Biomedical materials最新文献_第2页

Hesperidin nanoparticles for prostate cancer therapy: preparation, characterization and cytotoxic activity. 用于前列腺癌治疗的橙皮甙纳米颗粒：制备、表征和细胞毒性活性。

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-23 DOI: 10.1088/1748-605X/ad4221

Mohammad Amin Bakhshan, Sanaz Sheikhzadeh, N. Delirezh

{"title":"Hesperidin nanoparticles for prostate cancer therapy: preparation, characterization and cytotoxic activity.","authors":"Mohammad Amin Bakhshan, Sanaz Sheikhzadeh, N. Delirezh","doi":"10.1088/1748-605X/ad4221","DOIUrl":"https://doi.org/10.1088/1748-605X/ad4221","url":null,"abstract":"Hesperidin, a phytochemical renowned for its therapeutic effects including anticancer, antioxidant, and anti-inflammatory properties, encounters a significant limitation in its application due to its low bioavailability and restricted solubility in water. To surmount these challenges, we employed a spontaneous emulsification method to produce hesperidin nanoparticles. These nanoparticles, averaging 197.2±2.8 nm, exhibited uniform dispersion (Polydispersity index (PDI): 0.13), a zeta potential (ZP) of -28 mV, encapsulation efficiency of 84.04±1.3%, and demonstrated stable and controlled release across various environments. assessment of the nanoemulsion's stability revealed remarkably high stability levels. Cytotoxicity evaluations (3-(4,5-dimethylthiazol-2-yl)-2,5diphenyl-2-H-tetrazolium bromide (MTT), Neutral red (NR), Trypan blue (TB), and Lactate dehydrogenase (LDH)) indicated that cancer cell viability following treatment with hesperidin nanoemulsion was concentration and time-dependent, significantly lower compared to cells treated with free hesperidin. The colony formation assay and cell morphology evaluation further corroborated the heightened efficacy of hesperidin in its nano form compared to the free form. In summary, hesperidin nanoparticles not only exhibited more potent anticancer activity than free hesperidin but also demonstrated high biocompatibility with minimal cytotoxic effects on healthy cells. These findings underscore the potential for further exploration of hesperidin nanoparticles as an adjunctive therapy in prostate cancer therapy. .","PeriodicalId":9016,"journal":{"name":"Biomedical materials","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140671642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double-layer hollow mesoporous silica nanoparticles for ultrasound-guided photodynamic treatment. 用于超声引导光动力治疗的双层中空介孔二氧化硅纳米粒子。

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-23 DOI: 10.1088/1748-605X/ad4246

Zhihui Chen, Wei Liu, Kaiwen Liu, Siqi Wang, Cuiying Li, Feiyun Wu, Shouju Wang, Yuxia Tang

{"title":"Double-layer hollow mesoporous silica nanoparticles for ultrasound-guided photodynamic treatment.","authors":"Zhihui Chen, Wei Liu, Kaiwen Liu, Siqi Wang, Cuiying Li, Feiyun Wu, Shouju Wang, Yuxia Tang","doi":"10.1088/1748-605X/ad4246","DOIUrl":"https://doi.org/10.1088/1748-605X/ad4246","url":null,"abstract":"Cervical carcinoma persists as a major global public health burden. While conventional therapeutic modalities inevitably cause ablation of adjacent non-tumorous tissues, photodynamic therapy (PDT) offers a targeted cytotoxic strategy through a photosensitizing agent (PS). However, the hydrophobicity and lack of selective accumulation of promising PS compounds such as zinc(II) phthalocyanine (ZnPc) impedes their clinical translation as standalone agents. The present study sought to incorporate ZnPc within double-layer hollow mesoporous silica nanoparticles (DHMSN) as nanocarriers to enhance aqueous dispersibility and tumor specificity. Owing to their compartmentalized design, the hollow mesoporous silica nanoparticles (HMSN) demonstrated enhanced ultrasonic imaging contrast. Combined with the vaporization of the perfluorocarbon perfluoropentane (PFP), the HMSN-encapsulated ZnPc enabled real-time ultrasound monitoring of PDT treatment. In vivo, the innate thermal energy induced vaporization of the DHMSN-carried PFP to significantly amplify ultrasound signals from the tumor site. Results demonstrated biocompatibility, efficient PFP microbubble generation, and robust photocatalytic activity. Collectively, this investigation establishes ultrasound-guided PDT utilizing multi-layer HMSN as a targeted therapeutic strategy for cervical malignancies with mitigated toxicity.","PeriodicalId":9016,"journal":{"name":"Biomedical materials","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140670296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-precision 3D printing of multi-branch vascular scaffold with plasticized PLCL thermoplastic elastomer. 使用塑化 PLCL 热塑性弹性体高精度 3D 打印多分支血管支架。

