Journal of aging science最新文献_第5页

Drug-Induced Nutrient Deficiencies Among Older Adults 老年人药物引起的营养缺乏

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329-8847.20.08.235

E. Kose, N. Yasuno

引用次数: 0

Aging Science: New Stage of Growing Old 衰老科学:衰老的新阶段

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329-8847.20.8.E225

Rajajeyakumar Manivel

引用次数: 0

Aging: Ongoing Process of Life 衰老:生命的持续过程

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329

Rajajeyakumar Manivel

引用次数: 0

Exploring the Views of Care Staff and of the Members of a Local Open Care Centre About Quality of Life (QoL) and Active Healthy Ageing 探讨护理人员及本地开放护理中心成员对生活质素及积极健康乐颐年的看法

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329-8847.20.08.227

E. Evangelou

引用次数: 1

Schizoaffective Disorder: A Challenge 精神分裂情感障碍:一个挑战

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329-8847.20.08.221

Ueberberg Bianca, Assion Hans-Joerg

引用次数: 2

Malnutrition is Associated with Cognitive Function, Tiredness and Sleep Quality in Elderly Living Nursing Home 老年人营养不良与认知功能、疲劳和睡眠质量的关系

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329-8847.20.08.233

Mehdi Kushkestani, Mohsen Parvani, Ki, okhtMoradi, M. Moghadassi

{"title":"Malnutrition is Associated with Cognitive Function, Tiredness and Sleep Quality in Elderly Living Nursing Home","authors":"Mehdi Kushkestani, Mohsen Parvani, Ki, okhtMoradi, M. Moghadassi","doi":"10.35248/2329-8847.20.08.233","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.233","url":null,"abstract":"Background: The last studies have shown that aging is associated with an increase in the risk of malnutrition and related complications. The aim of this study was to investigate the relationship between malnutrition and cognitive function, tiredness and sleep quality in the elderly living in nursing home. Methods: The subjects of this study were 119 elderly people over the age of 65 living in nursing homes in Tehran. The demographic characteristics of the subjects were collected and recorded. Then, body composition and anthropometric indices including weight, body mass index [BMI], height and calf circumferences [CC], waist circumferences [WC] and hip circumferences were measured using a digital scale of OMRON and meter tape. nutritional status, cognitive function, sleep quality and level of tiredness were measured by Mini Nutritional Status, Mini-Mental State Examination, Pittsburgh Sleep Quality Index and FACIT-Fatigue scale, respectively. Results: The results of statistical analysis of the data showed a positive relationship between malnutrition with dementia [p<0.024],fatigue [p<0.000] and sleep quality [p<0.008]. Conclusion: Taken together, the use of strategies to improve the nutritional status of the elderly in nursing homes can play an important role in preventing the symptoms of geriatric syndrome and increasing the level of health in the elderly.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70003603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

TGF-Beta Signaling Pathways in the Study of Expression in Patients with Atrial Fibrillation Atrial Tissue tgf - β信号通路在房颤患者心房组织中的表达研究

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329-8847.20.08.228

Zhiliang Huang, Yu Gao, Dianchen Hua

{"title":"TGF-Beta Signaling Pathways in the Study of Expression in Patients with Atrial Fibrillation Atrial Tissue","authors":"Zhiliang Huang, Yu Gao, Dianchen Hua","doi":"10.35248/2329-8847.20.08.228","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.228","url":null,"abstract":"Objective: To explore the relationship between TGF-beta signaling pathway and atrial fibrillation in patients with mitral valve disease, and reveal the mechanism of TGF-beta signaling pathway in development of atrial fibrillation. Methods: Firstly, the fibrosis extent of right atrial appendage tissues were tested by Masson’s trichrome staining. Secondly, the protein expression of TGF-beta1, TGF-beta RI, RII, RIII, P-Smad2/3, Smad2/3, Smad4, Smad7, TAK1, p38, ATF-2 were tested by Western blot. Results: There were significant difference between atrial fibrillation group and control group in fibrosis extent and the diameter of left atria (p0.05). The patients with atrial fibrillation are associated with the more serious fibrosis and larger diameter of left atria. For further study, the Western bolt results reveal that protein expression of TGF-beta1 and Smad4 were significant higher in atrial fibrillation and sever fibrosis group, other factors were no difference between trial and control group. Conclusion: There are severing atrial fibrosis in atrial fibrillation patients with mitral valve diseases. The over expression of TGF-beta1 and Smad4 maybe is an important reason that induces atrial fibrosis in atrial fibrillation, and the atrial fibrosis appears to play a role in the development of atrial fibrillation. Fibrosis response by TGF-beta1 initiating maybe only depends on mutations of the TGF-beta Smad signaling pathway.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"42 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70002796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age Related Physiological and Psychological Behavior 与年龄相关的生理和心理行为

