Journal of lung cancer最新文献_第3页

Comparison of ThinPrep Cytology and Conventional Cytology in Bronchial Washing for Lung Cancer. 肺癌支气管冲洗的薄prep细胞学与常规细胞学比较。

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.84

Jungsuk An, H. Cho, D. Chung, S. Ha

{"title":"Comparison of ThinPrep Cytology and Conventional Cytology in Bronchial Washing for Lung Cancer.","authors":"Jungsuk An, H. Cho, D. Chung, S. Ha","doi":"10.6058/JLC.2012.11.2.84","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.2.84","url":null,"abstract":"Purpose: Liquid-based cytology have been developed and currently used to overcome the limitation of conventional cytology. This study aims to evaluate the differences between conventional cytology and ThinPrepⓇ in the bronchial washing. Materials and Methods: Both conventional cytology and ThinPrep Ⓡ were performed in the 2,551 cases of bronchial washing, of which, 116 cases of histologically diagnosed as lung cancer were evaluated. Results: Among the 116 cases, 23 and 4 cases were negative in conventional cytology and ThinPrepⓇ , respectively. The thirty eight cases in conventional cytology and 30 cases in ThinPrep Ⓡ were diagnosed as “atypical.” Malignant carcinoma was 54 cases and 82 cases in conventional cytology and ThinPrep Ⓡ , respectively. The positive predictive value, negative predictive value, sensitivity and specificity were 98.94%, 99.06%, 80.17%, and 99.96%, respectively in conventional cytology. Those were 99.12%, 99.83%, 96.55% and 99.96%, respectively in ThinPrepⓇ . Conclusion: ThinPrep Ⓡ (liquid-based cytology) revealed higher sensitivity and lower false negative rate than conventional cytology. ThinPrepⓇ has many advantages to diagnose the lung cancer from bronchial washing cytology. (J Lung Cancer 2012;11(2):84�� 88)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"84-88"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.2.84","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71162125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary Capillary Hemangioma of the Lung: A Report of Two Cases 孤立性肺毛细血管瘤附2例报告

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.102

H. Lee, Soomin Ahn, Y. Shim, Y. Choi, K. Lee, Joungho Han

引用次数: 8

Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Inhibitors and Overcoming Strategies in Lung Cancer. 肺癌对表皮生长因子受体抑制剂获得性耐药机制及克服策略

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.59

Chang-Min Choi, Jae Cheol Lee

{"title":"Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Inhibitors and Overcoming Strategies in Lung Cancer.","authors":"Chang-Min Choi, Jae Cheol Lee","doi":"10.6058/JLC.2012.11.2.59","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.2.59","url":null,"abstract":"Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFRTKIs) such as gefitinib and erlotinib show good response and survival benefit in EGFR-mutant lung cancer, acquired resistance inevitably develops which limits the median response duration to around 1 year. Secondary T790M gatekeeper mutation is the most common mechanism representing approximately 50% of resistance. The suggested strategies for overcoming T790M including irreversible EGFR-TKIs, mutant-selective EGFR-TKIs, EGFR dual targeting and HSP90 inhibitors should be further investigated for clinical application. Bypass signals through MET or AXL also contribute to resistance, which lead to development of MET or AXL inhibitors. Other mechanisms such as small cell transformation, epithelial-to-mesenchymal transition, PI3KCA mutation, ERK/ HER2 amplification and miRNAs are other suggested candidates awaiting validation. As many resistant mechanisms have been recognized, it is important to obtain tissue samples after resistance to provide appropriate treatment. In this review, recent advances in the understanding of resistance and novel ways of overcoming it are discussed. (J Lung Cancer 2012;11(2):59�� 65)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.2.59","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71162212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Mixed Squamous Cell and Glandular Papilloma Presented with Peripheral Lung Mass: A Case Report. 混合性鳞状细胞和腺状乳头状瘤伴周围性肺肿块1例。

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.94

S. Jang, Taesung Kim, J. Zo, Joungho Han

引用次数: 2

A Case of Lung Squamous Cell Carcinoma Mimicking Benign Solitary Cyst 肺鳞状细胞癌模拟良性孤立囊肿1例

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.108

Ji Young Park, Taehoon Lee, Hongyeul Lee, Hyo‐Jeong Lim, Jong-Sun Park, Y. Cho, H. Yoon, Jae Ho Lee, K. Lee, Bo-Seong Kim, Jin-Haeng Chung, Kwhanmien Kim, C. Lee

引用次数: 1

Never-Smoker Lung Cancer Is Increasing 从不吸烟的肺癌正在增加

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.89

Hyun-Wook Kang, Chanwoo Park, W. Kim, Sang‐Yun Song, K. Na, J. Jeong, M. Yoon, S. Ahn, Y. Choi, Chan Choi, Daun Lee, H. Seon, Y. Kim, S. Kwon, H. Bom, I. Oh, K. S. Kim, Young-chul Kim

