Journal of cancer research & therapy最新文献_第6页

Adjuvant radiotherapy for melanoma metastatic to axillary and inguinal nodes: Regional tumor control and late effects 腋窝和腹股沟淋巴结转移黑色素瘤的辅助放疗:局部肿瘤控制和晚期效果

Journal of cancer research & therapy Pub Date : 2014-09-01 DOI: 10.14312/2052-4994.2014-22

Ahmed. Sk, Kottschade La, Markov Sn, G. Yi, R. Foote

{"title":"Adjuvant radiotherapy for melanoma metastatic to axillary and inguinal nodes: Regional tumor control and late effects","authors":"Ahmed. Sk, Kottschade La, Markov Sn, G. Yi, R. Foote","doi":"10.14312/2052-4994.2014-22","DOIUrl":"https://doi.org/10.14312/2052-4994.2014-22","url":null,"abstract":"Background: Adjuvant radiotherapy reduces nodal recurrence in metastatic melanoma. The purpose of this study was to examine the effects of adjuvant radiotherapy on in-field nodal control of melanoma metastatic to axillary and inguinal lymph nodes. Methods: The medical records of patients who received adjuvant radiotherapy from January 1, 2003, through December 31, 2011, at Mayo Clinic were reviewed. Results: In the 20 patients identified, the rates of 2-year overall survival, nodal control, and freedom from distant metastases were 53%, 54%, and 44%, respectively. Intensity-modulated radiotherapy was used in 15 patients (75%) and 3-dimensional conformal radiotherapy in 5 (25%). Disease progression was documented in 13 patients, with a total of 10 distant metastases and 6 in-field nodal recurrences. Treatment complications occurred in 14 patients: lymphedema, 9; lymphedema and fibrosis, 1; lymphedema and wound dehiscence, 1; wound dehiscence, 1; lymphedema and seroma, 1; and lymphedema, seroma, and fibrosis, 1. Conclusion: Patients with axillary and inguinal nodal metastases from melanoma have poor overall survival. Surgery and adjuvant radiotherapy provided a 54% nodal control rate. No plexopathy or grade 3 lymphedema complications were seen; however, 20% developed wound dehiscence.","PeriodicalId":90205,"journal":{"name":"Journal of cancer research & therapy","volume":"164 1","pages":"144-152"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75974029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of tyrosine kinase inhibitors on spermatogenesis and pituitary gonadal axis in males with chronic myeloid leukemia 酪氨酸激酶抑制剂对慢性髓性白血病男性患者精子发生和垂体性腺轴的影响

Journal of cancer research & therapy Pub Date : 2014-08-01 DOI: 10.14312/2052-4994.2014-18

Yassin Ma, Soliman At, Sanctis Vd

引用次数: 2

Small satellite pulmonary nodules in operable lung cancer: Diagnosis and therapeutic strategy 可手术肺癌中的小卫星肺结节:诊断和治疗策略

Journal of cancer research & therapy Pub Date : 2014-08-01 DOI: 10.14312/2052-4994.2014-17

