Korean journal of audiology最新文献

{"title":"Nasal Colonization of Methicillin-Resistant Staphylococcus aureus in Patients with Chronic Suppurative Otitis Media.","authors":"Eun Jung Lee, Jin Ho Kwon, Ah Young Park, Won-Sang Lee, Eun Jin Son","doi":"10.7874/kja.2012.16.2.75","DOIUrl":"https://doi.org/10.7874/kja.2012.16.2.75","url":null,"abstract":"Background and Objectives Methicillin-resistant Staphylococcus aureus (MRSA) is one of major pathogens in patients with chronic suppurative otitis media (CSOM). In addition to intrinsic MRSA infection of the mastoid air cell system, nasal colonization of MRSA, a known predictor of postoperative surgical site infection, may pose increased risk of postoperative complications. The purpose of this study is to describe microbiology of preoperative nasal swab screening and localized middle ear specimens in patients undergoing otologic surgeries. Subjects and Methods Forty-nine consecutive patients with CSOM who underwent middle ear surgery were included. Preoperative nasal swabs for MRSA, and preoperative and intraoperative middle ear swabs were collected and compared for pathogens. Results Preoperative nasal swab screening confirmed MRSA colonization in 3/49 patients (6.1%) and methicillin-resistant coagulase-negative Staphylococcus (MRCNS) in 9/49 patients (18.4%). Correlation with preoperative culture results and nasal swab screening results were compatible in 2/4 patients with positive nasal swab for MRSA and 1/9 patients with positive nasal swab for MRCNS. Postoperative conversion to MRSA was observed in 3 patients. Conclusions The rate of nasal MRSA colonization among patients with CSOM was higher than among the general community. Preoperative MRSA colonization was associated with MRSA from middle ear specimens. Further studies are warranted to investigate the possible benefit of preoperative treatment of MRSA colonized patients undergoing middle ear surgeries.","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 2","pages":"75-9"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/45/kja-16-75.PMC3936563.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32195636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of linear scleroderma involving cerebellum with vertigo.","authors":"Eui Je Choi,&nbsp;Dong Won Lee,&nbsp;Chul Won Park,&nbsp;Seung Hwan Lee","doi":"10.7874/kja.2012.16.2.87","DOIUrl":"https://doi.org/10.7874/kja.2012.16.2.87","url":null,"abstract":"<p><p>Linear scleroderma is a kind of disease that can cause complication of the central nervous system. Sometimes, ipsilateral intracerebral or white matter lesions in the brain magnetic resonance imaging are noted. Nystagmus is important for the differential diagnosis of dizziness. Positional nystagmus was classified into regular direction nystagmus, direction changing positional nystagmus (DCPN) and irregular nystagmus by their character. DCPN is defined as a nystagmus that changes its direction with different head and body positions, and it can be the sign of lesion in the central vestibular system. Recently, we experienced a 17-year-old woman who had a scalp linear scleroderma, treated for about 10 years and showed DCPN induced by positional nystagmus test. We report a case of linear scleroderma accompanied by cerebellar lesion with a brief review of literature. </p>","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 2","pages":"87-90"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/69/kja-16-87.PMC3936567.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32195546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of bilateral postauricular sinuses.","authors":"Hong Jun Kim,&nbsp;Jae Heon Lee,&nbsp;Hyun Sang Cho,&nbsp;In Seok Moon","doi":"10.7874/kja.2012.16.2.99","DOIUrl":"https://doi.org/10.7874/kja.2012.16.2.99","url":null,"abstract":"<p><p>Preauricular sinuses are common congenital malformations that usually occur at the anterior margin of the ascending limb of the helix. There are rare cases in which the location of the preauricular sinus is posterior to the tragus, and the direction of the sinus tract is toward the posterior. This variant type of preauricular sinus is called, 'postauricular sinus'. Postauricular sinus is uncommon. Thus, diagnosis and treatment may be delayed due to its location of its opening and atypical clinical symptoms. Typical treatment is a single stage operation through bidirectional skin incision. However, we found out that according to the length and invasion depth of the sinus tract, there was an option between unidirectional and bidirectional skin incisions that we may choose from. </p>","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 2","pages":"99-101"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7874/kja.2012.16.2.99","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32195549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural differentiation of bone marrow-derived mesenchymal stem cells: applicability for inner ear therapy.","authors":"Jae-Hong Lee,&nbsp;Won Kyung Kang,&nbsp;Jae-Hyun Seo,&nbsp;Mi-Yung Choi,&nbsp;Yang Hyun Lee,&nbsp;Hyo Min Kim,&nbsp;Kyoung-Ho Park","doi":"10.7874/kja.2012.16.2.47","DOIUrl":"https://doi.org/10.7874/kja.2012.16.2.47","url":null,"abstract":"<p><strong>Background and objectives: </strong>Regeneration or replacement of damaged hair cells and neurons in the cochlea might be an ideal treatment for sensorineural hearing loss (SNHL). The purpose of the present study was to investigate whether mesenchymal stem cells (MSCs), derived from the bone marrow of rats, could differentiate into auditory hair cells and neurons.