Exosomes and microvesicles最新文献

Acknowledgments 致谢

Exosomes and microvesicles Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-816053-4.09989-2

引用次数: 0

Contributors 贡献者

Exosomes and microvesicles Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-816053-4.09992-2

Divya J Aickara, R. Alessandro, S. Alipoor, R. Andriantsitohaina, Jun Araya, Koji Asano, Evangelos V. Badiavas, M. Bailey, Scott E Bonner, Han Chen, Yong Cheng, Raul Coimbra, A. Conigliaro, Denis Corbeil, C. Corrado, Todd W. Costantini, D. Crețoiu, S. Crețoiu, A. Cronemberger-Andrade, J. Dear, A. Deftu, A. Deftu, Shinichiro Egawa, B. Eliceiri, S. Fontana, Y. Fujita, Andrew F. Hill, Robert W. Hunter, T. Kadota, Ju‐Seop Kang, N. Kosaka, K. Kuwano, S. Le Lay, A. Lorico, Imre Mäger, M. C. Martinez, J. McBride, E. Mortaz, Soumyalekshmi Nair, Denis Noble, Takahiro Ochiya, S. Pang, B. Radu, Stefania Raimondo, L. Saieva, C. Salomón, Jeff S. Schorey, J. Sundstrom, Sin-Yeang Teow, A. Torrecilhas, F. Urabe, Sarah Weber, Eduard Willms, M. Wood, P. Xander, Junjie Xiao, Zhongdang Xiao, Yuanjun Zhao, Mi Zhou, Yueyuan Zhou

引用次数: 0

Copyright 版权

Exosomes and microvesicles Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-816053-4.09995-8

引用次数: 0

Methods for exosome isolation and characterization 外泌体的分离和鉴定方法

Exosomes and microvesicles Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-816053-4.00002-x

Mi Zhou, Sarah Weber, Yuanjun Zhao, Han Chen, J. Sundstrom

引用次数: 21

The potential of exosomes as theragnostics in various clinical situations 外泌体在各种临床情况下作为诊断试剂的潜力

Exosomes and microvesicles Pub Date : 2019-10-18 DOI: 10.1016/B978-0-12-816053-4.00020-1

Ju‐Seop Kang

引用次数: 12

The potential of exosomes for the diagnosis and treatment of Duchenne muscular dystrophy 外泌体诊断和治疗杜氏肌营养不良的潜力

Exosomes and microvesicles Pub Date : 2019-09-09 DOI: 10.24075/brsmu.2019.049

I. Galkin, T. Egorova

引用次数: 0

Efficiency of image visualization simulator technology for physical rehabilitation of children with cerebral palsy through play 图像可视化模拟器技术在脑瘫儿童游戏康复中的应用效果

Exosomes and microvesicles Pub Date : 2019-09-09 DOI: 10.24075/brsmu.2019.051

V. Gorelik, S. Filippova, V. Belyaev, E. Karlova

{"title":"Efficiency of image visualization simulator technology for physical rehabilitation of children with cerebral palsy through play","authors":"V. Gorelik, S. Filippova, V. Belyaev, E. Karlova","doi":"10.24075/brsmu.2019.051","DOIUrl":"https://doi.org/10.24075/brsmu.2019.051","url":null,"abstract":"The number of children born with cerebral palsy (CP) remains stably high. Novel approaches for rehabilitation of such patients are being sought. This study aimed to define the efficiency of the image visualization technologies in play activity for the physical rehabilitation of children with cerebral palsy. Sixteen boys with spastic diplegia aged 7–9 participated in the study. They were divided into treatment group (TG) and control group (CG), 8 children each. The TG patients were trained using the virtual reality based Krisaf training simulator twice a week for 40 minutes during 8 months. The child was suspended in the horizontal position and looked at the monitor through the specialised eyeglasses. Under the conditions of the marine environment immersion simulation with reduced gravity children performed motor tasks through play: searched for treasures, competed with dolphins etc. The CG patients attended the physical therapy lessons. Rehabilitation lessons using the virtual reality based Krisaf training simulator for children affected with spastic cerebral palsy led to a significant improvement of motor skills. Various motion tests showed an improvement over baseline, the average indicators increased 1.30–1.48 times. The difference between TG and CG results was statistically significant. In the CG referred to physical therapy the indicators increase was less than 10%, in the TG the increase reached 30–40%. It was concluded that the use of virtual reality based technologies promotes the optimization of neurophysiological processes in the motor analyzer cortical areas and better adaptation to motor loads.","PeriodicalId":90498,"journal":{"name":"Exosomes and microvesicles","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73837832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Contrast-enhanced ultrasonography for assessing neovascularization of carotid atherosclerotic plaque 超声造影评价颈动脉粥样硬化斑块新生血管

