BJS Open最新文献

{"title":"Comparative analysis of robotic, laparoscopic, and open ileal pouch-anal anastomosis outcomes: retrospective cohort study.","authors":"Tommaso Violante, Sacha P Broccard, Marco Novelli, Luca Stocchi, Dorin T Colibaseanu, Michelle F DeLeon, Kevin T Behm, Nitin Mishra, David W Larson, Amit Merchea","doi":"10.1093/bjsopen/zraf084","DOIUrl":"10.1093/bjsopen/zraf084","url":null,"abstract":"<p><strong>Introduction: </strong>Ileal pouch-anal anastomosis (IPAA) is a common surgical procedure for patients with ulcerative colitis or familial adenomatous polyposis. This study compared the outcomes of robotic, laparoscopic, and open IPAA techniques, with a focus on surgical complications and pouch failure rates.</p><p><strong>Methods: </strong>A retrospective study was conducted of patients who underwent IPAA at three Mayo Clinic locations between 2015 and 2020. Data on patient demographics, surgical details, and postoperative outcomes were collected and compared across the three surgical approaches. Pouch failure was defined as the need for pouch excision or a diverting loop ileostomy.</p><p><strong>Results: </strong>In all, 401 patients underwent IPAA with either an open (149, 37.2%), robotic (145, 36.2%), or laparoscopic (107, 26.7%) technique. The overall rate of pouch failure was 6.5% and did not differ significantly between the three surgical approaches. Compared with laparoscopy, robotic IPAA was associated with a lower conversion rate to open surgery (1.4 versus 17.8%; P < 0.0001) and fewer 30-day readmissions (15.9% versus 28.0%; P = 0.02). However, robotic and laparoscopic IPAA approaches had higher rates of venous thromboembolism/pulmonary embolism and readmission than the open approach. Pouchitis was the most common cause of pouch failure across all surgical techniques.</p><p><strong>Conclusion: </strong>Robotic IPAA had lower conversion and reduced 30-day admission rates compared with a laparoscopic approach. However, open surgery had lower rates of 30-day readmission and rates thromboembolism than robotic IPAA. The surgical approach itself does not appear to significantly impact long-term pouch failure rates.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of 18F-choline PET-CT or PET-MRI on surgical strategy in patients with primary hyperparathyroidism.","authors":"Jose Luis Carrillo Lizarazo, Diego Cecchin, Valentina Camozzi, Filippo Crimì, Francesca Torresan, Maurizio Iacobone","doi":"10.1093/bjsopen/zraf069","DOIUrl":"10.1093/bjsopen/zraf069","url":null,"abstract":"<p><strong>Background: </strong>Accurate preoperative localization is essential for successful, focused, minimally invasive surgery in primary hyperparathyroidism (PHPT). New imaging techniques have recently been proposed. This study evaluated the impact of 18F-choline positron emission tomography (PET)-computed tomography or 18F-choline PET-magnetic resonance imaging (FCh) in patients with negative or inconclusive results on neck ultrasonography (US) and 99mTc-sestamibi (MIBI) scintigraphy.</p><p><strong>Methods: </strong>Baseline biochemical characteristics (preoperative calcemia and PTH), parathyroid gland features (size and weight), preoperative imaging localization techniques accuracy, and surgical results were compared in a series of patients operated for PHPT who underwent only preoperative US and MIBI scintigraphy with concordant results (MIBI Group) or also FCh as additional imaging following US and MIBI with negative or inconclusive results (FCh Group).</p><p><strong>Results: </strong>The overall cure rate was 100% in 185 patients operated for PHPT. The overall sensitivity of imaging was 63.9% in the MIBI group (n = 116), compared with 94.4% (P < 0.001) in the FCh group (n = 69). FCh provided clear unilateral localization in 86.9% of patients, avoiding unnecessary bilateral neck exploration; in contrast, based on MIBI results, unilateral localization would have been theoretically possible in only 61.6% of patients. Compared with the MIBI group, patients in the FCh group had significantly lower preoperative calcium levels (2.71 versus 2.79 mmol/l; P = 0.012), lower preoperative parathyroid hormone levels (177 versus 250 pg/ml; P = 0.032), and smaller (17 versus 21 mm; P <0.001) and lighter (1.47 versus 2.58 g, P = 0.005) parathyroid glands removed.