J. Guo, X. Chu, Y. Liu, C. Liang

{"title":"Small satellite pulmonary nodules in operable lung cancer: Diagnosis and therapeutic strategy","authors":"J. Guo, X. Chu, Y. Liu, C. Liang","doi":"10.14312/2052-4994.2014-17","DOIUrl":"https://doi.org/10.14312/2052-4994.2014-17","url":null,"abstract":"Objective: The use of high-resolution computed tomography (HRCT) has improved the management of non-small cell lung cancer (NSCLC), but has also increased the detection of indeterminate satellite nodules. Obtaining differential diagnosis of nodules less than 10 mm is difficult but essential for choosing optimal therapeutic strategies. Here, we evaluated the characteristics of small satellite nodules in patients with operable NSCLC and examined the optimal diagnostic and therapeutic approach in patients with small satellite nodules. Methods: Using data from a prospective database, all surgically treated patients diagnosed with NSCLC from 2008 to 2011 were retrospectively reviewed. Patients presenting with small pulmonary non-GGO nodule(s) were identified. Results: A total of 1206 patients underwent complete resection for NSCLC, out of which 45 patients presented with 60 nodules less than 10 mm on thoracic CT. Twenty-six nodules (43%) were malignant, 31 (52%) were benign, and 3 (5%) were of undetermined nature. Tumor histology (adenocarcinoma vs. nonadenocarcinoma), TNM stage (advanced stage vs. early stage), and nodule size (6–10 vs.  5 mm) were associated with nodule malignancy. The incidence of metastatic nodules in patients with stage III NSCLC was significantly higher than that in patients with stage I NSCLC. In contrast, the incidence of multiple primary lung cancers in patients with stage I NSCLC was significantly higher than that in patients with stage III NSCLC. Conclusion: Differential diagnosis of indeterminate satellite lesions in patients with operable NSCLC is critical. Surgery should be performed cautiously in patients with stage III NSCLC having nodules larger than 5 mm.","PeriodicalId":90205,"journal":{"name":"Journal of cancer research & therapy","volume":"5 1","pages":"111-115"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79947523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Trastuzumab therapy in metastatic bladder carcinoma: The proof of concept 曲妥珠单抗治疗转移性膀胱癌:概念证明

Journal of cancer research & therapy Pub Date : 2014-08-01 DOI: 10.14312/2052-4994.2014-20

Y. Moussaid, C. Chargari, M. Mansouri, G. Bonardel, A. Houlgatte, L. Védrine

引用次数: 1

Breast cancer receptor status assessment and clinicopathological association in Nigerian women: A retrospective analysis 尼日利亚妇女乳腺癌受体状态评估和临床病理关联:回顾性分析

Journal of cancer research & therapy Pub Date : 2014-08-01 DOI: 10.14312/2052-4994.2014-19

Samira Bl, S. Ayodele, F. Javid, J. Obafunwa, M. Oludara, A. Popoola, Lagos Nigeria

{"title":"Breast cancer receptor status assessment and clinicopathological association in Nigerian women: A retrospective analysis","authors":"Samira Bl, S. Ayodele, F. Javid, J. Obafunwa, M. Oludara, A. Popoola, Lagos Nigeria","doi":"10.14312/2052-4994.2014-19","DOIUrl":"https://doi.org/10.14312/2052-4994.2014-19","url":null,"abstract":"Background: Breast cancer markers are becoming increasingly important in breast cancer research due to their impact on prognosis, treatment and survival. The present retrospective study was carried out to quantify the proportion of estrogen (ER), progesterone (PR), and human epithelial receptor 2 (HER2) expressions and their association with tumour grade, age, and tumour size in breast cancer patients in Nigeria. Materials and methods: The paraffin embedded tissue sections were analysed for breast cancer markers using monoclonal antibody SP1 for ER and SP2 for PR and polyclonal antibody ErbB2 for HER2. Results: A total of 286 breast cancer paraffin wax tissue sections were analysed for ER, PR and HER2 expression. Of all the tissue samples examined, 20 (7%) were ERpositive, 6 (2.1%) were PR-positive, 11 (3.8%) were HER2-positive whereas 248 (87%) were triple-negative breast carcinoma. ER- and PR-positivity was associated with early grade I and II tumours (P  0.010-0.009) and tumour sizes of  50mm (p  0.001). HER2positivity was positively (P  0.009) associated with grade II tumours and negatively (P  0.0001) associated with grade III tumours. Triple-negative breast cancer was associated with grade III tumours (P  0.0001) and larger tumour sizes of  50mm (P  0.0001). Conclusion: A small proportion of Nigerian women with breast cancer are ER/PR-positive which are associated with less aggressive, better prognosis and benefit from endocrine therapy. An even smaller proportion of patients with aggressive tumors were HER2posivite but responsive to Herceptin treatment. Unfortunately, a very high proportion of cases were triple-negative which is associated with very aggressive tumours and no targeted treatment, which may explain the high mortality rates from breast cancer in Nigeria.","PeriodicalId":90205,"journal":{"name":"Journal of cancer research & therapy","volume":"76 1","pages":"122-127"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80110577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Apocrine carcinoma of the scalp – A case report and highlights for diagnosis 头皮大汗腺癌1例报告及诊断要点

