Journal of lung cancer最新文献

{"title":"Recent Advances in Immunotherapy of Lung Cancer","authors":"C. Iclozan, D. Gabrilovich","doi":"10.6058/JLC.2012.11.1.1","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.1.1","url":null,"abstract":"Immunotherapy was long considered as an attractive modality in the treatment of lung cancer. However, clinical successes were hampered by the inability to achieve potent activation of the antitumor immune system and effectively overcome the immune suppressive environment associated with lung cancer. Recent advances in cancer immunotherapy demonstrate that these limitations can be surmounted. In this review, we discuss the recent advances in immunotherapy of lung cancer and their potential implication for management of this disease. (J Lung Cancer 2012;11(1):1�� 11)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.1.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Minimal Immunohistochemical Panel for Subtyping Poorly Differentiated Non-Small Cell Lung Carcinoma: A Tissue Microarray Study Simulating Small Biopsy Conditions","authors":"G. Kim, Sung‐Jig Lim, W. Kim, G. Lee","doi":"10.6058/JLC.2012.11.1.21","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.1.21","url":null,"abstract":"Purpose: Given the emerging evidence for differential responses to new targeted therapies and the identification of molecular differences between specific subtypes of non-small cell lung carcinoma (NSCLC), there is an increased need for greater accuracy in subtyping NSCLC. In a substantial proportion of cases, standard morphology cannot specifically subtype the tumor, resulting in a final diagnosis of NSCLC-not otherwise specified. In this study, we added newly proposed markers (napsin A, desmocollin-3) to conventional markers (p63, thyroid transcription factor-1 [TTF-1], cytokeratin 5/6 [CK5/6], high molecular weight cytokeratin [HMWCK], cytokeratin 7 [CK7]) and evaluated for the minimal panel of immunohistochemical markers required for subtyping poorly differentiated (PD) NSCLC. Materials and Methods: Resection specimens of 110 adenocarcinomas (ADCs) and 171 squamous cell carcinomas (SCCs) were collected and tissue microarrays were constructed to simulate small biopsy conditions. All specimens were stained with TTF-1, napsin A, CK7, p63, CK5/6, HMWCK, desmocollin-3 and mucicarmine. Results: For 32 PD ADC, a combination of TTF-1 and napsin A increased sensitivity (81%). With regard to the 29 PD SCC, a combination of desmocollin-3 and p63 did not substantially increase diagnostic performance. Logistic regression analysis identified napsin A, p63 and TTF-1 as the optimal panel to separate PD ADC and PD SCC. Mucin stains for PD NSCLC increased accuracy rate (88%) for diagnosis of PD ADC. Conclusion: We recommend a minimal panel of immunohistochemical and histochemical markers to include TTF-1, p63, napsin A and one of mucin stains for tumor subtyping of PD NSCLC in a small biopsy sample. (J Lung Cancer 2012;11(1):21󰠏 32)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.1.21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Pathogenesis of Non-Small Cell Lung Carcinomas.","authors":"I. Wistuba","doi":"10.6058/JLC.2012.11.1.12","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.1.12","url":null,"abstract":"Non-small cell lung carcinoma (NSCLC) from histological and biological perspectives is a complex neoplasm. The sequential preneoplastic changes have been defined for centrally arising squamous cell carcinomas (SCCs) of the lung, and they are less documented for peripherally arising adenocarcinomas. The main morphologic forms of preneoplastic lesions recognized in the lung are squamous dysplasias for SCC, and atypical adenomatous hyperplasia for adenocarcinoma. Several studies have provided information regarding the molecular characterization of lung preneoplastic changes, especially for SCC. These molecular changes have been detected in the histologically normal and abnormal respiratory epithelium of smokers and patients with lung cancer, phenomenon known as field of cancerization. Our improved understanding of the changes and origins of the field of cancerization can be applied clinically to improve early detection of lung cancer. In the last decade, significant progress has been made in the characterization of molecular abnormalities