Austin journal of pharmacology and therapeutics最新文献

In Silico Screening of Compounds Similar to Codeine, Tramadol, and Morphine with Better Pharmacodynamic and Pharmacokinetics Profiles 硅学筛选与可待因、曲马多和吗啡相似且药效学和药代动力学特征更佳的化合物

Austin journal of pharmacology and therapeutics Pub Date : 2024-01-12 DOI: 10.26420/austinjpharmacolther.2024.1183

Kamakia Faith, Ouma Stephen, Richard Kagia

{"title":"In Silico Screening of Compounds Similar to Codeine, Tramadol, and Morphine with Better Pharmacodynamic and Pharmacokinetics Profiles","authors":"Kamakia Faith, Ouma Stephen, Richard Kagia","doi":"10.26420/austinjpharmacolther.2024.1183","DOIUrl":"https://doi.org/10.26420/austinjpharmacolther.2024.1183","url":null,"abstract":"Introduction: Pain alleviation is the primary intervention in promoting quality of life. Among the compounds used in management of pain are opioids. Codeine is mostly used as antitussive and is commonly present in cough syrups. Tramadol and Morphine are used as analgesics based on severity of pain. Although these drugs provide instant pain relief, they are associated with many side effects and the most worrying once are addiction, respiratory depression and tolerance. Methods: Codeine, Tramadol, and Morphine were used as query compounds to generate similar compounds using SwissSimilarity. Similar compounds were docked to mu, kappa, and delta receptors and those that showed better docking scores to mu receptor and lower scores to kappa and delta were analyzed for toxicity profiles using ProTox II and pharmacokinetics profiles using SwissADME. Results: ZINC13831510; 0.992, ZINC03629718; 0. 995; ZINC03870350; 0.993; ZINC28256912; 0.992; and ZINC71774151; 0.977 showed highest binding score to mu receptors and lower to both kappa and delta. All compounds were predicted to inhibit CYP2D6 enzyme. All compounds permeated Blood Brain Barrier with the exceptions of ZINC04102208; 0.992; and ZINC13831510; 0.992. Tramadol, its zinc compounds and ZINC03629718; 0.995. were not substrates for P-glycoprotein. Tramadol and ZINC03639132; 0.976; were predicted immunoactive. All compounds conformed to Lipinski rule of five. Conclusion: In conclusion, ZINC13831510; 0.992; showed the highest binding score to morphine. ZINC02509756; 0.986; and ZINC26259212; 0.995; were considered the safest as compared to Tramadol and Codeine and their zinc compounds respectively. Further invitro studies are recommended for the following promising compounds ZINC13831510; 0.992, ZINC03629718; 0. 995; ZINC03870350; 0.993; ZINC28256912; 0.992; and ZINC71774151; 0.977 ZINC02509756; 0.986; and ZINC26259212; 0.995;.","PeriodicalId":90448,"journal":{"name":"Austin journal of pharmacology and therapeutics","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139625392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small Molecule Inhibitors Targeting Endothelial IL-1β Receptor (IL-1R1): A Novel Approach to Atherosclerosis Therapy 靶向内皮细胞IL-1β受体（IL-1R1）的小分子抑制剂：一种新的动脉粥样硬化治疗方法

Austin journal of pharmacology and therapeutics Pub Date : 2023-03-16 DOI: 10.26420/austinjpharmacolther.2023.1170

{"title":"Small Molecule Inhibitors Targeting Endothelial IL-1β Receptor (IL-1R1): A Novel Approach to Atherosclerosis Therapy","authors":"","doi":"10.26420/austinjpharmacolther.2023.1170","DOIUrl":"https://doi.org/10.26420/austinjpharmacolther.2023.1170","url":null,"abstract":"The current study identified small molecule inhibitors targeting IL-1β receptor in inhibiting the atherosclerosis. IL-1β plays an important role in the progression of atherosclerosis by binding to the IL-1R1 receptor. IL-1β secreted by the macrophage induces the expression of cell adhesion molecules on the endothelial cell which causes recruitment of immune cells to the intimal site, promoting the atherosclerosis progression. It also releases IL-6 and MMPs which helps in thrombus formation. Thus, targeting IL-1β can help in limiting the recruitment of immune cell to the intimal site. IL-1RA is an antagonist which binds to the IL-1R1 receptor and limit its interaction with the IL-1β. Thus, critical residues on the IL-1R1 interacting with both the IL-1β and IL-1RA were analyzed. A total of 17 residues were found to be common between both the complexs in the 4A region. Further, in-vitro study suggests 12 critical residues on the IL-1R1 mediating the interaction with the IL-1β. Thus, small molecule inhibitors were used to target the critical residues on the IL-1R1 receptor binding with the IL-1β. Virtual screening in Schrodinger and Auto Dock Vina suggested six compounds interacting with most of the critical residues on the IL-1R1 receptor. Further, physicochemical and ADMET analysis of those compounds suggested good values in all the parameters. Thus, the screened compounds hold good potential to act as an anti-IL-1β inhibitor in limiting the progression of atherosclerosis. Further studies would be to check the efficacy and effectivity of the compounds at the in-vitro and in-vivo levels.","PeriodicalId":90448,"journal":{"name":"Austin journal of pharmacology and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43580746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Potential Drugs for Colorectal Cancer Chemoprevention through Computational Analysis 计算分析法鉴定癌症化学预防的潜在药物

