New horizons in translational medicine最新文献

{"title":"Putting the “bio” in “biotherapeutics”/checkpoints for biosimilars/application of biosimilars","authors":"Juan V. Esplugues ,&nbsp;Bruno Flamion ,&nbsp;Lluis Puig","doi":"10.1016/j.nhtm.2016.10.002","DOIUrl":"10.1016/j.nhtm.2016.10.002","url":null,"abstract":"<div><p>The number of biosimilar medicines on the market is steadily increasing, due, in part, to patent expiration of several top-selling biologic medicines. These three e-learning modules discuss the basic concepts behind biosimilar medicines and highlight key regulatory considerations when using biosimilar medicines in medical practice.</p></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"3 3","pages":"Page 161"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2016.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91097737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts: Joint 2nd annual conference of Ziauddin University, HEC Pakistan with European Society for Translational Medicine (EUSTM) International Conference on Translational Medicine: From discovery to health care, 1–3 February 2016, Karachi, Pakistan","authors":"","doi":"10.1016/j.nhtm.2016.11.001","DOIUrl":"10.1016/j.nhtm.2016.11.001","url":null,"abstract":"","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"3 3","pages":"Pages 175-219"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77580209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent biohybrid systems for functional brain repair","authors":"Gabriella Panuccio,&nbsp;Marianna Semprini,&nbsp;Michela Chiappalone","doi":"10.1016/j.nhtm.2016.10.001","DOIUrl":"10.1016/j.nhtm.2016.10.001","url":null,"abstract":"<div><p>In the quest for novel neurotechnologies to defeat brain diseases, intelligent biohybrid systems have earned a privileged role among unconventional brain repair strategies. These systems are based on the functional interaction between the nervous tissue and engineered devices, the establishment of which is mediated by artificial intelligence. As novel, previously unimaginable neurotechnologies are emerging, what are the translational impact and the practical consequences carried by these tools for the clinical practice?</p><p>In this review, we describe the progression of brain repair strategies, from the early pioneering demonstration of their feasibility to their recent implementation in the experimental and clinical settings. We will show how the convergence of different disciplines across the decades has led to the emergence of innovative concepts based on intelligent biohybrid designs. We discuss the advantages and limitations of the described approaches and we conclude by proposing possible solutions to the current shortcomings of available paradigms.</p></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"3 3","pages":"Pages 162-174"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2016.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85392787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled delivery systems of cellulose matrix for oxytetracycline: In vitro dissolution","authors":"D. Mishra, P. Khare, K. Shanker, D. Singh, Suaib Luqman","doi":"10.1016/J.NHTM.2016.06.001","DOIUrl":"https://doi.org/10.1016/J.NHTM.2016.06.001","url":null,"abstract":"","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"53 1","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80645190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled delivery systems of cellulose matrix for oxytetracycline: In vitro dissolution","authors":"Disha Mishra ,&nbsp;Puja Khare ,&nbsp;K. Shanker ,&nbsp;Dhananjay K. Singh ,&nbsp;Suaib Luqman","doi":"10.1016/j.nhtm.2016.06.001","DOIUrl":"https://doi.org/10.1016/j.nhtm.2016.06.001","url":null,"abstract":"<div><p><span>Microfibrillated cellulose (MFC) has recently been explored as a novel nanostructured system for controlled drug<span><span> delivery. The present study examines the releasing behavior and antibacterial efficacy of cellulose (CC) and tempo-oxidized- microfibrillated cellulose (TO-MFC) loaded with oxytetracycline at three different physiological pH (2.1, 6.8 and 9.0). The releasing mechanism from cellulosic matrix was assessed by applying zero order, first order, and second order &amp; Ritger-Peppas model. The well diffusion assay was carried out to investigate the antibacterial efficacy of the prepared MFCs. Results indicate that the stability for the drug loaded on TO-MFC at all the pH was significant. TO-MFC and CC both showed </span>sustained release of OTC and followed Ritger-Peppas model signifying the diffusion process. The sustained </span></span>antibacterial activities<span> of these cellulosic matrixes were also observed. Results indicate that both drug delivery systems retained their medicinal properties against bacteria. The application of MFC could be very promising since it allows a sustained release of drug conserving long-term antibacterial efficiency.</span></p></div><div><h3>Focal points</h3><p></p><ul><li><span>•</span><span><p>Microfibrillated cellulose (MFC) loaded with oxytetracycline at three different physiological pH (2.1, 6.8 and 9.0) was examined.</p></span></li><li><span>•</span><span><p>The OTC and RO-MFC drug delivery system was stable at all pH.</p></span></li><li><span>•</span><span><p>Riteger-peppas model was favourable for the drug release phenomenon signifying the diffusion process.</p></span></li><li><span>•</span><span><p>The antibacterial activities of three matrixes appear in the similar manner as reported for releasing.</p></span></li></ul></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"3 2","pages":"Pages 66-72"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2016.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91635269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of Precision Medicine","authors":"Dimitris Kalaitzopoulos","doi":"10.1016/j.nhtm.2016.05.001","DOIUrl":"https://doi.org/10.1016/j.nhtm.2016.05.001","url":null,"abstract":"<div><p>The evolving field of Precision Medicine is revolutionizing drug<span> discovery and healthcare delivery. In this article, we take a look at how this nascent field has already impacted drug development for targeted therapy and the widespread use of genetic testing to assist clinical decision making at point-of-care. We also examine how the interaction of people and technology plays a critical role in Precision Medicine delivery. Finally, we conclude with how Precision Medicine can bring healthcare's spiralling costs down, while improving patient outcomes.