</p><p><strong>Conclusion: </strong>FCh enables successful focused parathyroidectomy in PHPT patients with negative or inconclusive MIBI results, reducing unnecessary bilateral neck exploration in 33% of patients; it may also allow for a successful focused approach in patients with milder PHPT, characterized by lower preoperative calcium and PTH levels and smaller pathological parathyroid glands.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of chronic low-grade inflammation with adverse outcomes after gastrointestinal surgery: observational and Mendelian randomization study.","authors":"Doruk Orgun, Christina Ellervik, Henrik Enghusen Poulsen, Børge Grønne Nordestgaard, Ismail Gogenur, Ask Tybjærg Nordestgaard","doi":"10.1093/bjsopen/zraf087","DOIUrl":"10.1093/bjsopen/zraf087","url":null,"abstract":"<p><strong>Background: </strong>Although overt systemic inflammation immediately before gastrointestinal surgery has been associated with postoperative complications and mortality, it remains unclear whether baseline low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) in a non-surgery-related state is associated with the same outcomes.</p><p><strong>Methods: </strong>This study included a subset of individuals from the Copenhagen General Population Study (CGPS) who underwent any type of gastrointestinal surgery between 2003 and 2015 after enrolment in the CGPS. Exposures were baseline hs-CRP levels (used in observational analyses) and two genetic variants that affect hs-CRP levels, namely interleukin 6 receptor (IL6R) rs4537545 and CRP rs1130864 (used in Mendelian randomization analyses), all of which were tested routinely at CGPS enrolment. Primary outcomes were 30-day complications and 90-day and 5-year mortality after the index surgery. Associations between exposures and outcomes were assessed using multivariable Cox regression models.</p><p><strong>Results: </strong>Of the 107 536 individuals in the CGPS, 12 803 were included in the present study. Of these individuals, 1236 (9.7%) experienced 30-day complications, 865 (6.8%) died within 90 days, and 2789 (21.8%) died within 5 years. Adjusted hazard ratios for the highest hs-CRP quartile (hs-CRP ≥ 2.73 mg/l) versus the lowest quartile (hs-CRP < 1.04 mg/l) were 1.19 (95% confidence interval (c.i.) 1.02 to 1.40; P = 0.029) for 30-day complications, 1.29 (95% c.i. 1.07 to 1.57; P = 0.009) for 90-day mortality, and 1.17 (95% c.i. 1.06 to 1.31; P = 0.003) for 5-year mortality. Sensitivity analyses restricted to those with hs-CRP measurements within 1 year before surgery had larger point estimates. Genetically predicted elevations in hs-CRP were not associated with any outcomes.</p><p><strong>Conclusion: </strong>Baseline hs-CRP levels ≥ 2.73 mg/l, consistent with chronic low-grade systemic inflammation, were associated with higher risk of 30-day complications, 90-day mortality, and 5-year mortality after gastrointestinal surgery.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of postoperative complications in oesophageal cancer on survival, hospital outcomes, and long-term quality of life: retrospective cohort study.","authors":"Nerma Crnovrsanin, Stefan Giring, Antonia Oppel, Ingmar F Rompen, Sabine Schiefer, Nicolas Jorek, Thomas Schmidt, Beat P Müller-Stich, Leila Sisic, Henrik Nienhüser","doi":"10.1093/bjsopen/zraf083","DOIUrl":"10.1093/bjsopen/zraf083","url":null,"abstract":"<p><strong>Introduction: </strong>Postoperative complications pose a major challenge in oesophageal surgery, affecting survival, recovery, and healthcare resource utilization. The aim of this study was to quantify the proportional contribution of specific complications to survival and adverse outcomes and to evaluate their effects on long-term quality of life (QoL) in patients with oesophageal and gastro-oesophageal junction cancer.