in NSCLC tumors that are being used as molecular targets and predictive biomarkers for patients’ selection for targeted therapy. As our understanding of the biology of the molecular pathogenesis of lung cancer evolves, there is an opportunity to use this knowledge for the development of novel chemoprevention strategies using those molecularly targeted agents used to treat advanced lung cancer, a concept coined as reverse migration. The rapid development of technologies for large-scale molecular analysis, includeing microarrays and next-generation sequencing will facilitate high-throughput molecular analysis of lung cancer preneoplastic lesions and the field of cancerization.","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.1.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multilocular Thymic Cyst with Prominent Lymphoid Follicular Hyperplasia: A Case Report","authors":"N. Yoon, J. Jeong, Joungho Han, Jhingook Kim, C. Yi","doi":"10.6058/JLC.2012.11.1.45","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.1.45","url":null,"abstract":"We present herein an unusual case of multilocular thymic cyst, with prominent lymphoid follicular hyperplasia, in a 64-year-old man. It was incidentally founded as a mediastinal mass on chest radiography, during a routine health check-up. Computed tomography revealed a cystic lesion, which contains thick septa involving the thymus. The resected mass, 8×4 cm in diameter, involved the thymus and there is no adhesion or invasion into the adjacent tissue. The cut surface showed cystic spaces with thick white-tan firm wall, which cysts contained gelatinous material. Microscopically, the lesion was characterized by multiple cysts, lined by flattened cuboidal epithelium that was separated by thick walls, having a dense lymphoid tissue with lymphoid follicles. The patient was discharged without any complication and is well without evidence of recurrence for sixteen months. (J Lung Cancer","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"45-47"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.1.45","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Transforming Growth Factor β1 and Cadherins in Lung Adenocarcinoma","authors":"S. Park, Jinyoung Yoo","doi":"10.6058/JLC.2012.11.1.38","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.1.38","url":null,"abstract":"Purpose: There is evidence supporting the concept of tumor progression from pulmonary adenocarcinoma in situ (formerly bronchioloalveolar carcinoma, BAC) to adenocarcinoma with varying degrees of invasion. The aim of this study was to investigate the role of transforming growth factor β1 (TGFβ1) in tumor invasiveness in lung adenocarcinoma, and to determine the potential relationships between its expression and immunophenotypes of cell adhesion molecules. Materials and Methods: Tumor samples from adenocarcinoma in situ (n=13), minimally invasive adenocarcinoma (formerly BAC with ≤5 mm invasion, n=2), and lepidic predominant invasive adenocarcinoma (formerly mixed adenocarcinoma showing non-mucinous BAC features with >5 mm invasion, n=25) were examined for the expression of TGF β1, E-cadherin, N-cadherin, and H-cadherin proteins using immunohistochemistry. Results: Of a total of 40 cases, 25 (63%) were positive for TGFβ1. The frequency of immunoreactivity in patients with adenocarcinoma in situ, minimally invasive adenocarcinoma, and lepidic predominant invasive adenocarcinoma was 23% (3/13), 50% (1/2), and 84% (21/25), respectively (p=0.001). TGF β1 correlated with T classification (p=0.006) and stage (p=0.001). Loss of E-cadherin expression was more frequently observed in invasive adenocarcinomas than in adenocarcinomas in situ (p=0.034). E-cadherin expression inversely correlated with T classification (p=0.009). TGFβ1 expression showed a statistically significant correlation with H-cadherin expression (p=0.040), but not with E-cadherin expression (p=0.752). Conclusion: These results suggest that TGFβ1 and E-cadherin may play an important role in invasive progression of lung adenocarcinoma through regulating epithelial-to-mesenchymal transition. (J Lung Cancer 2012;11(1):38�� 44)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"38-44"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.1.38","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Cyclin