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Early inflammatory signal in late-diagnosed anastomotic leakage after anterior resection. 吻合口前切除术后晚期诊断瘘的早期炎症信号。
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag127
Martin Rutegård, Josefin Segelman, Peter Matthiessen, Marie-Louise Lydrup, Jennifer Park
{"title":"Early inflammatory signal in late-diagnosed anastomotic leakage after anterior resection.","authors":"Martin Rutegård, Josefin Segelman, Peter Matthiessen, Marie-Louise Lydrup, Jennifer Park","doi":"10.1093/bjsopen/zrag127","DOIUrl":"10.1093/bjsopen/zrag127","url":null,"abstract":"","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Completion, publication, and outcome reporting of registered randomized trials in abdominal surgery: registry-based cohort study. 腹部外科注册随机试验的完成、发表和结果报告:基于注册的队列研究。
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag160
Klaudia Narbekovas, Christoph Kuemmerli, Sandro Huegli, Jasper P Sijberden, Lukas W Widmer, Oliver Strobel, Max F Stauffer, Ethan B Ludmir, Carl-Stephan Leonhardt
{"title":"Completion, publication, and outcome reporting of registered randomized trials in abdominal surgery: registry-based cohort study.","authors":"Klaudia Narbekovas, Christoph Kuemmerli, Sandro Huegli, Jasper P Sijberden, Lukas W Widmer, Oliver Strobel, Max F Stauffer, Ethan B Ludmir, Carl-Stephan Leonhardt","doi":"10.1093/bjsopen/zrag160","DOIUrl":"https://doi.org/10.1093/bjsopen/zrag160","url":null,"abstract":"<p><strong>Background: </strong>Abdominal surgery poses unique challenges to the conduct of randomized clinical trials (RCTs). However, trial discontinuation, non-publication, and selective reporting may result in an incomplete picture of the available evidence base. This study assessed the trajectories of RCTs in abdominal surgery from trial registration to the publication and reporting of results.</p><p><strong>Methods: </strong>RCTs in adult abdominal surgery were identified through a systematic search of ClinicalTrials.gov, the EU Clinical Trials Register, and the International Clinical Trials Registry Platform from database inception until 31 January 2018. Corresponding trial publications were identified by searching PubMed, Google Scholar, and Google. Selective reporting was evaluated by examining consistency of primary endpoints and reported P values in published trials.</p><p><strong>Results: </strong>After screening 2654 registry records, 295 trials were deemed eligible for inclusion. Among these, 160 (54%) were reported as completed in trial registries. An elective non-cancer trial population was associated with lower odds of non-completion (odds ratio (OR) 0.46; 95% c.i. 0.27 to 0.78), whereas trials with no reported funding had higher odds of non-completion compared with funded trials (OR 2.05; 95% c.i. 1.16 to 3.66). Among completed trials, a corresponding publication was identified for 119 trials (74%). Completed superiority trials with added or modified primary endpoints were more likely to report P values < 0.050 than primary endpoint-unmodified trials (OR 4.28; 95% c.i. 2.23 to 8.22).</p><p><strong>Conclusion: </strong>Nearly half of registered trials are not reported as completed, and a significant proportion of completed trials are not published. Among published trials, discrepancies between registered and published primary outcomes are common. This is consistent with possible selective outcome reporting and evidentiary bias in abdominal surgery, with implications for both guidelines and meta-analytical work.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13692691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149262313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic impact of low versus high inferior mesenteric artery ligation in rectosigmoid cancer: individual patient data meta-analysis of randomized trials. 低或高肠系膜下动脉结扎对直肠乙状结肠癌预后的影响:随机试验的个体患者数据荟萃分析。
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag120
Alberto Aiolfi, Francesco Cammarata, Emanuele Rausa, Gianluca Bonitta, Antonio Biondi, Luigi Bonavina, Davide Bona
