Regeneration (Oxford, England)最新文献

{"title":"Position-specific induction of ectopic limbs in non-regenerating blastemas on axolotl forelimbs.","authors":"Catherine McCusker,&nbsp;Jeffrey Lehrberg,&nbsp;David Gardiner","doi":"10.1002/reg2.10","DOIUrl":"https://doi.org/10.1002/reg2.10","url":null,"abstract":"<p><p>Ectopic retinoic acid (RA) has been hypothesized to reprogram the positional identity of cells in developing and regenerating limbs to a single positional value corresponding to the posterior-ventral-proximal (PVPr) position on the limb. We tested this hypothesis by using RA to reprogram the information of blastema cells that were induced to form at different positions around the limb circumference. We observed that RA treatment of blastemas in anterior and dorsal locations, but not posterior and ventral locations, resulted in the induction of complete ectopic limbs. These position-specific differences in limb induction are probably due to differences in the positional disparity between the RA-reprogrammed blastema cells and the cells at the periphery of the wound. These observations are consistent with the hypothesis that RA treatment reprograms the information in blastema cells to the PVPr position on the limb, since anterior and dorsal positions have the largest disparity and posterior and ventral have the smallest disparity from the PVPr identity. </p>","PeriodicalId":90316,"journal":{"name":"Regeneration (Oxford, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/reg2.10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34737524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regeneration of reptilian scales after wounding: neogenesis, regional difference, and molecular modules.","authors":"Ping Wu,&nbsp;Lorenzo Alibardi,&nbsp;Cheng-Ming Chuong","doi":"10.1002/reg2.9","DOIUrl":"https://doi.org/10.1002/reg2.9","url":null,"abstract":"<p><p>Lizard skin can produce scales during embryonic development, tail regeneration, and wound healing; however, underlying molecular signaling and extracellular matrix protein expression remains unknown. We mapped cell proliferation, signaling and extracellular matrix proteins in regenerating and developing lizard scales in different body regions with different wound severity. Following lizard tail autotomy (self-amputation), de novo scales regenerate from regenerating tail blastema. Despite topological differences between embryonic and adult scale formation, asymmetric cell proliferation produces the newly formed outer scale surface. Regionally different responses to wounding were observed; open wounds induced better scale regeneration from tail skin than trunk skin. Molecular studies suggest NCAM enriched dermal regions exhibit higher cell proliferation associated with scale growth. β-catenin may be involved in epidermal scale differentiation. Dynamic tenascin-C expression suggests its involvement in regeneration. We conclude that different skin regions exhibit different competence for de novo scale formation. While cellular and morphogenetic paths differ during development and regeneration of lizard scale formation, they share general proliferation patterns, epithelial-mesenchymal interactions and similar molecular modules composed of adhesion and extracellular matrix molecules.</p>","PeriodicalId":90316,"journal":{"name":"Regeneration (Oxford, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/reg2.9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32205548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EDITORIAL.","authors":"Susan V Bryant","doi":"10.1002/reg2.7","DOIUrl":"https://doi.org/10.1002/reg2.7","url":null,"abstract":"I am both honored and excited to be announcing the launch of Regeneration, the first ever major journal dedicated exclusively to research on regeneration and repair mechanisms in animals and plants. My goal as Editor-in-Chief is for Regeneration to emerge quickly as the venue of choice for publication of research on regeneration by the large community of scientists whose works range from appendage and organ regeneration in species from across the evolutionary spectrum, to stem cells and the in vitro creation of organs with multiple cell types. We launch Regeneration as an open access journal with an experienced Managing Editor, Lisa Hannan, an internationally stellar group of Associate Editors, and members of the Editorial Board representing the breadth and depth of the field. We are indebted to our colleagues Kiyo Agata and Wiley Editor Pernille Hammelsoe for the initial impetus to create this new and important venue for expanding the field of regeneration. Throughout the history of regeneration research, there has always been the hope that what we learn from regenerating animals will lead eventually to improved healing and regeneration of form and function for humans. The combination of the fields of developmental, regenerative and stem cell biology is providing an avenue for organ development in vitro, as recently shown by the successful development of an eye from mouse stem cells in a dish. The need for a better understanding of the guiding cues and cellular responses by which cells form tissues and tissues form organs is starting to be appreciated; and at the same time, the basic molecular and cellular tools needed for these next steps are now in place. The launch of a new journal devoted to regeneration reignites the hope of regeneration, but this time with a difference, because now we have tools, technologies and insights emerging from the rapidly advancing new fields of genomics and stem cell biology. Genomics is opening up a treasure trove of new and unanticipated information about how genes are regulated, leading to a possible future in which reagents will be developed that are capable of controlling tissue-specific repair processes. The rapidly developing stem cell field has already shown that stem cells have the potential to ameliorate the negative consequences of a number of degenerative disease conditions. The next major challenge on the horizon is not just patching up damaged organs but the complete regeneration of damaged or missing organs and appendages. Understanding the way in which both animals and plants are able to accomplish complete, total and repeated regeneration of body parts is an essential first step. Humans are unable to match the regenerative feats of our close vertebrate relatives who share the same basic body design and developmental processes. Some amphibians can regenerate arms and legs as well as many other organs, whereas humans can only regenerate components of these organs (bone and muscle and skin), not the","PeriodicalId":90316,"journal":{"name":"Regeneration (Oxford, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/reg2.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34737521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}