{"title":"Never-Smoker Lung Cancer Is Increasing","authors":"Hyun-Wook Kang, Chanwoo Park, W. Kim, Sang‐Yun Song, K. Na, J. Jeong, M. Yoon, S. Ahn, Y. Choi, Chan Choi, Daun Lee, H. Seon, Y. Kim, S. Kwon, H. Bom, I. Oh, K. S. Kim, Young-chul Kim","doi":"10.6058/JLC.2012.11.2.89","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.2.89","url":null,"abstract":"Purpose: Lung cancer has been the leading cause of death in South Korea since the year 2000. Adenocarcinoma became the most frequent type in the national survey of lung cancer since year 2005. Materials and Methods: We analyzed 5,456 cases with lung cancer from 2004 to 2012 in a community cancer center. The mean age was 69.9 years, and 78.9% was male. Results: Adenocarcinoma (ADC, 40.8%) was the most frequent type, followed by squamous cell carcinoma (SQC, 36.4%), small cell carcinoma (SCC, 14.8%) and non-small cell lung cancer (NSCLC) not otherwise specified (8.1%). In male patients, SQC was the most frequent type (43.5%), while ADC showed highest incidence in females (72.6%). Anatomic stage at diagnosis in NSCLC was I (10.3%), II (5.8%), IIIA (15.7%), IIIB (19.2%), and IV (49.0%). In SCC, 41.7% was in limited stage and 58.3% was diagnosed in extensive stage. The proportion of never smoker has been increased from 19.1% in 2004 ∼2008 to 25.4% in 2009∼2012. Never-smokers are more likely to be female (68.2% vs. 4.0%, p<0.001), have ADC (69.9% vs. 31.3%, p<0.001), and manifest as stage IV disease (58.5% vs. 45.2%, p<0.001), compared to smokers. Among 1,908 cases whose initial treatment was recorded, 42.5% received chemotherapy, 25.7% received radiation treatment, 20.5% received surgery and the remaining 11.3% received supportive cares only or transferred to other health care facilities. Conclusion: In conclusion, proportion of lung cancer in never-smoker is increasing. As screening for smokers will miss this growing population, we need to discover biomarkers to find high risk population of lung cancer. (J Lung Cancer 2012;11(2):89�� 93)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"18 1","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.2.89","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71162201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and the Survival of Non-Small Cell Lung Cancer 全基因组关联研究发现的肺癌易感性变异与非小细胞肺癌生存之间的关系

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.66

M. Hong, Y. Choi, S. K. Do, H. Jeon, S. Yoo, W. Lee, Shin‐Yup Lee, Jaehee Lee, S. Cha, C. Kim, E. Lee, J. Park

{"title":"Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and the Survival of Non-Small Cell Lung Cancer","authors":"M. Hong, Y. Choi, S. K. Do, H. Jeon, S. Yoo, W. Lee, Shin‐Yup Lee, Jaehee Lee, S. Cha, C. Kim, E. Lee, J. Park","doi":"10.6058/JLC.2012.11.2.66","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.2.66","url":null,"abstract":"Purpose: Nowadays, chromosomal regions containing genes associated with the risk of lung cancer are identified by a number of genome-wide association studies (GWASs). As part of the study, GWAS has identified the association of six chromosomal regions, 1q23, 4q22, 4q31, 5p15, 6p21, and 15q25, as being associated with lung cancer risk in the European population. We investigated the impact of genetic variants identified in GWASs for lung cancer susceptibility on the survival outcomes in patients with early stage non-small cell lung cancer (NSCLC). Materials and Methods: Three hundred and sixty-three patients with surgically resected NSCLC were enrolled. Eight single nucleotide polymorphisms (SNPs), rs2808630 on 1q23, rs7671167 on 4q22, rs1489759 and rs2202507 on 4q31, rs2736100 and rs402710 on 5p15, rs1052486 on 6p21 and rs16969968 on 15q25, were genotyped using a polymerase chain reaction-restriction fragment length polymorphism assay. The associations between genotypes and overall survival (OS) and disease-free survival (DFS) were analyzed. Results: None of the eight SNPs were significantly associated with OS or DFS. In addition, when the patients were categorized according to age, gender, smoking status, tumor histology and pathologic stage, there were no significant associations between the eight SNPs and the survival outcomes. Conclusion: These results suggest that the genetic variants identified by GWASs for lung cancer susceptibility may not affect the prognosis of early stage NSCLC. (J Lung Cancer 2012;11(2):66�� 70)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"122 1","pages":"66-70"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.2.66","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71162488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

MDA-7/IL-24 Expression and Its Relation with Clinicopathologic Factors in Lung Adenocarcinomas of 3 cm or Less in Diameter. MDA-7/IL-24在直径小于等于3cm的肺腺癌中的表达及其与临床病理因素的关系