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329-8847.20.08.231

I. Sindhuja

引用次数: 0

Psychosomatic Health in Elderly People for Preventing Frailty: The role of IGF-1 and BDNF in the Muscle and the Brain 老年人身心健康预防衰弱:IGF-1和BDNF在肌肉和大脑中的作用

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329-8847.20.08.223

M. Hachisu, M. Obayashi, M. Kogo, K. Ihara

{"title":"Psychosomatic Health in Elderly People for Preventing Frailty: The role of IGF-1 and BDNF in the Muscle and the Brain","authors":"M. Hachisu, M. Obayashi, M. Kogo, K. Ihara","doi":"10.35248/2329-8847.20.08.223","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.223","url":null,"abstract":"The elderly population of people aged > 65 years is rapidly growing up in developed countries, including Japan, and becoming a burden by increasing caregiving and social security costs. Prolonging a healthy life span without caregiver help would reduce the social burden. Frailty in elderly people can cause accidental falls causing them to be bed ridden, but constant exercise could help prevent such accidents. Various exercises enhance the synthesis and release of neurotrophic factors such as IGF-1 and BDNF; these neurotrophic factors enhance neuronal growth and survival in the brain prevent muscle atrophy and sometimes contribute to muscle hypertrophy in elderly people. These exercise-induced neurotrophic factors can thereby help prevent the lowering of cognitive performance, processing speed and mood in elderly people including those with Alzheimer’s disease or Parkinson’s disease. In this review, we emphasize that IGF-1 and BDNF work as anabolic growth factors for skeletal muscle, play a role in the neurogenesis, synaptogenesis, and neuronal survival in the brain, ameliorate cognition, and stabilize psychiatric mood. IGF-1, further, has activities in the elimination of amyloid-β protein by activating protein transportation at the choroid plexus and angiogenesis acting on brain vessels. Thus, elderly people are recommended to exercise regularly for their health and avoid the condition of frailty.","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70002846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antidepressant Treatment for Depression in Alzheimerandrsquo;s Dementia: Systematic Review Article 抗抑郁药治疗阿尔茨海默氏痴呆患者的抑郁:系统综述文章

Journal of aging science Pub Date : 2020-01-01 DOI: 10.35248/2329-8847.20.08.229

Andrei Buciuta, Vinasi Rc, H. Coman

{"title":"Antidepressant Treatment for Depression in Alzheimerandrsquo;s Dementia: Systematic Review Article","authors":"Andrei Buciuta, Vinasi Rc, H. Coman","doi":"10.35248/2329-8847.20.08.229","DOIUrl":"https://doi.org/10.35248/2329-8847.20.08.229","url":null,"abstract":"Introduction: Alzheimer's Dementia (AD) is a neurodegenerative disease characterized by progressive cognitive decline. Neuropsychiatric symptoms (NPS) are frequently described in AD. Among the non-cognitive symptoms that can occur in AD, depression is the most common one. Objective: The aim was to review published studies in order to examine the efficacy and safety of antidepressant medication for depression in AD. Methods: An electronic database search was performed using the keywords: ” antidepressant ” , “ randomized controlled trial (RCT)”, “depression”, “dementia”, ”Alzheimer’s disease”. For the evaluation of efficacy, the reduction of scores on the evaluation scales of depression and the rate of response or remission were used and for the safety evaluation the rate of dropout and the rate of adverse effects were considered. The effect of antidepressant therapy on cognitive performances was also tracked. Results: According to inclusion criteria, 14 RCT studies that aimed at assessing the efficacy and safety of an antidepressant in the treatment of AD associated depression have been selected, as well as 6 additional studies that use two or more antidepressants. The results show a debatable efficacy of these treatments. Among the included antidepressants, selective serotonin reuptake inhibitors (SSRIs) have proven to be most tolerated and without negative effects on cognition. Conclusions: The available evidence does not provide sufficient support to uphold the efficacy and safety of antidepressant in the treatment of AD associated depression","PeriodicalId":90884,"journal":{"name":"Journal of aging science","volume":"8 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70002950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0