BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2025.103933
R. Iosifidou, G. Xepapadakis, V. Venizelos, C. Markopoulos, K. Papazisis, N. Tsoulos, G. Kapetsis, S. Giannoulakis, M. Paraskeva, M. Kaparelou, G. Lainakis, A. Fotarelli, F. Pavlidou, E. Fountzilas, E. Saloustros, S. Karageorgopoulou, S. Triantafillidou, S. Intzes, F Koinis
{"title":"P050: Genomic risk assessment with Oncotype DX in youngwomen (age ≤ 40 years old) with early-stage ER+/HER2-/N0 breast cancer","authors":"R. Iosifidou, G. Xepapadakis, V. Venizelos, C. Markopoulos, K. Papazisis, N. Tsoulos, G. Kapetsis, S. Giannoulakis, M. Paraskeva, M. Kaparelou, G. Lainakis, A. Fotarelli, F. Pavlidou, E. Fountzilas, E. Saloustros, S. Karageorgopoulou, S. Triantafillidou, S. Intzes, F Koinis","doi":"10.1016/j.breast.2025.103933","DOIUrl":"10.1016/j.breast.2025.103933","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"80 ","pages":"Article 103933"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2025.103929
S. Sun, X. Wang, S. Zhang, Y. Xu, X Ma
{"title":"P046: Preclinical efficacy and safety evaluation of CAR-T cell therapy against TROP2 for treatment of triple negative breast cancer","authors":"S. Sun, X. Wang, S. Zhang, Y. Xu, X Ma","doi":"10.1016/j.breast.2025.103929","DOIUrl":"10.1016/j.breast.2025.103929","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"80 ","pages":"Article 103929"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2025.103984
V. Mitova, M.D. Plachkova, I Gavrilov
{"title":"P118: Role of artificial intelligence and mHealth for the prevention, detection and management of breast cancer patients","authors":"V. Mitova, M.D. Plachkova, I Gavrilov","doi":"10.1016/j.breast.2025.103984","DOIUrl":"10.1016/j.breast.2025.103984","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"80 ","pages":"Article 103984"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2025.103915
J. Zhao, Z. Zhou, L. Ding, J. Ye, T. Long, G. Zou, Y. Cai, J. Chai, H. Yao, Y Wang
{"title":"P028: Confronting Barriers in HER2-Positive Metastatic Breast Cancer: Insights from a Phase II Trial of Inetetamab, Pyrotinib, and Chemotherapy","authors":"J. Zhao, Z. Zhou, L. Ding, J. Ye, T. Long, G. Zou, Y. Cai, J. Chai, H. Yao, Y Wang","doi":"10.1016/j.breast.2025.103915","DOIUrl":"10.1016/j.breast.2025.103915","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"80 ","pages":"Article 103915"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2025.103896
C.S. Rubenstein, N. Turner, J.S. Reis-Filho, M.P. Goetz, C. Desmedt, S. Chandarlapaty, H. Sasano, C.L. Arteaga, S. Loi, S.L. Graff, D. Liu, V. Rodrik-Outmezguine, A. Sireci, H. Won, L.M. Litchfield, M. Munoz, S Johnston
{"title":"P002: Genomic And Transcriptomic Profiling of Primary Tumors From Patients with HR+, HER2-, Node-positive, High-risk Early Breast Cancer (EBC) in the monarchE Trial","authors":"C.S. Rubenstein, N. Turner, J.S. Reis-Filho, M.P. Goetz, C. Desmedt, S. Chandarlapaty, H. Sasano, C.L. Arteaga, S. Loi, S.L. Graff, D. Liu, V. Rodrik-Outmezguine, A. Sireci, H. Won, L.M. Litchfield, M. Munoz, S Johnston","doi":"10.1016/j.breast.2025.103896","DOIUrl":"10.1016/j.breast.2025.103896","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"80 ","pages":"Article 103896"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2024.103863
L. Foffano , L. Cucciniello , E. Nicolò , I. Migliaccio , C. Noto , C. Reduzzi , L. Malorni , M. Cristofanilli , L. Gerratana , F. Puglisi
{"title":"Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i): Mechanisms of resistance and where to find them","authors":"L. Foffano , L. Cucciniello , E. Nicolò , I. Migliaccio , C. Noto , C. Reduzzi , L. Malorni , M. Cristofanilli , L. Gerratana , F. Puglisi","doi":"10.1016/j.breast.2024.103863","DOIUrl":"10.1016/j.breast.2024.103863","url":null,"abstract":"<div><div>CDK4/6 inhibitors (CDK4/6i) have significantly impacted on the treatment of HR + HER2 negative (HER2-) metastatic breast cancer (BC) when combined with endocrine therapy. Nonetheless, despite significant research efforts, the mechanisms of de novo and acquired resistance to CDK4/6i have not yet been fully elucidated, highlighting the need for a deeper understanding of these process. Additionally, the importance of dissecting CDK4/6i resistance from endocrine resistance for personalized treatment is increasingly recognized.