Bone Reports最新文献

{"title":"Vasorin-deficient mice display disturbed vitamin D and mineral homeostasis in combination with a low bone mass phenotype","authors":"Marco Eijken ,&nbsp;A. Michaela Krautzberger ,&nbsp;Manuela Scholze-Wittler ,&nbsp;Bianca Boers-Sijmons ,&nbsp;Marijke Koedam ,&nbsp;Barbara Kosiol ,&nbsp;Heinrich Schrewe ,&nbsp;Johannes P. van Leeuwen ,&nbsp;Bram C. van der Eerden","doi":"10.1016/j.bonr.2024.101792","DOIUrl":"10.1016/j.bonr.2024.101792","url":null,"abstract":"<div><p>Vasorin (Vasn) is a pleiotropic molecule involved in various physiological and pathological conditions, including cancer. Vasn has also been detected in bone cells of developing skeletal tissues but no function for Vasn in bone metabolism has been implicated yet. Therefore, this study aimed to investigate if Vasn plays a significant role in bone biology. First, we investigated tissue distribution of <em>Vasn</em> expression, using lacZ knock-in reporter mice. We detected clear Vasn expression in skeletal elements of postnatal mice. In particular, osteocytes and bone forming osteoblasts showed high expression of Vasn, while the bone marrow was devoid of signal. Vasn knockout mice (<em>Vasn</em>^{<em>−/−</em>}) displayed postnatal growth retardation and died after four weeks. MicroCT analysis of femurs from 22- to 25-day-old <em>Vasn</em>^{<em>−/−</em>} <em>mice</em> demonstrated reduced trabecular and cortical bone volume corresponding to a low bone mass phenotype. <em>Ex vivo</em> bone marrow cultures demonstrated that osteoclast differentiation and activity were not affected by <em>Vasn</em> deficiency. However, osteogenesis of <em>Vasn</em>^−/− bone marrow cultures was disturbed, resulting in lower numbers of alkaline phosphate positive colonies, impaired mineralization and lower expression of osteoblast marker genes. In addition to the bone phenotype, these mice developed a vitamin D₃-related phenotype with a strongly reduced circulating 25-hydroxyvitamin D₃ and 1,25-dihydroxyvitamin D3 and urinary loss of vitamin D binding protein. In conclusion, Vasn-deficient mice suffer from severe disturbances in bone metabolism and mineral homeostasis.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000597/pdfft?md5=7a597eed62295540e98b2527843458a5&pid=1-s2.0-S2352187224000597-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical and molecular characterization of a Pakistani family with multicentric osteolysis, nodulosis and arthropathy (MONA) syndrome","authors":"Safeer Ahmad ,&nbsp;Mari Muurinen ,&nbsp;Petra Loid ,&nbsp;Muhammad Zeeshan Ali ,&nbsp;Muhammad Muzammal ,&nbsp;Sana Fatima ,&nbsp;Jabbar Khan ,&nbsp;Muzammil Ahmad Khan ,&nbsp;Outi Mäkitie","doi":"10.1016/j.bonr.2024.101789","DOIUrl":"10.1016/j.bonr.2024.101789","url":null,"abstract":"<div><p>Multicentric osteolysis nodulosis and arthropathy (MONA) is a rare skeletal dysplasia characterized primarily by progressive osteolysis, particularly affecting the carpal and tarsal bones, accompanied by osteoporosis. In addition, it features subcutaneous nodules on the palms and soles, along with the progressive onset of arthropathy, encompassing joint contractures, pain, swelling and stiffness. It is caused by a deficiency of the Matrix Metalloproteinase-2 (MMP2). In the current study we present a comprehensive clinical, radiological, genetic and <em>in silico</em> analysis of MONA in a consanguineous Pakistani family. Clinical and radiological examinations of the three severely affected siblings demonstrated a progressive MONA syndrome with phenotypic variability. The patients presented unusual facial appearance, thickened skin, severe short stature, short hands and feet. Radiographs revealed extensive bone deformities affecting upper and lower arms, legs, vertebrae and hip. Genetic analysis revealed a homozygous missense variant [c.539 A &gt; T p.(Asp180Val)] in the <em>MMP2</em> gene. <em>In silico</em> findings suggested a mutant MMP2 protein with a decreased stability and an altered pattern of interactions. Our findings add to the existing literature on the skeletal phenotype of MONA syndrome, including the specific clinical and radiological patterns observed. Moreover, the study will aid in genetic counseling and accurate diagnosis of families affected by the same disorder within the Pakistani population.