Journal of mammalian ova research最新文献

Embryonic Modulation of Endometrial Receptivity 子宫内膜容受性的胚胎调节

Journal of mammalian ova research Pub Date : 2018-10-01 DOI: 10.1274/jmor.35.53

Sakae Goto

{"title":"Embryonic Modulation of Endometrial Receptivity","authors":"Sakae Goto","doi":"10.1274/jmor.35.53","DOIUrl":"https://doi.org/10.1274/jmor.35.53","url":null,"abstract":"Abstract: Implantation requires a receptive endometrium, a functionally normal embryo and communication between the developing embryo and maternal tissues (cross-talk). Two-step embryo transfer (two-step ET) and stimulation of endometrium embryo transfer (SEET) are procedures for ET based on concept of embryonic modulation of endometrial receptivity. In two-step ET, a cleaved embryo is transferred on day 2, and a blastocyst is transferred on day 5. The pregnancy and implantation rates with two-step ET were found to be higher than those with cleaved ET and double blastocyst transfer. We speculated that the cleaved embryos transferred on day 2 modulate endometrial receptivity and improve the implantation rate for blastocysts transferred on day 5. In SEET, embryo culture supernatant (ECS) is injected into the uterine cavity prior to blastocyst transfer to stimulate the endometrium and provide an optimum environment for implantation of forthcoming blastocysts. The pregnancy and implantation rates with SEET were found to be higher than those with blastocyst transfer. Higher implantation and pregnancy rates with SEET could be explained by embryonic factors produced in the culture medium that modulate endometrial receptivity. Lysophosphatidic acid was detected in ECS. Two-step ET and SEET are effective options for ET based on the concept of crosstalk between embryos and maternal tissues.","PeriodicalId":90599,"journal":{"name":"Journal of mammalian ova research","volume":"55 1","pages":"53 - 59"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84594441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expression of Genes Involved in the Non-Neuronal Cholinergic System and Their Possible Functions during Ovarian Follicular Development in Mice 小鼠卵巢卵泡发育过程中非神经元胆碱能系统相关基因的表达及其可能功能

Journal of mammalian ova research Pub Date : 2018-10-01 DOI: 10.1274/jmor.35.61

Mizuki Ueno, Haruka Ito, Takuya Kanke, Yuta Matsuno, W. Fujii, K. Naito, K. Sugiura

{"title":"Expression of Genes Involved in the Non-Neuronal Cholinergic System and Their Possible Functions during Ovarian Follicular Development in Mice","authors":"Mizuki Ueno, Haruka Ito, Takuya Kanke, Yuta Matsuno, W. Fujii, K. Naito, K. Sugiura","doi":"10.1274/jmor.35.61","DOIUrl":"https://doi.org/10.1274/jmor.35.61","url":null,"abstract":"Abstract: The regulatory roles of the non-neuronal cholinergic system, such as its growth promoting effects on mural granulosa cells during ovarian folliculogenesis, have been reported for several mammalian species; however, its roles in the early stages of follicles are not well-understood. This study was conducted to examine the expression of transcripts involved in the non-neuronal cholinergic system, and the effects of activating acetylcholine (ACh) signaling in mouse ovaries. The transcripts encoding proteins required in processes critical for ACh metabolism and a nicotinic cholinergic receptor, CHRNA7, were detected in ovaries and isolated mural granulosa cells. Stimulation with carbachol, a cholinergic agonist, promoted proliferation of mural granulosa cells in vitro. Moreover, carbachol treatment of neonatal ovaries significantly increased the numbers of primordial follicles compared with control untreated ovaries in organ cultures. These results suggest that a functional non-neuronal cholinergic system exists in mouse ovaries, and that it promotes the proliferation of mural granulosa cells and the formation/survival of primordial follicles.","PeriodicalId":90599,"journal":{"name":"Journal of mammalian ova research","volume":"35 1","pages":"61 - 69"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82022347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Phospholipase in Sperm Physiology and its Therapeutic Potential in Male Infertility 磷脂酶在精子生理中的作用及其在男性不育症中的治疗潜力

Journal of mammalian ova research Pub Date : 2018-10-01 DOI: 10.1274/jmor.35.43

F. Kimura, K. Kishida, Chisako Horikawa, M. Izuno, Akiko Nakamura, Jun Kitazawa, Aina Morimune, Shoko Tsuji, A. Takebayashi, A. Takashima, S. Kaku, T. Murakami