</div><div>Liquid biopsy has emerged as a minimally invasive tool for identifying circulating biomarkers of resistance through the integration of multiparametric and dynamic assessments that encompass ctDNA, CTCs, exosomes, and epigenetic ctDNA alterations, representing a promising perspective for the clinical characterization of treatment resistance and guiding post-progression strategies to improve patient outcomes.</div><div>Aim of this review is summarize potential mechanisms of CDK4/6i resistance, along with the advantages of using liquid biopsy to identify resistance biomarkers in HR+/HER2- MBC patients treated with CDK 4/6 inhibitors.</div></div>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"79 ","pages":"Article 103863"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2024.103869
Megan Chua Wern Ee , Ashley Lee Shi Hui , Wong Hung Chew , Emmeline Elaine Cua-Delos Santos , Sean Li Siwei , Sng Ming Xian , Qin Xiang Ng , Serene Goh Si Ning
{"title":"Oncological outcomes following extreme oncoplastic breast conserving surgery (eOPBCS) for locally advanced breast cancer (LABC): A systematic review and meta-analysis","authors":"Megan Chua Wern Ee , Ashley Lee Shi Hui , Wong Hung Chew , Emmeline Elaine Cua-Delos Santos , Sean Li Siwei , Sng Ming Xian , Qin Xiang Ng , Serene Goh Si Ning","doi":"10.1016/j.breast.2024.103869","DOIUrl":"10.1016/j.breast.2024.103869","url":null,"abstract":"<div><h3>Introduction</h3><div>Locally advanced breast cancer (LABC) accounts for 5 % of new breast cancer diagnoses in developed countries and 30–60 % in developing regions. Historically, treatment relied on mastectomy guided by the Halstedian theory. Advances in neoadjuvant chemotherapy (NACT), breast-conserving surgery (BCS), and radiation have transformed treatment into a multimodal approach. Extreme oncoplastic BCS (eOPBCS) has expanded the boundaries of BCS, enabling large-volume resections with breast reshaping. However, its oncologic outcomes compared to mastectomy remain unclear, particularly in LABC.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted following PRISMA guidelines (PROSPERO: CRD42024535182). Studies involving eOPBCS for LABC were reviewed, and those comparing outcomes with mastectomy were included in the meta-analysis. The primary outcomes were overall survival (OS), disease-free survival (DFS), and local recurrence rates (LRR). Data were synthesized using a random-effects model.</div></div><div><h3>Results</h3><div>Of 866 identified studies, 33 were included in the systematic review and 4 in the meta-analysis, involving 2902 patients with LABC. Among them, 16.1 % underwent eOPBCS. Patients receiving eOPBCS were younger, had larger tumours, and more frequently underwent axillary clearance. The pooled hazard ratio (HR) for OS comparing mastectomy to eOPBCS was 1.72 (95% CI 1.04-2.83). Meanwhile, HRs for DFS (1.11, 95% CI 0.60-2.08) and LRR (0.67, 95% CI 0.38-1.18) showed that there were no statistically significant differences but a trend toward lower recurrence rates with mastectomy.</div></div><div><h3>Conclusion</h3><div>eOPBCS demonstrates comparable to superior oncological outcomes to mastectomy in LABC, offering a promising option for selected patients. However, slightly elevated local recurrence rates, though not statistically significant, highlight the importance of careful patient selection and further research. High-quality prospective studies are essential to validate these findings and refine criteria for incorporating eOPBCS into routine clinical practice.</div></div>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"79 ","pages":"Article 103869"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2025.103909
A. Kortoma, H. El Wakeel, N. Gobran, H Elghazawy
{"title":"P016: Real-World Clinical Outcomes and Toxicity in Metastatic Breast Cancer Patients Treated With first or second line CDK 4/6 Inhibitors and Endocrine Therapy in Egypt","authors":"A. Kortoma, H. El Wakeel, N. Gobran, H Elghazawy","doi":"10.1016/j.breast.2025.103909","DOIUrl":"10.1016/j.breast.2025.103909","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"80 ","pages":"Article 103909"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}