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.71

M. Roh, P. Choi, C. Son, Soo Keol Lee

{"title":"MDA-7/IL-24 Expression and Its Relation with Clinicopathologic Factors in Lung Adenocarcinomas of 3 cm or Less in Diameter.","authors":"M. Roh, P. Choi, C. Son, Soo Keol Lee","doi":"10.6058/JLC.2012.11.2.71","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.2.71","url":null,"abstract":"Purpose: The melanoma differentiation-associated gene-7 (MDA-7) protein, also known as interleukin 24 (IL-24), is a novel candidate of tumor suppressor that has been found to experimentally induce apoptosis and growth inhibition in a variety of human malignant cells. However, there have been few studies about its role in lung adenocarcinoma. Even at the same stage and with similar pathologic characteristics, lung adenocarcinomas with a diameter of 3 cm or less can have a variable prognosis depending on their biologic characteristics. The purpose of this study is to define the relationship between MDA-7/IL-24 expression and the progression of small-sized lung adenocarcinomas. Materials and Methods: We performed immunohistochemical detection of MDA-7/ IL-24 in forty-seven tissue samples from primary lung adenocarcinomas of ≤3 cm in diameter by using tissue microarray. Results: MDA-7/IL-24 immunoreactivity was observed in 20 (42.6%) of the 47 adenocarcinoma cases. MDA-7/IL-24 expression was positive in 66.7% of the adenocarcinomas ≤2 cm, and in 31.3% of the adenocarcinomas ＞2 cm or ≤3 cm in diameter. A statistically significant association was found between MDA-7/IL-24 expression and tumor size (p=0.03). Although this difference did not reach statistical significance, tumors with a negative MDA-7/IL-24 expression tended to more frequently show lymph node metastasis (p=0.07). There were no significant associations for other clinicopathologic characteristics. Conclusion: These results suggest the possible involvement of MDA-7/IL-24 in the growth and progression of small-sized lung adenocarcinoma. MDA-7/IL-24 immunoreactivity could be used to identify a subset of adenocarcinomas of the lung of 3 cm or less in diameter that have different biologic behavior. (J Lung Cancer 2012;11(2): 71�� 76)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.2.71","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71162433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bilateral Diffuse Radiation Pneumonitis Caused by Unilateral Thoracic Irradiation: A Case Report 单侧胸部照射致双侧弥漫性放射性肺炎1例

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.97

S. H. Song, Y. Oh, C. Ha, Soo-Min Chae

引用次数: 2

Screening of Epidermal Growth Factor Receptor Gene Mutation in Non-Small Cell Lung Cancer Using a PCR-Based Enzymatic Digestion Method 基于pcr的酶切法筛选非小细胞肺癌表皮生长因子受体基因突变

Journal of lung cancer Pub Date : 2012-12-01 DOI: 10.6058/JLC.2012.11.2.77

Y. Jung, Sun Jung Park, S. Lee, Y. T. Kim, JooYeon Park, I. Park, C. Kang, Joo Hyun Kim

{"title":"Screening of Epidermal Growth Factor Receptor Gene Mutation in Non-Small Cell Lung Cancer Using a PCR-Based Enzymatic Digestion Method","authors":"Y. Jung, Sun Jung Park, S. Lee, Y. T. Kim, JooYeon Park, I. Park, C. Kang, Joo Hyun Kim","doi":"10.6058/JLC.2012.11.2.77","DOIUrl":"https://doi.org/10.6058/JLC.2012.11.2.77","url":null,"abstract":"Purpose: We applied a simplified method using polymerase chain reaction (PCR)-based enzymatic digestion for the detection of epidermal growth factor receptor ( EGFR) mutation. Materials and Methods: We selected 74 samples of adenocarcinoma of the lung with EGFR exons 19 and 21 that had been previously sequenced. We designed PCR primers and chose a DNA restriction enzyme. Seventy four additional lung cancer samples were tested as a test set. For test sets, the PCR-based method was performed first, followed by validation of the result by DNA sequencing. Results: In the first sample group, we found 15 (20.3%) mutations in exon 19, and 9 (12.2%) mutations in exon 21 using the sequencing method. By using the PCR-based method, we were able to identify all of the mutated samples detected by the sequencing method. The PCR-based method also detected mutations in exon 19 in three additional samples and in exon 21 in one additional sample. In the second sample group, by performing the PCR-based method, we found 10 (13.5%) and 7 (9.5%) mutations in exons 19 and 21, respectively. Additional mutations in exon 19 were identified in 2 samples by the sequencing method. However, the sequencing method failed to identify a mutation in exon 21 in one sample. Conclusion: The sensitivity of the PCR-based enzymatic digestion method seems to be comparable to that of the traditional sequencing method for detecting EGFR mutations. Our method can be widely used as a screening test to select patients who may benefit from EGFR targeted therapy. (J Lung Cancer 2012;11(2):77�� 83)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"11 1","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2012.11.2.77","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71162061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0