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000561/pdfft?md5=96cda048ba4b842ca9fd3802eb1eae21&pid=1-s2.0-S2352187224000561-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination treatment with whole body vibration and simvastatin improves the early osseointegration in aged rats","authors":"Zheng-Bo Qiao ,&nbsp;Ming-Zhong Gu ,&nbsp;Yu-Wu Wang ,&nbsp;Bin-Bin Ma ,&nbsp;Shan-Shan Pang","doi":"10.1016/j.bonr.2024.101790","DOIUrl":"10.1016/j.bonr.2024.101790","url":null,"abstract":"<div><h3>Background</h3><p>Current research has demonstrated that Simvastatin (SIM) and Whole Body Vibration (WBV) actively contributes to the repair of osteoporotic bones. However, there is still limited knowledge regarding the impact of this combined therapy on osseointegration in elderly individuals. Objective: The objective of this study was to verify the influence of WBV and SIM combination treatment on Titanium implants' fixation strength in aged rats.</p></div><div><h3>Methods</h3><p>Male Sprague-Dawley rats at 24 months old were utilized for this investigation. Titanium rods were surgically inserted into the distal femoral canal on their left side. Subsequently, all animals were randomly assigned to one of four groups: Control group; WBV group; SIM group; and WBV + SIM group. Each group received Saline, Whole Body Vibration, Simvastatin, or a combination of Whole Body Vibration plus Simvastatin treatment until they reached their natural death after 12 weeks. The bilateral femurs and serum samples from these rats were collected for evaluation purposes.</p></div><div><h3>Results</h3><p>Both WBV and SIM treatments exhibited an increase in bone mass, osseointegration, and push-out force compared to the Control group (all, <em>P</em> &lt; 0.05). Additionally, levels of oxidative stress and inflammatory factors decreased with both treatments when compared to the Control group alone (all, <em>P</em> &lt; 0.05). Notably, the WBV + SIM group displayed superior effects on new bone formation, biomechanical strength, BMP2 expression in bone tissue as well as SOD2 expression regulation related to bone repair genes when compared to other groups involved in this study (all, <em>P</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>These findings suggest that combining physiotherapy (WBV) with drug therapy (SIM) proves beneficial for enhancing implant fixation in aged rats.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000573/pdfft?md5=e7816163a7e80395bf3b74970a44bf72&pid=1-s2.0-S2352187224000573-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloid-β peptide treatment reverses bone loss in the mandibular condyle via Wnt signalling pathway","authors":"Qiang Chen ,&nbsp;Shaoqin Tu ,&nbsp;Dongxiao Tang ,&nbsp;Jiaming Wei ,&nbsp;Nan Wei ,&nbsp;Hong Ai ,&nbsp;Bu Yang ,&nbsp;Zheng Chen","doi":"10.1016/j.bonr.2024.101788","DOIUrl":"https://doi.org/10.1016/j.bonr.2024.101788","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the effect of amyloid-β peptide (Aβ) on mandibular condyle to develop a new treatment for postmenopausal women with Temporomandibular joint osteoarthritis.</p></div><div><h3>Methods</h3><p>A murine bone loss model was established by ovariectomy. Microstructure parameters of the condyle were measured by microcomputed tomography before and after intraperitoneal injection with Aβ. Flow cytometry, Alizarin red staining, RT-qPCR assays, FITC/PI staining, Oil Red O staining and western blotting were used to evaluate the effect of Aβ on the osteogenic differentiation of mouse bone marrow stromal stem cells (mBMSCs).</p></div><div><h3>Results</h3><p>In vivo, condylar microstructure parameters increased. Serum osteoprotegerin and procollagen type 1 N propeptide increased in a dose-dependent manner after the injection of Aβ, which were opposite the changes observed in c-terminal telopeptides of type I collagen, tumor necrosis factor-α and the high serum level of leptin. In vitro, Aβ promoted calcium nodule formation in the cells. The expression of ALP, Runx2, osteorix and osteocalcin increased significantly. The expression of mRNAs related to the Wnt signaling pathway was significantly upregulated, which could be blocked by DKK1.</p></div><div><h3>Conclusion</h3><p>Aβ can reverse bone loss in the mandibular condyle in ovariectomized mice through promoting the osteogenic differentiation of mBMSCs via the Wnt pathway.