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-18 DOI: 10.1088/1748-605X/ad407c

Yunda Han, Heran Wang, Yuheng Guan, Song Li, Zewei Yuan, Lihua Lu, Xiongfei Zheng

{"title":"High-precision 3D printing of multi-branch vascular scaffold with plasticized PLCL thermoplastic elastomer.","authors":"Yunda Han, Heran Wang, Yuheng Guan, Song Li, Zewei Yuan, Lihua Lu, Xiongfei Zheng","doi":"10.1088/1748-605X/ad407c","DOIUrl":"https://doi.org/10.1088/1748-605X/ad407c","url":null,"abstract":"Three-dimensional (3D) printing has emerged as a transformative technology for tissue engineering, enabling the production of structures that closely emulate the intricate architecture and mechanical properties of native biological tissues. However, the fabrication of complex microstructures with high accuracy using biocompatible, degradable thermoplastic elastomers poses significant technical obstacles. This is primarily due to the inherent soft-matter nature of such materials, which complicates real-time control of micro-squeezing, resulting in low fidelity or even failure. In this study, we employ Poly (L-lactide-co-ε-caprolactone) (PLCL) as a model material and introduce a novel framework for high-precision 3D printing based on the material plasticization process. This approach significantly enhances the dynamic responsiveness of the start-stop transition during printing, thereby reducing harmful errors by up to 93%. Leveraging this enhanced material, we have efficiently fabricated arrays of multi-branched vascular scaffolds that exhibit exceptional morphological fidelity and possess elastic moduli that faithfully approximate the physiological modulus spectrum of native blood vessels, ranging from 2.5 to 45 MPa. The methodology we propose for the compatibilization and modification of elastomeric materials addresses the challenge of real-time precision control, representing a significant advancement in the domain of melt polymer 3D printing. This innovation holds considerable promise for the creation of detailed multi-branch vascular scaffolds and other sophisticated organotypic structures critical to advancing tissue engineering and regenerative medicine. .","PeriodicalId":9016,"journal":{"name":"Biomedical materials","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent trends in bone tissue engineering: a review of materials, methods, and structures. 骨组织工程的最新趋势：材料、方法和结构综述。

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-18 DOI: 10.1088/1748-605X/ad407d

Armaghan Moghaddam, Mehran Bahrami, Motahareh Mirzadeh, Mehrdad Khatami, S. Simorgh, Mohammadreza Chimehrad, B. Kruppke, Zohre Bagher, Davood Mehrabani, Hossein Ali Khonakdar

引用次数: 0

Performance evaluation of carbon quantum dots impregnated glass ionomer cement to avoid peri-implant disease. 碳量子点浸渍玻璃离子黏合剂的性能评估，以避免种植体周围疾病。

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-18 DOI: 10.1088/1748-605X/ad407b

Febina Josephraj, Ashwin Kumar N, Vidyashree Nandini V, Sujatha S, V. Karthik

{"title":"Performance evaluation of carbon quantum dots impregnated glass ionomer cement to avoid peri-implant disease.","authors":"Febina Josephraj, Ashwin Kumar N, Vidyashree Nandini V, Sujatha S, V. Karthik","doi":"10.1088/1748-605X/ad407b","DOIUrl":"https://doi.org/10.1088/1748-605X/ad407b","url":null,"abstract":"Dental cement residues exacerbate peri-implant tissue irritation and peri-implantitis. The present study aims to evaluate the cytotoxicity, physiochemical, optical, and rheological properties of Carbon Quantum Dots (CQDs) impregnated Glass Ionomer Cement (GIC). Surface passivated fluorescent CQDs were synthesized using citric acid via thermal decomposition and blended with GIC. Characterization studies and rheological measurements were made to evaluate their performance. 3D-printed dental implant models cemented with GIC and GIC-CQD were compared to analyze excess cement residues. MTT assay was performed with human Dental Pulp Stem Cells (hDPSCs) and statistically analyzed using ANOVA and Tukey's test. CQDs with a particle dimension of ~2 nm were synthesized. The amorphous property of GIC-CQD was confirmed through XRD. The fluorescence properties of GIC-CQD showed three times higher emission intensity than conventional GIC. GIC-CQD attained maturation with a setting time extended by 64 seconds than GIC. Cement residue of size 2 mm was detected with a UV light excitation at a distance between 5 to 10 cm. Biocompatibility at 0.125 mg/ml dilution concentrations of GIC-CQD showed viability greater than 80% to hDPSCs. For the first time, we report that CQDs-impregnated GIC is a unique and cost-effective strategy for in-situ detection of excess cement rapidly using a hand-held device. A novel in-situ rapid detection method enables the dentist to identify residual cement of size less than 2 mm during the implantation. Therefore, GIC-CQD would replace conventional GIC and help in the prevention of peri-implant diseases.","PeriodicalId":9016,"journal":{"name":"Biomedical materials","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140689935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hemostatic performance and mechanism of palygorskite with structural regulate by oxalic acid gradient leaching. 草酸梯度浸出法调节结构的钙钛矿的止血性能和机制