{"title":"Prognostic impact of low versus high inferior mesenteric artery ligation in rectosigmoid cancer: individual patient data meta-analysis of randomized trials.","authors":"Alberto Aiolfi, Francesco Cammarata, Emanuele Rausa, Gianluca Bonitta, Antonio Biondi, Luigi Bonavina, Davide Bona","doi":"10.1093/bjsopen/zrag120","DOIUrl":"10.1093/bjsopen/zrag120","url":null,"abstract":"<p><strong>Background: </strong>The optimal level of inferior mesenteric artery ligation in rectosigmoid cancer surgery remains a matter of debate. This study evaluated the prognostic impact of low ligation (LL) versus high ligation (HL) after rectal or sigmoid cancer resection.</p><p><strong>Methods: </strong>A reconstructed individual patient data meta-analysis of randomized clinical trials (RCTs) was performed using restricted mean survival time difference (RMSTD) estimation. PubMed, MEDLINE, Scopus, Web of Science, ClinicalTrials.gov, Cochrane Central Library, and Google Scholar were searched. Primary outcomes were 5-year overall (OS) and disease-free survival (DFS). The RMSTD, risk ratio (RR), standardized mean difference (SMD), and 95% confidence interval (c.i.) were used as pooled effect size measures. The certainty of evidence was categorized with the GRADE framework.</p><p><strong>Results: </strong>Overall, 1152 patients from five RCTs were included; 34% underwent LL. Baseline demographics and pathological tumour stage were balanced among the LL and HL groups. At the 60-month follow-up, the OS and DFS estimates for LL versus HL were 1.40 months (95% c.i. -0.18 to 2.98; moderate level of certainty) and 0.71 months (95% c.i. -1.55 to 3.03; moderate level of certainty). Anastomotic leak (RR 0.71), overall complications (RR 0.79), total number of lymph nodes retrieved (SMD 0.01), and operating time (SMD 0.08) were comparable.</p><p><strong>Conclusion: </strong>This meta-analysis did not detect a statistically significant difference in 5-year OS and DFS between LL and HL in patients with rectosigmoid cancer.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictability of symptom changes following hemithyroidectomy due to compression symptoms assessed by specific questionnaires: prospective multicentre study. 由特定问卷评估的压迫症状对甲状腺切除术后症状变化的可预测性:前瞻性多中心研究。
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag163
Ervin Beka, Ivan Shabo, David Fornander, Kenth Johansson, Oliver Gimm
{"title":"Predictability of symptom changes following hemithyroidectomy due to compression symptoms assessed by specific questionnaires: prospective multicentre study.","authors":"Ervin Beka, Ivan Shabo, David Fornander, Kenth Johansson, Oliver Gimm","doi":"10.1093/bjsopen/zrag163","DOIUrl":"https://doi.org/10.1093/bjsopen/zrag163","url":null,"abstract":"","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149294261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tolerability of dose-escalating early postoperative intraperitoneal chemotherapy in colorectal cancer with peritoneal disease: EFFIPEC single-arm phase I study. 结直肠癌合并腹膜疾病术后早期剂量递增腹腔化疗的耐受性:EFFIPEC单臂I期研究
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag121
Elinor Bexe Lindskog, Lana Ghanipour, Gabriella Jansson Palmer, Dan Asplund, Caroline Nordenvall, Helgi Birgisson, Ingvar Syk, Torbjörn Swartling, Per J Nilsson, Jan-Erik Frödin, Victor Verwaal, Wilhelm Graf, Peter Cashin
{"title":"Tolerability of dose-escalating early postoperative intraperitoneal chemotherapy in colorectal cancer with peritoneal disease: EFFIPEC single-arm phase I study.","authors":"Elinor Bexe Lindskog, Lana Ghanipour, Gabriella Jansson Palmer, Dan Asplund, Caroline Nordenvall, Helgi Birgisson, Ingvar Syk, Torbjörn Swartling, Per J Nilsson, Jan-Erik Frödin, Victor Verwaal, Wilhelm Graf, Peter Cashin","doi":"10.1093/bjsopen/zrag121","DOIUrl":"https://doi.org/10.1093/bjsopen/zrag121","url":null,"abstract":"","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrawound vancomycin for prevention of surgical site infection: meta-analysis of randomized clinical trials. 万古霉素用于预防手术部位感染:随机临床试验的meta分析。
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag131
Shaan Patel, Shiva A Nischal, Kush M Kale, Angelette Mendonca, Nelson Sofoluke, Srinivas K Prasad, James S Harrop, Daniel Refai
{"title":"Intrawound vancomycin for prevention of surgical site infection: meta-analysis of randomized clinical trials.","authors":"Shaan Patel, Shiva A Nischal, Kush M Kale, Angelette Mendonca, Nelson Sofoluke, Srinivas K Prasad, James S Harrop, Daniel Refai","doi":"10.1093/bjsopen/zrag131","DOIUrl":"10.1093/bjsopen/zrag131","url":null,"abstract":"<p><strong>Background: </strong>Surgical site infection remains a major cause of postoperative morbidity. Intrawound vancomycin has been proposed as an adjunct to standard prophylaxis, but its effectiveness across surgical settings remains uncertain. This systematic review and meta-analysis of randomized clinical trials aimed to evaluate the association between intraoperative intrawound vancomycin and surgical site infection in adults undergoing surgery.