Journal of gerontology & geriatric research最新文献_第2页

Correlates of Cognitive Impairment among Indian Urban Elders. 印度城市老年人认知障碍的相关性。

Journal of gerontology & geriatric research Pub Date : 2018-01-01 Epub Date: 2018-11-06 DOI: 10.4172/2167-7182.1000489

Poojitha Reddy Konda, Pawan Kumar Sharma, Atul R Gandhi, Enakshi Ganguly

{"title":"Correlates of Cognitive Impairment among Indian Urban Elders.","authors":"Poojitha Reddy Konda, Pawan Kumar Sharma, Atul R Gandhi, Enakshi Ganguly","doi":"10.4172/2167-7182.1000489","DOIUrl":"https://doi.org/10.4172/2167-7182.1000489","url":null,"abstract":"Background: Cognitive impairment among elderly is increasing owing to increases in life expectancy globally. The problem is multifactorial. The objective of the present paper was to study the correlates of cognitive impairment in an urban elderly population in India.Methods: A cross sectional study was conducted among 100 randomly selected urban elderly population. Data was collected upon household visits using a predesigned pretested questionnaire administered by a trained investigator. Measurements included cognitive function assessment using Mini Mental State Examination, depression assessment using Geriatric Depression Scale, blood pressure measurement and anthropometry. Cognitive impairment was defined at MMSE score <24. Logistic regression was done to identify independently associated factors with cognitive impairment.Results: Prevalence of cognitive impairment among elderly was 10%. Women had a higher prevalence than men. Higher age, no schooling, living single, lower weight, lower waist and hip ratios, difficulty in activities of daily living, poor self-reported health, bedridden and depression significantly associated with cognitive impairment. The independently associated factors upon logistic regression were increasing age, no schooling and bedridden status for past six months.Conclusion: Although the current prevalence of cognitive impairment among Indian urban elderly is low, several associated factors exist in this population that may increase the burden in future. Geriatric health policy should address the modifiable risk factors to manage the problem of cognitive impairment and its consequent outcomes.","PeriodicalId":90221,"journal":{"name":"Journal of gerontology & geriatric research","volume":"7 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7182.1000489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41223241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Cerebral and Retinal Neurovascular Changes: A Biomarker for Alzheimer's Disease. 脑和视网膜神经血管改变:阿尔茨海默病的生物标志物。

Journal of gerontology & geriatric research Pub Date : 2017-08-01 Epub Date: 2017-09-08 DOI: 10.4172/2167-7182.1000447

Karru Venkata Ravi Teja, Tjm Tos Berendschot, Harry Steinbusch, A B Carroll Webers, R Praveen Murthy, P S Mathuranath

{"title":"Cerebral and Retinal Neurovascular Changes: A Biomarker for Alzheimer's Disease.","authors":"Karru Venkata Ravi Teja, Tjm Tos Berendschot, Harry Steinbusch, A B Carroll Webers, R Praveen Murthy, P S Mathuranath","doi":"10.4172/2167-7182.1000447","DOIUrl":"https://doi.org/10.4172/2167-7182.1000447","url":null,"abstract":"Objectives: Biomarker quest for Alzheimer's disease (AD) has gone a long way by studying various anatomical, physiological and biochemical parameters for detecting disease onset and predicting prognosis. Almost all the studies converge on the single hypothesis of the amyloid and Tau pathway. Recently, vascular hypothesis has evolved drawing attention towards a complex dynamic anatomical and physiological entity, neuro-vascular (NV) unit. Pathological changes at this level, altering the normal physiology such as auto-regulation and dynamics of blood brain barrier have been hypothesized as a probable basis for AD. This paper attempts to review the existing data on the vascular hypothesis and the current trends in analyzing the NV unit in AD.Design: This review initially focuses on the cerebral NV coupling followed by the retinal neurovascular coupling that mirrors the cerebral pathophysiology. The pathophysiology and the potential tools to diagnose AD at the level of NV unit are analyzed. Further, it examines the drawbacks in existing methods for analyzing the same.Findings: None of the current studies have emphasized the importance of studying the complex dynamic NV unit as a whole. This review strongly recommends the combination of vascular and neuro-glial parameters using objective methods for estimating the physiological and pathological changes in the NV unit.Discussion and conclusion: This review highlights the importance of retina for non-invasive estimation of the same. Also, novel algorithms for retinal image analysis have been proposed. The purpose of this review is to highlight the importance of retinal findings in neurodegenerative disorders and to create awareness among the neuroophthalmologists, of the potential benefits of ophthalmological tools in screening dementia patients.","PeriodicalId":90221,"journal":{"name":"Journal of gerontology & geriatric research","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7182.1000447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35629834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Increased Energy Cost of Mobility in Chronic Stroke. 慢性中风患者活动能力的能量消耗增加。