</p><p><strong>Methods: </strong>This retrospective cohort study included patients with oesophageal or gastro-oesophageal junction cancer who underwent surgery with curative intent between January 2010 and July 2022. Postoperative complications were categorized following Esophageal Complications Consensus Group guidelines. Population-attributable fractions (PAFs) were calculated to estimate the proportion of adverse outcomes and survival effects theoretically preventable if specific complications were avoided.</p><p><strong>Results: </strong>In 632 patients who underwent surgery, the most frequently observed complications were pulmonary (31%), infectious (29%), and gastrointestinal (24%). Pneumonia had the highest adjusted PAF for overall survival (8.3% after 2 years; 95% confidence interval (c.i.) 1.8 to 14.7), suggesting that preventing pneumonia could substantially reduce mortality. Anastomotic leak had the highest PAF for recurrence-free survival (6.6%; 95% c.i. 1.8 to 11.5) and was the complication most significantly contributing to reoperations (PAF 39.8%; 95% c.i. 22.2 to 52.1) and prolonged hospital stays (PAF 56.9%; 95% c.i. 46.8 to 66.2). Respiratory failure had the largest effect on 90-day mortality (PAF 53.5%; 95% c.i. 30.9 to 73.9). In contrast, no significant effect of complications on long-term QoL was observed.</p><p><strong>Conclusion: </strong>This study underscores the critical importance of targeted strategies to prevent postoperative complications, particularly pneumonia and anastomotic leakage, which contribute significantly to adverse outcomes such as reduced survival and prolonged hospital stays. Effective complication management may enhance oncological outcomes and optimize healthcare resource utilization.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolving concept of conversion surgery for upfront unresectable upper gastrointestinal and hepato-pancreato-biliary cancers: comprehensive review.","authors":"Giampaolo Perri, Jennie Engstrand, Robin D Wright, Sebastiaan F C Bronzwaer, Tiuri E Kroese, Biying Huang, Belkacem Acidi, Alessandro Vitale, Hop S Tran Cao, Richard van Hillegersberg, Magnus Nilsson, Ernesto Sparrelid, Matthew H G Katz, Giovanni Marchegiani, Umberto Cillo","doi":"10.1093/bjsopen/zraf070","DOIUrl":"10.1093/bjsopen/zraf070","url":null,"abstract":"<p><strong>Background: </strong>In the absence of a commonly accepted definition, conversion surgery is generally considered as surgical resection with the intent of prolonging survival after non-surgical induction therapy in patients with upfront unresectable disease at diagnosis. Despite the heterogeneity of possible targets, conversion surgery is a quickly evolving concept, with commonalities for upper gastrointestinal (UGI) and hepato-pancreato-biliary (HPB) malignancies.</p><p><strong>Methods: </strong>A comprehensive narrative review of the most recent and relevant literature was conducted by experts in the field of different UGI and HPB tumours.</p><p><strong>Results: </strong>The increased interest of the surgical scientific community in the concept of conversion surgery can be explained by the continuous improvements in non-surgical therapies aimed at controlling the systemic tumour burden and the local extension of cancer, supported by improvements in surgical outcomes for advanced resections in expert centres. The toolbox of the surgical oncologist seeking conversion in the case of unresectable UGI and HBP tumours is large and includes (but is not limited to) systemic chemotherapy, (chemo)radiation, targeted therapy/immunotherapy, locoregional ablation techniques, intra-arterial therapies, liver hypertrophy induction techniques, treatments of underlying medical conditions, and prehabilitation.</p><p><strong>Conclusions: </strong>Conversion surgery represents a powerful instrument to prolong the survival of patients with unresectable UGI and HPB malignancies. However, most of the available evidence is of a low level and at very high risk of selection bias. Alongside a profound understanding of (and respect for) the biology of cancer, which remains key to selecting appropriate patients and avoiding non-therapeutic surgeries, a commonly accepted definition is urgently needed to standardize practice, monitor outcomes, and improve the quality of research.