Bone Reports最新文献

{"title":"Interdisciplinarity of secondary osteons: relevance of bioarchaeological and palaeontological research in biomedical cortical bone histology studies","authors":"Justyna J. Miszkiewicz ,&nbsp;Karen M. Cooke ,&nbsp;Holly E. Reid ,&nbsp;Julien Louys","doi":"10.1016/j.bonr.2025.101893","DOIUrl":"10.1016/j.bonr.2025.101893","url":null,"abstract":"<div><div>Secondary osteons are fundamental products of bone metabolic processes. They accumulate, crowd, and superimpose over themselves over the lifespan of the individual and capture significant biological, environmental, and even social information. They are crucial in biomedical research as a reflection of bone health and disease. Because bone preserves after death, secondary osteons offer a window into past human and animal lives. They are arguably one of very few biological traits that have been examined across multiple disciplines that work with modern and ancient samples. Here, we review articles indexed in PubMed that examine secondary osteons but span beyond biomedicine, such as palaeontology and bioarchaeology. We aim to identify commonalities and differences across these disciplines to highlight potential for exchange of existing complementary data and future collaborative avenues. We find that 9 % of articles reporting new secondary osteon data (622 obtained) represent archaeological or fossil material. The key shared positive outcome across these disciplines has been data and histology images that provide insights into age, sex, behaviour, species discrimination, and anatomical variation. The main limitations of using ancient samples are the unknown and thus estimated demographic information of human and animal remains studied, and artifacts of taphonomy and bioerosion seen in bone histology that originate from post-mortem, burial, and diagenetic processes, which are not present in biomedical samples. We conclude that a histological analysis of secondary osteons can be a versatile tool in different fields of bone research and encourage transdisciplinary collaboration to better improve our knowledge of bone remodelling processes.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"28 ","pages":"Article 101893"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing cortical bone changes with Romosozumab after one year: Insights from an exploratory HR-pQCT study","authors":"María Belén Zanchetta ,&nbsp;Mariana Gonzalez-Pernas ,&nbsp;Fernando Jerkovich ,&nbsp;Jesica Pingel ,&nbsp;Nadia Schwartz ,&nbsp;Luciana Erdociain ,&nbsp;José Rubén Zanchetta","doi":"10.1016/j.bonr.2026.101902","DOIUrl":"10.1016/j.bonr.2026.101902","url":null,"abstract":"<div><h3>Purpose</h3><div>To describe changes in bone microarchitecture after 6 and 12 months of romosozumab (ROMO), identify responders based on cortical thickness (Ct.Th) increase at the distal radius (≥3% at 12 months), and explore factors associated with treatment response.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study of postmenopausal women with osteoporosis at very high fracture risk who started ROMO between August 2021 and February 2023. HR-pQCT, BMD, and bone turnover markers were assessed at baseline, 6, and 12 months. Patients were classified as responders or non-responders based on 12-month Ct.Th changes.</div></div><div><h3>Results</h3><div>Sixteen patients were analyzed. Although improvements in distal tibial microarchitecture were observed at 12 months, treatment responses were heterogeneous. Nine patients were classified as responders and seven as non-responders. Baseline characteristics were similar, though responders had lower trabecular bone parameters at the distal radius. At 12 months, responders showed significant gains in Ct.Th and cortical area at both distal tibia (+5% and + 5%) and radius (+7% and + 6%), while non-responders showed no improvement or decline. These trends were evident by 6 months. Lumbar spine and hip BMD increased significantly only in responders (+14% and + 6%). PTH levels rose in both groups at 6 months but continued increasing only in non-responders, despite comparable vitamin D status.