Journal of gerontology & geriatric research Pub Date : 2016-12-01 Epub Date: 2016-10-22 DOI: 10.4172/2167-7182.1000356

Monica C Serra, Margarita S Treuth, Charlene E Hafer-Macko, Alice S Ryan

{"title":"Increased Energy Cost of Mobility in Chronic Stroke.","authors":"Monica C Serra, Margarita S Treuth, Charlene E Hafer-Macko, Alice S Ryan","doi":"10.4172/2167-7182.1000356","DOIUrl":"https://doi.org/10.4172/2167-7182.1000356","url":null,"abstract":"The purpose of this study was to compare the energy cost of completing mobility-related activities in chronic stroke to the estimated energy cost found in the compendium of physical activities, a resource that estimates and classifies energy cost of various human physical activities. Men (n=18) and women (n=10) with chronic hemiparetic gait (stroke latency: 4 ± 2 years, age: 60.4 ± 1.6 years, BMI: 31.5 ± 1.1 kg/m2) participated in the study. Portable energy cost monitoring (COSMED K4b2) was performed during five mobility activities of varying intensity to determine metabolic equivalents (METs, or oxygen consumption in multiples of resting level) for each activity. The METs achieved during the five activities were compared to the following compendium MET values for: 1) floor sweeping; 2) stepping in place; 3) over-ground walking; 4) lower speed treadmill walking (1.0 mph at 4% incline); and 5) higher speed treadmill walking (2.0 mph at 4% incline). Measurements were obtained for 10 min at rest and 5 minutes during each of the five activities. The energy cost of rest was only 85% of Compendium METS, while mobility-related activities were ~1.25-1.50 fold greater when measured in stroke vs. Compendium METS for all measures (P's<0.05), except floor sweeping, which was similar between groups. These data indicate that MET levels provided in the compendium are not applicable to chronic stroke survivors as they overestimate energy expenditure at rest and underestimate energy expenditure during physical activity, indicating poor efficiency in movement, thus elevating the oxygen cost of completing general daily activities.","PeriodicalId":90221,"journal":{"name":"Journal of gerontology & geriatric research","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7182.1000356","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35090465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Elderly Cancer Survivors Reflect on Coping Strategies During the Cancer Journey. 老年癌症幸存者反思在癌症之旅中的应对策略。

Journal of gerontology & geriatric research Pub Date : 2016-10-01 Epub Date: 2016-08-19 DOI: 10.4172/2167-7182.1000337

Eva Kahana, Boaz Kahana, Kaitlyn Barnes Langendoerfer, Baruch Kahana, Alicia Smith-Tran

{"title":"Elderly Cancer Survivors Reflect on Coping Strategies During the Cancer Journey.","authors":"Eva Kahana, Boaz Kahana, Kaitlyn Barnes Langendoerfer, Baruch Kahana, Alicia Smith-Tran","doi":"10.4172/2167-7182.1000337","DOIUrl":"https://doi.org/10.4172/2167-7182.1000337","url":null,"abstract":"Purpose This paper focuses on perspectives of elderly cancer survivors on their experiences of coping with cancer during various phases of their illness journey, ranging from diagnosis phase to treatment and finally considering post treatment survivorship. Anchored in the stress paradigm, the purpose of this study was to explore the meaning of living with cancer and older adults’ orientations to coping with stressors encountered during their cancer journey as reflected in narratives of elderly cancer survivors. Methods A nonclinical sample of 174 older adults who reported a cancer diagnosis were selected from a panel study of successful aging. In-depth interviews with respondents focused on perceived stressors and coping strategies at different phases of their cancer experience. Themes were derived from narratives based on consensus by two raters. Results Most of the elderly patients accepted their diagnosis without dismay. Resolve and determination during the diagnosis phase was followed by assuming a more passive role during the treatment phase, relying on expert medical care. During the longer term survivorship phase older adults looked back at the adaptations they found most useful. The majority reported valuing active coping styles. These include seeking social support and instrumental orientations to dealing with the illness followed by religious or spiritual approaches. Conclusions The “on time” interpretation of having a cancer diagnosis in old age may diminish the stressfulness of the diagnosis and may enhance the patients’ ability to proactively deal with the reality of their illness.","PeriodicalId":90221,"journal":{"name":"Journal of gerontology & geriatric research","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7182.1000337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35629833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Factors Associated with Unmet Needs among African-American Dementia Care Providers. 与非裔美国人痴呆症护理提供者未满足需求相关的因素。

