Recent advances in DNA & gene sequences最新文献

Challenges in Lung Cancer Approaches: from the Clinical Issues to the Novel Therapies. 肺癌治疗方法的挑战:从临床问题到新疗法。

Recent advances in DNA & gene sequences Pub Date : 2015-03-31 DOI: 10.2174/2352092210666151214110725

Sílvia Coelho, M. Capelas, S. Alves, Luís Sá, R. D. De Mello

{"title":"Challenges in Lung Cancer Approaches: from the Clinical Issues to the Novel Therapies.","authors":"Sílvia Coelho, M. Capelas, S. Alves, Luís Sá, R. D. De Mello","doi":"10.2174/2352092210666151214110725","DOIUrl":"https://doi.org/10.2174/2352092210666151214110725","url":null,"abstract":"BACKGROUND\u0000Lung cancer is currently one of the most common malignant neoplasms worldwide. Distress symptoms related to the primary disease or in combination with disease progression have challenges faced by the patients, family, and their multidisciplinary team. The aim of this study was to demonstrate the benefits of an integrated palliative care approach for lung cancer patients at the time of diagnosis and to analyze the main symptoms and its treatment.\u0000\u0000\u0000METHODS\u0000We performed an integrative review of the databases ISI Web of Knowledge, PubMed, CINAHL and Academic Search Complete using the keywords \"lung cancer\", \"palliative care\", \"approaches\" and \"therapies\". The research and documentation were carried in accordance with the guideline PRISMA 2009.\u0000\u0000\u0000RESULTS\u0000Among 164 articles found in the searched databases, only 33 were selected due to their suitability and relevance to the subject with respect to the inclusion criteria defined. The evidence showed that early inclusion of palliative or supportive care could originate a satisfactory resolution of most of the symptoms and promote quality of life for the patients and their families.\u0000\u0000\u0000CONCLUSION\u0000Early palliative care led to significant improvements in the patient's quality of life and mood. The focus on care was the management of symptoms and the well-being of the patients be in a hospital or in a home setting.","PeriodicalId":90715,"journal":{"name":"Recent advances in DNA & gene sequences","volume":"9 1 1","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2015-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77663514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Proteolytic Systems of Muscle Wasting. 肌肉萎缩的蛋白质水解系统。

Recent advances in DNA & gene sequences Pub Date : 2015-01-01 DOI: 10.2174/2352092209999150911121502

Bianca Maria Scicchitano, Martina Faraldi, Antonio Musarò

引用次数: 18

The Study of HFE Genotypes and Its Expression Effect on Iron Status of Iranian Haemochromatosis, Iron Deficiency Anemia Patients, Iron-Taker and Non Iron-Taker Controls. 伊朗血色素沉着病、缺铁性贫血患者、铁接受者和非铁接受者HFE基因型及其表达对铁状态的影响研究

Recent advances in DNA & gene sequences Pub Date : 2015-01-01 DOI: 10.2174/2352092209666150211233434

Elham Beiranvand, Saeid Abediankenari, Mosayeb Rostamian, Behnoush Beiranvand, Saeed Naazeri

{"title":"The Study of HFE Genotypes and Its Expression Effect on Iron Status of Iranian Haemochromatosis, Iron Deficiency Anemia Patients, Iron-Taker and Non Iron-Taker Controls.","authors":"Elham Beiranvand, Saeid Abediankenari, Mosayeb Rostamian, Behnoush Beiranvand, Saeed Naazeri","doi":"10.2174/2352092209666150211233434","DOIUrl":"https://doi.org/10.2174/2352092209666150211233434","url":null,"abstract":"The role of HFE gene mutations or its expression in regulation of iron metabolism of hereditary haemochromatosis (HH) patients is remained controversial. Therefore here the correlation between two common HFE genotype (p.C282Y, p.H63D) and HFE gene expression with iron status in HH, iron deficiency anemia (IDA) and healthy Iranian participants was studied. For this purpose genotype determination was done by polymerase chain reaction--restriction fragment length polymorphism (PCR-RFLP). Real-Time PCR was applied for evaluation of HFE gene expression. Biochemical parameters and iron consumption were also assessed. Homozygote p.H63D mutation was seen in all HH patients and p.C282Y was not observed in any member of the population. A significant correlation was observed between serum ferritin (SF) level and gender or age of HH patients. p.H63D homozygote was seen to be able to significantly increase SF and transferrin saturation (TS) level without affecting on liver function. Our results also showed that iron consumption affects on TS level increasing. HFE gene expression level of IDA patients was significantly higher than other groups. Also the HFE gene expression was negatively correlated with TS. Finally, the main result of our study showed that loss of HFE function in HH is not derived from its gene expression inhibition and much higher HFE gene expression might lead to IDA. However we propose repeating of the study for more approval of our finding.","PeriodicalId":90715,"journal":{"name":"Recent advances in DNA & gene sequences","volume":"9 1","pages":"58-64"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2352092209666150211233434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33060439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susceptibility Risk Alleles of -238G/A, -308G/A and -1031T/C Promoter Polymorphisms of TNF-α Gene to Uterine Leiomyomas. TNF-α基因-238G/A、-308G/A和-1031T/C启动子多态性对子宫平滑肌瘤的易感风险等位基因