Journal of cancer research & therapy Pub Date : 2014-07-01 DOI: 10.14312/2052-4994.2014-14

R. Arden, L. Williams, D. Golbin

引用次数: 3

Pseudocystic pheochromocytoma: An incidental finding and a rare entity 假性嗜铬细胞瘤:偶然发现和罕见的实体

Journal of cancer research & therapy Pub Date : 2014-07-01 DOI: 10.14312/2052-4994.2014-16

Petramala L, Zinnamosca L, Marinelli C, Calvieri C, Settevendemmie A, Concistrè A, Salvi D, Ciardi A, D. G, D. G, Letizia C

{"title":"Pseudocystic pheochromocytoma: An incidental finding and a rare entity","authors":"Petramala L, Zinnamosca L, Marinelli C, Calvieri C, Settevendemmie A, Concistrè A, Salvi D, Ciardi A, D. G, D. G, Letizia C","doi":"10.14312/2052-4994.2014-16","DOIUrl":"https://doi.org/10.14312/2052-4994.2014-16","url":null,"abstract":"Cystic adrenal neoplasms are uncommon and may be incidentally discovered during radiologic procedure not directly performed for the evaluation of adrenal disease. Cystic pheochromocytomas are uncommon neoplasms that originate from the adrenal medulla, clinically differing from the more frequent solid pheochromocytomas. Here, we report a case of 72 year-old woman affected by asymptomatic pseudocystic pheochromocytoma (70x50mm), incidentally discovered, with a false negative 123I-monoiodobenzylguanidine (123IMIBG) scintigraphy. Histopathological examination led to diagnosis of pseudocystic pheochromocytoma with typical architecture. The screening for germline mutation of succinate dehydrogenase complex subunits (SDHB, SDHC), Von Hipple-Lindau syndrome (VHL) and multiple endocrine neoplasia type 2 (RET) genes were negative, finding only some polymorphisms for RET and SDHB. We emphasize the relevance of an accurate pre-operative diagnosis, especially in rare diseases, and the requirement of experience and multidisciplinary management in these rare pathologies.","PeriodicalId":90205,"journal":{"name":"Journal of cancer research & therapy","volume":"18 1","pages":"105-110"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77285942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical presentation of Merkel cell carcinoma positive to polyomavirus DNA detection: Experience from a single center 多瘤病毒DNA检测阳性的默克尔细胞癌的不典型表现:来自单一中心的经验

Journal of cancer research & therapy Pub Date : 2014-07-01 DOI: 10.14312/2052-4994.2014-15

F. Iovino, A. Fabozzi, P. P. Auriemma, F. Bara, R. Sergio, E. Buommino, M. Laterza, J. Ventriglia, B. Savastano, A. Petrillo, G. Tirino, M. Orditura, F. Devita