</p><p><strong>Materials and methods: </strong>The centrifuge gradient method was used to isolate MSCs from the bone marrow of rats. To confirm whether bone marrow-derived MSCs can differentiate into neuronal cells, culture medium with glial cell-derived neurotrophic factor, brain-derived neurotrophic factor and neurotrophin-3 for 14 days. In addition, immunofluorescence staining and RT-PCR were performed for characterization of the neurospheres and differentiated cells from 7 and 14 day cultures.</p><p><strong>Results: </strong>The results showed that MSCs could differentiate into neuron-positive and hair cell-positive cells, using different compositions of growth factors. And RT-PCR result was identified high or low of gene expression all these differentiated cells.</p><p><strong>Conclusions: </strong>Rat bone marrow-derived MSCs differentiated into neuronal progenitor cells. These cells might be useful for the treatment of SNHL.</p>","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 2","pages":"47-53"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/44/kja-16-47.PMC3936568.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32195632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of delayed spontaneous aneurismal rupture after ear surgery under general anesthesia.","authors":"Kyung Seok Lee,&nbsp;Jong Min Lee,&nbsp;Eun Jung Lee,&nbsp;Yong Joo Yoon","doi":"10.7874/kja.2012.16.2.83","DOIUrl":"https://doi.org/10.7874/kja.2012.16.2.83","url":null,"abstract":"<p><p>Many complications have been reported after ear surgery to treat chronic inflammation. These complications include facial nerve paralysis, perichondritis, injury of the dura or of the sigmoid sinus, cyst formation or mucocele in the healed mastoid cavity, and the recurrence of cholesteatoma, granulation tissue, or otorrhea. It might be believed that there could be no relation between ear surgery and spontaneous aneurysmal rupture, and only one other case of spontaneous aneurysmal rupture after ear surgery under general anesthesia has been previously reported in Korea. However, recently, the authors encountered a case of delayed spontaneous aneurysmal rupture 3 weeks after surgery. No problem was experienced during the operation, and it is suspected that an unidentified pre-existing aneurysm was responsible for the intracerebral hemorrhage. </p>","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 2","pages":"83-6"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/c2/kja-16-83.PMC3936562.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32195545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination therapy with systemic steroids, an antiviral agent, anticoagulants, and stellate ganglion block for treatment of sudden sensorineural hearing loss.","authors":"Kye Hoon Park,&nbsp;Chi-Kyou Lee,&nbsp;Jong Dae Lee,&nbsp;Moo Kyun Park,&nbsp;Byung Don Lee","doi":"10.7874/kja.2012.16.2.71","DOIUrl":"https://doi.org/10.7874/kja.2012.16.2.71","url":null,"abstract":"<p><strong>Background and objectives: </strong>Sudden sensorineural hearing loss (SSNHL) is commonly defined as a loss of at least 30 dB in three contiguous frequencies occurring within 3 days. Systemic steroid administration has become the most widely accepted treatment option for SSNHL. Since viral infection and vascular compromise are considered specific causes of SSNHL, antiviral agents, anticoagulants, and stellate ganglion block have been used for its treatment, although the evidence of their effectiveness is weak. The present study evaluated the hearing recovery rate in the combination therapy group (systemic steroids, antiviral agent, anticoagulants, and stellate ganglion block) in comparison with patients treated with systemic steroids alone.</p><p><strong>Subjects and methods: </strong>A total of 85 patients diagnosed with SSNHL were treated with combination therapy (group A, 46 patients) or systemic steroids only (group B, 39 patients). Hearing improvement was defined as a hearing gain of more than slight improvement using Siegel's criteria. All patients were treated with a 10-day course of systemic steroids (10-mg dexamethasone for 5 days, followed by tapering for 5 days). Acyclovir, heparin, and stellate ganglion block were included in the group A treatment regimen.</p><p><strong>Results: </strong>The overall rate of hearing improvement was 60.9% (28/46 patients) in group A, which was significantly higher than that (38.5%, 15/39 patients) in group B. The distribution of prognostic factors was not significantly different between the two groups with the exception of the degree of initial hearing loss, which was more severe in group A. Upon analysis according to prognostic factors, group A showed a better hearing improvement recovery rate than group B in patients with hearing loss >70 dB, age >41 years, dizziness, and early treatment (<1 week).</p><p><strong>Conclusions: </strong>Thus SSNHL patients treated with combination therapy have a higher likelihood of hearing improvement than those treated with systemic steroids alone.</p>","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 2","pages":"71-4"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/a8/kja-16-71.PMC3936560.