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235218722400055X/pdfft?md5=66ad14a98e70bbc6d64ae7aba01cdd70&pid=1-s2.0-S235218722400055X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning progressive CKD risk prediction model is associated with CKD-mineral bone disorder","authors":"Joseph Aoki,&nbsp;Omar Khalid,&nbsp;Cihan Kaya,&nbsp;Tarush Kothari,&nbsp;Mark Silberman,&nbsp;Con Skordis,&nbsp;Jonathan Hughes,&nbsp;Jerry Hussong,&nbsp;Mohamed E. Salama","doi":"10.1016/j.bonr.2024.101787","DOIUrl":"https://doi.org/10.1016/j.bonr.2024.101787","url":null,"abstract":"<div><h3>Background</h3><p>Recently, we developed the machine learning (ML)-based Progressive CKD Risk Classifier (PCRC), which accurately predicts CKD progression within 5 years. While its performance is robust, it is unknown whether PCRC categorization is associated with CKD-mineral bone disorder (CKD-MBD), a critical, yet under-recognized, downstream consequence. Therefore, we aimed to 1) survey real-world testing utilization data for CKD-MBD and 2) evaluate ML-based PCRC categorization with CKD-MBD.</p></div><div><h3>Methods</h3><p>The cohort study utilized deidentified data from a US laboratory outpatient network, composed of 330,238 outpatients, over 5 years. The main outcomes were: 1) Laboratory testing utilization of eGFR, urine albumin creatinine ratio (UACR), parathyroid hormone (PTH), calcium, phosphate; and 2) PCRC categorization and biochemical abnormalities associated with CKD-MBD over 5 years.</p></div><div><h3>Results</h3><p>We identified significant under-utilization of laboratory testing for UACR, phosphate and PTH, which ranged from −40 % to −100 % against the minimum standard-of-care. At five years, the CKD progression group, as predicted by the PCRC, was associated with 15.5 % increase in phosphate (<em>P</em> value &lt;&lt;0.01) and 94.9 % increase in PTH (P value &lt;&lt;0.01), consistent with CKD-MBD.</p></div><div><h3>Conclusions</h3><p>We identified significant under-utilization of laboratory testing for CKD-MBD. Moreover, we demonstrated that CKD progression, as predicted by the PCRC, is associated with CKD-MBD, several years in advance of disease. To our knowledge, this investigation is the first to examine the role of predictive analytics for CKD progression on mineral bone disorder. While further studies are required, these findings have the potential to advance AI/ML-based risk stratification and treatment of CKD and CKD-MBD.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000548/pdfft?md5=20cfeb812db521b791af9be7514b3fb6&pid=1-s2.0-S2352187224000548-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141595668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QCT-based spatio-temporal aging atlas of the proximal femur BMD and cortical geometry","authors":"Alice Dudle ,&nbsp;Yvan Gugler ,&nbsp;Osman Berk Satir ,&nbsp;Jan Gewiess ,&nbsp;Stefan Klein ,&nbsp;Philippe Zysset","doi":"10.1016/j.bonr.2024.101786","DOIUrl":"https://doi.org/10.1016/j.bonr.2024.101786","url":null,"abstract":"<div><p>Aging is associated with an increased risk of fragility fractures at the hip, resulting from a loss of bone mass. While this loss is typically reported as a decreased mean areal bone mineral density (aBMD) in the proximal femur or the femoral neck, its evolution is spatially inhomogeneous, which might also contribute to the increased risk of fractures. Yet, little is known about the evolution of BMD distribution and cortical thickness with age in the proximal femur. We propose a 3D spatio-temporal atlas of the proximal femur to identify regions with high BMD losses and cortical thinning. The atlas is based on 532 post-mortem QCT scans from donors aged 20 to 94, including 179 female subjects. A point cloud with anatomically corresponding positions was defined for each femur based on a personalized coordinate system. The evolution of BMD and cortical thickness was computed as a multiple linear regression with age and BMI, for female and male subjects separately. The average BMD decrease with age was significant in all subregions for both sexes but higher in females. High BMD losses were observed in the superior and middle neck regions, in the medial part of the head, and in the trochanteric trabecular bone. BMD was well preserved in the inferior neck and, for males, in cortical regions. In both sexes, the cortical thickness decreased significantly in the superior and posterior neck cortex and increased significantly in the inferior neck. Higher BMI was associated with increased BMD in the inferior neck and medial shaft cortex, as well as with increased cortical thickness in all neck and shaft regions for both sexes. The spatio-temporal atlas showed the evolution of BMD distribution and cortical thickness in the proximal femur, with high losses in typical fracture locations, such as the femoral neck and pertrochanteric regions.