Blood最新文献

{"title":"Two strikes, base hit: odronextamab after CAR T cells in LBCL.","authors":"Jason Westin","doi":"10.1182/blood.2024027961","DOIUrl":"https://doi.org/10.1182/blood.2024027961","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"145 14","pages":"1441-1442"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD44-mediated metabolic rewiring is a targetable dependency of IDH-mutant leukemia.","authors":"Junhua Lyu, Yuxuan Liu, Ningning Liu, Hieu S Vu, Feng Cai, Hui Cao, Pranita Kaphle, Zheng Wu, Giovanni A Botten, Yuannyu Zhang, Jin Wang, Sarada Achyutuni, Xiaofei Gao, Ilaria Iacobucci, Charles G Mullighan, Stephen S Chung, Min Ni, Ralph J DeBerardinis, Jian Xu","doi":"10.1182/blood.2024027207","DOIUrl":"10.1182/blood.2024027207","url":null,"abstract":"<p><strong>Abstract: </strong>Recurrent isocitrate dehydrogenase (IDH) mutations catalyze nicotinamide adenine dinucleotide phosphate (NADPH)-dependent production of oncometabolite (R)-2-hydroxyglutarate (R-2HG) for tumorigenesis. IDH inhibition provides clinical response in a subset of acute myeloid leukemia (AML) cases; however, most patients develop resistance, highlighting the need for more effective IDH-targeting therapies. By comparing transcriptomic alterations in isogenic leukemia cells harboring CRISPR base-edited IDH mutations, we identify the activation of adhesion molecules including CD44, a transmembrane glycoprotein, as a shared feature of IDH-mutant leukemia, consistent with elevated CD44 expression in IDH-mutant AML patients. CD44 is indispensable for IDH-mutant leukemia cells through activating pentose phosphate pathway and inhibiting glycolysis by phosphorylating glucose-6-phosphate dehydrogenase and pyruvate kinase muscle isozyme M2, respectively. This metabolic rewiring ensures efficient NADPH generation for mutant IDH-catalyzed R-2HG production. Combining IDH inhibition with CD44 blockade enhances the elimination of IDH-mutant leukemia cells. Hence, we describe an oncogenic feedforward pathway involving CD44-mediated metabolic rewiring for oncometabolite production, representing a potentially targetable dependency of IDH-mutant malignancies.</p>","PeriodicalId":9102,"journal":{"name":"Blood","volume":" ","pages":"1553-1567"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prizloncabtagene autoleucel: a new CAR T cell for B-NHL.","authors":"Alberto Mussetti, Anna Sureda","doi":"10.1182/blood.2024028030","DOIUrl":"https://doi.org/10.1182/blood.2024028030","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"145 14","pages":"1444-1445"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromoplexy and FNDC3B::RARB fusion: deciphering a rare case of PML::RARA-negative APL.","authors":"Audrey Bidet, Emilie Klein","doi":"10.1182/blood.2024027991","DOIUrl":"https://doi.org/10.1182/blood.2024027991","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"145 14","pages":"1588"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"iPSCs unlock clues to pediatric AML onset.","authors":"Cornelis Jan Pronk, Charlotta Böiers","doi":"10.1182/blood.2024027101","DOIUrl":"https://doi.org/10.1182/blood.2024027101","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"145 14","pages":"1442-1444"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immunotherapy real estate of Hodgkin lymphoma.","authors":"Christian Steidl","doi":"10.1182/blood.2024027782","DOIUrl":"https://doi.org/10.1182/blood.2024027782","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"145 14","pages":"1445-1447"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant cytoplasmic inclusions (Alder-Reilly bodies) in Hurler syndrome (mucopolysaccharidosis type 1H).","authors":"Bhaumik Shah, Gerald B Wertheim","doi":"10.1182/blood.2024025158","DOIUrl":"https://doi.org/10.1182/blood.2024025158","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"145 14","pages":"1589"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"When I'm 64\": functional shift of aging platelets.","authors":"Laura Gutiérrez","doi":"10.1182/blood.2024027996","DOIUrl":"https://doi.org/10.1182/blood.2024027996","url":null,"abstract":"","PeriodicalId":9102,"journal":{"name":"Blood","volume":"145 14","pages":"1447-1449"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification and risk stratification in T-lineage acute lymphoblastic