</p><p><strong>Methods: </strong>MEDLINE, Embase, and CENTRAL were searched from database inception to March 2026 for randomized clinical trials comparing intrawound vancomycin with standard care in adults undergoing operative procedures. Two reviewers independently performed screening, data extraction, and risk-of-bias assessment using the Cochrane Risk of Bias 2 tool. Random-effects meta-analyses were undertaken, with certainty of evidence rated using the Grading of Recommendations Assessment, Development and Evaluation framework. Primary outcomes were overall surgical site infection, deep surgical site infection, superficial surgical site infection, and Gram-positive surgical site infection.</p><p><strong>Results: </strong>Twenty-two trials enrolling 8424 patients (vancomycin 4228, control 4196) were included. Intrawound vancomycin was associated with a lower risk of overall surgical site infection (risk ratio 0.79, 95% confidence interval 0.64 to 0.99) and Gram-positive surgical site infection (risk ratio 0.53, 0.35 to 0.79), corresponding to numbers needed to treat of 82 and 78, respectively. No significant differences were observed for deep or superficial surgical site infection, Gram-negative infection, reoperation, wound complications, mortality, or length of hospital stay. The certainty of evidence was moderate.</p><p><strong>Conclusion: </strong>Intrawound vancomycin was associated with a modest reduction in surgical site infection, driven by reductions in Gram-positive infections. These findings support a selective, context-specific use rather than routine application across all procedures.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preventing pancreatic fistula following pancreatectomy: meta-analysis of randomized clinical trials. 胰腺切除术后预防胰瘘:随机临床试验的荟萃分析。
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag088
Roberto M Montorsi, Alessio Marchetti, Tessa E Hendriks, Freek Daams, Olivier R Busch, Bas Groot Koerkamp, Matteo De Pastena, Hjalmar C van Santvoort, Bert A Bonsing, Salvatore Paiella, Giuseppe Malleo, Marc G Besselink, Roberto Salvia
{"title":"Preventing pancreatic fistula following pancreatectomy: meta-analysis of randomized clinical trials.","authors":"Roberto M Montorsi, Alessio Marchetti, Tessa E Hendriks, Freek Daams, Olivier R Busch, Bas Groot Koerkamp, Matteo De Pastena, Hjalmar C van Santvoort, Bert A Bonsing, Salvatore Paiella, Giuseppe Malleo, Marc G Besselink, Roberto Salvia","doi":"10.1093/bjsopen/zrag088","DOIUrl":"10.1093/bjsopen/zrag088","url":null,"abstract":"<p><strong>Background: </strong>The majority of postoperative morbidity and mortality after partial pancreatectomy is attributable to postoperative pancreatic fistula. Several interventions to prevent postoperative pancreatic fistula have been assessed in randomized clinical trials but consensus on their efficacy is lacking. This is the first systematic review and meta-analysis of randomized trials focusing on strategies to prevent postoperative pancreatic fistula after all types of partial pancreatectomy.</p><p><strong>Methods: </strong>Eligible randomized clinical trials assessing postoperative pancreatic fistula following partial pancreatectomy were included from the Evidence Map of Pancreatic Surgery database (2005-2025). As primary endpoint, both the 2005 and 2016 International Study Group for Pancreatic Surgery definitions of grade B/C postoperative pancreatic fistula were accepted. Interventions shown to reduce postoperative pancreatic fistula in at least one randomized trial were identified, and meta-analysis undertaken for those with at least three available trials, irrespective of their outcome.</p><p><strong>Results: </strong>Overall, 193 RCTs were included with 29 408 patients from 24 countries. The pooled rate of postoperative pancreatic fistula grade B/C was 15.1%: 14.2% after pancreatoduodenectomy and 19.1% after left pancreatectomy. Overall, 24 trials identified 18 interventions as effective in reducing the rate of postoperative pancreatic fistula: 11 intraoperative and 7 postoperative. Eight interventions were eligible for meta-analysis, involving 46 trials. Following meta-analysis, three interventions remained effective: drain omission in left pancreatectomy, perioperative use of somatostatin analogues, and administration of perioperative corticosteroids. The certainty of evidence was high for drain omission, moderate for somatostatin analogues, and low for corticosteroids. Eleven trials focused specifically on high-risk patients and four on ongoing postoperative pancreatic fistula. No trial combined interventions.</p><p><strong>Conclusion: </strong>Omission of drains in left pancreatectomy, perioperative use of somatostatin analogues, and administration of perioperative corticosteroids are effective strategies to prevent postoperative pancreatic fistula after partial pancreatectomy. However, current evidence remains immature and further RCTs evaluating these interventions are warranted, as they are likely to change the conclusions of subsequent meta-analyses. Such trials could potentially focus on high-risk patient cohorts and/or assess combinations of interventions.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental benefits of reintroducing reusable drapes and gowns in the operating room. 在手术室重新引入可重复使用的窗帘和长袍的环境效益。