</div></div><div><h3>Conclusion</h3><div>By stratifying patients based on Ct.Th changes, we identified treatment responders (56%) with rapid cortical bone improvements detectable at 6 monthsIdentifying clinical predictors of ROMO responsiveness and determining whether shorter treatment durations may be justified in selected patients warrant further investigation.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"28 ","pages":"Article 101902"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenesis Imperfecta with a gross deletion including the COL1A1 gene, induced by Alu-driven microhomology-mediated end joining","authors":"Kenichi Yamamoto ,&nbsp;Hirofumi Nakayama ,&nbsp;Yusaku Ito ,&nbsp;Masaya Hattori ,&nbsp;Takaaki Shimada ,&nbsp;Ikumi Ueda ,&nbsp;Takeshi Ishimi ,&nbsp;Chieko Yamada ,&nbsp;Yukako Nakano ,&nbsp;Makoto Fujiwara ,&nbsp;Takuo Kubota ,&nbsp;Yasuhisa Ohata ,&nbsp;Yasuji Kitabatake","doi":"10.1016/j.bonr.2026.101901","DOIUrl":"10.1016/j.bonr.2026.101901","url":null,"abstract":"<div><div>Osteogenesis Imperfecta (OI) is a rare hereditary brittle bone disorder typically caused by <em>COL1A1</em> and <em>COL1A2</em> variants impairing type I collagen. However, gross deletions involving <em>COL1A1</em> are uncommon. Here, we report a family with type I OI harboring a 101-kbp deletion encompassing <em>COL1A1</em>, identified through whole genome analysis. Affected individuals presented mild phenotypes. Breakpoint analysis revealed a 5-bp microhomology-mediated end joining involving an Alu element. This report expands the understanding of genetic mechanisms underlying OI.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"28 ","pages":"Article 101901"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent fasting alleviates obesity-associated impairments in bone fracture healing: Exploring the role of gut microbiome","authors":"Honey Hendesi ,&nbsp;Dana A. Godfrey ,&nbsp;Ana Ferreira Ruble ,&nbsp;Aaron M. Tran ,&nbsp;David A. Villani ,&nbsp;Samantha H. Landgrave ,&nbsp;Nur A. Hasan ,&nbsp;Douglas J. Adams ,&nbsp;Michael J. Zuscik","doi":"10.1016/j.bonr.2025.101876","DOIUrl":"10.1016/j.bonr.2025.101876","url":null,"abstract":"<div><div>Intermittent Fasting (IF) is a dietary strategy with metabolic benefits that can reverse certain obesity-related pathologies. This study aimed to investigate whether IF can mitigate delayed bone fracture healing associated with obesity. Using cohorts of mice on high-fat or control diets, we applied either an ad libitum feeding or an alternate-day fasting regimen to animals from both diet groups. We assessed bone healing outcomes by evaluating callus mineralization and adipocyte accumulation within the callus through micro computed tomography (micro-CT), histology, and immunohistochemical analyses. Since IF is known to modulate gut microbiome composition, often associated with improvement in various metabolic and inflammatory processes, particularly in high-fat-fed mice, we also explored the microbial community changes in IF mice through 16S rRNA sequencing of cecal samples. Metabolically, IF led to reduced body weight and improved glucose tolerance in obese mice. Regarding fracture healing outcomes, reduced/delayed mineralization and adipocyte accumulation in fracture callus tissue in the high-fat-fed cohort were significantly attenuated when the high-fat-fed mice were subjected to alternate-day fasting. These benefits of IF were not observed in lean mice fed a control diet. Furthermore, IF significantly altered the gut microbiota of mice on a high-fat diet, including an increased abundance of short-chain fatty acid producing bacteria, known for their positive effect on bone density, and a reduction in various pro-inflammatory taxa. While the mechanistic role remains unknown, these findings suggest that the improved fracture healing observed in obese mice following IF may be associated with alterations in gut microbiome composition and function.