Austin journal of pharmacology and therapeutics Pub Date : 2023-01-27 DOI: 10.26420/austinjpharmacolther.2023.1168

{"title":"Identification of Potential Drugs for Colorectal Cancer Chemoprevention through Computational Analysis","authors":"","doi":"10.26420/austinjpharmacolther.2023.1168","DOIUrl":"https://doi.org/10.26420/austinjpharmacolther.2023.1168","url":null,"abstract":"Introduction: Colorectal cancer is one of the common causes of hospitalizations, readmission, and poor quality of life due to disability, pain, and death. Most drugs identified to provide chemoprevention in colorectal cancer, such as NSAIDs, have a high level of toxicity. There is need to find novel drugs targeting colorectal cancer with favorable clinical profiles. Objective: The study aimed to identify possible colorectal cancer prevention drugs by comparing the docking scores (representing potential biologic activity) of Aspirin, Sulindac, and Celecoxib with their structurally similar analogs. Materials and Methods: Ligand-based virtual screening and structure-based virtual screening were done for aspirin, sulindac and celecoxib to identify potential drug-like compounds. Compounds that passed the screening, pharmacokinetic profiling, and toxicity testing were considered possible drugs for colorectal cancer chemoprevention. Results: The study identified 7 drug-like compounds from the ZINC database. ZINC02570895, with a better docking score than celecoxib coupled with favorable toxicity and metabolic profiles, was the most appropriate drug candidate for the inhibition of PDK-1. ZINC22309227, with a better docking score and favorable pharmacokinetic profile than sulindac was the most appropriate compound for further development into a MAP Kinase inhibitor. ZINC39406706, ZINC26469982, ZINC01847506, ZINC3382343, and ZINC01682308 had favorable toxicity profiles compared to aspirin and were most suitable for development of cyclooxygenase inhibitors in colorectal cancer prevention. Conclusion: In-vivo and in-vitro tests are needed to ascertain the biological activity, synthesizability and clinical use of the compounds.","PeriodicalId":90448,"journal":{"name":"Austin journal of pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48417686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of TCM Medication Rules against Aging based on Network Pharmacology and Data Mining 基于网络药理学和数据挖掘的中药抗衰老用药规律研究

Austin journal of pharmacology and therapeutics Pub Date : 2023-01-25 DOI: 10.26420/austinjpharmacolther.2023.1167

Bo Li, Wei-feng Meng, Mengnan Liu, Feilong Wang, Huairong Luo, Li Wang, Li Dong

{"title":"Study of TCM Medication Rules against Aging based on Network Pharmacology and Data Mining","authors":"Bo Li, Wei-feng Meng, Mengnan Liu, Feilong Wang, Huairong Luo, Li Wang, Li Dong","doi":"10.26420/austinjpharmacolther.2023.1167","DOIUrl":"https://doi.org/10.26420/austinjpharmacolther.2023.1167","url":null,"abstract":"Background and Objective: Aging and age-related diseases have become a global concern. There may be a lot of room for the development of TRADITIONAL CHINESE MEDICINE (TCM) in the future. However, it has yet to fully form a system. Therefore, this study aims to explore the material basis and rules of TCM anti-aging based on network pharmacology and data mining. Methods: In this study, potential targets were searched using the HAGR and Aging Atlas databases, followed by compounds and traditional Chinese herbs from the TCMSP database. On this basis, the target-compound network, compound-Chinese herb network and target-compound-herb network were constructed and visualized using Cytoscape 3.7.2. These networks were used to identify potential targets, compounds and herbs. Finally, the rules of Chinese herbs were summarized by the analysis of properties, flavors, and meridian tropism. Results: A total of 25 potential targets, 210 candidate small compounds and 135 kinds of herbs were obtained. The top five targets included PTGS2, AR, ESR1, GSK3B and CCNA2, and diosgenin, formononetin, tanshinone IIA, phaseolin and phaseollidin were identified as the top 5 compounds. In addition, five core herbs (Huluba, Tiandong, Danshen, Kushen and Shandougen) were confirmed. Moreover, according to the frequency statistics, the Chinese herbs that interfere with aging were mainly bitter, acrid, and sweet, had both cold and warm properties, and belonged to the liver and lung meridians. Conclusion: We explored the potential mechanisms of TCM anti-aging by using network pharmacology and summarized the general rules of traditional Chinese herbs medicine. TCM has great potential in the treatment of aging, and this study provides a new approach and idea for the clinical application of integrated Chinese and Western medicine in the treatment of aging.","PeriodicalId":90448,"journal":{"name":"Austin journal of pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47519152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Alcohol Affect Gastrointestinal Cancer Risk: A Review Updating the Briefings of Related Factors? 酒精是否影响胃肠道癌症风险：相关因素简介更新综述？