Journal of gerontology & geriatric research Pub Date : 2016-02-01 Epub Date: 2016-01-22 DOI: 10.4172/2167-7182.1000267

P J Desin, A M Caban-Holt, E L Abner, L J Van Eldik, F A Schmitt

引用次数: 26

Skeletal Muscle CAP Expression Increases after Dietary Restriction and Aerobic Training in Women with a History of Gestational Diabetes. 有妊娠糖尿病史的妇女在饮食限制和有氧训练后骨骼肌CAP表达增加。

Journal of gerontology & geriatric research Pub Date : 2016-01-01 Epub Date: 2016-10-19 DOI: 10.4172/2167-7182.1000354

Alice S Ryan, Monica C Serra

{"title":"Skeletal Muscle CAP Expression Increases after Dietary Restriction and Aerobic Training in Women with a History of Gestational Diabetes.","authors":"Alice S Ryan, Monica C Serra","doi":"10.4172/2167-7182.1000354","DOIUrl":"10.4172/2167-7182.1000354","url":null,"abstract":"The purpose is to determine the effects of 6 months caloric restriction and aerobic training (3x/wk) (CR+AEX) on c-CBL associated protein (CAP) gene expression in women with a history of GDM. CAP is involved in cell signaling and protein ubiquitination, and is linked to the development of insulin resistance. Obese (BMI=32 ± 1 kg/m2, % fat=46 ± 2, X ± SEM), sedentary (VO2 max=21.2 ± 1.2 ml/kg/min), women aged 52 ± 2 years participated in 6 months D+WL (n=10) with body composition, fitness (VO2 max), and glucose tolerance testing. Insulin sensitivity was assessed during the last 30 min of 2-hour hyperinsulinemic-euglycemic clamps (40 mU.m-2.min-1) pre and post interventions. Vastus lateralis skeletal muscle biopsies (n=7) were conducted and CAP, GLUT4 and glycogen synthase (GS) gene expression measured by RT-PCR. No change in FFM by DXA was observed, but body weight decreased 8% with losses of total body fat mass (P<0.05) and a 10% increase in VO2 max (P<0.01). Glucose and insulin areas under the curve by OGTT decreased (P<0.05). Glucose utilization during the clamp increased 27% (23.1 ± 3.8 vs. 29.4 ± 3.6 umol.kg.min-1, P<0.05). Vastus lateralis skeletal muscle CAP expression increased 21% (P<0.05) but GLUT4 did not. Results suggest that changes in CAP could be involved in the improvement in glucose metabolism with caloric restriction and aerobic training in women with a history of gestational diabetes.","PeriodicalId":90221,"journal":{"name":"Journal of gerontology & geriatric research","volume":"5 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628746/pdf/nihms862503.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35426503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptin, Adiponectin and Cognition in Middle-aged HIV-infected and Uninfected Women. The Brooklyn Women's Interagency HIV Study. 中年艾滋病病毒感染妇女和未感染妇女的瘦素、脂肪连接蛋白和认知能力。布鲁克林妇女机构间艾滋病研究。

Journal of gerontology & geriatric research Pub Date : 2015-10-01 Epub Date: 2015-09-23 DOI: 10.4172/2167-7182.1000240

Deborah R Gustafson, Michelle M Mielke, Sheila A Keating, Susan Holman, Howard Minkoff, Howard A Crystal