A, B1, D1, D3, and E in Non-Small Lung Cancers","authors":"S. Ha, H. Kim, J. Im, H. Cho, D. Chung, Jungsuk An","doi":"10.6058/JLC.2012.11.1.33","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.1.33","url":null,"abstract":"Purpose: Cyclins, and their associated cyclin dependent kinases, regulate progression of the cell cycle through the G1 phase and into the S-phase during the DNA replication process. Cyclin E regulation is an important event in cell proliferation. Despite its importance, abnormalities of these genes and their protein products have yet to be found in lits asoociation with lung cancer. Materials and Methods: The relationships between expression of cyclin A, cyclin B1, cyclin D1, cyclin D3, and cyclin E and clinicopathologic factors were investigated in 103 cases with non-small cell carcinomas, using immunohistochemical analysis. Results: The positive immunoreactivity was observed in 51 cases (50%) for cyclin A, 33 cases (32%) for cyclin B1, 83 cases (81%) for cyclin D1, 19 cases (18%) for cyclin D3, and 11 cases (11%) for cyclin E. Expression of cyclin E was significant for lymph node metastasis (p=0.004, Chi-square test). There was no relationship between cyclin A, B1, D1, and E and histological typing, tumor size, lymph node metastasis, or pathological tumor, node and metastasis staging. Conclusion: These findings suggest that the expression of cyclin E played a role, to some degree, in the lymph node metastasis. (J Lung Cancer 2012;11(1):33�� 37)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.1.33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inconclusive Result from CT Guided Transthoracic Needle Aspiration and Biopsy: Affecting Factors and Final Outcome","authors":"Y. Lee, Y. Hwang, Tae Jeong Kim, H. Yoon, K. Lee, C. Lee, Jae Ho Lee","doi":"10.6058/JLC.2011.10.2.94","DOIUrl":"https://doi.org/10.6058/JLC.2011.10.2.94","url":null,"abstract":"Purpose: Inconclusive results from computed tomography (CT)-guided transthoracic needle aspiration and biopsy (TNAB) performed for lung lesions presents a clinical dilemma. The purpose of this study was to determine the factors affecting an inconclusive result from a CT guided TNAB, and to evaluate the final outcomes of these inconclusive results. Materials and Methods: The medical records and radiologic features of 331 patients with lung lesion who received CT guided TNAB were analyzed retrospectively. The results of the TNAB were classified as conclusive (malignancy or specific benign diagnosis) or inconclusive (nonspecific benign or nondiagnostic). Results: Of the 331 cases, 269 (81.3% ) were diagnosed as a m alignancy (210) or a specific benign lesion (59) after the first TNAB. The remaining 62 (18.7%) were inconclusive. Benign disease, a lesion size ≤15 mm, and morphology of the consolidation type were features significantly correlated with inconclusive results. Of these 62 inconclusive cases a second TNAB was performed in 23, and conclusive diagnoses were obtained in 19 (82.6%). Surgery or radiographic follow up was done in other cases. Finally, among the 62 inconclusive results on the first CT guided TNAB, 16 lesions were diagnosed as malignant, 26 were classified as specific benign disease, and the remaining 20 were defined as nonspecific inflammation. Age over 50 and morphology of a nodule or a mass type were significantly correlated with a m alignancy in these 62 cases with inconclusive results on the first TNAB. Conclusion: A final diagnosis of benign disease was significantly higher after the CT guided TNAB was inconclusive for lesions ≤15 mm that had consolidation type morphology. Despite the application of core biopsy procedures, there continue to be appreciable numbers of inconclusive results after the first CT guided TNAB. A repeat CT guided TNAB had a high diagnostic yield in these cases and therefore should be considered for cases with inconclusive results.","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"10 1","pages":"94-101"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2011.10.2.94","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Array-based Comparative Genomic Hybridization and Its Application to Cancer Genomes and Human Genetics","authors":"E. Cho","doi":"10.6058/JLC.2011.10.2.77","DOIUrl":"https://doi.org/10.6058/JLC.2011.10.2.77","url":null,"abstract":"Microarray