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag139
Florine I de Haes, Meis Uijttewaal, Nicolaas H Sperna Weiland, Martijn L M Broeren, Dorien A Salentijn
{"title":"Environmental benefits of reintroducing reusable drapes and gowns in the operating room.","authors":"Florine I de Haes, Meis Uijttewaal, Nicolaas H Sperna Weiland, Martijn L M Broeren, Dorien A Salentijn","doi":"10.1093/bjsopen/zrag139","DOIUrl":"10.1093/bjsopen/zrag139","url":null,"abstract":"<p><strong>Background: </strong>The healthcare sector contributes significantly to environmental pollution, which adversely affects human health. Operating rooms are a major source of this impact, partially due to the routine use of disposable materials prepacked in surgical trays. The main objective of this study was to compare the environmental impacts of fully disposable surgical trays with those of hybrid surgical trays, which replace disposable drapes and gowns with reusable ones.</p><p><strong>Methods: </strong>This multicentre study included surgical trays from three types of surgeries: gynaecological laparoscopy surgery, extremity surgery, and caesarean section. This selection captures a broad range of surgical workflows and instrument requirements, enabling the development of an average tray composition and enhancing the generalizability of the findings across various surgical specialties. The hybrid trays, including reusable drapes and gowns, were developed and tested specifically for this study. A life cycle assessment was conducted according to ISO 14040/44 standards to compare the environmental impacts of the hybrid and disposable trays across 18 impact categories.</p><p><strong>Results: </strong>Hybrid trays demonstrated lower environmental impacts than disposable trays across almost all impact categories. For climate change, hybrid trays reduced impact by 40-51%. In disposable trays, drapes and gowns contributed to approximately 69% of the total climate change impact, whereas in hybrid trays this contribution decreased to 38%, primarily because the production and end-of-life impacts of reusable drapes and gowns are distributed over multiple uses.</p><p><strong>Conclusion: </strong>These results provide a robust evidence base to inform and support a broader European Union-wide transition to hybrid trays, incorporating reusable drapes and gowns, in operating rooms.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elective cholecystectomy benchmarks: nationwide registry study. 选择性胆囊切除术基准:全国登记研究。
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag175
Ebba Kihlstedt Pasquier, Ellen Andersson, Johanna Österberg, Per Sandström, Bergthor Björnsson
{"title":"Elective cholecystectomy benchmarks: nationwide registry study.","authors":"Ebba Kihlstedt Pasquier, Ellen Andersson, Johanna Österberg, Per Sandström, Bergthor Björnsson","doi":"10.1093/bjsopen/zrag175","DOIUrl":"https://doi.org/10.1093/bjsopen/zrag175","url":null,"abstract":"<p><strong>Background: </strong>Laparoscopic cholecystectomy is the treatment of choice for symptomatic gallstone disease. The aim of this study was to establish clinically relevant benchmarks for elective laparoscopic cholecystectomy (ELC) to guide quality initiatives and support improvements in patient outcomes.</p><p><strong>Method: </strong>The Swedish Registry for Gallstone Surgery and Endoscopic Retrograde Cholangiopancreatography provided data on patients treated with primary ELC for a benign indication between 2015 and 2023. Exclusion criteria were common bile duct stones or stents detected before surgery, suspicion of bile duct obstruction, abnormal or unperformed intraoperative cholangiogram, previous major upper abdominal surgery, concomitant surgical procedures, and robotic surgery. The Achievable Benchmark of Care methodology was used to develop intra- and postoperative benchmarks, with severe postoperative complications (Clavien-Dindo ≥ III) representing the primary outcome. During surgery, serious adverse events were defined as intestinal perforation, bile leakage, or bleeding requiring transfusion or conversion to open surgery. Postoperative outcomes were assessed up to 30 days after surgery. Logistic regression identified risk factors for severe postoperative complications.