{"title":"Leptin, Adiponectin and Cognition in Middle-aged HIV-infected and Uninfected Women. The Brooklyn Women's Interagency HIV Study.","authors":"Deborah R Gustafson, Michelle M Mielke, Sheila A Keating, Susan Holman, Howard Minkoff, Howard A Crystal","doi":"10.4172/2167-7182.1000240","DOIUrl":"10.4172/2167-7182.1000240","url":null,"abstract":"Context: Case-control study of women with and without HIV infection.Objective: To explore the association of cognition and the adipokines, leptin and adiponectin (total; high molecular weight, HMW), in women with (HIV+) and without HIV (HIV-) infection.Design: Cross-sectional analyses of adipokines and cognition using linear regression models of log-transformed adipokines, and Trails A, Trails B, Stroop interference time, Stroop word recall, Stroop color naming and reading, and Symbol Digit Modalities Test (SDMT) with consideration for age, HIV infection status, education, CD4 count, diabetes, body mass index (BMI), waist circumference (WC) and race/ethnicity.Setting: Brooklyn, NY.Participants: 354 participants (247 HIV+, 107 HIV-), in the Brooklyn Women's Interagency HIV Study (WIHS), average age 38.9 years, with measured levels of leptin and adiponectin (total and high molecular weight, HMW).Main outcome measure: Cognition.Results: Higher levels of leptin were positively associated with worse cognition on the basis of Trails A completion time and SDMT score. Among at risk HIV- women, leptin was associated with worse performance on Trails B. No associations were observed for total or HMW adiponectin.Conclusion: Blood adipokine levels were measured to provide mechanistic insights regarding the association of adipose with cognitive function. These data suggest that higher levels of leptin, consistent with more adipose tissue, are associated with worse cognitive function in middle age. Monitoring leptin over time and with increasing age in relation to cognition and dementia, may lend insights to the role of adipose tissue in successful body and brain aging among women with HIV infection.","PeriodicalId":90221,"journal":{"name":"Journal of gerontology & geriatric research","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984413/pdf/nihms807482.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34316980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between Markers of Glucose and Insulin Function and Cognitive Function in Healthy African American Elders. 健康非裔美国老年人葡萄糖和胰岛素功能与认知功能标志物之间的关系

Journal of gerontology & geriatric research Pub Date : 2015-07-23 DOI: 10.4172/2167-7182.1000232

Jeannine S. Skinner, Amy Morgan, Hector Hernandez-Saucedo, Angela Hansen, Selena M. Corbett, Matthew Arbuckle, J. Leverenz, C. Wilkins, S. Craft, L. Baker

{"title":"Associations between Markers of Glucose and Insulin Function and Cognitive Function in Healthy African American Elders.","authors":"Jeannine S. Skinner, Amy Morgan, Hector Hernandez-Saucedo, Angela Hansen, Selena M. Corbett, Matthew Arbuckle, J. Leverenz, C. Wilkins, S. Craft, L. Baker","doi":"10.4172/2167-7182.1000232","DOIUrl":"https://doi.org/10.4172/2167-7182.1000232","url":null,"abstract":"BACKGROUND\u0000Glucose and insulin are important moderators of cognitive function. African Americans have poorer glycemic control across the glycemic spectrum and are at increased risk for type 2 diabetes and poor cognitive health. It is unclear which glucoregulatory markers predict cognitive function in this at-risk population. The purpose of this study was to examine the association between cognitive function and common markers of glucoregulation in non-diabetic African Americans elders.\u0000\u0000\u0000METHODS\u0000Thirty-four, community-dwelling African Americans, aged 50-75 years completed cognitive testing and blood collection as part of a health screening assessment. Cognitive outcomes were composite scores derived from neuropsychological tests of executive function and verbal memory. Linear regression was used to examine relationships between cognitive composite scores and fasting blood levels of glucose, insulin, and hemoglobin A1C, with adjustments for age, education, body mass index, and antihypertensive medication use.\u0000\u0000\u0000RESULTS\u0000Fasting plasma glucose was negatively associated with executive function (β=-0.41, p=0.03). There was a trend of an association between fasting plasma glucose and verbal memory (β=-0.34, p=0.06). Fasting insulin and hemoglobin A1c were not associated with cognitive function.\u0000\u0000\u0000CONCLUSION\u0000High non-diabetic fasting glucose levels were associated with poorer executive function and verbal memory. These results provide preliminary support for proactive glucose control in older African Americans even before glycemic criteria for type 2 diabetes are met. Our findings suggests that high-normal FPG levels may represent an early red-flag to signify increased risk of cognitive impairment or decline.","PeriodicalId":90221,"journal":{"name":"Journal of gerontology & geriatric research","volume":"4 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7182.1000232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70828589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Why They Stay: Understanding Research Participant Retention in Studies of Aging, Cognitive Impairment and Dementia. 他们为什么留下来:了解研究参与者在衰老、认知障碍和痴呆研究中的保留。

