Journal of leukemia (Los Angeles, Calif.)最新文献_第8页

Inherited and Acquired Bone Marrow Failure Syndromes: In the Era of DeepGene Sequencing 遗传和获得性骨髓衰竭综合征:在深度基因测序的时代

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-12-12 DOI: 10.4172/2329-6917.1000E119

Ling Zhang

引用次数: 0

Concomitant Secondary Peripheral T-cell Lymphoma with Therapy-related Chronic Myelomonocytic Leukemia in a Patient with History of High-grade Follicular Lymphoma 伴有高级别滤泡性淋巴瘤病史的患者伴发继发性外周t细胞淋巴瘤与治疗相关的慢性髓单核细胞白血病

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-11-26 DOI: 10.4172/2329-6917.1000222

Lynh Nguyen, J. Bowers, Dahui Qin, Ling Zhang

{"title":"Concomitant Secondary Peripheral T-cell Lymphoma with Therapy-related Chronic Myelomonocytic Leukemia in a Patient with History of High-grade Follicular Lymphoma","authors":"Lynh Nguyen, J. Bowers, Dahui Qin, Ling Zhang","doi":"10.4172/2329-6917.1000222","DOIUrl":"https://doi.org/10.4172/2329-6917.1000222","url":null,"abstract":"A secondary myeloid or lymphoid neoplasm is not infrequently associated with a primary tumor, solid or \u0000 hematopoietic, post cytotoxic treatment or radiation. Concurrent secondary neoplasms derived from distinct myeloid \u0000 and lymphoid cell origins are rare. It is not only a diagnostic challenge, but makes for difficult treatment \u0000 management. We report a very rare occurrence in 63-year-old male with a history of high-grade follicular lymphoma who was treated with multiple courses of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP) \u0000 and then developed a concurrent secondary peripheral T-cell lymphoma, not otherwise specified (sPTCL, \u0000 NOS) and therapy-related myeloid neoplasm (tMN), under an umbrella of myelodysplastic/myeloproliferative \u0000 neoplasm, namely chronic myelomonocytic leukemia (CMML). Despite aggressive therapeutic management, the \u0000 patient passed away secondary to disease progression, complications of infection, and multi-organ failure. An \u0000 appropriate diagnostic approach for complicated cases as described aided in providing the correct diagnosis.","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70269878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of a High Frequency of e1a3/BCR-ABL in Chronic Myeloid Leukemia Patients of Sulaimania Province by RT-PCR RT-PCR检测苏莱曼尼亚省慢性髓系白血病患者e1a3/BCR-ABL的高频表达

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-11-25 DOI: 10.4172/2329-6917.1000221

G. Salih

{"title":"Detection of a High Frequency of e1a3/BCR-ABL in Chronic Myeloid Leukemia Patients of Sulaimania Province by RT-PCR","authors":"G. Salih","doi":"10.4172/2329-6917.1000221","DOIUrl":"https://doi.org/10.4172/2329-6917.1000221","url":null,"abstract":"Introduction: In order to detect the mutation variants of BCR-ABL fusion genes that lead to leukemia in human, \u0000 30 blood samples from chronic myeloid leukemia patients and 10 blood samples from apparently healthy people \u0000 (as control) were collected and tested hematologically, morphologically and by amplification of the fusion mRNA by \u0000 RT-PCR. The e1a3 variant was detected by amplification of 309 bp from the fusion of exons 1 of bcr and exon 3 of \u0000 abl gene. \u0000 Materials and method: Application of RT-PCR assay to detect the prevalence and frequency of ela3 and ela2 \u0000 variants in CML patients and in routine diagnosis of the most common leukemia translocations. \u0000 Results: The RT-PCR showed that out of 30 patients, 23 (76.6%) were with e1a3 mutation variant and 7 (23.3%) \u0000 were negative for e1a2 and e1a3 variants. All the 10 control samples showed no mutations related to these variants. \u0000 Conclusion: The e1a3 variant was detected by amplification of 309 bp from the fusion of exons 1 of bcr and \u0000 exon 3 of abl gene and the RT-PCR showed that out of 30 patients, 23 (76.6%) were with e1a3 mutation variant and \u0000 7 (23.3%) were negative for e1a2 and e1a3 variants, while the 10 control samples showed no mutations related to \u0000 these variants.","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"4 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70269836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Late-onset Imatinib-induced Liver Failure Treated with Dasatinib for Two Years Resulted in Long-term Undetectable Response 迟发性伊马替尼引起的肝衰竭用达沙替尼治疗两年导致长期无法检测到的反应

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-10-31 DOI: 10.4172/2329-6917.1000220

