{"title":"Delayed Onset of Infection Development after Polyalkylimide Treatment for HIV-Associated Lipoatrophy","authors":"A. Kumar, M. Camacho, R. Capasso","doi":"10.4172/2324-8785.1000115","DOIUrl":"https://doi.org/10.4172/2324-8785.1000115","url":null,"abstract":"Delayed Onset of Infection Development after Polyalkylimide Treatment for HIV-Associated Lipoatrophy \u0000Bio-Alcamid, a polyalkylimide, is a non-reabsorbable polymeric substance and has been used in cosmetic and reconstructive surgery. The material is widely used because it is non-toxic, non-allergenic, easily injectable, and quickly removable. Polyalkylimide has been used for the cosmetic treatment of atrophy of subcutaneous tissue and HIV-associated lipoatrophy due to highly active antiretroviral therapy (HAART). In HIV-patients who received this treatment, immediate therapy within zero to six weeks proved more beneficial in reducing facial lipoatrophy compared to the delayed therapy within twelve to eighteen weeks. Furthermore, in the duration of four years after the polyalkylimide treatment is administered, patients have not experienced necrosis, nodules, or infection.","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":"2013 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42407487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adenoids and Its Management: A Review of Surgical Methods","authors":"Olajide Tg","doi":"10.4172/2324-8785.1000316","DOIUrl":"https://doi.org/10.4172/2324-8785.1000316","url":null,"abstract":"Adenoids remained unrecognized because of their inaccessible location and the fact that most adenoidal pathology occurred in young children. Adenoidectomy is the surgical procedure in which the adenoids are removed. Removal of the adenoids is indicated when they are chronically infected or causing obstruction. Since the earliest descriptions of adenoidectomy, numerous techniques have been described and used successfully. All techniques are based on the principle of adequate visualization and removal of the adenoids without damage to the surrounding structures. The advent of endoscopic sinus surgery has popularized the use of endoscopes. The aim of this paper is to review various surgical techniques of adenoidectomy.","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":" ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44859667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of Anatomical Variants on Computed Tomography of Nose and Paranasal Sinuses","authors":"Bhatia Jss, B. Sk, D. Dalmia","doi":"10.4172/2324-8785.1000317","DOIUrl":"https://doi.org/10.4172/2324-8785.1000317","url":null,"abstract":"Objective: Aim of the study was to determine the prevalence of anatomical variations of nose and paranasal sinuses based on the findings seen on computed tomography. \u0000Methodology: CT SCAN of the patients with sinonasal symptoms was performed for evaluation of the anatomical variants of nose and paranasal sinuses. The sections were then analysed for anatomical variations. The data collected was subjected to statistical analysis. \u0000Results: The most commonly encountered anatomical variation was DNS, present in 86.25% (69) of patients. Pneumatised septum was present in 25% (20) of patients. Concha bullosa was present in 28.75% (23) while Concha lamella was seen in 17.5% (14) of patients. Paradoxical middle turbinate was present in 13.75% (11) while pneumatization of uncinate process in 10% (8), pneumatized superior turbinate in 5% (4), Haller cells in 8.75% (7), prominent Agger nasi cells in 15% (12), pneumatized crista gali in 8.75% (7), Onodi cells in 20% (16), pneumatization of anterior clinoid process in 17.5% (14) while pneumatization of greater wing of sphenoid/ pterygoid process was present in 11.25% (9) of patients. \u0000Conclusion: It is very important to recognize the clinical and surgical significance of these variations. Thus, prior to FESS, imaging with CT scan is mandatory to evaluate the anatomy of PNS and its variations.","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":" ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49125990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Juvenile Xanthogranuloma of Middle Ear and External Auditory Canal: A Rare Case Report","authors":"E. Saleh, A. Shaikh, R. Jastania, Zuraiqi Ba","doi":"10.4172/2324-8785.1000313","DOIUrl":"https://doi.org/10.4172/2324-8785.1000313","url":null,"abstract":"Juvenile xanthogranuloma (JXG) is a benign self-limiting non langerhans cell histiocytic lesion of unknown etiology and pathogenesis. It commonly affects infants and adolescents only 15% cases reported from the adult population. It characteristically appears as yellow to brown solitary papule, affecting the skin of head, neck and trunk region. Extra cutaneous JXG are reported from various sites including central nervous system, gastrointestinal system, kidney, larynx, tongue with single case report from tympanic membrane and external auditory