Exosomes and microvesicles Pub Date : 2019-09-09 DOI: 10.24075/brsmu.2019.057

A. Evdokimenko, A. Chechetkin, L. D. Druina, M. Tanashyan

{"title":"Contrast-enhanced ultrasonography for assessing neovascularization of carotid atherosclerotic plaque","authors":"A. Evdokimenko, A. Chechetkin, L. D. Druina, M. Tanashyan","doi":"10.24075/brsmu.2019.057","DOIUrl":"https://doi.org/10.24075/brsmu.2019.057","url":null,"abstract":"Neovascularization of a carotid atherosclerotic plaque (AP) is associated with an increased risk of stroke. Contrast-enhanced ultrasonography (CEUS) is a widely used method for imaging intraplaque neovascularization in vivo. Unfortunately, there are no standardized guidelines for CEUS interpretation. The aim of this study was to identify the most reliable method for CEUS-based assessment of AP neovascularization. Seventy-eight AP were removed during carotid endarterectomy in 73 patients, of whom 5 had AP on both sides, and examined morphologically. All patients underwent preoperative duplex scanning and CEUS; Sonovue was used as a contrast agent. AP neovascularization was assessed on a 4-grade visual scale and with 3 different quantitative methods using QLAB software. On the visual scale (method 1), poorly (37%) and moderately (51%) vascularized plaques were the most common. Quantitative analysis (data were presented as Me (Q1; Q3)) revealed that the number of blood vessels per 1 cm2 of the plaque (method 2) was 16 (10; 26), the ratio of the total vessel area to the plaque area (method 3) was 6% (3; 9), and AP ROI (method 4) was 2.6 dB (1.8; 4.1). Significant correlations were demonstrated between the results produced by method 2 and method 3 (р < 0.0001), method 3 and method 2 (p = 0.0006), and between pathomorphological findings and the results produced by methods 1–3, especially method 2 (p < 0.004). AP ROI brightness did not correlate with other results. The presence of hyperechoic components (calcifications) in AP dramatically reduced the reliability of US-based intraplaque neovascularization assessment. The most accurate CEUS-based quantitative method for assessing intraplaque neovascularization is estimation of blood vessel number per 1 cm2 of the plaque.","PeriodicalId":90498,"journal":{"name":"Exosomes and microvesicles","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78327393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hirudotherapy in treatment of chronic generalised periodontitis 湿疗治疗慢性全身性牙周炎

Exosomes and microvesicles Pub Date : 2019-09-09 DOI: 10.24075/brsmu.2019.052

И. Сашкина, А И Абдуллаева, Г. С. Рунова, И. В. Салдусова, О. В. Зайченко, Д. К. Фасхутдинов, С. И. Соколова, Е. П. Пустовая, A. Abdullaeva, G. S. Runova, I. V. Saldusova, OV Zajchenko, D. Faskhutdinov, S. I. Sokolova, E. P. Pustovaya, Россия Москва, Москва Российский университет дружбы народов, Россия

