Stem cell and translational investigation最新文献

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A human experimental model of laminopathy based on adult stem cells establishes the relevance of Oct1 transcription factor in the aging process 基于成体干细胞的人椎板病实验模型建立了Oct1转录因子在衰老过程中的相关性
Stem cell and translational investigation Pub Date : 2014-08-12 DOI: 10.14800/SCTI.276
A. Infante, A. Gago, C. I. Rodríguez
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引用次数: 3
New insight of leukemic stem cell 白血病干细胞的新认识
Stem cell and translational investigation Pub Date : 2014-06-26 DOI: 10.14800/SCTI.178
S. Qiu, Ming Wang, Jianxiang Wang
{"title":"New insight of leukemic stem cell","authors":"S. Qiu, Ming Wang, Jianxiang Wang","doi":"10.14800/SCTI.178","DOIUrl":"https://doi.org/10.14800/SCTI.178","url":null,"abstract":"Human acute myeloid leukemia (AML) derives from rare leukemic stem cells (LSCs). Relapse of disease can be ascribed to LSCs to some degree. Currently, a number of surface markers of AML LSCs have been identified, including CD123, CD44, CLL-1, CD96, CD47, CD32, CD25 and TIM-3. Moreover, monoclonal antibodies targeting some markers have demonstrated efficacy in xenotransplantation models. In our recent work, we found that N-cadherin and Tie2 positive CD34 + CD38 - CD123 + populations could develop acute myeloid leukemia more effectively in NOD/SCID mice than their negative counterparts at the same doses. Meanwhile, the blast cells from the bone marrow of leukemic mice are transplantable. It is speculated that FLT3-ITD mutation could make the LSCs more capable of expanding in the environment. These data suggested that N-cadherin and Tie2 were very important in development of leukemia as LSC markers.","PeriodicalId":90974,"journal":{"name":"Stem cell and translational investigation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66657764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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