canal. We describe a very rare case of adult JXG occurring as multiple papules from the external auditory canal and granulations from middle ear, which presented as persistent otorrhea. We discuss the clinical presentation, imaging, pathological findings and review of literature for this case. To the best of our knowledge this is first reported case of JXG from the middle ear cavity.","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":" ","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43076822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using Tympanometry to Evaluate Middle Ear Function in Children and Adolescents with Signs of Peripheral Facial Nerve Palsy","authors":"W. Kopala, A. Kukwa","doi":"10.4172/2324-8785.1000318","DOIUrl":"https://doi.org/10.4172/2324-8785.1000318","url":null,"abstract":"Facial nerve is the seventh paired cranial nerve. The main trunk of CN VII consists of motor fibers and the intermediate nerve which is a part of CN VII has parasympathetic and sensory fibers. One of the branches of CN VII is the chorda tympani which may play a significant role in responses related to normal Eustachian tube function. Other branches of CN VII, such as the greater petrosal nerve and tympanic branch, have motor fibers that open the Eustachian tube, which connects the tympanic cavity with the nasopharynx. It is located at the base of the cranium and consists of bone and cartilage. To evaluate the Eustachian tube and middle ear function, impedance audiometry (IA) is used. It is specifically used in hearing organ evaluation in children. The impedance audiometry consists of tympanometry, registration of reflex from the stapedius muscle and evaluation of Eustachian tube function. Tympanometry is an examination, evaluating response of the tympanic membrane and related structures of the middle ear on artificially induced pressure changes in the external auditory meatus. The main aim of the article is to evaluate middle ear function in children and adolescents with peripheral facial nerve palsy using results obtained in tympanometry and comparing the values for pressure, amplitude, and tympanometric curve gradient between the side with CV VII palsy (affected side) and the opposite side (healthy side).","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":"2017 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41669443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Pauna, Serrano Tli, Moreira Apsm, Cabrini Mam, M. Cunha, Bartarini Gcs, M. Bussi, Valerio Cc, Costa Iom, A. C. Faria, E. Zancanella
{"title":"Multidisciplinary Approach to the Patient with Obstructive Sleep Apnea","authors":"H. Pauna, Serrano Tli, Moreira Apsm, Cabrini Mam, M. Cunha, Bartarini Gcs, M. Bussi, Valerio Cc, Costa Iom, A. C. Faria, E. Zancanella","doi":"10.4172/2324-8785.1000315","DOIUrl":"https://doi.org/10.4172/2324-8785.1000315","url":null,"abstract":"Obstructive sleep apnea syndrome is characterized by episodes of upper airway obstruction with respiratory effort, during sleep. It is one of the most frequent diagnosed sleep disorder, it is frequently identified among men and women, and it has many symptoms and morbidities. Beyond the multifactorial origin, obstructive sleep disorders patients have low rates of adherence. Multidisciplinary and multi-professional approaches are a good alternative to be offered, independently of the chosen method. Here we describe the multidisciplinary approach offered to obstructive sleep apnea patients in a teaching hospital, in Southeastern Brazil. The best choice for therapeutic option has not yet been clarified, but multidisciplinary and multi-professional involvement seems to be a good alternative to improve patient’s adherence.","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":" ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48194619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A New Treatment Option for Ceruminous Adenocarcinoma of External Auditory Canal","authors":"S. Bilici, O. Yigit, A. V. Sünter","doi":"10.4172/2324-8785.1000314","DOIUrl":"https://doi.org/10.4172/2324-8785.1000314","url":null,"abstract":"Ceruminous adenocarcinomas of external auditory canal (EAC) are uncommon malignant tumors. They originate from the apocrin ceruminous glands of EAC. These tumors have varied clinical and histological manifestations. Therefore, controverseries currently exist are regarding their terminology, classification, histopathological features, diagnosis and treatment. Wetli et al categorized these tumors in to the four types according to histological features. These types are ceruminous adenomas, ceruminous adenocarcinomas, adenoid cystic carcinomas and pleomorphic adenomas.","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":"2017 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2017-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45865618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic Transcanal Approach to Remove Extensive