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000536/pdfft?md5=417b40852f9b43fee0ab72e35bd0ddce&pid=1-s2.0-S2352187224000536-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeing the unseen: The role of bioimaging techniques for the diagnostic interventions in intervertebral disc degeneration","authors":"Gyanoday Tripathi,&nbsp;Lahanya Guha,&nbsp;Hemant Kumar","doi":"10.1016/j.bonr.2024.101784","DOIUrl":"https://doi.org/10.1016/j.bonr.2024.101784","url":null,"abstract":"<div><p>Intervertebral Disc Degeneration is a pathophysiological condition that primarily affects the spinal discs, causing back pain and neurological deficits. It is caused by the contribution of several factors such as genetic predisposition, age-related degeneration, and lifestyle choices like obesity and physical activity. Even though there are medications to treat pain, there is a lack of medicines for a complete cure. The main difficulty lies in poor diagnosis of the morphological and functional changes in the disc. With the ever-increasing research on bioimaging techniques, new techniques are being developed and repurposed to evaluate disc shape and composition, and their defects like thinning or deformities on the disc, leading to the proper diagnostic intervention in intervertebral disc degeneration. In this review, we aim to present a comprehensive overview of the imaging techniques used in the pre-clinical and clinical stages for the diagnosis of intervertebral disc degeneration. First, we will discuss about patho-anatomy and the pathophysiology of degenerative disc disease with the significance and a brief description of various dyes and tracers utilized for bioimaging. Then we will shed light on the latest advancements in diagnostic modalities in intervertebral disc degeneration; concluded by an analysis of the repercussions of the methodologies and experimental systems employed in identifying mechanisms and developing therapeutic strategies in intervertebral disc degeneration.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000512/pdfft?md5=161837d2579e0d0d51097c13c63571c8&pid=1-s2.0-S2352187224000512-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141486238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between nonalcoholic fatty liver disease and bone mineral density: Mendelian randomization and mediation analysis","authors":"Minzhe Zheng,&nbsp;Junxiang Xu,&nbsp;Zongxian Feng","doi":"10.1016/j.bonr.2024.101785","DOIUrl":"10.1016/j.bonr.2024.101785","url":null,"abstract":"<div><h3>Background</h3><p>Observational studies have reported significant association between non-alcoholic fatty liver disease (NAFLD) and bone mineral density (BMD), a critical indicator of bone health. We aimed to investigate whether NAFLD is a cause for changes in BMD.</p></div><div><h3>Methods</h3><p>We selected 29 independent SNPs as instrumental variables for NAFLD. A range of Mendelian randomization (MR) methods, namely the inverse variance-weighted (IVW) method, weighted-median, weighted-mode, and MR-Egger regression, were utilized to determine the causal effects of NAFLD on BMD. Two-step MR analysis was conducted to determine the mediating effect of fasting glucose, insulin, glycosylated hemoglobin, low-density cholesterol, and body-mass index on the association between NAFLD and BMD. False-discovery-rate (FDR) was used to correct for multiple testing bias.</p></div><div><h3>Results</h3><p>The IVW-method indicated a significantly inverse association between genetically predicted NAFLD and total body BMD (β = −0.04, 95 % CI -0.07 to −0.02, FDR = 0.010). Notably, the relationship was more pronounced in participants over 60 years of age (β = −0.06, 95 % CI -0.11 to −0.02, FDR = 0.030). Inverse associations were observed in other subpopulations and in site-specific BMD, though they were not statistically significant after correcting for multiple testing. We observed a significantly positive association between NAFLD and the risk of osteoporosis. Consistency in results was observed across multiple MR methods and in the repeated analysis. Fasting glucose, insulin, and glycosylated hemoglobin mediated 25.4 % (95 % CI 17.6–31.5 %), 18.9 % (12.0–24.9 %), and 27.9 % (19.9–36.7 %) of the effect of NAFLD on BMD, respectively.</p></div><div><h3>Conclusion</h3><p>Our findings underscore a probable causal negative link between NAFLD and BMD, indicating that NAFLD might detrimentally affect bone health, especially in older individuals.