</span></p></div>","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"3 2","pages":"Pages 63-65"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2016.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91679943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of Precision Medicine","authors":"Dimitris Kalaitzopoulos","doi":"10.1016/J.NHTM.2016.05.001","DOIUrl":"https://doi.org/10.1016/J.NHTM.2016.05.001","url":null,"abstract":"","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"102 1","pages":"63-65"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77092468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Pleurotus ostreatus (Jacq. Ex Fr.) P.kumm. on 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats","authors":"K. Deepalakshmi, S. Mirunalini","doi":"10.1016/J.NHTM.2016.06.002","DOIUrl":"https://doi.org/10.1016/J.NHTM.2016.06.002","url":null,"abstract":"","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"166 1","pages":"73-82"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82039235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Pleurotus ostreatus (Jacq. Ex Fr.) P.kumm. on 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats","authors":"Krishnamoorthy Deepalakshmi,&nbsp;Sankaran Mirunalini","doi":"10.1016/j.nhtm.2016.06.002","DOIUrl":"https://doi.org/10.1016/j.nhtm.2016.06.002","url":null,"abstract":"&lt;div&gt;&lt;p&gt;&lt;span&gt;Neoplastic growth of the breast is the most common malignancy in women worldwide and its incidence has increased in most countries. In this study, we have evaluated the efficacy of &lt;/span&gt;&lt;em&gt;Pleurotus ostreatus&lt;/em&gt; (Jacq. Ex Fr.) P.kumm. (&lt;em&gt;P. ostreatus&lt;/em&gt;&lt;span&gt;) an edible mushroom on modulating levels of xenobiotic&lt;span&gt; metabolizing enzymes, hormonal status of estrogen and progesterone receptor (ER/PR), protein expressions and histopathological analysis in 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis using a rat model. DMBA was induced by single subcutaneous injection at a dosage of 25&lt;/span&gt;&lt;/span&gt; &lt;!--&gt;mg in 1&lt;!--&gt; &lt;!--&gt;mL vehicle. The ethanolic extract of &lt;em&gt;P. ostreatus&lt;/em&gt; (POEet) was administered orally at a concentration of 600&lt;!--&gt; &lt;span&gt;mg/kg bwt as pre- and post-initiation stage of treatment&lt;span&gt; throughout the experimental period which was also compared with standard tamoxifen (TAM) (10&lt;/span&gt;&lt;/span&gt; &lt;span&gt;&lt;span&gt;&lt;span&gt;mg/kg bwt). At the end of 16 weeks, our results showed the elevated phase I and depleted phase II metabolizing enzymes, over expression of (ER/PR) and the expression pattern of the proteins such as fas, fasL, caspase 3, &lt;/span&gt;caspase 8&lt;span&gt;, caspase 9, Bax were found to be down regulated whereas p53, Bcl2, cox-2 and &lt;/span&gt;&lt;/span&gt;cyclin D1 were markedly upregulated in DMBA-induced Sprague-Dawley rats, which were significantly reversed on &lt;/span&gt;&lt;em&gt;P. ostreatus&lt;/em&gt; administration. Moreover, pre-treatment with &lt;em&gt;P. ostreatus&lt;/em&gt; showed improved response when compared to that of posttreatment. Based on scientific appraisal, we conclude that the dietary consumption of &lt;em&gt;P. ostreatus&lt;/em&gt;&lt;span&gt; might offer maximum protection against DMBA-induced mammary carcinogenesis and improving human health if used as a regular basis.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Focal points&lt;/h3&gt;&lt;p&gt;&lt;/p&gt;&lt;ul&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;p&gt;Benchside&lt;/p&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;&lt;p&gt;○ The potential of &lt;em&gt;Pleurotus ostreatus&lt;/em&gt;&lt;span&gt; on DMBA induced rat mammary carcinogenesis were determined by the analysis of xenobiotic metabolizing enzymes, hormonal status of ER/PR, as well as the expression of protein using western blotting techniques and histological examination of liver and mammary tissues.&lt;/span&gt;&lt;/p&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;p&gt;Bedside&lt;/p&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;&lt;p&gt;○ The pharmaceutical potential of &lt;em&gt;P. ostreatus&lt;/em&gt; are analysed for is markedly available, edible one with high protein as well as fiber with low fat content and cost effective for patient convenience.&lt;/p&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;p&gt;Industry&lt;/p&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;&lt;p&gt;○ Mushrooms are considered as a nutraceutical&lt;span&gt; functional food which can contain enriched prolific produced of novel “mycochemicals” responsible for the human health potential on various diseases and malignancies.&lt;/span&gt;&lt;/p&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;•&lt;/span&gt;&lt;span&gt;&lt;p&gt;Community&lt;/p&gt;&lt;/span&gt;&lt;/li&gt;&lt;li&gt;&lt;span&gt;&lt;p&gt;○ Standardization and refinement of mycochemical from ","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"3 2","pages":"Pages 73-82"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2016.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91635268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts: 4th Annual Congress of the European Society for Translational Medicine (EUSTM-2016) 17–20 October 2016, Prague, Czech Republic","authors":"Aamir Shahzad ,&nbsp;Randall J. Cohrs","doi":"10.1016/j.nhtm.2016.09.001","DOIUrl":"10.1016/j.nhtm.2016.09.001","url":null,"abstract":"","PeriodicalId":90660,"journal":{"name":"New horizons in translational medicine","volume":"3 2","pages":"Pages 83-159"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nhtm.2016.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84832675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}