引用次数: 0

Ovarian Stimulation in in vitro Fertilization 体外受精中的卵巢刺激

Journal of mammalian ova research Pub Date : 2018-10-01 DOI: 10.1274/jmor.35.35

Y. Fukuda, Y. Katagiri, M. Morita

{"title":"Ovarian Stimulation in in vitro Fertilization","authors":"Y. Fukuda, Y. Katagiri, M. Morita","doi":"10.1274/jmor.35.35","DOIUrl":"https://doi.org/10.1274/jmor.35.35","url":null,"abstract":"Abstract: In assisted reproductive technology (ART) treatments, the ovarian stimulation method is important for obtaining many good quality oocytes. The first ovarian stimulation treatments used high stimulation in long and short protocols with gonadotropin releasing hormone (GnRH) agonists. It was formulated to suppress the luteinizing hormone (LH) surge while the follicles are developing. Subsequently, a moderate stimulation with an antagonist was introduced following the development of GnRH antagonists, and low stimulation that inhibits the LH surge with continuous administration of clomiphene citrate. However, cases have been reported occurred in which estrogen replacement therapy was selected to facilitate follicular development by supplementing estrogen in ovarian insufficiency. Otherwise ART cryopreservation technology has also developed. These practices are referred to as oncofertility, and have given rise to new ovarian stimulation methods in infertility treatment. Ovarian stimulation with the random start or double stimulation methods, which are not readily affected by the menstrual cycle, and progestin-primed ovarian stimulation (PPOS) that inhibits the LH surge with a progestogen have come to be performed and are showing good outcomes. As the social and medical backgrounds change, the methods of ovarian stimulation may futher improve in the future.","PeriodicalId":90599,"journal":{"name":"Journal of mammalian ova research","volume":"43 1","pages":"35 - 41"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73375526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Steroid Hormones and Related Substances Involved in Primordial Follicle Activation 性类固醇激素及相关物质参与原始卵泡活化

Journal of mammalian ova research Pub Date : 2018-05-02 DOI: 10.1274/jmor.35.3

F. Kimura, Luyi Zheng, Chisako Horikawa, Yuji Tanaka, Aina Morimune, T. Murakami

{"title":"Sex Steroid Hormones and Related Substances Involved in Primordial Follicle Activation","authors":"F. Kimura, Luyi Zheng, Chisako Horikawa, Yuji Tanaka, Aina Morimune, T. Murakami","doi":"10.1274/jmor.35.3","DOIUrl":"https://doi.org/10.1274/jmor.35.3","url":null,"abstract":"Abstract: Primordial follicles maintain dormancy in the ovary and only a small number of them are activated towards ovulation every day. Several signaling pathways in oocytes and the surrounding flattened pre-granulosa cells have been shown to play crucial roles in primordial follicle activations and sex steroid hormones are also known to affect it. Intrinsic estrogen, estradiol, has been reported to suppress primordial follicle formation and the later primordial follicle activation in rodent neonatal ovaries. Conversely, some phytoestrogens and endocrine disruptors which possess intrinsic estrogen-like biological activity with different binding affinities to estrogen receptors, can activate primordial follicles. Testosterone and dehydroepiandrosterone have been used in fertility treatments in the expectation that they would activate primordial follicle, although evidence of their efficacy is inconclusive. Progesterone suppresses primordial follicle formation and the later primordial follicle activation in rodent neonatal ovaries. Synthetic progestins possess the ability to bind to steroid hormone receptors other than the progesterone receptor. Thus, progestins may regulate primordial follicle activation through other sex hormone receptors. It may be possible to regulate primordial follicle activation by sex steroid hormones in the future. However, it is not yet clear which pathway mediates the effect of these hormones on primordial follicle activation, and this will need to be studied in the future.","PeriodicalId":90599,"journal":{"name":"Journal of mammalian ova research","volume":"36 1","pages":"12 - 3"},"PeriodicalIF":0.0,"publicationDate":"2018-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90510064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Regulation of Ovarian Follicular Growth by Anti-Müllerian Hormone 抗<s:1>勒氏激素对卵巢卵泡生长的调节作用

Journal of mammalian ova research Pub Date : 2018-05-02 DOI: 10.1274/jmor.35.13

Tomoko Nakamura, Tomohiko Murase, S. Osuka, Maki Goto, A. Iwase

引用次数: 0

The Safety of Autotransplantation of Cryopreserved Ovarian Tissue in Cancer Patients 肿瘤患者自体冷冻卵巢组织移植的安全性

Journal of mammalian ova research Pub Date : 2018-05-02 DOI: 10.1274/jmor.35.27

Y. Iwahara

引用次数: 0

Histomorphological Aspects of the Ovarian Cortex Regarding Ovarian Reserve and Local Pelvic Inflammation 卵巢皮层与卵巢储备和局部盆腔炎的组织学关系

Journal of mammalian ova research Pub Date : 2018-05-02 DOI: 10.1274/jmor.35.21

Michio Kitajima, Naoko Murakami, K. Taniguchi, Yuriko Kitajima, Ozora Tsukamoto, K. Miura, H. Masuzaki

