Effect of isoflurane on the hearing in mice.

Korean journal of audiology Pub Date : 2012-04-01 Epub Date: 2012-04-30 DOI:10.7874/kja.2012.16.1.14

Joung Uk Kim, Yun Suk Ahn, Jin Kyung Suh, Jong Woo Chung

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引用次数: 3

Abstract

Background and objectives: The aim of this study was to investigate the relationship between inhalation anesthetics and hearing in mice.

Materials and methods: As inhalation anesthetics, isoflurane was used. Auditory brainstem response and distortion product otoacoustic emission were used as measurement of hearing. Mice were divided into 2 groups. 'Isoflurane group' consisted of mice that were anesthetized with an inspired concentration of 2.0 vol% isoflurane with 2 L/min of oxygen (n=10). 'Control group' consisted of mice that were anesthetized with ketamine and xylazine (n=10).

Results: Auditory brainstem response thresholds in mice anesthetized with ketamine and xylazine was not different from those in mice anesthetized with isoflurane. Threshold of DPOAE was higher in mice with isolurane than with ketamine and xylazine. Changes of efferent control may be induced by isoflurane and consequently change the threshold of DPOAE in mice.

Conclusions: These results infer that, there was a change of central nervous system induced by inhalation anesthetics, this change also can be applied to the strategies for prevention of hearing loss.

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异氟醚对小鼠听力的影响。

背景和目的:本研究的目的是探讨吸入麻醉剂与小鼠听力的关系。材料与方法:异氟醚作为吸入麻醉剂。听觉脑干反应和畸变产物耳声发射作为听力的测量指标。将小鼠分为两组。“异氟醚组”是指以2.0 vol%异氟醚和2l /min氧的激励浓度麻醉小鼠(n=10)。对照组用氯胺酮和噻嗪麻醉小鼠(n=10)。结果:氯胺酮和噻嗪麻醉小鼠的听觉脑干反应阈值与异氟醚麻醉小鼠的听觉脑干反应阈值无显著差异。异尿烷组小鼠DPOAE阈值高于氯胺酮和噻嗪组。异氟醚可引起传出控制的改变，从而改变小鼠DPOAE的阈值。结论:这些结果提示，吸入麻醉剂可引起中枢神经系统的改变，这种改变也可用于预防听力损失的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Korean journal of audiology

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