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of postoperative analgesic effects of ultrasound-guided intercostal nerve block and transversus abdominis plane block in patients undergoing laparoscopic cholecystectomy: randomized clinical trial.","authors":"Hongchun Xu, Dandan Song, Zhiqiang Wu, Chao Lin, Wuchang Fu, Fangjun Wang","doi":"10.1093/bjsopen/zraf022","DOIUrl":"10.1093/bjsopen/zraf022","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to compare the postoperative analgesic effects of ultrasound-guided intercostal nerve block and transversus abdominis plane block in patients undergoing laparoscopic cholecystectomy.</p><p><strong>Methods: </strong>Patients undergoing laparoscopic cholecystectomy for chronic cholecystitis with gallstones were randomly allocated to ultrasound-guided T7-11 intercostal nerve block or subcostal transversus abdominis plane block (both with 40 ml 0.3% ropivacaine). The primary outcome was the dose of tramadol required for remedial analgesia 24 h after surgery. The secondary outcomes included visual analogue scale scores at different time points after surgery, the time of initial use of tramadol for postoperative analgesia, patient satisfaction with postoperative pain control, the time to flatus, and the incidence of postoperative adverse events.</p><p><strong>Results: </strong>A total of 64 patients were included. Compared with the transversus abdominis plane block group, the intercostal nerve block group had lower visual analogue scale scores at 3 h after surgery (mean(s.d.) of 2.4(0.8) versus 1.6(0.6)), 6 h after surgery (mean(s.d.) of 2.2(0.3) versus 1.4(0.6)), and 8 h after surgery (mean of 1.7(0.5) versus 1.3(0.4)) (P < 0.001, P < 0.001, and P = 0.002 respectively), a lower dose of tramadol for remedial analgesia within 24 h after surgery (median of 100 (interquartile range 0-100) versus 50 (interquartile range 0-50) mg) (P = 0.012), and a significantly delayed time of initial use of tramadol for postoperative analgesia (mean(s.d.) of 9.1(7.5) versus 14.6(8.3) h) (P = 0.015). The incidences of postoperative dizziness and postoperative nausea and vomiting were higher in the transversus abdominis plane block group (47% and 69% respectively) than in the intercostal nerve block group (19% and 41% respectively) (P = 0.032 and 0.035 respectively). Patient satisfaction with postoperative analgesia was higher in the intercostal nerve block group than in the transversus abdominis plane block group (P = 0.037). The time to flatus was similar between the two groups (P > 0.050).</p><p><strong>Conclusion: </strong>Compared with ultrasound-guided subcostal transversus abdominis plane block, ultrasound-guided T7-11 intercostal nerve block with 0.3% ropivacaine provides better postoperative analgesia, requires a lower dose of tramadol for remedial analgesia 24 h after surgery, and significantly delays the time of initial use of tramadol for postoperative analgesia.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiseptic wound irrigation to prevent surgical site infection after laparotomy: meta-analysis.","authors":"Tara C Mueller, Niel Mehraein, Victoria Kehl, Rebekka Dimpel, Helmut Friess, Daniel Reim","doi":"10.1093/bjsopen/zraf072","DOIUrl":"10.1093/bjsopen/zraf072","url":null,"abstract":"<p><strong>Background: </strong>Surgical site infection after laparotomy is a major postoperative complication. The efficacy of prophylactic laparotomy wound irrigation to reduce surgical site infection rates remains controversial. This study evaluates the impact of antiseptic wound irrigation on surgical site infection prevention.</p><p><strong>Methods: </strong>A systematic review and meta-analysis, following PRISMA 2020, included randomized clinical trials and observational studies (published after 1999) comparing antiseptic or saline irrigation versus saline or no irrigation before laparotomy closure in adult patients with surgical site infection as the primary outcome. Databases searched included MEDLINE, EMBASE, Cochrane Library, and Google Scholar (September 2024). Risk of bias was assessed using RoB 2 and ROBINS-I; Grading of Recommendations Assessment, Development, and Evaluation evaluated evidence certainty.