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-18 DOI: 10.1088/1748-605X/ad407a

Y. Yang, Xiaomei Wang, Yalong Li, Bin Mu, Fangfang Yang, Aiqin Wang, Xinyue Liu

{"title":"The hemostatic performance and mechanism of palygorskite with structural regulate by oxalic acid gradient leaching.","authors":"Y. Yang, Xiaomei Wang, Yalong Li, Bin Mu, Fangfang Yang, Aiqin Wang, Xinyue Liu","doi":"10.1088/1748-605X/ad407a","DOIUrl":"https://doi.org/10.1088/1748-605X/ad407a","url":null,"abstract":"Palygorskite (Pal) is a naturally available one-dimensional clay mineral, featuring rod-shaped morphology, nanoporous structure, permanent negative charges as well as abundant surface hydroxyl groups, exhibiting promising potential as a natural hemostatic material. In this study, the hemostatic performance and mechanisms of Pal were systematically investigated based on the structural regulate induced by oxalic acid (OA) gradient leaching from perspectives of structure, surface attributes and ion release. In vitro and in vivo hemostasis evaluation showed that Pal with OA leaching for 1 h exhibited a superior blood procoagulant effect compared with the raw Pal as well as the others leached for prolonging time. This phenomenon might be ascribed to the synergistic effect of the intact nanorod-like morphology, the increase in the surface negative charge, the release of metal ions (Fe3+ and Mg2+), and the improved blood affinity, which promoted the intrinsic coagulation pathway, the fibrinogenesis and the adhesion of blood cells, thereby accelerating the formation of robust blood clots. This work is expected to provide experimental and theoretical basis for the construction of hemostatic biomaterials based on clay minerals.","PeriodicalId":9016,"journal":{"name":"Biomedical materials","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140686804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in electroactive bioscaffolds for repairing spinal cord injury. 用于修复脊髓损伤的电活性生物支架的进展。

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-18 DOI: 10.1088/1748-605X/ad4079

Zeqi Liu, Jiahui Lai, Dexin Kong, Yannan Zhao, Jiakang Zhao, Jianwu Dai, Mingming Zhang

{"title":"Advances in electroactive bioscaffolds for repairing spinal cord injury.","authors":"Zeqi Liu, Jiahui Lai, Dexin Kong, Yannan Zhao, Jiakang Zhao, Jianwu Dai, Mingming Zhang","doi":"10.1088/1748-605X/ad4079","DOIUrl":"https://doi.org/10.1088/1748-605X/ad4079","url":null,"abstract":"Spinal cord injury (SCI) is a devastating neurological disorder, leading to loss of motor or somatosensory function, which is the most challenging worldwide medical problem. Re-establishment of intact neural circuits is the basis of spinal cord regeneration. Considering the crucial role of electrical signals in the nervous system, electroactive bioscaffolds have been widely developed for SCI repair. They can produce conductive pathways and a pro-regenerative microenvironment at the lesion site similar to that of the natural spinal cord, leading to neuronal regeneration and axonal growth, and functionally reactivating the damaged neural circuits. In this review, we first demonstrate the pathophysiological characteristics induced by SCI. Then, the crucial role of electrical signals in SCI repair is introduced. Based on a comprehensive analysis of these characteristics, recent advances in the electroactive bioscaffolds for SCI repair are summarized, focusing on both the conductive bioscaffolds and piezoelectric bioscaffolds, used independently or in combination with external electronic stimulation. Finally, thoughts on challenges and opportunities that may shape the future of bioscaffolds in SCI repair are concluded.","PeriodicalId":9016,"journal":{"name":"Biomedical materials","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140687748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of chitosan/polyvinyl alcohol antibacterial sponge materials 壳聚糖/聚乙烯醇抗菌海绵材料的制备与表征