{"title":"Atypical presentation of Merkel cell carcinoma positive to polyomavirus DNA detection: Experience from a single center","authors":"F. Iovino, A. Fabozzi, P. P. Auriemma, F. Bara, R. Sergio, E. Buommino, M. Laterza, J. Ventriglia, B. Savastano, A. Petrillo, G. Tirino, M. Orditura, F. Devita","doi":"10.14312/2052-4994.2014-15","DOIUrl":"https://doi.org/10.14312/2052-4994.2014-15","url":null,"abstract":"Merkel cell carcinoma (MCC) is a rare malignant tumor of the skin with tendency to rapid local progression and frequent spread to regional lymph nodes. In this paper we retrospectively describe the atypical presentation of 5 cases of Merkel cell carcinoma observed in our surgical department in the last ten years. Four patients had buttock localization whilst one patient had primary nodal presentation. Since integration of Merkel cell polyomavirus (MCPyV) DNA into the tumor genome is frequently recorded in this type of cancer, we analyzed formalin-fixed paraffin embedded MCC tissue samples from our five patients for the presence of MCPyV DNA by means of polymerase chain reaction (PCR). MCPyV DNA was present in all five carcinomas. All patients were treated with wide surgical excision of the tumor and sentinel node biopsy. One patient had stage I disease, three patients had stage II disease, and one patient had stage III disease. Adjuvant radiotherapy was administered in all cases for local control. Chemotherapy was administered to the patient with primary nodal presentation and in stage III disease. Median time of follow-up was 84 months. None of the patients relapsed. Despite the low number of patients examined, our experience suggests that surgery is a necessary step whereas implementation of adjuvant therapy, radiotherapy and chemotherapy depends on individual risk assessment. Treatment outcome was very good, probably due to early detection of MCC.","PeriodicalId":90205,"journal":{"name":"Journal of cancer research & therapy","volume":"11 1","pages":"100-104"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75862770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The use of lacZ-transduced tumor cells enhances the sensitivity of micrometastasis detection: A comparative study of gemcitabine treatment efficacy in the mouse LM8 osteosarcoma cell model 使用lacz转导的肿瘤细胞增强微转移检测的敏感性:吉西他滨对小鼠LM8骨肉瘤细胞模型治疗效果的比较研究

Journal of cancer research & therapy Pub Date : 2014-06-01 DOI: 10.5167/UZH-104733

M. Arlt, I. Banke, D. Walters, Bernd Kersten, E. Strehler, W. Born, B. Fuchs

{"title":"The use of lacZ-transduced tumor cells enhances the sensitivity of micrometastasis detection: A comparative study of gemcitabine treatment efficacy in the mouse LM8 osteosarcoma cell model","authors":"M. Arlt, I. Banke, D. Walters, Bernd Kersten, E. Strehler, W. Born, B. Fuchs","doi":"10.5167/UZH-104733","DOIUrl":"https://doi.org/10.5167/UZH-104733","url":null,"abstract":"In osteosarcoma patients as well as in preclinical osteosarcoma animal models post-therapy detection of residual disease and of metastases in particular remains a great challenge. The therapeutic efficacy is often overestimated because disseminated tumor cells frequently persist undetectable as dormant micrometastases. This can be avoided in preclinical studies by tagging the tumor cells with reporter genes that allow their selective detection in normal tissue down to the single cell level. In the present study we made use of a lacZ reporter gene and reinvestigated the therapeutic effect of gemcitabine on subcutaneous primary tumor growth and metastasis of mouse LM8 osteosarcoma cells in syngeneic C3H mice. Furthermore we compared the sensitivity of LM8-lacZ and of non-transduced LM8 cells to gemcitabine in vitro and in vivo because it was recently demonstrated that expression of a GFP reporter gene in osteosarcoma cells altered their aggressiveness. The present study showed that, in contrast to previous reports, gemcitabine treatment did not completely eradicate metastasis although it efficiently suppressed the growth of primary tumors and macrometastases. The results also showed that minimal residual disease is not restricted to the lungs, but also occurs in the liver and the kidneys. The direct comparison of the LM8-lacZ with the LM8 cells furthermore demonstrated that constitutive expression of the lacZ reporter gene has no effect on the aggressiveness of the cells or their sensitivity to gemcitabine. The LM8-lacZ cell-derived osteosarcoma mouse model thus represents a highly sensitive and reliable model for evaluation of anticancer drug efficacy in vivo","PeriodicalId":90205,"journal":{"name":"Journal of cancer research & therapy","volume":"18 1","pages":"89-94"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84429416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathological investigation of differences between female and male rats on radioation-induced acute lung toxicity 雌雄大鼠放射性急性肺毒性差异的组织病理学研究

Journal of cancer research & therapy Pub Date : 2014-06-01 DOI: 10.14312/2052-4994.2014-12

Bilal Bu, Z. Koçak, R. Coşar, Ş. Altaner, M. Koçak

引用次数: 1