{"title":"Histomorphological Aspects of the Ovarian Cortex Regarding Ovarian Reserve and Local Pelvic Inflammation","authors":"Michio Kitajima, Naoko Murakami, K. Taniguchi, Yuriko Kitajima, Ozora Tsukamoto, K. Miura, H. Masuzaki","doi":"10.1274/jmor.35.21","DOIUrl":"https://doi.org/10.1274/jmor.35.21","url":null,"abstract":"Abstract: The ovaries of women of reproductive age may show specific histological structures that may relate to the maintenance of primordial follicles and the regulation of early follicular development, which are keys to understanding the dynamics of ovarian reserve. The pelvic environment of women is frequently exposed to physiological or pathological inflammatory stimuli. Endometriosis is a disorder that should be viewed as a chronic inflammatory disease manifested by pelvic pain and infertility. Inflammation surrounding the normal ovarian cortex may alter the histological structure which possesses primordial and early growing follicles. Fibrotic changes in histological niches in the nest of primordial follicles may provoke activation of dormant follicles and concomitant atresia. Along with decline in AMH, which is produced by early growing follicles, fibrotic changes may accelerate the demise of primordial follicles which has been described as “burn-out by inflammation”. As a result, women with endometriosis may suffer from diminished ovarian reserve, a possible cause of endometriosis-related infertility.","PeriodicalId":90599,"journal":{"name":"Journal of mammalian ova research","volume":"42 1","pages":"21 - 26"},"PeriodicalIF":0.0,"publicationDate":"2018-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86574392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Inability of Human Sperm with Chromosomal Abnormalities to Penetrate the Oocyte in Assisted Reproductive Technology (ART): Risk Factors and the Role of Seminal Plasma 辅助生殖技术(ART)中染色体异常的人类精子不能穿透卵母细胞:危险因素和精浆的作用

Journal of mammalian ova research Pub Date : 2017-10-01 DOI: 10.1274/jmor.34.65

Seiji Watanabe, A. Fukui, Rika Nakamura, R. Fukuhara, Ayano Funamizu

{"title":"The Inability of Human Sperm with Chromosomal Abnormalities to Penetrate the Oocyte in Assisted Reproductive Technology (ART): Risk Factors and the Role of Seminal Plasma","authors":"Seiji Watanabe, A. Fukui, Rika Nakamura, R. Fukuhara, Ayano Funamizu","doi":"10.1274/jmor.34.65","DOIUrl":"https://doi.org/10.1274/jmor.34.65","url":null,"abstract":"Abstract: The combination of ICSI and a sperm chromosome assay provides a useful opportunity to directly investigate relationships between chromosomal aberrations and head morphology, motility or in vitro aging. An increase of aneuploidy was identified in sperm with large heads. Structural chromosome aberrations were frequently found in elongated heads. These types of sperm should therefore be avoided for ICSI and can easily be identified under a microscope. In sperm with normal heads, the chromosomal aberration rate was initially low but increased gradually after removal of the seminal plasma (3.3% to 15.9%); in immotile sperm, the increase of DNA damage was more pronounced (4.5% to 48.1%). Therefore, there are motile and immotile sperm populations in human ejaculates that are potentially vulnerable to in vitro culture conditions. Since these sperm can maintain DNA integrity in the seminal plasma for at least 3 h, and even after cryopreservation, the seminal plasma appears to be an efficient suppressor of DNA damage. We report here our attempts at using ICSI using sperm stored in the seminal plasma (SP-ICSI) to treat infertile patients with normozoospermia and provide data to confirm the safety of this technique. For poor quality semen, SP-ICSI may be more effective in achieving a successful outcome.","PeriodicalId":90599,"journal":{"name":"Journal of mammalian ova research","volume":"11 1","pages":"65 - 73"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88671849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Inflammatory Process and Successful Implantation 炎症过程和植入成功

Journal of mammalian ova research Pub Date : 2017-10-01 DOI: 10.1274/jmor.34.75

F. Chishima, T. Nakajima, Takehiro Nakao, Chuyu Hayashi, G. Ichikawa, Atsushi Komatsu, K. Kawana

{"title":"The Inflammatory Process and Successful Implantation","authors":"F. Chishima, T. Nakajima, Takehiro Nakao, Chuyu Hayashi, G. Ichikawa, Atsushi Komatsu, K. Kawana","doi":"10.1274/jmor.34.75","DOIUrl":"https://doi.org/10.1274/jmor.34.75","url":null,"abstract":"Abstract: \u0000 Implantation is essential for successful reproduction. In humans, uterine receptivity is restricted to the mid-secretory phase, days 19 to 24 of the menstrual cycle; and this period is called the window of implantation (WOI). Large populations of decidual leukocytes infiltrate the implantation site, and the levels of cytokines, prostaglandins (PGs), and leukocytes are up-regulated in the endometrium during implantation. Implantation is like a local wound healing process which is characterized by a strong Th1, pro-inflammatory response in which high levels of pro-inflammatory cytokines such as IL-6, LIF, IL-8, and TNFα are involved. In addition, cyclooxygenase (COX)-2 expression increases between days 2 to 5, suggesting that PGs are necessary for the process of stromal cell decidualization in early pregnancy. Recently, it was reported that endometrial biopsies taken during spontaneous cycles that preceding IVF treatment improved the rate of implantation, clinical pregnancies, and live births in patients with recurrent implantation failure. These results suggest an ininflammatory environment is not adequately induced in some IVF patients with recurrent implantation failure in the absence of local injury provoked by biopsy treatment, further suggesting that uterine receptivity is mediated by the expression of molecules associated with a pro-inflammatory process.","PeriodicalId":90599,"journal":{"name":"Journal of mammalian ova research","volume":"99 1","pages":"75 - 81"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78347993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1