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-17 DOI: 10.1088/1748-605x/ad3c87

Xue Chen, Jing Xu, Alidha Gafur, Baoyu Chen, Yibo Han, Liyuan Zhang, Lingwen Kong, Guixue Wang and Zhiyi Ye

引用次数: 0

The effects of keratin-coated titanium on osteoblast function and bone regeneration. 角蛋白涂层钛对成骨细胞功能和骨再生的影响

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-16 DOI: 10.1088/1748-605X/ad3f5f

E. Ranjit, Stephen Hamlet, Todd Shelper, Ajay Sharma, Robert M Love

{"title":"The effects of keratin-coated titanium on osteoblast function and bone regeneration.","authors":"E. Ranjit, Stephen Hamlet, Todd Shelper, Ajay Sharma, Robert M Love","doi":"10.1088/1748-605X/ad3f5f","DOIUrl":"https://doi.org/10.1088/1748-605X/ad3f5f","url":null,"abstract":"INTRODUCTION\u0000Wool derived keratin, due to its demonstrated ability to promote bone formation, has been suggested as a potential bioactive material for implant surfaces. The aim of this study was to assess the effects of keratin-coated titanium on osteoblast function in vitro and bone healing in vivo. Methods: Keratin-coated titanium surfaces were fabricated via solvent casting and molecular grafting. The effect of these surfaces on the attachment, osteogenic gene, and osteogenic protein expression of MG-63 osteoblast-like cells were quantified in vitro. The effect of these keratin-modified surfaces on bone healing over three weeks using an intraosseous calvaria defect was assessed in rodents. Results: Keratin coating did not affect MG-63 proliferation or viability, but enhanced osteopontin, osteocalcin and bone morphogenetic expression in vitro. Histological analysis of recovered calvaria specimens showed osseous defects covered with keratin-coated titanium had a higher percentage of new bone area two weeks after implantation compared to that in defects covered with titanium alone. Conclusions: The keratin-coated surfaces were biocompatible and stimulated osteogenic expression in adherent MG-63 osteoblasts. Furthermore, a pilot preclinical study in rodents suggested keratin may stimulate earlier intraosseous calvaria bone healing. .","PeriodicalId":9016,"journal":{"name":"Biomedical materials","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mussel shell-derived pro-regenerative scaffold with conductive porous multi-scale-patterned microenvironment for spinal cord injury repair. 用于脊髓损伤修复的具有导电多孔多尺度图案微环境的贻贝壳再生支架。

IF 4 3区医学

Biomedical materials Pub Date : 2024-04-16 DOI: 10.1088/1748-605X/ad3f63

Wenming Yin, Chang Yang, Dan Liu, Shuhan Cha, Liu Cai, Genlan Ye, Xiao-Ying Song, Jifeng Zhang, Xiaozhong Qiu

{"title":"Mussel shell-derived pro-regenerative scaffold with conductive porous multi-scale-patterned microenvironment for spinal cord injury repair.","authors":"Wenming Yin, Chang Yang, Dan Liu, Shuhan Cha, Liu Cai, Genlan Ye, Xiao-Ying Song, Jifeng Zhang, Xiaozhong Qiu","doi":"10.1088/1748-605X/ad3f63","DOIUrl":"https://doi.org/10.1088/1748-605X/ad3f63","url":null,"abstract":"It is well-established that multi-scale porous scaffolds can guide axonal growth and facilitate functional restoration after spinal cord injury (SCI). In this study, we developed a novel mussel shell-inspired conductive scaffold for SCI repair with ease of production, multi-scale porous structure, high flexibility, and excellent biocompatibility. By utilizing the reducing properties of polydopamine, non-conductive graphene oxide (GO) was converted into conductive reduced graphene oxide (rGO) and crosslinked in situ within the mussel shells. In vitro experiments confirmed that this multi-scale porous Shell@PDA-GO could serve as structural cues for enhancing cell adhesion, differentiation, and maturation, as well as promoting the electrophysiological development of hippocampal neurons. After transplantation at the injury sites, the Shell@PDA-GO provided a pro-regenerative microenvironment, promoting endogenous neurogenesis, triggering neovascularization, and relieving glial fibrosis formation. Interestingly, the Shell@PDA-GO could induce the release of endogenous growth factors (NGF and NT-3), resulting in the complete regeneration of nerve fibers at 12 weeks. This work provides a feasible strategy for the exploration of conductive multi-scale patterned scaffold to repair SCI.","PeriodicalId":9016,"journal":{"name":"Biomedical materials","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140694767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0