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"27 ","pages":"Article 101876"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145047410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating intrinsic musculoskeletal pathology and genetics: Recent advances in unravelling the causative factors of adolescent idiopathic scoliosis","authors":"Ellie H. Northall ,&nbsp;Liam M. Grover ,&nbsp;Helen M. McGettrick ,&nbsp;Matthew Newton Ede ,&nbsp;Amy J. Naylor ,&nbsp;Simon W. Jones","doi":"10.1016/j.bonr.2025.101882","DOIUrl":"10.1016/j.bonr.2025.101882","url":null,"abstract":"<div><div>Adolescent Idiopathic Scoliosis (AIS) is a common paediatric spinal disorder of incompletely understood aetiology. Current interventions include bracing and invasive surgery. However, determining which patients will benefit from observation, bracing, or surgery remains challenging due to the difficulty in predicting disease progression. A number of factors have previously been purported to play a causative role including hormones and biomechanics. However, recently GWAS and in vitro studies have provided insight into the underlying signalling pathways and intrinsic factors that act as drivers of AIS pathology across different tissue types, including spinal bone tissue, paraspinal muscles and cartilage. This review will explore these recent findings and evaluate their links to systemic factors as possible intrinsic drivers underpinning AIS pathophysiology and development.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"27 ","pages":"Article 101882"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145358577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related bone loss in mouse lumbar vertebrae is affected by region, sex, and level: Implications for spinal loading and analysis methods","authors":"Charu Jain ,&nbsp;Neharika Bhadouria ,&nbsp;Justin Tiao ,&nbsp;Jonathan J. Huang ,&nbsp;Yunsoo Lee ,&nbsp;Saad Chaudhary ,&nbsp;Andrew C. Hecht ,&nbsp;Nilsson Holguin ,&nbsp;James C. Iatridis","doi":"10.1016/j.bonr.2025.101879","DOIUrl":"10.1016/j.bonr.2025.101879","url":null,"abstract":"<div><h3>Background</h3><div>Human bone quality varies with age and spinal level, with upper lumbar vertebrae more prone to fracture. Mouse studies of bone health often focus on a single lumbar vertebral level and limited regional analysis with no comprehensive study evaluating how sex, lumbar level, vertebral region, and reconstruction method contribute to patterns of age-related vertebral bone loss in mice.</div></div><div><h3>Methods</h3><div>This micro-computed tomography (μCT) study measured lumbar spinal level- and vertebral region of interest (ROI)-specific patterns of bone quantity, structure, and density in relation to age and sex in mice. Lumbar vertebrae (L1–L6; <em>n</em> = 4/sex/age) from young adult (4-month), middle-aged (12-month), and old (24-month) mice were analyzed for trabecular bone volume fraction (BV/TV), volumetric bone mineral density (vBMD), cortical thickness (Ct.Th), and tissue mineral density (TMD). Parameters were measured for full vertebrae, cranial, middle, and caudal vertebral regions, comparing both 1/3-vertebral and standardized 30-slice reconstruction approaches.</div></div><div><h3>Results</h3><div>Age was associated with a reduction in vBMD and BV/TV in both sexes, with bone volume, structure, and density most significantly reduced at L1 and cranial vertebral regions. Females exhibited greater declines than males, particularly in BV/TV and vBMD. Ct.Th was the greatest mid-spine but declined with age at L1 and L5. Regional differences were observed for both cortical parameters.</div></div><div><h3>Conclusions</h3><div>Trabecular bone is affected by age, sex, lumbar level, and vertebral region in mice. The greatest sensitivity to age-related bone loss was detected in the L1 lumbar level and cranial vertebral regions in female mice. These findings highlight the need for region- and method- specific analysis in bone research and exhibit age-related changes in vertebrate by level and region that exhibit similarities to humans.