Biopolymers & Cell最新文献

Effect of complexes of natural oligoribonucleotides with D-mannitol on the viability of cell cultures of different origin 天然寡核苷酸与d -甘露醇配合物对不同来源细胞培养活力的影响

Biopolymers & Cell Pub Date : 2023-09-25 DOI: 10.7124/bc.000a93

I. M. Kraievska, Z. Yu. Tkachuk

引用次数: 0

Effects of transplantation of preconditioned mesenchymal stem cells seeded on a biomimetic 3D scaffold 预调节间充质干细胞植入仿生3D支架的移植效果

Biopolymers & Cell Pub Date : 2023-09-25 DOI: 10.7124/bc.000a9a

I. O. Pokholenko, P. O. Pikus, M. V. Kovalchuk, O. K. Toporova, S. Y. Rymar, V. A. Kordium

引用次数: 0

Key models and theories of carcinogenesis 癌变的关键模型和理论

Biopolymers & Cell Pub Date : 2023-09-25 DOI: 10.7124/bc.000a99

G. V. Gerashchenko, V. I. Kashuba, M. A. Tukalo

引用次数: 0

Variation in highly repetitive DNA composition in rye and wild relatives discovered by FISH 用FISH发现的黑麦及其野生近缘种高度重复DNA组成的变异

Biopolymers & Cell Pub Date : 2023-09-25 DOI: 10.7124/bc.000a8f

O. G. Alkhimova, M. O. Twardovska, P. A. Portova, V. A. Kunakh

引用次数: 0

Alterations in lncRNAs H19 and TUG1 expression and their correlation with hemodynamics in myocardial infarction 心肌梗死中lncRNAs H19和TUG1表达的变化及其与血流动力学的相关性

Biopolymers & Cell Pub Date : 2023-09-25 DOI: 10.7124/bc.000a9b

M. Khetsuriani, T. I. Drevytska, L. Tumanovska, G. V. Portnichenko, Y. Hegel-Valentych, V. O. Niekrasova, A. M. Shysh, V. Ie. Dosenko

引用次数: 0

"Green" synthesis of metal nanoparticles. Application and future perspective 金属纳米颗粒的“绿色”合成。应用与未来展望

Biopolymers & Cell Pub Date : 2023-09-25 DOI: 10.7124/bc.000a98

I. M. Voloshyna, L. O. Lastovetska, A. A. Zurnadzhian, L. V. Shkotova

引用次数: 0

Alterations in S6K1 isoforms expression induce Epithelial to Mesenchymal Transition and Estrogen Receptor 1 Silencing in human breast adenocarcinoma MCF-7 cells 在人乳腺腺癌MCF-7细胞中，S6K1亚型表达的改变诱导上皮向间质转化和雌激素受体1沉默

Biopolymers & Cell Pub Date : 2023-09-25 DOI: 10.7124/bc.000a9d

O. M. Garifulin, I. V. Zaiets, V. R. Kosach, I. R. Horak, A. I. Khoruzhenko, N. Ya. Gotsulyak, L. O. Savinska, I. V. Kroupskaya, M. Ye. Martsynyuk, L. B. Drobot, V. V. Filonenko

引用次数: 0

Somatic genomic rearrangements in human leucocyte antigens region in solid ovarian tumors 实体卵巢肿瘤中人白细胞抗原区体细胞基因组重排