Recent advances in DNA & gene sequences Pub Date : 2015-01-01 DOI: 10.2174/2352092210999151214155858

Veronica Medikare, Altaf Ali, Venkateshwari Ananthapur, Mamata Deendayal, Pratibha Nallari

{"title":"Susceptibility Risk Alleles of -238G/A, -308G/A and -1031T/C Promoter Polymorphisms of TNF-α Gene to Uterine Leiomyomas.","authors":"Veronica Medikare, Altaf Ali, Venkateshwari Ananthapur, Mamata Deendayal, Pratibha Nallari","doi":"10.2174/2352092210999151214155858","DOIUrl":"https://doi.org/10.2174/2352092210999151214155858","url":null,"abstract":"Background: Uterine Leiomyomas (UL) are non-cancerous single celled mass of uterine smooth muscles distinguished by presence of large amounts of collagen, fibronectin and proteoglycans. Tumor necrosis factor-α (TNF-α), an inflammation inducing cytokine, plays a major role in various disorders of the immune system; is involved in tumor development and progression. It is proposed to study the influence of three functional promoter polymorphisms of TNF-α viz -238G/A, -308G/A and -1031T/C in the development and progression of UL.Methodology: Study included 146 individuals positive for uterine fibroids and 150 healthy individuals. Genomic DNA was isolated from white blood corpuscles and subjected to PCR-RFLP analysis and Allele Specific PCR (ARMS). The significance of the obtained data in controls and patients was estimated and computed by adopting appropriate statistical tools.Results: In this study an association between TNF-α -1031T/C polymorphism and UL was reported. A significant association of the TC genotype (χ(2) - 14.34; p=0.0008) and the C allele (χ(2) - 5.898 p=0.015) with uterine leiomyomas was observed. Likewise odds risk estimates of 2.56 (95% CI 1.56-4.20, p=0.0007) revealed a significant association of TC genotype and C allele with uterine leiomyomas.Conclusions: \"TC\" genotype and \"C\" allele of rs1799964 (-1031T/C) is associated with higher risks to leiomyomas. The \"C\" allele of -1031T/C results in an increased expression TNF-α leading to smooth cell proliferation and tumor progression, hence, may be a relevant molecular marker in the identification and establishment of UL.","PeriodicalId":90715,"journal":{"name":"Recent advances in DNA & gene sequences","volume":"9 1","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2352092210999151214155858","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34088694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Recent Patents on Hypocholesterolemic Therapeutic Strategies: An Update. 最近专利的低胆固醇治疗策略:更新。

Recent advances in DNA & gene sequences Pub Date : 2015-01-01 DOI: 10.2174/2352092210666151216143459

A. Potiron, P. Gérard, Tiphaine Le Roy, P. Lesnik, E. Maguin, M. Rhimi

引用次数: 2

The Development of Genetics in the Light of Thomas Kuhn's Theory of Scientific Revolutions. 从库恩的科学革命理论看遗传学的发展。

Recent advances in DNA & gene sequences Pub Date : 2015-01-01 DOI: 10.2174/2352092209666150921110920