</p><p><strong>Results: </strong>Eighteen studies (6368 patients) reported an overall surgical site infection rate of 14.7%. Thirteen studies compared antiseptic with saline irrigation, showing no significant effect (relative risk 0.80, 95% confidence interval 0.58 to 1.09; P = 0.159) with very low evidence certainty. Excluding laparoscopic cases and high-risk bias studies revealed a favourable effect for antiseptic irrigation (relative risk 0.75, 0.64 to 0.87; P < 0.001) with moderate certainty. Three studies compared antiseptic with no irrigation, and four compared saline with no irrigation. Meta-analysis indicated reduced surgical site infection rates with any irrigation (antiseptic or saline) versus no irrigation (relative risk 0.52, 0.37 to 0.74; P < 0.001) with moderate certainty.</p><p><strong>Conclusion: </strong>Wound irrigation (antiseptic or saline) likely reduces surgical site infection rates after laparotomy. Evidence comparing antiseptic versus saline is uncertain but suggests a potential benefit after excluding the high risk of bias studies. Further high-quality, standardized trials are needed.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality assurance of surgical interventions for pancreatic cancer: systematic review of multicentre randomized clinical trials.","authors":"Jack A Helliwell, Sophie Rozwadowski, Jing Yi Kwan, Melissa Bautista, Shailesh V Shrikhande, Deborah D Stocken, Natalie S Blencowe, Andrew M Smith, Samir Pathak","doi":"10.1093/bjsopen/zraf082","DOIUrl":"10.1093/bjsopen/zraf082","url":null,"abstract":"<p><strong>Background: </strong>Surgical interventions for pancreatic cancer are complex due to numerous interacting components. This complexity can make the design and conduct of randomized clinical trials (RCTs) challenging due to variations in how surgical interventions are delivered across centres and surgeons. Quality assurance (QA) methods, such as those described within the CONSORT recommendations for non-pharmacological interventions (CONSORT-NPT), attempt to mitigate this. The extent of the adoption of such QA methods in RCTs evaluating surgical interventions for pancreatic cancer is unclear.</p><p><strong>Methods: </strong>A systematic review was conducted on multicentre RCTs evaluating surgical interventions for pancreatic cancer. Data were extracted within four QA domains described within the CONSORT-NPT checklist: surgical intervention description, standardization, adherence, and clinician and unit expertise.</p><p><strong>Results: </strong>Of 2374 studies identified, 45 were eligible for inclusion in this review. Thirty-eight RCTs (84%) described the intervention and 20 (44%) attempted to standardize techniques. Information about permitted flexibility in surgical interventions was described in 14 RCTs (31%). Fourteen studies (31%) described methods used to measure adherence to the intervention, with intra-operative photographs/videos (ten studies) being the most common. Nineteen studies (42%) detailed surgeon or unit expertise, and six (13%) used credentialing criteria.</p><p><strong>Conclusion: </strong>Although most RCTs described the intervention, reporting on standardization, adherence, and expertise was often lacking. This may affect RCT results and compromise the extent to which observed differences in clinical outcomes are due to the actual intervention being delivered. More rigorous application and reporting of QA measures are needed to improve confidence in the results of future RCTs, which may, in turn, enhance implementation in clinical practice.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate versus early urinary catheter removal after gastrectomy under enhanced recovery after surgery protocols: randomized clinical trial.","authors":"Chen Wei, Gang Wang, Hai-Feng Wang, Hua-Feng Pan, Zhi-Wei Jiang, Mu-Wen Qu","doi":"10.1093/bjsopen/zraf088","DOIUrl":"10.1093/bjsopen/zraf088","url":null,"abstract":"<p><strong>Background: </strong>Compliance with enhanced recovery after surgery (ERAS) protocols in gastrectomy, including urinary catheter management, remains poor. This study evaluated the feasibility of immediate urinary catheter removal after radical gastrectomy.