Biopolymers & Cell Pub Date : 2021-04-30 DOI: 10.7124/BC.000A50

N. Hryshchenko, V. Gordiyuk, S. Kravchenko, S. Arbuzova, V. Kashuba

{"title":"Somatic genomic rearrangements in human leucocyte antigens region in solid ovarian tumors","authors":"N. Hryshchenko, V. Gordiyuk, S. Kravchenko, S. Arbuzova, V. Kashuba","doi":"10.7124/BC.000A50","DOIUrl":"https://doi.org/10.7124/BC.000A50","url":null,"abstract":"The success of immunotherapy for ovarian cancer is determined by the effectiveness of the patient’s immune response, as well as the qualitative and quantitative representation of antigens of the main histocompatibility complex in tumor cells and microenvironment. The level of the HLA (Human Leukocyte Antigens) genes expression in tumor tissue does not always correctly reflect the expression of these genes in different populations of tumor cells. Aim. To analyze the frequency and range of somatic deletions and duplications in the HLA locus. Methods. LOH-analysis (Loss of Heterozyhosity) of the STR-markers (Short Tandem Repeats) in the ovarian tumors of affected patients. Results. We have shown that complex somatic genomic reorganizations, involving several HLA loci, are quite common in ovarian tumors. The detected genetic alterations vary by both the type (deletions and mutations in STR alleles) and proportion of the sub-population of cells with the alterations. Conclusion. The results obtained allow us to propose the LOH-analysis for highly effective detection of aneuploidy and different types of somatic genomic reorganizations in the HLA region even in minor cell populations. This analysis provides the additional prognostic information for predic ting the effectiveness of different types of ovarian cancer immunotherapy at the indi vidual level.","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"1 1","pages":"105-116"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75631721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteriocins Lactobacillus — an alternative to antimicrobial drugs 乳酸菌素-抗菌药物的替代品

Biopolymers & Cell Pub Date : 2021-04-30 DOI: 10.7124/BC.000A4E

I. Voloshyna, K. Soloshenko, V. Krasinko, I. Lych, L. Shkotova

引用次数: 1

Antimicrobial and cytotoxic activities of thiazolo[4,5-b]pyridine derivatives 噻唑[4,5-b]吡啶衍生物的抗菌和细胞毒活性

Biopolymers & Cell Pub Date : 2021-04-30 DOI: 10.7124/BC.000A53

A. Lozynskyi, H. Derkach, V. Zasidko, Y. Konechnyi, N. Finiuk, Y. Len, R. Kutsyk, M. Regeda, R. Lesyk

{"title":"Antimicrobial and cytotoxic activities of thiazolo[4,5-b]pyridine derivatives","authors":"A. Lozynskyi, H. Derkach, V. Zasidko, Y. Konechnyi, N. Finiuk, Y. Len, R. Kutsyk, M. Regeda, R. Lesyk","doi":"10.7124/BC.000A53","DOIUrl":"https://doi.org/10.7124/BC.000A53","url":null,"abstract":"Aim. The screening of antimicrobial and cytotoxic activities of thiazolo[4,5- b ]pyridine derivatives was accomplished. Methods. The antibacterial and antifungal activities of synthesized thiazolopyridines were evaluated in vitro with the agar diffusion and broth microdilution methods using clinical and reference strains of Gram-positive, Gram-negative bacteria and yeasts. The structure-antibacterial/antifungal activity relationships of the screened compounds were established. The target compounds were screened for their cytotoxicity effects on HaCaT and HEK293 cells using MTT assay. Results. The highest antimicrobial activity was observed for compound V 2-oxo-7-thiophen-2-yl-2,3-dihydrothiazolo[4,5- b ]pyridine-5-carboxylic acid with minimal inhibitory concentration (MIC) 12.5 μg/mL against Candida albicans . At the same time, the synthesized compounds were explored in the interaction with amoxicillin against multidrug resistant clinical isolates of ESβL + Klebsiella pneumonie and Staphylococcus haemolyticus (MRSH). The best synergistic activity with amoxicillin was exhibited by compound VI. HaCaT human keratinocytes and HEK293 human embryonic kidney cells demonstrated resistance to the thiazolopyridine derivatives treatment and did not reach the IC 50 value up to 100 µM. Conclusions. The tested thiazolopyridines constitute an interesting background for further development of new chemotherapeutic agents.","PeriodicalId":9017,"journal":{"name":"Biopolymers & Cell","volume":"30 1","pages":"153-164"},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90078855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4