Austin journal of pharmacology and therapeutics Pub Date : 2022-12-07 DOI: 10.26420/austinjpharmacolther.2022.1166

Niharika K, S. S, K. P

引用次数: 0

2,3,5,4-Tetrahydroxystilbene-2-O-Β-D-Glucoside Inhibiting Hepatocytes Injury Through Reducing the Expression of Tumor Necrosis Factor-a in LPSStimulated Kupffer Cells via Regulating PPAR-γ/NFκB 2,3,5,4-四羟基二苯乙烯-2-O-β-D-葡糖苷通过调节PPAR-γ/NFκB降低LPSS刺激的库普弗细胞中肿瘤坏死因子-a的表达抑制肝细胞损伤

Austin journal of pharmacology and therapeutics Pub Date : 2022-11-22 DOI: 10.26420/austinjpharmacolther.2022.1165

W. D, J. R., Z. H, L. Q

{"title":"2,3,5,4-Tetrahydroxystilbene-2-O-Β-D-Glucoside Inhibiting Hepatocytes Injury Through Reducing the Expression of Tumor Necrosis Factor-a in LPSStimulated Kupffer Cells via Regulating PPAR-γ/NFκB","authors":"W. D, J. R., Z. H, L. Q","doi":"10.26420/austinjpharmacolther.2022.1165","DOIUrl":"https://doi.org/10.26420/austinjpharmacolther.2022.1165","url":null,"abstract":"2,3,5,4'-Tetrahydroxystilbene-2-O-Β-D-Glucoside (TSG), a main bioactive component of polygonum multiflorum Thumb, exerts anti-oxidant, antitumor, anti-inflammatory effects. However, the protective effects of TSG on hepatocytes through anti-inflammatory effects have rarely been investigated. Mouse liver macrophages (Kupffer cells, KUP5 cells) were primed with various concentrations of TSG before Lipopolysaccharide (LPS) treatment, and AML12 hepatocytes were cultured with the supernatants of KUP5 cells. The results showed that TSG inhibits the expression of iNOS in KUP5 cells. Meanwhile, Tumor Necrosis Factor-a (TNF-a) and interleukin-1Β (IL-1Β) expression in KUP5 cells were reversed after TSG treatment. Additionally, the expression of Peroxisome Proliferators-Activated Receptors-γ (PPAR-γ) was up-regulated while the phosphorylation of p65 and IκB-a were decreased in KUP5 cells after TSG treatment. Furthermore, GW9662 (PPAR-γ antagonist) treatment could eliminate the anti-inflammatory effects of TSG. In AML12 hepatocytes, the level of AST, ALT, and apoptosis was decreased after being cultured with the supernatants of KUP5 cells pretreated with TSG. Moreover, TNF-a neutralization of KUP5 cells supernatants could decrease the level of AST, ALT, and AML12 hepatocyte apoptosis. These results indicate that TSG activates PPAR-γ, thereby decreasing nuclear factor kappa-B (NFκB) activation and reducing the release of TNF-a in macrophages to protect hepatocytes from injury. Our study may help further understand the protective effects of TSG on hepatocytes by suppressing liver inflammation.","PeriodicalId":90448,"journal":{"name":"Austin journal of pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47101491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress of Hollow Materials in Diagnosis of Covid-19 空心材料在新冠肺炎诊断中的研究进展

Austin journal of pharmacology and therapeutics Pub Date : 2022-09-16 DOI: 10.26420/austinjpharmacolther.2022.1163