leukemia.","authors":"Petri Pölönen, Charles G Mullighan, David T Teachey","doi":"10.1182/blood.2023022920","DOIUrl":"10.1182/blood.2023022920","url":null,"abstract":"<p><strong>Abstract: </strong>Cure rates for patients with acute lymphoblastic leukemia (ALL) have improved markedly in recent decades, in part because of risk stratification incorporating leukemia genomics, response to treatment, and clinical features to be able to determine at diagnosis which patients are more likely to relapse or have refractory disease. Although risk stratification is well developed for patients with B-lineage ALL, it remains challenging for those with T-lineage ALL (T-ALL). Prognostic factors validated across clinical trials and real-world data in T-ALL include age, central nervous system involvement, and measurable residual disease (MRD) response. Immunophenotype, including early T-cell precursor ALL, is widely used to classify T-ALL but is not consistently associated with outcome in multivariable risk models. Historically, few genetic alterations have been consistently associated with outcome, but recent comprehensive, large-scale genomic profiling has identified multiple genetic subtypes and alterations associated with outcome independent of MRD. This review highlights ongoing efforts to identify reliable prognostic biomarkers and underscores the potential of genomics-based classification to guide future T-ALL treatment strategies.</p>","PeriodicalId":9102,"journal":{"name":"Blood","volume":" ","pages":"1464-1474"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging platelets shift their hemostatic properties to inflammatory functions.","authors":"Afra Anjum, Magdalena Mader, Shaan Mahameed, Abhinaya Muraly, Frederik Denorme, Fabian P Kliem, Dario Rossaro, Sezer Agköl, Lea Di Fina, Maité Mulkers, Lisa Laun, Lukas Li, Nadja Kupper, Keyang Yue, Marie-Louise Hoffknecht, Anastassia Akhalkatsi, Quentin Loew, Joachim Pircher, Raphael Escaig, Erwin Strasser, Christian Wichmann, Kami Pekayvaz, Bernhard Nieswandt, Christian Schulz, Maria S Robles, Rainer Kaiser, Steffen Massberg, Robert Campbell, Leo Nicolai","doi":"10.1182/blood.2024024901","DOIUrl":"10.1182/blood.2024024901","url":null,"abstract":"<p><strong>Abstract: </strong>Platelets are crucial players in hemostasis and thrombosis but also contribute to immune regulation and host defense, using different receptors, signaling pathways, and effector functions, respectively. Whether distinct subsets of platelets specialize in these diverse tasks is insufficiently understood. Here, we used a pulse-labeling method in Mus musculus models for tracking in vivo platelet aging and its functional implications. Using in vitro and in vivo assays, we reveal that young, reticulated platelets show heightened responses in the setting of clot formation, with corresponding, increased responses to agonists, adhesion, and retractile function. Unexpectedly, aged platelets lose their hemostatic proficiency but are more prone to react to inflammatory challenge: compared with reticulated platelets, this cohort was more likely to form platelet-leukocyte aggregates and showed increased adhesion to neutrophils in vitro, as well as enhanced bactericidal function. In vivo, this was reflected in increased pulmonary recruitment of aged platelets in an acute lung injury model. Proteomic analyses confirmed the upregulation of immune pathways in this cohort, including enhanced procoagulant function. In mouse models of prolonged platelet half-life, this resulted in increased pulmonary leukocyte infiltration and inflammation upon acute lung injury. Similarly, human platelet concentrates decreased their hemostatic function and elevated their putative immunomodulatory potential in vitro over time, and in a mouse model of platelet transfusion, aged platelet concentrates resulted in augmented inflammation. In summary, we show that platelets exhibit age-dependent phenotypic shifts, allowing them to fulfill their diverse tasks in the vasculature. Because functional alterations of aging platelets extend to platelet concentrates, this may hold important implications for transfusion medicine.</p>","PeriodicalId":9102,"journal":{"name":"Blood","volume":" ","pages":"1568-1582"},"PeriodicalIF":21.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}