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000524/pdfft?md5=89607b0b94a86add72513368be51bc63&pid=1-s2.0-S2352187224000524-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone hierarchical organization through the lens of materials science: Present opportunities and future challenges","authors":"Chiara Micheletti,&nbsp;Furqan A. Shah","doi":"10.1016/j.bonr.2024.101783","DOIUrl":"https://doi.org/10.1016/j.bonr.2024.101783","url":null,"abstract":"<div><p>Multiscale characterization is essential to better understand the hierarchical architecture of bone and an array of analytical methods contributes to exploring the various structural and compositional aspects. Incorporating X-ray tomography, X-ray scattering, vibrational spectroscopy, and atom probe tomography alongside electron microscopy provides a comprehensive approach, offering insights into the diverse levels of organization within bone. X-ray scattering techniques reveal information about collagen-mineral spatial relationships, while X-ray tomography captures 3D structural details, especially at the microscale. Electron microscopy, such as scanning and transmission electron microscopy, extends resolution to the nanoscale, showcasing intricate features such as collagen fibril organization. Additionally, atom probe tomography achieves sub-nanoscale resolution and high chemical sensitivity, enabling detailed examination of bone composition. Despite various technical challenges, a correlative approach allows for a comprehensive understanding of bone material properties. Real-time investigations through in situ and <em>in operando</em> approaches shed light on the dynamic processes in bone. Recently developed techniques such as liquid, in situ transmission electron microscopy provide insights into calcium phosphate formation and collagen mineralization. Mechanical models developed in the effort to link structure, composition, and function currently remain oversimplified but can be improved. In conclusion, correlative analytical platforms provide a holistic perspective of bone extracellular matrix and are essential for unraveling the intricate interplay between structure and composition within bone.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000500/pdfft?md5=0467c214373ede185f74a2dfc951bb42&pid=1-s2.0-S2352187224000500-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141595669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DXA evaluation of bone fragility 2 years after bariatric surgery in patients with obesity","authors":"Marine Fauny ,&nbsp;Marion Halin ,&nbsp;Edem Allado ,&nbsp;Laurent Brunaud ,&nbsp;Claire Nomine-Criqui ,&nbsp;Eliane Albuisson ,&nbsp;Isabelle Chary-Valckenaere ,&nbsp;Didier Quilliot ,&nbsp;Damien Loeuille","doi":"10.1016/j.bonr.2024.101782","DOIUrl":"https://doi.org/10.1016/j.bonr.2024.101782","url":null,"abstract":"<div><h3>Purpose</h3><p>The primary objective was to evaluate bone fragility on dual X-ray absorptiometry (DXA) in patients with obesity before and 2 years after bariatric surgery. The secondary objective was to identify risk factors for the development of a bone mineral density ≤ −2 SD at 2 years.</p></div><div><h3>Methods</h3><p>This descriptive study included patients with obesity who underwent DXA before and 2 years (±6 months) after bariatric surgery. The BMD and the T-score were assessed at the lumbar spine, femoral neck and total hip. Data on body composition on DXA were also collected. The diagnosis of osteoporosis was retained for a T-score ≤ − 2.5 SD at any measured location. Osteopenia, or low bone mass, was defined by −2.5 SD &lt; T-score ≤ −1 SD.</p></div><div><h3>Results</h3><p>Among the 675 included patients, 77.8 % were women, with a mean age of 49.5 years (±11.1). After bariatric surgery, there were significantly more patients with osteoporosis: 3.6 % vs. 0.9 % (<em>p</em> = 0.0001). Multivariate analysis revealed that the risk factors for developing a bone mineral density ≤ −2 SD 2 years after bariatric surgery in patients with normal BMD before surgery were age and lower lean and fat mass before the surgery (OR = 1.07, 95%CI = [1.03–1.12], OR = 0.83, 95%CI = [0.77–0.91], OR = 1.08, 95%CI = [1.02–1.15], respectively).</p></div><div><h3>Conclusion</h3><p>There was a significantly higher prevalence of osteoporosis and low bone mass 2 years after bariatric surgery. Older age and lower lean and fat mass at baseline were risk factors for the development of a BMD ≤ -2SD at 2 years.</p></div>","PeriodicalId":9043,"journal":{"name":"Bone Reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352187224000494/pdfft?md5=2af139fe90844d4d4ac4f8c2a4bff14b&pid=1-s2.0-S2352187224000494-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}