Hussain A, Shabbir S, Faizan M

{"title":"Progress of Hollow Materials in Diagnosis of Covid-19","authors":"Hussain A, Shabbir S, Faizan M","doi":"10.26420/austinjpharmacolther.2022.1163","DOIUrl":"https://doi.org/10.26420/austinjpharmacolther.2022.1163","url":null,"abstract":"Since the outbreak of COVID-19 in Wuhan, China, it has dramatically changed the global geopolitics, economics, and even society standard norms. The present world scenario is changed regarding business, traveling, and education. Rapid global dissemination and the high mortality rate of coronaviruses are the greatest challenges for drug developers. It will be moving forward toward the identification and treatment of emerging coronaviruses with the aid of nanotechnology. The COVID-19 pandemic raised the question of researchers’ capability to manage this dilemma in a short period. In the present review, we described how hallow material could be developed as a pro-drug that shows an excellent therapeutic effect. Hollow nanoparticles that exploration of antiviral or diagnostic agents against emerging coronaviruses. Hollow nanomaterials in vaccine development are essential because hollow nanocomposites are suitable for mimicking viral structures and antigen delivery. A biosensor that generates a signal from a transducer for comparing and analyzing biological conjugates such as cell receptors, antibodies, RNA, DNA, and nucleic acids. Different biosensors, such as graphene-based biosensors, nanoplasmonic sensor chips, nanomaterial biosensors, electrochemical biosensors, dual modality biosensors, and optical biosensors, have several advantages, characteristics, and a wide range of applications, most remarkably in medical treatment and are used for monitoring and diagnosis. This review focuses on modern experimental studies to identify intelligent and innovative bio/nanomaterials and matrices for developing targeted and controlled drug release systems, nanosensors and nanovaccines to combat pathogenic viruses.","PeriodicalId":90448,"journal":{"name":"Austin journal of pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48370105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Biomarkers in Sub-Acute Hepatorenal Toxicity against Bulk and Zinc Oxide Nanoparticles Exposed Mice 生物标志物对大块和氧化锌纳米粒子暴露小鼠亚急性肝肾毒性的研究

Austin journal of pharmacology and therapeutics Pub Date : 2022-08-17 DOI: 10.26420/austinjpharmacolther.2022.1162

Monika Deore, Jasleen Kaur, S. Naqvi

{"title":"Investigation of Biomarkers in Sub-Acute Hepatorenal Toxicity against Bulk and Zinc Oxide Nanoparticles Exposed Mice","authors":"Monika Deore, Jasleen Kaur, S. Naqvi","doi":"10.26420/austinjpharmacolther.2022.1162","DOIUrl":"https://doi.org/10.26420/austinjpharmacolther.2022.1162","url":null,"abstract":"Zinc oxide nanoparticles have been utilized and produced at a very large scale due to their wide range of applications. Nevertheless, its toxicity is one of the concerns addressed by various researchers. Widely used methods of measuring plasma zinc have poor sensitivity and impaired specificity. Currently, there is no specific biomarker for determination of excess zinc inside our body is explored well. Furthermore, it is vital to know the toxic effects of zinc oxide nanoparticles and their bulk counterparts at early exposure level on human health due to day to day increased use of zinc oxide nanoparticles in various applications. In current study we investigate the kidney and liver as the primary target organs for toxicity and their oxidative stress parameters. Twenty-four male mice were divided into three groups(n=8). Control (group I) served as vehicle control; group II:50mg/kg ZnO (bulk) and group III:ZnO NPs (50mg/kg nano). The mice were sacrificed after 14 days exposure, liver and kidney tissue toxicity biomarkers were performed. Our results demonstrate increased levels of GPx, metallothionein, GST, and decrease level of ceruloplasmin, GSH:GSSG ratio in bulk ZnO administered animals. The acute kidney toxicity was further confirmed by increased levels of their biomarkers i.e. Kim-1 and Clusterin. The levels of serum cytokines and caspase were also analyzed. Hence, this study investigated the comparative effect of early exposure of zinc oxide nanoparticles (nZnO) and its bulk form and we conclude that at 50mg/kg b.wt dose, ZnO NPs is comparatively safe to bulk ZnO.","PeriodicalId":90448,"journal":{"name":"Austin journal of pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48663323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioequivalence Estimation of Two Formulations of Cefixime Tablets among Healthy Chinese Volunteers under Fasting Condition 两种头孢克肟片制剂在禁食条件下的生物等效性评价

Austin journal of pharmacology and therapeutics Pub Date : 2022-04-01 DOI: 10.26420/austinjpharmacolther.2022.1160