{"title":"Hirudotherapy in treatment of chronic generalised periodontitis","authors":"И. Сашкина, А И Абдуллаева, Г. С. Рунова, И. В. Салдусова, О. В. Зайченко, Д. К. Фасхутдинов, С. И. Соколова, Е. П. Пустовая, A. Abdullaeva, G. S. Runova, I. V. Saldusova, OV Zajchenko, D. Faskhutdinov, S. I. Sokolova, E. P. Pustovaya, Россия Москва, Москва Российский университет дружбы народов, Россия","doi":"10.24075/brsmu.2019.052","DOIUrl":"https://doi.org/10.24075/brsmu.2019.052","url":null,"abstract":"Chronic generalized periodontitis (CGP) is a disease associated with low susceptibility to the therapeutic protocols applied; practitioners tend to characterize it as a disease presenting certain difficulties. Therefore, the search for drugs and methods capable of increasing the efficacy of CGP therapy is an ongoing process. Additional problems, which have to do with either with antibiotic resistance or increased sensitivity to drugs, also occur quite often. This study aimed to assess the possibility of applying hirudotherapy in the context of conservative treatment of CGP. 50 patients with CGP without somatic pathology were examined and treated. The participants were divided into two groups (n = 25), all group members of about the same age. At the first stage, the treatment followed the accepted standard: professional oral hygiene procedures, antimicrobial and anti-inflammatory drugs, demonstration of proper personal oral hygiene routines. Then, first group went through a monthlong hirudotherapy course that consisted of 6 to 8 individual procedures. Second group was observed throughout this period with the aim to control the level of their compliance with the oral hygiene routines they were trained. Having analyzed the results, we found that hirudotherapy was more effective than what was prescribed to the second (control) group. The papillary marginal alveolar index (PMA), which reflects the severity of inflammation and gum bleeding, decreased significantly in the first group, where medicinal leeches were used: in the patients with severe CGP it went down by 6%, in those with moderately severe CGP the index decreased by 24% and the participants whose CGP was only light had the PMA go down by 2%. Thus, we have demonstrated the efficacy of hirudotherapy in the context of conservative CGP treatment, which allows recommending this method for inclusion into clinical practice.","PeriodicalId":90498,"journal":{"name":"Exosomes and microvesicles","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91288470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effectiveness of intraosseous infiltration of autologous platelet-rich plasma in the area of the bone marrow edema in osteoarthritis of the knee joint 自体富血小板血浆骨内浸润治疗膝关节骨性关节炎骨髓水肿的疗效

Exosomes and microvesicles Pub Date : 2019-09-09 DOI: 10.24075/brsmu.2019.053

A. Lychagin, A. Garkavi, O. Islaieh, P. I. Katunyan, D. Bobrov, R. Yavlieva, E. Tselisheva

{"title":"Effectiveness of intraosseous infiltration of autologous platelet-rich plasma in the area of the bone marrow edema in osteoarthritis of the knee joint","authors":"A. Lychagin, A. Garkavi, O. Islaieh, P. I. Katunyan, D. Bobrov, R. Yavlieva, E. Tselisheva","doi":"10.24075/brsmu.2019.053","DOIUrl":"https://doi.org/10.24075/brsmu.2019.053","url":null,"abstract":"Osteoarthritis (OA) affects both elderly people, for whom it is one of the main causes of disability, and people of active working age and is an urgent clinical and social problem of resistance of pain syndrome to therapy. The disease is characterized by both destruction of intra-articular and paraarticular structures, such as subchondral bone. While OA is an important sign of pathological changes believe the bone marrow edema (BME). This work examines the effect of BME on development osteoarthritis, and therapeutic approaches to the management of patients with OA. The aim of the study was to develop a method of treatment of BME in OA of the knee joint by locally intraosseous injection of autologous thrombotic-rich plasma (PRP) into the edema zone. In this study 17 patients with the diagnosis: Osteoarthritis II-IV Grade. according to the classification of Kellgren–Lawrence, in which areas of local inflammation in the form of BME were detected on MRI in the subchondral zone in accordance with the international classification of WORMS (Whole Organ Magnetic Resonance Imaging Score). The mean age of patients was 41,7 ± 14,3 years, 10 of them were women and 7 men. Patients were treated with autological platelet-rich plasma under x-ray control injected from extra-articular intraosseous access in the area of BME. Evaluation of effectiveness of treatment performed by VAS, WOMAC and KOOS scales, before the introduction of autoplasma, after 1 and 3 months after the start of treatment. Three months after the manipulation, there was a statistically significant decrease in the intensity of inflammatory syndrome: for WOMAC by 17.5%, for KOOS by 19.4% and for VAS by 33,1% (p < 0,01). Thus, the efficiency of intraosseous Infiltration of autologous platelet-rich plasma in the treatment of patients with OA, accompanied by edema of the bone marrow in the subchondral zone, was proved.","PeriodicalId":90498,"journal":{"name":"Exosomes and microvesicles","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78379212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4