</p><p><strong>Results: </strong>Overall, 48 564 patients undergoing ELCs across 81 surgical facilities were included. Among these, 69% were women. Median age was 50 (range 18-95) years and 91.4% were classified as American Society of Anesthesiologists classification ≤ II. Ten benchmarks were developed, capturing either intraoperative events (3) or postoperative complications (7). During surgery, 0.5% of the total cohort experienced a serious adverse event (median 0.3%, interquartile range 0.2-0.7% between facilities)-benchmark was 0.2%. Severe postoperative complications occurred in 1.7% of patients (median 1.6%, interquartile range 1.0-2.2% between facilities)-benchmark was 1.0%. Postoperative mortality was low (7 deaths, < 0.1%). At multivariable analysis, American Society of Anesthesiologists classification ≥ III (odds ratio 1.35, 95% confidence interval 1.05 to 1.72; P = 0.018), previous abdominal surgery (odds ratio 2.15, 1.24 to 3.75; P = 0.007), and intraoperative assessment of an altered gallbladder morphology (odds ratio 1.24, 1.01 to 1.52; P = 0.044) were independently associated with severe postoperative complications.</p><p><strong>Conclusion: </strong>This study provides benchmarks for elective laparoscopic cholecystectomy. When compared with real-world performance, these benchmarks highlight potential areas for quality improvement.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Costs and health burden of surgical site infections and anastomotic leakage in major abdominal surgery. 腹部大外科手术部位感染和吻合口瘘的费用和健康负担。
IF 4.9 3区 医学
BJS Open Pub Date : 2026-09-04 DOI: 10.1093/bjsopen/zrag111
Nathan Bontekoning, Hannah Groenen, Stijn W de Jonge, Markus W Hollmann, Marja A Boermeester, Marcel G W Dijkgraaf, Niels Wolfhagen
{"title":"Costs and health burden of surgical site infections and anastomotic leakage in major abdominal surgery.","authors":"Nathan Bontekoning, Hannah Groenen, Stijn W de Jonge, Markus W Hollmann, Marja A Boermeester, Marcel G W Dijkgraaf, Niels Wolfhagen","doi":"10.1093/bjsopen/zrag111","DOIUrl":"10.1093/bjsopen/zrag111","url":null,"abstract":"<p><strong>Background: </strong>Surgical site infection (SSI) is a common postoperative complication. SSI, including anastomotic leakage (AL), is a burden for patients and leads to increased costs, although insights as to the true costs from prospective data are limited. This study aimed to provide an overview of the impact of SSI and AL specifically on total societal costs and the quality of life (QoL) of patients.</p><p><strong>Method: </strong>This is a secondary analysis from the EPO2CH trial conducted between 2016 and 2020, which randomized patients scheduled for elective abdominal surgery with incisions > 5 cm to either standard care or standard care plus a bundle aiming to reduce SSI. Prospectively collected clinical data from the EPO2CH trial were used to ascertain the occurrence of SSI (superficial/deep/organ space and AL). The costs and QoL of patients with versus without SSI within 90 days after surgery were evaluated. The primary outcomes were costs (€) and (loss of) health utility, measured as quality-adjusted life-years (QALYs). QoL data were collected using patient questionnaires (EQ-5D™-3L). Unit costs were based on national guidelines for health economic evaluations and locally available unit costs of care.</p><p><strong>Results: </strong>Overall, 1119 of 1777 patients were analysed. Costs in the SSI and non-SSI groups were €53 562 (bias-corrected and accelerated (BCa) 95% confidence interval (c.i.) 45 356 to 68 600]) and €23 969 (BCa 95% c.i. 22 961 to 25 075), respectively, with a mean difference of €29 592 (BCa 95% c.i. 21 206 to 45 674). The greatest mean difference was observed between patients with AL and patients without SSI (€56 401; BCa 95% c.i. 39 487 to 90 892). The maximum attainable mean QALY score over 3 months was 0.25. The mean(standard deviation) QALY score in SSI and non-SSI patients was 0.171(0.050) and 0.205(0.037), respectively, with a mean difference of -0.035 (BCa 95% c.i. -0.042 to -0.029). This corresponds to a loss of 12.78 days in perfect health over the 3-month period.</p><p><strong>Conclusion: </strong>Patients with SSI, regardless of its type, had substantially higher healthcare costs and lower QoL after major abdominal surgery than patients without SSI.</p>","PeriodicalId":9028,"journal":{"name":"BJS Open","volume":"10 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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