H. Q., Z. W, M. X., H. L, L. X

{"title":"Bioequivalence Estimation of Two Formulations of Cefixime Tablets among Healthy Chinese Volunteers under Fasting Condition","authors":"H. Q., Z. W, M. X., H. L, L. X","doi":"10.26420/austinjpharmacolther.2022.1160","DOIUrl":"https://doi.org/10.26420/austinjpharmacolther.2022.1160","url":null,"abstract":"Objective: To assess the bioequivalence of 200mg Cefixime tablets after oral administration to healthy adults under fasting condition. Method: This study was an open-label, balanced, randomized singledose, two-treatment, two-sequence, two-period, crossover oral bioequivalence study in healthy adult, human subjects under fasting condition. Subjects were fasted overnight for at least 10.00 hours before scheduled time of start of dosing. Investigational Product, one tablet of the test formulation or one tablet of reference formulation (allocated as per the randomization schedule) was administered orally to each subject. The pharmacokinetic parameters maximum plasma concentration (Cmax), area under the plasma concentration-time curve (AUC0-t), AUC extrapolated to infinity (AUC0-8) was estimated to prove bioequivalence. Acceptance range for bioequivalence was 80.00%-125.00% for 90% confidence intervals of the geometric least square means ratio for Cmax, AUC0-t and AUC0-8. Results: For the test formulation, the Cefixime Mean Cmax was 3891.31ng/ mL (vs. 3676.32ng/mL for reference), AUC0-t was 33299.52ng•h/mL (vs. 32182.07ng•h/mL) and AUC0-8 was 34234.88ng•h/mL (vs. 33162.95ng•h/mL). The 90% confidence intervals for the Geometric Least Squares Means ratios for Cefixime were 105.85% (90% CI: 98.73%-113.48%), 103.47% (90% CI: 96.34%-111.13%) and 103.23% (90% CI: 96.28%-110.69%) for Cmax, AUC0-t and AUC0-8 respectively, which are within the acceptance range of 80.00% to 125.00% for pharmacokinetic parameter Cmax, AUC0-t and AUC0-8 required for concluding bioequivalence between the test and reference formulations. There were no deaths or serious adverse events during the conduct of the study. Conclusion: Test product when compared with the reference product meets the bioequivalence criteria in terms of rate and extent of absorption of cefixime after administration of single dose under fasting condition.","PeriodicalId":90448,"journal":{"name":"Austin journal of pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49292132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial and Antioxidant Properties of Endophytic Fungi Extracts from Cola acuminata (Sterculiaceae) 可乐内生真菌提取物的抗菌和抗氧化性能

Austin journal of pharmacology and therapeutics Pub Date : 2022-02-24 DOI: 10.26420/austinjpharmacolther.2022.1159

H. Jb, Lung Pk, Momo Er, Manaoda Av, Yi Lv, Mbetyoumoun Hm, Lazar Im, Boyom Ff

{"title":"Antibacterial and Antioxidant Properties of Endophytic Fungi Extracts from Cola acuminata (Sterculiaceae)","authors":"H. Jb, Lung Pk, Momo Er, Manaoda Av, Yi Lv, Mbetyoumoun Hm, Lazar Im, Boyom Ff","doi":"10.26420/austinjpharmacolther.2022.1159","DOIUrl":"https://doi.org/10.26420/austinjpharmacolther.2022.1159","url":null,"abstract":"Currently, the disease burden from pneumonia remains a major public health problem. In this regard, exploring endophytic fungal extracts from traditionally used plants could be a promising approach in this light. Therefore, this work was conceived with the aim of evaluating the antibacterial and antioxidant activities of two endophytic extracts of Cola acuminata against pneumoniacausing bacteria. The identification led to the acquisition of two endophytic fungi: Trichoderma harzianum and Trichoderma afroharzianum. From ten (10) extracts, two (CAB31P1 and CAF71N2) were active on the tested bacteria, and their MICs ranged from 12.5 to 100 μg/ml. CAF71N2 displayed better antioxidant activity with IC50 values of 74.75, 12.70 and 5.66 μg/ml for the reducing power of Fe3+, NO and OH radical scavenging capacities, respectively. The extracts revealed no cytotoxicity (CC50>100 μg/ml) on the two cell lines tested. These results suggest that the endophytic extracts from Cola acuminata could serve as a source for the isolation of potent antibacterial and antioxidant compounds for the treatment of pneumonia.","PeriodicalId":90448,"journal":{"name":"Austin journal of pharmacology and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44699202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1