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"27 ","pages":"Article 101879"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of burosumab conversion on calciuria and nephrocalcinosis in children with XLH: A real-world cohort study","authors":"Guido Filler ,&nbsp;Harry Chandrakumaran ,&nbsp;Funmbi Babalola ,&nbsp;Dougenie Emile ,&nbsp;Shih-Han Susan Huang ,&nbsp;Robert Stein","doi":"10.1016/j.bonr.2025.101877","DOIUrl":"10.1016/j.bonr.2025.101877","url":null,"abstract":"<div><h3>Background</h3><div>Burosumab, a monoclonal antibody to fibroblast growth factor 23 (FGF23), is effective for X-linked hypophosphatemic rickets (XLH). Renal effects, particularly calciuria and nephrocalcinosis, remain incompletely characterized.</div></div><div><h3>Methods</h3><div>In this retrospective cohort, 13 children with genetically confirmed XLH (7 females, 6 males; 0.6–16.3 years) were evaluated after conversion from conventional therapy to burosumab. Longitudinal changes in serum phosphate, TmP/GFR, TRP, 1,25(OH)₂D, intact parathyroid hormone (PTH), and urinary calcium/creatinine (Ca:Cr) were assessed. Hypercalciuria was defined using age-specific SI thresholds; Ca:Cr was also expressed as ×ULN (Ca:Cr divided by the age-specific upper limit).</div></div><div><h3>Results</h3><div>Burosumab improved serum phosphate (<em>p</em> &lt; 0.001), TmP/GFR (p &lt; 0.001), and TRP (<em>p</em> = 0.007). Despite normalized phosphate handling, two patients developed de novo nephrocalcinosis. No child was hypercalciuric at washout or Day 14; two had ≥1 episode later. A repeated-measures analysis of log10(×ULN) showed no overall time effect from washout to Day 56 (F(4,29) = 1.66, <em>p</em> = 0.185). A larger decline in PTH correlated with higher Ca:Cr (<em>p</em> &lt; 0.05), whereas 1,25(OH)₂D did not.</div></div><div><h3>Conclusion</h3><div>Burosumab improves phosphate homeostasis in children with XLH, but a minority may develop hypercalciuria and nephrocalcinosis, potentially linked to PTH suppression. Vigilant biochemical and ultrasound monitoring—particularly early after conversion—and consideration of prophylaxis in high-risk cases are advisable.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"27 ","pages":"Article 101877"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can transient neonatal osteosclerosis be differentiated from malignant infantile osteopetrosis?","authors":"Sarah A. Ackah ,&nbsp;Boaz Karmazyn ,&nbsp;Alden Dewey ,&nbsp;Michael J. Econs ,&nbsp;Gang Peng ,&nbsp;Corinne Parks-Schenck ,&nbsp;Jodi L. Skiles ,&nbsp;Paul Niziolek ,&nbsp;Linda A. DiMeglio ,&nbsp;Stuart J. Warden ,&nbsp;Erik A. Imel","doi":"10.1016/j.bonr.2025.101885","DOIUrl":"10.1016/j.bonr.2025.101885","url":null,"abstract":"<div><div>Osteosclerosis in infancy requires careful evaluation as it may indicate the presence of osteopetrosis. Osteopetrosis is a rare disorder of high bone density due to impaired osteoclast resorption. Infantile forms of osteopetrosis have neurological and hematopoietic defects. However, some infants may present with a transient neonatal osteosclerosis (TNO) appearance without skeletal consequences. The aim of this case series is to compare TNO with infantile osteopetrosis.</div><div>Radiographic reports of infants less than 12 months old were searched for the terms osteosclerosis and osteopetrosis from 2006 to 2025 at a single tertiary care children's hospital. Serial radiographs performed clinically were extracted and assessed for resolution and the clinical features described.</div><div>TNO was identified in 7 infants and osteopetrosis was identified in 6 infants. The children with TNO presented at younger age (median age 6 days) than those with osteopetrosis (median age 73 days). All infants with osteopetrosis had genetic confirmation (TCIRG1 <em>n</em> = 3, CLCN7 <em>n</em> = 2 [one dominant, one recessive], IKBKG <em>n</em> = 1). Four of 6 infants with autosomal recessive osteopetrosis had thrombocytopenia and 3 had hypocalcemia, 5 had elevated parathyroid hormone, and 3 had elevated alkaline phosphatase. One of the 7 infants with TNO had thrombocytopenia and 2 had mild hypocalcemia. Rachitic changes were present in 3 infants with osteopetrosis, and metaphyseal widening in all 6 infants, but none of the TNO infants had these features. In TNO, resolution was evident by mean age of 8.5 months (range 1 to 31 months).