comparative genomic hybridization (CGH) has proven to be a specific, sensitive, and rapid technique, with considerable advantages com pared to other m ethods used for analysis of DNA copy number changes. Array C GH allows for the mapping of genomic copy number alterations at the sub-microspecifi c level, thereby directly linking disease phenotypes to gene dosage alterations. The whole human genome can be scanned for deletions and duplications at over 30,000 loci simultaneously by array CGH ( ∼40 kb resolution). Array CGH can be used for analysis of DNA copy number aberrations that cause not only cancer and human genetic disease, but also normal human variation. This review gives the various array CGH platforms and their applications in cancer and human genetics. (J Lung Cancer 2011;10(2):77 �� 86)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"10 1","pages":"77-86"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2011.10.2.77","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic Implications of ALK Gene Copy Number Gain in Non-small Cell Lung Cancer.","authors":"S. Yoo, Hyojin Kim, Xianhua Xu, P. Sun, Yan-Ze Jin, J. Paik, S. Jheon, C. Lee, Jin-Haeng Chung","doi":"10.6058/JLC.2011.10.2.87","DOIUrl":"https://doi.org/10.6058/JLC.2011.10.2.87","url":null,"abstract":"Purpose: The anaplastic lymphoma kinase (ALK) gene is a potential m olecular target in non-small cell lung carcinoma (NSCLC). The clinicopathologic implication of a change in the ALK gene copy number (GCN) is unclear. Materials and Methods: A total of 434 primary NSCLC samples were analyzed by fluorescence in situ hybridization (FISH) for ALK GCN. Results: Ninety-six cases (22.1%) showed ALK GCN gain with amplification in 16 (3.7%) cases. The cases with ALK GCN gain consisted of 47 adenocarcinomas (49.0%), 41 squamous cell carcinomas (42.7%), 5 adenosquamous carcinomas (5.2%) and 3 other NSCLCs (3.1%). ALK gene am plification was identified in 7 adenocarcinom as (43.7%) and 9 squamous cell carcinomas (56.3%). There was no significant difference between ALK GCN gain/amplificati on and histologic subtypes. Univariate survival analysis revealed that patients with ALK GCN gain/amplificati on showed shorter progression-free survival durations and decreased overall survival rates (p ＜0.001). However, multivariate analysis proved that ALK GCN gain/ampl ification is not an independent prognostic factor for progression-free survival or overall survival. Conclusion: ALK GCN gain is frequently identified in NSCLCs and the incidence is similar among histologic subtypes. Although ALK G CN gain/ampl ification is not an independent prognostic m arker, it is associated with tumor progression in NSCLC. (J Lung Cancer 2011;10(2):87 �� 93)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"10 1","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2011.10.2.87","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal Broncho-Mediastinal Fistula in a Patient with Non-Small Cell Lung Cancer after Photodynamic Therapy.","authors":"E. Heo, Y. J. Kim, S. Yang","doi":"10.6058/JLC.2011.10.2.102","DOIUrl":"https://doi.org/10.6058/JLC.2011.10.2.102","url":null,"abstract":"Photodynamic therapy (PDT) can be used as palliative therapy to reduce obstructive sym ptoms in patients with advanced lung cancer. Herein, we report on the case of a patient w ith fatal broncho-m ediastinal fistula after PDT . A 57-year-old woman was diagnosed as no n-smal l cell lung cancer (squamous cell carcinoma, cT4N3). She received PDT on the endobronchial mass obstructing her right main bronchus twice in 48 hours interval. Two weeks later, concurrent chemoradiation therapy (CCRT) with weekly Paclitaxel/Carbo platin was started. During maintenance chemotherapy, a new nodule in her scalp developed and turned out to be a metastatic nodule. A broncho-medias tinal fistula was suspicious on follow-up chest computed tomography and a broncoscopy revealed an extensively damaged medial right main bronchial wall. On the day following bronchoscopy, the patient died of sudden massive hemoptysis.","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"10 1","pages":"102-104"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2011.10.2.102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71161917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}