American journal of pharmacological sciences最新文献

{"title":"Knowledge, Attitude, Self-care Practice and Health-related Quality of Life (HRQoL) among Heart Failure Patients in a Malaysian Tertiary Hospital","authors":"S. A. Hisham, R. Hashim, A. Mohamed, Y. Hoo","doi":"10.12691/ajps-7-1-4","DOIUrl":"https://doi.org/10.12691/ajps-7-1-4","url":null,"abstract":"Heart failure (HF) has been associated with poor morbidity and survival despite advancement in its medical therapy. Poor knowledge, self-care practice and adherence to therapies which lead to poor disease outcomes have been previously reported. However, knowledge, attitude, self-care practice and HRQoL of Malaysian HF population have yet been described. This baseline information is crucial in designing educational programs aimed at improving adherence to therapies hence optimizing clinical outcomes. This single-centred, cross-sectional study utilizing self-administered, validated questionnaire involving 125 randomly selected HF patients found that most study subjects have moderate knowledge, attitude and self-care practice with good HRQoL. Weak and inverse correlations were found between age and knowledge and attitude scores. Subjects with NYHA Class I had significantly poorer knowledge level compared to those in other classes and female subjects had significantly better attitude compared to male subjects. Knowledge score was also found to be weakly but significantly correlated to attitude and self-care practice scores suggesting that improving knowledge among these patients can improve attitude and self-care practice. This study supports the need for continuous and individualized educational programs to improve knowledge hence attitude and self-care practice among these patients.","PeriodicalId":90784,"journal":{"name":"American journal of pharmacological sciences","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83571856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of the Kinetic Parameters of the Inhibition of Tyrosinase by an Extract of S. Mombin (Root Bark) and the Investigation of Likely Interactions of Composite Phytochemicals Using Molecular Docking Calculations","authors":"Oyasowo O., Fadare O.A., Olawuni J.I., A. M.M., Kolawole A.O., Obuotor E.M.","doi":"10.12691/ajps-6-1-3","DOIUrl":"https://doi.org/10.12691/ajps-6-1-3","url":null,"abstract":"","PeriodicalId":90784,"journal":{"name":"American journal of pharmacological sciences","volume":"38 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86372186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoeconomics of Antimalarials in Private-for-Profit (PFP) Drug-Outlets in Gulu and Kitgum Towns, Northern Uganda.","authors":"Mshilla Maghanga, Obai Gerald, Musoke David","doi":"10.12691/ajps-3-2-2","DOIUrl":"10.12691/ajps-3-2-2","url":null,"abstract":"<p><strong>Background: </strong>Clinically-diagnosed malaria is the leading cause of morbidity and mortality in Uganda accounting for 25 to 40% of outpatients, 15 to 20% of all hospital admissions, and 9 to 14% of all hospital deaths. This situation was exacerbated by The Lord's Resistance Army (LRA) rebellion in northern Uganda which completely ran down the health care system. While malaria remains the number one killer disease in northern Uganda, antimalarials are lacking in the public health facilities. Consequently, Private-for-profit drug-outlets have come up to help bridge the gap. However, the cost-effectiveness and treatment outcome ratings of antimalarials are not clear. Objective: To assess the pharmacoeconomics of malaria treatment in Private-for-profit (PFP) drug-outlets in Gulu Municipality and Kitgum Town Council.</p><p><strong>Methodology: </strong>This was a descriptive cross-sectional study sites were registered drug outlets. Study participants were drug-outlet owners, their employees, and malaria patients. We employed both purposive and random sampling methods to select the study participants. Data were collected using questionnaires and analysed using the SPSS computer package.</p><p><strong>Results: </strong><b>Up to</b> 91.1% of the respondents indicated that antimalarials are expensive. The prices varied from less than 5,000 to over 20,000 Ugandan shillings per dose <i>(Exchange rate: 1$ = Ush 2,650).</i> Fansidar and chloroquine were rated as being relatively cheap and ACTs expensive (Ush 11,000 to 15,000). Duration of treatment, frequency of administration, needles and syringes, raised the cost of some medicines. Most patients preferred cheap medicines (76.2%); those with low administration frequencies (77.5%); and those with short treatment duration (95%). Most patients (80.9%) buy antimalarials without testing, while 66.6% do not buy full doses.</p><p><strong>Conclusion: </strong>The cost benefit analysis of the use of antimalarials is unfavourable. The unit price of the medicines, their irrational use and the lack of professionals in the outlets together add up to high overall costs and poor treatment outcomes.</p>","PeriodicalId":90784,"journal":{"name":"American journal of pharmacological sciences","volume":"3 2","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477041/pdf/emss-63425.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33302504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}