</div><div>TNO and infantile osteopetrosis have distinguishing clinical, radiographic and laboratory features.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"27 ","pages":"Article 101885"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric non-infectious inflammatory lytic lesions of the skull: The pitfalls of diagnosis","authors":"Peggy Alkefrawi ,&nbsp;Sylvain Breton ,&nbsp;Geneviève Baujat ,&nbsp;Isabelle Melki ,&nbsp;Benjamin Fournier ,&nbsp;Brigitte Bader-Meunier","doi":"10.1016/j.bonr.2025.101888","DOIUrl":"10.1016/j.bonr.2025.101888","url":null,"abstract":"<div><div>Chronic non-bacterial osteomyelitis of the skull is a rare entity that should be taken into account in the differential diagnosis of lacunar lesions of the skull. Here, we present four challenging cases of non-infectious inflammatory lytic lesions of the neurocranium with a diagnostic delay of one to five years.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"27 ","pages":"Article 101888"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of clinically meaningful bone mineral density gains with romosozumab: An explainable machine leaning analysis of a real-world cohort","authors":"David Castro Corredor ,&nbsp;Luis Ángel Calvo Pascual","doi":"10.1016/j.bonr.2025.101890","DOIUrl":"10.1016/j.bonr.2025.101890","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the real-world effectiveness of Romosozumab in postmenopausal women with severe osteoporosis and to identify baseline clinical and biochemical predictors of clinically meaningful bone mineral density (BMD) gains (≥10 %, used for exploratory classification) using an explainable machine-learning approach.</div></div><div><h3>Methods</h3><div>We conducted a retrospective, observational multicentre study across seven hospitals in Castilla-La Mancha, Spain. Postmenopausal women aged ≥50 years who initiated romosozumab between May 2023 and November 2024 for severe osteoporosis or high fracture risk were included. Lumbar-spine, femoral-neck, and total-hip BMD were assessed by dual-energy X-ray absorptiometry (DXA) at baseline and 12 months. Baseline biochemical variables included serum P1NP, CTX, PTH, vitamin D, calcium, phosphate, alkaline phosphatase, and creatinine. Predictors of a ≥ 10 % BMD gain were examined using elastic-net logistic regression combined with SHapley Additive exPlanations (SHAP) for model interpretability.</div></div><div><h3>Results</h3><div>Fifty-eight women were analysed (mean ± SD age 71.7 ± 10.0 years; BMI 26.1 ± 4.8 kg/m²; mean age at menopause 47.3 ± 6.0 years). Mean 12-month BMD increases were + 15,35 % at the lumbar spine, +12,42 % at the femoral neck, and + 8,62 % at the total hip. The proportion achieving a ≥ 10 % gain was 39 %, 38.1 %, and 31.7 %, respectively. SHAP analysis identified consistent predictors of response: lower baseline BMD, higher phosphate levels, and younger age at menopause were associated with greater gains, whereas elevated PTH and alkaline phosphatase predicted a reduced response. Patients who had not received corticosteroids or NSAIDs in the six months prior to treatment initiation, typically for pain or inflammation, also showed greater increases in BMD.</div></div><div><h3>Conclusions</h3><div>Romosozumab was effective and well-tolerated in routine clinical practice, yielding meaningful and site-specific gains in BMD. Explainable machine-learning analysis identified physiologically coherent and consistent clinical predictors of ≥10 % response.</div></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":"27 ","pages":"Article 101890"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145620177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}