BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2025.103904
D. Alexandrou, M. Papakonstantinou, G. Kolympa, V.N Papadopoulos
{"title":"P012: 5-year vs 10-year Hormone Therapy: Comparison of Recurrence in Patients with Luminal A and Luminal B Breast Cancer","authors":"D. Alexandrou, M. Papakonstantinou, G. Kolympa, V.N Papadopoulos","doi":"10.1016/j.breast.2025.103904","DOIUrl":"10.1016/j.breast.2025.103904","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"80 ","pages":"Article 103904"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2025.103912
H. Yao, M. Yan, Z. Tong, X. Wu, Y. Yin, M.-H. Ryu, J.J. Park, T. Dai, Y. Zhao, J.H. Kim, S. Wang, Y. Zhong, M. Voskoboynik, J. Zhang, A. Kaubisch, C. Liu, Y. Chen, S.-A. Im, L. Wu, Y. Liu, E Song
{"title":"P024: Updated efficacy and safety of SHR-A1811, an anti-HER2 antibodydrug conjugate, in heavily pretreated advanced solid tumors with HER2-expression or mutations: a global, multicenter, phase 1 study","authors":"H. Yao, M. Yan, Z. Tong, X. Wu, Y. Yin, M.-H. Ryu, J.J. Park, T. Dai, Y. Zhao, J.H. Kim, S. Wang, Y. Zhong, M. Voskoboynik, J. Zhang, A. Kaubisch, C. Liu, Y. Chen, S.-A. Im, L. Wu, Y. Liu, E Song","doi":"10.1016/j.breast.2025.103912","DOIUrl":"10.1016/j.breast.2025.103912","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"80 ","pages":"Article 103912"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2025.103898
K. Hudson, W. Gathirua-Mwangi, Z.L. Cui, M. Richey, B. Grimes, J. Wang, A.M Liepa, E. Brechtelsbauer, R. Volodarsky, K. Moreira, H Soliman
{"title":"P004: Clinical Characteristics and Treatment Persistence in US Patients with HR+/HER2-, Node Positive Early Breast Cancer Treated with Abemaciclib: Real-World Study from First Year After Approval","authors":"K. Hudson, W. Gathirua-Mwangi, Z.L. Cui, M. Richey, B. Grimes, J. Wang, A.M Liepa, E. Brechtelsbauer, R. Volodarsky, K. Moreira, H Soliman","doi":"10.1016/j.breast.2025.103898","DOIUrl":"10.1016/j.breast.2025.103898","url":null,"abstract":"","PeriodicalId":9093,"journal":{"name":"Breast","volume":"80 ","pages":"Article 103898"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2024.103855
Katie Elliott , Emily Haworth , Iakov Bolnykh , R. Hamish McAllister-Williams , Alastair Greystoke , Adam Todd , Linda Sharp
{"title":"Breast cancer patients with a pre-existing mental illness are less likely to receive guideline-recommended cancer treatment: A systematic review and meta-analysis","authors":"Katie Elliott , Emily Haworth , Iakov Bolnykh , R. Hamish McAllister-Williams , Alastair Greystoke , Adam Todd , Linda Sharp","doi":"10.1016/j.breast.2024.103855","DOIUrl":"10.1016/j.breast.2024.103855","url":null,"abstract":"<div><div>Breast cancer is the most commonly diagnosed cancer worldwide, with early detection and advanced treatments contributing to declining mortality rates. However, managing comorbid conditions, particularly mental illness, presents significant challenges for cancer treatment. This study systematically reviews and meta-analyses the impact of having a pre-existing mental illness on breast cancer treatment utilisation, focusing on specific treatments and comparing different mental illnesses. MEDLINE, EMBASE, CINAHL, and APA PsycInfo databases were searched. After screening, fifteen studies were identified as meeting the inclusion criteria. The included studies were predominantly from high-income countries, and compared breast cancer treatment in patients with and without pre-existing mental illnesses including anxiety, mood disorders, schizophrenia and psychotic disorders, and neurodevelopmental disorders. Meta-analysis revealed that patients with mental illnesses were significantly less likely to receive guideline-recommended treatments (OR = 0.78, 95 % CI 0.72–0.83, N = 5), chemotherapy (OR = 0.56, 95 % CI 0.34–0.78, N = 6), or radiotherapy (OR = 0.79, 95 % CI 0.66–0.93, N = 5). They were also significantly more likely to undergo mastectomy instead of breast-conserving surgery (OR = 1.38, 95 % CI 1.24–1.52, N = 4). Findings were consistent across different mental illnesses. This review highlights the need for targeted interventions to improve healthcare access and address provider biases, promoting better integration of mental health and oncology care.</div></div>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"79 ","pages":"Article 103855"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BreastPub Date : 2025-02-01DOI: 10.1016/j.breast.2024.103857
Ji Soo Kim , Jihun Song , Seulggie Choi , Sang Min Park
{"title":"General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors","authors":"Ji Soo Kim , Jihun Song , Seulggie Choi , Sang Min Park","doi":"10.1016/j.breast.2024.103857","DOIUrl":"10.1016/j.breast.2024.103857","url":null,"abstract":"<div><h3>Background</h3><div>To assess the association between discrepancies between general obesity and abdominal obesity and the risk of subsequent cardiovascular disease (CVD), including stroke, in breast cancer survivors.</div></div><div><h3>Methods</h3><div>We undertook a retrospective cohort study using data from the National Health Insurance Service of South Korea. Among 72,174 5-year breast cancer survivors aged 40 years and above, body mass index (BMI) and waist circumference (WC) were used to determine obesity status. Cox proportional hazards models were used to evaluate the association of obesity and risk of CVD, including stroke.</div></div><div><h3>Results</h3><div>Compared to those with normal WC and BMI, those who were overweight without abdominal obesity, had abdominal obesity only, and overweight with abdominal obesity, had higher risks of CVD [aHR(95 % CI) 1.23(1.02–1.48), 1.51(1.16–1.95), and 1.55(1.31–1.75), respectively] and total stroke [1.09(0.86–1.38), 1.63(1.20–2.23), and 1.40(1.17–1.68), respectively]. Compared to those overweight, those with abdominal obesity only had a significantly higher risk of ischemic stroke [2.04(1.14–3.65)].</div></div><div><h3>Conclusions</h3><div>Breast cancer survivors with higher BMI and/or abdominal obesity were associated with an elevated risk of CVD, including stroke.</div></div>","PeriodicalId":9093,"journal":{"name":"Breast","volume":"79 ","pages":"Article 103857"},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11699294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}