</p><p><strong>Methods: </strong>This was a non-inferiority randomized clinical trial performed at a university-affiliated hospital in China. Patients undergoing radical gastrectomy were randomized in a 1 : 1 ratio to either immediate removal (IR) or early removal (ER) of the urinary catheter. The randomization sequence was computer generated; the investigators and patients were not blinded to group allocation. ERAS protocols were applied in all patients. The primary outcome measure was postoperative urinary retention with a non-inferiority margin of 10% to compare IR with ER. Secondary outcomes were patient comfort, patient anxiety, and depression. Data were analysed using intention-to-treat analysis.</p><p><strong>Results: </strong>Initially, 248 patients were assessed for eligibility for this study. Data were analysed for 92 patients in the IR group and 89 patients in the ER group. The incidence of postoperative urinary retention was 4.4% and 3.4% in the IR and ER groups, respectively (P = 0.733; 1.0% difference, 95% confidence interval -4.6 to 6.6%). Patient comfort levels were significantly higher in IR than ER group (mean(standard deviation) Kolcaba General Comfort Questionnaire score 74.9(7.6) versus 72.5(8.0), respectively; P = 0.041).</p><p><strong>Conclusion: </strong>IR of the urinary catheter after gastrectomy is feasible under ERAS perioperative care protocols. It does not increase the incidence of postoperative urinary retention and can provide a more comfortable postoperative experience. Successful IR implementation probably relies on multimodal analgesia and goal-directed fluid therapy.</p><p><strong>Registration number: </strong>NCT06718114 (http://www.clinicaltrials.gov).</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capsular contractures following implant-based breast reconstruction in women undergoing risk-reducing mastectomy: national register-based study.","authors":"Signe Hägglund, Johan Svensson, Emma Hansson, Martin Halle, Rebecca Wiberg","doi":"10.1093/bjsopen/zraf080","DOIUrl":"10.1093/bjsopen/zraf080","url":null,"abstract":"<p><strong>Background: </strong>The majority of women undergoing risk-reducing mastectomy have implant-based breast reconstruction, with capsular contracture being one of the most common complications. The primary aim of this study was to establish the national incidence rate of severe capsular contracture requiring surgery following risk-reducing mastectomy with implant-based breast reconstruction. The secondary aim was to establish the incidence rate of other complications and associated risk factors.</p><p><strong>Methods: </strong>Women undergoing implant-based breast reconstruction following risk-reducing mastectomy were identified from the Swedish Breast Implant Register. Data were extracted from the Swedish Breast Implant Register and the National Patient Register on women undergoing implant-based breast reconstruction from 2014 to 2021. The primary outcome was severe capsular contracture corresponding to Baker grade III-IV requiring surgery, and the secondary outcomes were other complications observed perioperatively.</p><p><strong>Results: </strong>In total, 656 women with 1095 implant-based breast reconstructions were included in the analysis. Median follow-up was 3.5 (interquartile range 1.5-5.4) years. Capsular contracture was observed in 39 of 1095 breasts (3.6%), and the cumulative incidence increased from 1.9% at 1 year to 4.7% after 5 years. Stratified by implant type, the estimated risk of capsular contracture increased for patients with a permanent tissue expander compared with a permanent fixed-volume implant (adjusted hazard ratio 19.33, 95% confidence interval 3.92 to 95.43; P < 0.001).</p><p><strong>Conclusion: </strong>This study has highlighted that the risk of developing severe capsular contracture requiring surgery seems to differ between implant types, emphasizing the need for further investigation regarding permanent tissue expanders. Moreover, the continuous increase in capsular contracture incidence rates over 5 years underscores the importance of long-term follow-up.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"9 4","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}