Kristy A Campbell, Kolton T Drake, Elisa H Barney Smith
{"title":"Pulse Shape and Timing Dependence on the Spike-Timing Dependent Plasticity Response of Ion-Conducting Memristors as Synapses.","authors":"Kristy A Campbell, Kolton T Drake, Elisa H Barney Smith","doi":"10.3389/fbioe.2016.00097","DOIUrl":"10.3389/fbioe.2016.00097","url":null,"abstract":"<p><p>Ion-conducting memristors comprised of the layered materials Ge<sub>2</sub>Se<sub>3</sub>/SnSe/Ag are promising candidates for neuromorphic computing applications. Here, the spike-timing dependent plasticity (STDP) application is demonstrated for the first time with a single memristor type operating as a synapse over a timescale of 10 orders of magnitude, from nanoseconds through seconds. This large dynamic range allows the memristors to be useful in applications that require slow biological times, as well as fast times such as needed in neuromorphic computing, thus allowing multiple functions in one design for one memristor type-a \"one size fits all\" approach. This work also investigated the effects of varying the spike pulse shapes on the STDP response of the memristors. These results showed that small changes in the pre- and postsynaptic pulse shape can have a significant impact on the STDP. These results may provide circuit designers with insights into how pulse shape affects the actual memristor STDP response and aid them in the design of neuromorphic circuits and systems that can take advantage of certain features in the memristor STDP response that are programmable <i>via</i> the pre- and postsynaptic pulse shapes. In addition, the energy requirement per memristor is approximated based on the pulse shape and timing responses. The energy requirement estimated per memristor operating on slower biological timescales (milliseconds to seconds) is larger (nanojoules range), as expected, than the faster (nanoseconds) operating times (~0.1 pJ in some cases). Lastly, the memristors responded in a similar manner under normal STDP conditions (pre- and post-spikes applied to opposite memristor terminals) as they did to the case where a waveform corresponding to the difference between pre- and post-spikes was applied to only one electrode, with the other electrode held at ground potential. By applying the difference signal to only one terminal, testing of the memristor in various applications can be achieved with a simplified test set-up, and thus be easier to accomplish in most laboratories.</p>","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"801 1","pages":"97"},"PeriodicalIF":5.7,"publicationDate":"2016-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69769126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andressa R. Pereira, J. D. Souza, R. M. Iost, F. Sales, F. Crespilho
{"title":"Application of carbon fibers to flexible enzyme electrodes","authors":"Andressa R. Pereira, J. D. Souza, R. M. Iost, F. Sales, F. Crespilho","doi":"10.1016/J.JELECHEM.2016.01.004","DOIUrl":"https://doi.org/10.1016/J.JELECHEM.2016.01.004","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"780 1","pages":"396-406"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JELECHEM.2016.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55097731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of anodization temperature on optical properties of nanoporous anodic alumina (NAA) films","authors":"L. Cantelli, J. S. Santos, F. Trivinho-Strixino","doi":"10.1016/J.JELECHEM.2016.01.009","DOIUrl":"https://doi.org/10.1016/J.JELECHEM.2016.01.009","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"42 1","pages":"386-390"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JELECHEM.2016.01.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55097905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photoelectrochemical activity of colloidal TiO2 nanostructures assembled at polarisable liquid/liquid interfaces","authors":"D. Plana, D. Fermín","doi":"10.1016/J.JELECHEM.2015.09.030","DOIUrl":"https://doi.org/10.1016/J.JELECHEM.2015.09.030","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"780 1","pages":"373-378"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JELECHEM.2015.09.030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55097588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical and structural study of electrodeposited zinc selenide thin films","authors":"M. F. Gromboni, L. Mascaro","doi":"10.1016/J.JELECHEM.2016.04.037","DOIUrl":"https://doi.org/10.1016/J.JELECHEM.2016.04.037","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"32 1","pages":"360-366"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JELECHEM.2016.04.037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55098121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Near-surface solution pH measurements during the pitting corrosion of AISI 1020 steel using a ring-shaped sensor","authors":"M. M. D. Silva, L. Mascaro, E. Pereira, A. Zimer","doi":"10.1016/J.JELECHEM.2016.02.017","DOIUrl":"https://doi.org/10.1016/J.JELECHEM.2016.02.017","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"780 1","pages":"379-385"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JELECHEM.2016.02.017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55097449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina Y. Suzuki, P. Santiago, Thalita S. Galhardo, W. Carvalho, J. Souza-Garcia, C. A. Angelucci
{"title":"Insights of glycerol electrooxidation on polycrystalline silver electrode","authors":"Nina Y. Suzuki, P. Santiago, Thalita S. Galhardo, W. Carvalho, J. Souza-Garcia, C. A. Angelucci","doi":"10.1016/J.JELECHEM.2016.02.020","DOIUrl":"https://doi.org/10.1016/J.JELECHEM.2016.02.020","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"780 1","pages":"391-395"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JELECHEM.2016.02.020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55098013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mireia Mato Prado, Adam E Frampton, Elisa Giovannetti, Justin Stebbing, Leandro Castellano, Jonathan Krell
{"title":"Investigating miRNA-mRNA regulatory networks using crosslinking immunoprecipitation methods for biomarker and target discovery in cancer.","authors":"Mireia Mato Prado, Adam E Frampton, Elisa Giovannetti, Justin Stebbing, Leandro Castellano, Jonathan Krell","doi":"10.1080/14737159.2016.1239532","DOIUrl":"10.1080/14737159.2016.1239532","url":null,"abstract":"<p><strong>Introduction: </strong>MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. Recently, different experimental approaches, such as RNA Sequencing, crosslinking immunoprecipitation (CLIP) methods and its variations, together with computational approaches have been developed to elucidate the miRNA-mRNA targetome. Areas covered: This report focuses on comparing the different experimental and computational approaches, describing their advantages and disadvantages and providing several examples of preclinical (in vitro and in vivo) and clinical studies that have identified miRNA target genes in various tumour types, including breast, ovary, colorectal and pancreas. Expert commentary: The combination of CLIP methods with bioinformatic analyses is essential to better predict miRNA-mRNA interactions and associate their specific pathways within the extensive regulatory network. Nevertheless, further studies are needed to overcome the difficulties these methods have, in order to find a gold standard method that identifies, without any bias, the regulatory association between miRNAs and their target mRNAs.</p>","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"813 1","pages":"1155-1162"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59845787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Band structure and charge carrier dynamics in (W,N)-codoped TiO2 resolved by electrochemical impedance spectroscopy combined with UV–vis and EPR spectroscopies","authors":"A. Folli, J. Bloh, D. Macphee","doi":"10.1016/J.JELECHEM.2015.10.033","DOIUrl":"https://doi.org/10.1016/J.JELECHEM.2015.10.033","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"780 1","pages":"367-372"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/J.JELECHEM.2015.10.033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55097691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outbreak of human astrovirus 1 lineage 1d in a childcare center in China.","authors":"Meiling Hou, Xuexue Liang, Liqian Tan, Pengfei Liu, Wei Zhao","doi":"10.1007/s12250-015-3701-5","DOIUrl":"10.1007/s12250-015-3701-5","url":null,"abstract":"","PeriodicalId":90591,"journal":{"name":"Journal of electroanalytical chemistry and interfacial electrochemistry","volume":"434 1","pages":"258-61"},"PeriodicalIF":5.5,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77507906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}