Petter Portin

{"title":"The Development of Genetics in the Light of Thomas Kuhn's Theory of Scientific Revolutions.","authors":"Petter Portin","doi":"10.2174/2352092209666150921110920","DOIUrl":"https://doi.org/10.2174/2352092209666150921110920","url":null,"abstract":"The concept of a paradigm is in the key position in Thomas Kuhn's theory of scientific revolutions. A paradigm is the framework within which the results, concepts, hypotheses and theories of scientific research work are understood. According to Kuhn, a paradigm guides the working and efforts of scientists during the time period which he calls the period of normal science. Before long, however, normal science leads to unexplained matters, a situation that then leads the development of the scientific discipline in question to a paradigm shift--a scientific revolution. When a new theory is born, it has either gradually emerged as an extension of the past theory, or the old theory has become a borderline case in the new theory. In the former case, one can speak of a paradigm extension. According to the present author, the development of modern genetics has, until very recent years, been guided by a single paradigm, the Mendelian paradigm which Gregor Mendel launched 150 years ago, and under the guidance of this paradigm the development of genetics has proceeded in a normal fashion in the spirit of logical positivism. Modern discoveries in genetics have, however, created a situation which seems to be leading toward a paradigm shift. The most significant of these discoveries are the findings of adaptive mutations, the phenomenon of transgenerational epigenetic inheritance, and, above all, the present deeply critical state of the concept of the gene.","PeriodicalId":90715,"journal":{"name":"Recent advances in DNA & gene sequences","volume":"9 1","pages":"14-25"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2352092209666150921110920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34192511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Schizophrenia-associated Risk and Protective Variants of c-Fos Encoding Gene. 精神分裂症相关风险和c-Fos编码基因的保护性变异。

Recent advances in DNA & gene sequences Pub Date : 2015-01-01 DOI: 10.2174/2352092209666150223113334

Anna Boyajyan, Roksana Zakharyan, Sofi Atshemyan, Andranik Chavushyan, Gohar Mkrtchyan

{"title":"Schizophrenia-associated Risk and Protective Variants of c-Fos Encoding Gene.","authors":"Anna Boyajyan, Roksana Zakharyan, Sofi Atshemyan, Andranik Chavushyan, Gohar Mkrtchyan","doi":"10.2174/2352092209666150223113334","DOIUrl":"https://doi.org/10.2174/2352092209666150223113334","url":null,"abstract":"Defects in synaptic plasticity play a key role in pathophysiology of schizophrenia. Pathomechanisms responsible for synaptic plasticity alterations in schizophrenia are very complicated and not well defined. Transcription factor c-Fos plays an important role in regulation of synaptic plasticity. In the present study we evaluated the association of rs7101 and rs1063169 single nucleotide polymorphisms (SNPs) of c-Fos encoding gene (FOS) with schizophrenia. A total of 604 DNA samples of schizophrenia-affected and healthy subjects of Armenian ancestry were genotyped using polymerase chain reaction with sequence-specific primers. Also, comparative determination of the blood levels of c-Fos protein in schizophrenia patients and controls was performed using the enzyme-linked immunosorbent assay. Potential interaction between protein level and genotypes as well as relationships between genotypes/protein level and clinical-demographic characteristics of schizophrenia patients were assessed. The results obtained demonstrated that mutant allele of FOS rs1063169 SNP is negatively associated with schizophrenia and may be nominated as a protective factor for this disorder. On the other hand, according to our results, the FOS rs7101T mutant allele is positively associated with schizophrenia and, therefore, may be considered as a risk factor for this disorder. In addition, decreased c-Fos plasma levels in schizophrenia patients compared to controls were found. In conclusion, the results of this study suggest that FOS is among the candidate genes of schizophrenia and that changes in the expression of c-Fos protein may contribute to molecular pathomechanisms of schizophrenia-related alterations in synaptic plasticity. ","PeriodicalId":90715,"journal":{"name":"Recent advances in DNA & gene sequences","volume":"9 1","pages":"51-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/2352092209666150223113334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33075946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Recent Advances in Factors and Methods for Stimulation of Biomethane Production. 生物甲烷增产因素与方法研究进展。

Recent advances in DNA & gene sequences Pub Date : 2015-01-01 DOI: 10.2174/235209220901160126152924

N. Thakur, A. Khardenavis, H. Purohit

引用次数: 4

The potential use of genetics to increase the effectiveness of treatment programs for criminal offenders. 遗传学的潜在用途，以提高对刑事罪犯的治疗方案的有效性。

Recent advances in DNA & gene sequences Pub Date : 2014-01-01 DOI: 10.2174/2352092209666150205111839

Kevin M Beaver, Dylan B Jackson, Dillon Flesher

引用次数: 3

Methods and compositions for amplification and detection of microRNAs (miRNAs) and noncoding RNAs (ncRNAs) using the signature sequence amplification method (SSAM). 使用特征序列扩增法(SSAM)扩增和检测微小rna (miRNAs)和非编码rna (ncRNAs)的方法和组合物。

Recent advances in DNA & gene sequences Pub Date : 2014-01-01 DOI: 10.2174/2352092208666141001154206

Stephen D Ginsberg, Shaoli Che

引用次数: 3