K. Inokuchi, Muneo Okamoto, K. Nakayama, H. Tamai, H. Yamaguchi

{"title":"Late-onset Imatinib-induced Liver Failure Treated with Dasatinib for Two Years Resulted in Long-term Undetectable Response","authors":"K. Inokuchi, Muneo Okamoto, K. Nakayama, H. Tamai, H. Yamaguchi","doi":"10.4172/2329-6917.1000220","DOIUrl":"https://doi.org/10.4172/2329-6917.1000220","url":null,"abstract":"A 21-year-old man who was diagnosed with chronic-phase CML and treated with imatinib (400 mg/day) during September 2004 achieved a complete molecular response within 14 months. His liver function remained normal during this period. The results of liver function tests after four years of treatment showed AST, 547 IU/L; ALT, 1124 IU/L, and viral hepatitis and autoimmune hepatitis were undetectable. Drug toxicity was suspected and imatinib was immediately discontinued. A liver biopsy showed hemorrhagic necrosis and hemosiderin deposition around the central vein indicating a diagnosis of imatinib-induced liver failure. Aminotransferases normalized within three months after imatinib withdrawal. Seven months after imatinib discontinuation, bcr-abl transcripts were detected twice during the next four months. Thus, dasatinib (100 mg) was administered, which resulted in an undetectable molecular response within two months. The patient decided to stop taking dasatinib two years after achieving the undetectable molecular response and he has remained in this condition for four years since. Patients with liver damage require follow-up. To confirm the benefit of changing medication from imatinib or other drugs to dasatinib will require more information from accumulated cases.","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70269826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methylated SFRP1,2 and CD25 Expression in Acute Myeloid Leukemia Play an Important Role in the Pathogenesis of the Disease and in Turn in its Treatment 急性髓系白血病中甲基化的SFRP1,2和CD25表达在疾病的发病机制和治疗中发挥重要作用

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-10-30 DOI: 10.4172/2329-6917.1000219

M. Elrahman, D. Nigm, Azza A Abo Elfadle

引用次数: 3

Bacillus cereus Catheter-Related Infection in Acute Lymphoblastic Leukemia(ALL) Patient: A Case Report and Review of Literature 急性淋巴细胞白血病(ALL)患者蜡样芽孢杆菌导管相关感染1例报告及文献复习

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-10-15 DOI: 10.4172/2329-6917.1000218

Piro Eugenio, L. Luciano, Kropp Mariagrazia, Molica Stefano

引用次数: 0

Human Endogenous Retrovirus: Their Relationship with Hematological Diseases 人内源性逆转录病毒与血液病的关系

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-09-15 DOI: 10.4172/2329-6917.1000217

Sabrina Fischer, N. Echeverría, J. Cristina, P. Moreno

引用次数: 2

Anterior Chest Wall Bulging: A Rare Initial Manifestation of Acute Lymphoblastic Leukemia in a Child 前胸壁突出:儿童急性淋巴细胞白血病的一种罕见的初始表现

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-09-07 DOI: 10.4172/2329-6917.1000215

S. Zareifar, N. Shakibazad, Gholamreza Fathpour, Mehrpour Moradi, Fazl Saleh

引用次数: 3

Detection of EpsteinÃ¢ÂÂBarr virus in Pediatric Lymphoma: A Single Center Study 儿童淋巴瘤EpsteinÃⅱÂÂBarr病毒检测:单中心研究

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-09-07 DOI: 10.4172/2329-6917.1000213

S. Zareifar, B. Kazemi, Arzanian Mt, M. ehpour

{"title":"Detection of EpsteinÃ¢ÂÂBarr virus in Pediatric Lymphoma: A Single Center Study","authors":"S. Zareifar, B. Kazemi, Arzanian Mt, M. ehpour","doi":"10.4172/2329-6917.1000213","DOIUrl":"https://doi.org/10.4172/2329-6917.1000213","url":null,"abstract":"Background: Efforts were made in order to identify the etiologic factors in pediatric cancers. Several studies have suggested a probable etiologic association between lymphoma and Epstein-Barr virus (EBV); therefore, the aim of this study was to investigate the association of EBV in childhood lymphoma. \u0000Materials and method: Paraffin block of 63 pediatric patients with lymphoma was studied for detection of EBV latent membrane protein 1 (LMP-1). The clinical data regarding age, sex, type of lymphoma and histology, stage of the disease of the patients treated in a retrospective consecutive manner for 5 years were used. \u0000Results: Sixty-three eligible patients including 41 (65%) patients with non-Hodgkin lymphoma (NHL) and 22 (34.9%) of Hodgkin lymphoma (HL) were assessed. The male to female ratio was 3.84/1. Regarding the gender, the overall difference between NHL and HL was statistically significant. With respect to age, the difference between HL and NHL was not significant. EBV LMP1 gene transcripts were found in 65.8% of children with NHL and 59% of children with HL. Regarding the type of lymphoma, LMP1 positivity was not statistically significant (P=0.087). \u0000Conclusion: EBV infection may be a factor involved in the high incidence of pediatric lymphoma; our study suggests a positive influence of EBV infection in pediatric lymphomas.","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"4 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2329-6917.1000213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70269668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: Classical Hodgkin Lymphoma and the Measles Virus 致编辑的信:经典霍奇金淋巴瘤和麻疹病毒

Journal of leukemia (Los Angeles, Calif.) Pub Date : 2016-09-07 DOI: 10.4172/2329-6917.1000216

D. Benharroch

引用次数: 2