Philipp Berning,Annika Scheller,Klaus Wethmar,Hartmut Schmidt,Bernhard Schlüter,Wolfgang E Berdel,Benjamin N Ostendorf,Sohail F Tavazoie,Jan-Henrik Mikesch,Georg Lenz,Katharina Fleischhauer,Johannes Schetelig,Matthias Stelljes,Christoph Schliemann","doi":"10.1182/blood.2024026886","DOIUrl":"https://doi.org/10.1182/blood.2024026886","url":null,"abstract":"Apolipoprotein E (APOE) has multiple functions in metabolism and immunoregulation. Its common germline variants APOE2, APOE3 and APOE4 give rise to three functionally distinct gene products. Previous studies reported yin-yang roles of APOE2 and APOE4 in immunological processes, but their effects in hematopoietic stem cell transplantation (HSCT) have never been studied. We performed APOE genotyping in two contemporary cohorts of 348 and 447 patients with acute myeloid leukemia (AML) who had received allogeneic HSCT and evaluated associations of recipient and donor APOE genetic variation with posttransplant outcome. Patients who carried at least one APOE2 allele had a higher risk of posttransplant death compared to APOE4 carriers in the discovery (hazard ratio [HR] 2.09, P = .024) and validation cohorts (HR 1.96, P = .040). Detrimental APOE2 effects were driven by an increased risk of severe chronic graft-versus-host disease (GvHD; HRadj 1.85, P = .034) and non-relapse death (HRadj 1.72, P = .044). In non-APOE2 recipients, transplantation of an APOE2-positive allograft was associated with an increased incidence of grade III-IV acute GvHD (HRadj 2.82, P = .012) and severe chronic GvHD (HRadj 2.54, P = .022) compared to APOE2-negative grafts. In summary, the APOE2 allele, typically considered a longevity gene in the general population, was associated with a higher risk of acute GvHD (HRadj 2.75, P = .002), chronic GvHD (HRadj 2.57, P = .001), and posttransplant mortality (HRadj 1.79, P = .004), when present either in the host or transplanted from the donor.","PeriodicalId":9102,"journal":{"name":"Blood","volume":"45 1","pages":""},"PeriodicalIF":20.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salvage Autologous Transplant in Relapsed Multiple Myeloma: Long-Term Follow-Up of the Phase 3 GMMG ReLApsE Trial.

IF 21 1区医学

Blood Pub Date : 2025-01-14 DOI: 10.1182/blood.2024027342

Marc-Andrea Baertsch, Jana Schlenzka, Thomas Hielscher, Marc S Raab, Sandra Sauer, Maximilian Merz, Elias K Mai, Carsten Müller-Tidow, Steffen Luntz, Anna Jauch, Peter Brossart, Martin Goerner, Stefan Klein, Bertram Glass, Peter Reimer, Ullrich Graeven, Roland Fenk, Mathias Haenel, Ivana von Metzler, Hans-Walter Lindemann, Christof Scheid, Igor-Wolfgang W Blau, Hans J Salwender, Richard Noppeney, Britta Besemer, Katja C Weisel, Hartmut Goldschmidt

{"title":"Salvage Autologous Transplant in Relapsed Multiple Myeloma: Long-Term Follow-Up of the Phase 3 GMMG ReLApsE Trial.","authors":"Marc-Andrea Baertsch, Jana Schlenzka, Thomas Hielscher, Marc S Raab, Sandra Sauer, Maximilian Merz, Elias K Mai, Carsten Müller-Tidow, Steffen Luntz, Anna Jauch, Peter Brossart, Martin Goerner, Stefan Klein, Bertram Glass, Peter Reimer, Ullrich Graeven, Roland Fenk, Mathias Haenel, Ivana von Metzler, Hans-Walter Lindemann, Christof Scheid, Igor-Wolfgang W Blau, Hans J Salwender, Richard Noppeney, Britta Besemer, Katja C Weisel, Hartmut Goldschmidt","doi":"10.1182/blood.2024027342","DOIUrl":"https://doi.org/10.1182/blood.2024027342","url":null,"abstract":"The multicenter, phase III GMMG ReLApsE trial (EudraCT-No:2009-013856-61) randomized relapsed and/or refractory multiple myeloma (RRMM) patients equally to lenalidomide/dexamethasone (LEN/DEX, 25mg days 1-21/40mg weekly, 4-week cycles) re-induction, salvage high dose chemotherapy (sHDCT, melphalan 200mg/m2), autologous stem cell transplantation (ASCT) and LEN maintenance (10mg/day; transplant arm, n=139) versus continuous LEN/DEX (control arm, n=138). Ninety-four percent of patients had received frontline HDCT/ASCT. We report an updated analysis of survival endpoints with a median follow-up of 99 months. Median progression-free survival (PFS) was 20.5 and 19.3 months in the transplant and control arm, respectively (HR 0.98; 95% CI 0.76-1.27; p=0.9). Median overall survival (OS) was 67.1 and 62.7 months (HR 0.89; 95% CI 0.66-1.20; p=0.44). Landmark analyses from sHDCT and the contemporaneous LEN/DEX cycle 5 were performed due to dropout of 29% of patients before sHDCT/ASCT in the transplant arm but did not reveal significant differences in PFS (23.0 vs. 20.3 months; HR 0.91; 95% CI 0.68-1.22; p=0.52) or OS (76.3 vs. 66.0 months; HR 0.8; 95% CI 0.56-1.13; p=0.2). Time to progression after frontline HDCT/ASCT (TTP1) was a prognostic factor but did not predict benefit from sHDCT/ASCT. The GMMG ReLApsE trial does not support use of sHDCT/ASCT in RRMM after frontline HDCT/ASCT. EudraCT-No: 2009-013856-61.","PeriodicalId":9102,"journal":{"name":"Blood","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How I diagnose and treat systemic mastocytosis with an associated hematologic neoplasm.

IF 21 1区医学

Blood Pub Date : 2025-01-14 DOI: 10.1182/blood.2023022416

Deepti H Radia

{"title":"How I diagnose and treat systemic mastocytosis with an associated hematologic neoplasm.","authors":"Deepti H Radia","doi":"10.1182/blood.2023022416","DOIUrl":"https://doi.org/10.1182/blood.2023022416","url":null,"abstract":"Over the last decade significant advances have been made by honing in on the diagnostic evaluation and the significance of molecular profiles in patients with systemic mastocytosis (SM), non-advanced and advanced.This is reflected in the 2022 iterations of the World Health Organization Edition 5 and International Consensus Criteria classifications.The impact of targeted KIT inhibitor therapies on patients treated within global trials has demonstrated significant improvements in the prognosis and overall survival for patients, leading to a change the treatment paradigm.Patients with SM and an associated hematologic neoplasm (SM-AHN) comprise of up to 70% of those in the advanced SM category, posing varying challenges in diagnosis and clinical heterogeneity due to the occupation of the bone marrow niche by two hematologic neoplasms.We are constantly learning about the complex, heterogenous genotypic and phenotypic spectrum of these patients with a view to provide personalised treatment options, aiming to improve outcomes, quality of life and ultimately a cure. This paper focuses on the management of patients with advanced systemic mastocytosis with an associated hematologic neoplasm and is a personal perspective using some illustrative patient cases treated at our centre, Guys and St Thomas's Hospitals, London: UK centre of excellence in Mastocytosis.","PeriodicalId":9102,"journal":{"name":"Blood","volume":" ","pages":""},"PeriodicalIF":21.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0