Petrous Cholesteatoma","authors":"W. Chang, J. Thong, M. Tong","doi":"10.4172/2324-8785.1000303","DOIUrl":"https://doi.org/10.4172/2324-8785.1000303","url":null,"abstract":"Petrous cholesteatoma is a rare clinical entity and surgical treatment is difficult because the anatomical location of the petrous bone. It poses potential surgical risk of injury to the facial nerve, labyrinth, carotid artery, dura and risk of cerebrospinal fluid leak. We report a case of a young patient with extensive petrous cholesteatoma with erosion of basal turn of the cochlea, posterior semicircular canals and dehiscence of tegmen, facial nerve, carotid canal and roof of the internal auditory canal. It was successfully treated via the endoscopic transcanal approach. This surgical approach provides an excellent anatomical advantage of reaching the tumor with minimal destruction to the vital structures. It minimises soft tissue dissection and left the normally aerated mastoid untouched. It gave excellent functional aesthetic outcome with complete disease clearance.","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":" ","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48794972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Branchiootorenal Syndrome (BOR)-3 Very Illustrative Cases","authors":"Oliveira Ca","doi":"10.4172/2324-8785.1000305","DOIUrl":"https://doi.org/10.4172/2324-8785.1000305","url":null,"abstract":"Although the association of hearing loss, preauricular pits and branchial fistulae occurring in families was known since 1932 it was only in 1976 that Melnick et al. described a family with the father and 3 living children-1 boy and 2 girls-presenting with bilateral small ears, cup shaped anti verted pinnae, bilateral preauricular pits, cervical branchial fistulae and mixed hearing loss. In addition bilateral aplasia of the inferior lacrimal duct was present in the proband. Renal anomalies were present in all 3 members of this family in intravenous pyelography (IVP). They called this combination of symptoms BOR dysplasia. Due to the extreme variability of the phenotype of families affected as many as 6 different syndromes have been described in the past related to these anomalies. However only two syndromes are now accepted in the spectrum of BOR disorders: Branchiootorenal (BOR) and Branchiooto Syndromes (BOS). Extreme variability can be seen from one side to the other in the same patient and between different siblings. BOR and BOS may be present in one family. Mild to severe renal dysplasia can be seen in different siblings. Renal disease may progress to terminal disease in some patients. Mutations in EY1 cover 40% of patients with BOR and BOS. Testing of SIX5 (BOR2) and SIX1 (BOR 3, BOS3) cover another 5% of BOR and BOS patients. We present 3 patients, 2 from the same family, two of them submitted to middle ear surgery and with radically different temporal bone anomalies illustrating the great variability of phenotype among these patients.","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":" ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41810537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Promoter Methylation of Dual Specificity Phosphatase-6 Gene effect on Invasion and Metastasis of Nasopharyngeal Carcinoma","authors":"Yang Jh, S. Zhang","doi":"10.4172/2324-8785.1000307","DOIUrl":"https://doi.org/10.4172/2324-8785.1000307","url":null,"abstract":"Objective: The dual-specificity phosphatase-6 (DUSP-6) is a member of dual-specificity protein phosphatase (DUSP) family, it can make residues of threonine and tyrosine dephosphorylate. In recent years, it was found that DUSP-6 is correlated with tumour generation and progress. In this study we have detected the effect of DUSP-6 gene methylation on invasion and metastasis of nasopharyngeal carcinoma. Methods: RT-PCR and methylation-specific PCR are used to detect mRNA expression and methylation state of DUSP-6 gene in nasopharyngeal carcinoma tissues and CNE2 cell line. The changes of mRNA expression and methylation state of DUSP-6 gene, proliferation and invasion of cells were detected after 5-aza- 2’-deoxycytidine (5-aza-cdR) treated CNE2 cell line. Results: These results showed that DUSP-6 gene expression is related to its promoter methylation state, cervical lymph node metastasis is related to DUSP-6 gene promoter methylation state in patients with nasopharyngeal carcinoma, 5-aza-cdR can inhibit invasion of CNE2 cells, and make re-expression of DUSP-6 gene by promoter demethylation in CNE2 cells. Conclusion: DUSP-6 gene promoter methylation state is possibly an important factor that effected invasion and metastasis of nasopharyngeal carcinoma. DUSP-6 gene may make a novel marker for prognostic evaluation in nasopharyngeal carcinoma.","PeriodicalId":90613,"journal":{"name":"Journal of otology & rhinology","volume":" ","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45778388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}