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32195635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Institutional review boards and bioethical issues for otologists and audiologists.","authors":"Moo Kyun Park,&nbsp;Byung Don Lee","doi":"10.7874/kja.2012.16.2.43","DOIUrl":"https://doi.org/10.7874/kja.2012.16.2.43","url":null,"abstract":"<p><p>Otologists and audiologists care for patients and conduct clinical research to find more effective treatments that benefit patients. Institutional Review Board (IRB) permission is necessary for conducting clinical trials on humans. Furthermore, many bioethical conflicts are encountered while conducting research. However, few otologists and audiologists in Korea know bioethics and the principles and regulations of IRBs in detail. This paper reviews the history of ethics in clinical research and current bioethical principles and IRB regulations. We outline what you need as otologists or audiologists to get IRB approval while considering the principles of bioethics. </p>","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 2","pages":"43-6"},"PeriodicalIF":0.0,"publicationDate":"2012-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/72/ef/kja-16-43.PMC3936566.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32195631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of next generation sequencing upon the molecular genetic diagnosis of deafness.","authors":"Byung Yoon Choi,&nbsp;Bong Jik Kim","doi":"10.7874/kja.2012.16.1.1","DOIUrl":"https://doi.org/10.7874/kja.2012.16.1.1","url":null,"abstract":"<p><p>The main objective of this review is to describe the new sequencing technologies called next generation sequencing (NGS) and its utility as a molecular genetic diagnosis tool in a medical field. Sanger method has dominated the genome sequencing industry for the past 30 years since its invention in 1975. It produced first human genome and still remains the gold standard for genome sequencing. However, it cannot meet the needs for enormous genetic data gathering and process because of its relatively long sequencing time and high cost per sample. NGS which parallelise the sequencing process, thereby increasing processing speed at a reduced cost per sample emerged to compensate for the weakness of the previous method. Currently NGS is used in some medical areas and its use is being widened. NGS also plays an important role in a study of genetically heterogenous hearing diseases. NGS is expected to mark a significant milestone in genomic research filed in a near future. </p>","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/8d/kja-16-1.PMC3936532.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32194616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of middle ear adenoma.","authors":"Myung Joo Shim,&nbsp;Chan-Il Song,&nbsp;Tae Hyun Yoon","doi":"10.7874/kja.2012.16.1.27","DOIUrl":"https://doi.org/10.7874/kja.2012.16.1.27","url":null,"abstract":"<p><p>Middle ear adenoma can be a rare cause of a middle ear mass. These benign tumors can have epithelial and/or neuroendocrine differentiation. In 1976, Hyams was the first to describe a series of these tumors. It is still thought that these tumors are indistinguishable in composition from each other. We report a case of middle ear adenoma, the clinical and pathologic findings of which illustrate the biological behavior of the middle ear. A 17-year-old male presented with a history of recurrent, bloody otorrhea and high-pitched tinnitus. We diagnosed him with congenital cholesteatoma and performed surgery to remove the entire tumor as well as the incus. However, on postoperative pathology examination, we finally diagnosed the tumor as middle-ear adenoma with neuroendocrine differentiation. In the two years following surgery, the patient's adenoma has not recurred, although long-term observation will be required. </p>","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 1","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/6d/kja-16-27.PMC3936528.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32194621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of isoflurane on the hearing in mice.","authors":"Joung Uk Kim,&nbsp;Yun Suk Ahn,&nbsp;Jin Kyung Suh,&nbsp;Jong Woo Chung","doi":"10.7874/kja.2012.16.1.14","DOIUrl":"https://doi.org/10.7874/kja.2012.16.1.14","url":null,"abstract":"<p><strong>Background and objectives: </strong>The aim of this study was to investigate the relationship between inhalation anesthetics and hearing in mice.</p><p><strong>Materials and methods: </strong>As inhalation anesthetics, isoflurane was used. Auditory brainstem response and distortion product otoacoustic emission were used as measurement of hearing. Mice were divided into 2 groups. 'Isoflurane group' consisted of mice that were anesthetized with an inspired concentration of 2.0 vol% isoflurane with 2 L/min of oxygen (n=10). 'Control group' consisted of mice that were anesthetized with ketamine and xylazine (n=10).</p><p><strong>Results: </strong>Auditory brainstem response thresholds in mice anesthetized with ketamine and xylazine was not different from those in mice anesthetized with isoflurane. Threshold of DPOAE was higher in mice with isolurane than with ketamine and xylazine. Changes of efferent control may be induced by isoflurane and consequently change the threshold of DPOAE in mice.</p><p><strong>Conclusions: </strong>These results infer that, there was a change of central nervous system induced by inhalation anesthetics, this change also can be applied to the strategies for prevention of hearing loss.</p>","PeriodicalId":90252,"journal":{"name":"Korean journal of audiology","volume":"16 1","pages":"14-7"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/ae/kja-16-14.PMC3936527.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32194619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}