Journal of gerontology & geriatric research Pub Date : 2014-10-01 DOI: 10.4172/2167-7182.1000170

Judith Neugroschl, Mary Sano, Xiaodong Luo, Margaret Sewell

{"title":"Why They Stay: Understanding Research Participant Retention in Studies of Aging, Cognitive Impairment and Dementia.","authors":"Judith Neugroschl, Mary Sano, Xiaodong Luo, Margaret Sewell","doi":"10.4172/2167-7182.1000170","DOIUrl":"https://doi.org/10.4172/2167-7182.1000170","url":null,"abstract":"Background: Retaining participants in longitudinal research in aging and Alzheimer's disease remains a significant challenge. \"Study partners\" are often required to insure participation and accuracy of information because cognitive impairment may interfere with accurate reporting. The purpose of the present report was to identify attitudes and reasons for continued participation in observational research.Methods: 53 individuals (33 participants and 20 study partners) who were participating in the longitudinal cohort at the Mount Sinai Alzheimer's Disease Research Center were available for this survey. They were asked a single open-ended question about why they continued in our study. Seven categories of answers (e.g., Altruism, Value relationship with staff, and Concern about health) were identified and frequency of endorsement was summarized for participants and study partners separately.Results: There were 82 responses from the 53 individuals. Forty five percent of the participants and 55% of the study partners identified altruism as one reason they participate in research over time, and 75% of study partners and 30% of participants mentioned valuing the relationship with staff as a reason they stayed in research.Conclusions: This data suggests that retention efforts should be directed toward fostering strong relationships between research staff and study participants and reinforcing the opportunity to contribute to others, which fosters a sense of altruism.","PeriodicalId":90221,"journal":{"name":"Journal of gerontology & geriatric research","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7182.1000170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32918578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Use of non-benzodiazepine sedative hypnotics and risk of falls in older men. 使用非苯二氮卓类镇静催眠药和老年男性跌倒的风险。

Journal of gerontology & geriatric research Pub Date : 2014-07-01 DOI: 10.4172/2167-7182.1000158

Susan J Diem, Susan K Ewing, Katie L Stone, Sonia Ancoli-Israel, Susan Redline, Kristine E Ensrud

{"title":"Use of non-benzodiazepine sedative hypnotics and risk of falls in older men.","authors":"Susan J Diem, Susan K Ewing, Katie L Stone, Sonia Ancoli-Israel, Susan Redline, Kristine E Ensrud","doi":"10.4172/2167-7182.1000158","DOIUrl":"https://doi.org/10.4172/2167-7182.1000158","url":null,"abstract":"Background: To ascertain whether use of non-benzodiazepine sedative-hypnotics is associated with risk of falls and compare this to risk of falls associated with use of benzodiazepines.Methods: Among 4450 community-dwelling men, aged 71 years and older, enrolled in the population-based prospective cohort study, Osteoporotic Fractures in Men (MrOS), use of nonbenzodiazepine sedative-hypnotics and benzodiazepines was assessed by interview and verified from medication containers at the third annual visit of the MrOS study. Falls in the subsequent one-year period were ascertained by tri-annual questionnaires and a computerized dictionary used to categorize type of medication.Results: In age-adjusted models, non-benzodiazepine sedative hypnotic use was associated with an increased risk of any falls (one or more falls) (RR 1.44, 95% CI 1.15, 1.81) and recurrent falls (2 or more falls) (RR 1.51, 95% CI 1.07, 2.14). Use of benzodiazepines was associated with a similar increase in age-adjusted risk of falling. Depressive symptoms, inability to stand from a chair, and instrumental activities of daily living (IADL) impairment modestly attenuated these associations. The association between non-benzodiazepine sedative-hypnotic use and falls was most pronounced among men without a history of falls in the previous year: in a multivariable model controlling for multiple potential confounders, the RR of any falls was 1.74 (95% CI 1.13, 2.68) in this subgroup.Conclusions: Use of non-benzodiazepine sedative-hypnotics is associated with an increased risk of falls. Non-pharmacologic approaches to sleep disturbances may represent the safest approach to sleep difficulties in older adults.","PeriodicalId":90221,"journal":{"name":"Journal of gerontology & geriatric research","volume":"3 3","pages":"158"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2167-7182.1000158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32973838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43