Syed Minhaj Rahman, Matthew Wang, Fahad Ahmed, Mohammad Jafferany
{"title":"Assessing the Relationship Between Vitiligo and Cardiovascular Disease Risk Factors","authors":"Syed Minhaj Rahman, Matthew Wang, Fahad Ahmed, Mohammad Jafferany","doi":"10.33590/emj/10308019","DOIUrl":"https://doi.org/10.33590/emj/10308019","url":null,"abstract":"Advancements in novel combination immunotherapies as well as innovative downstream management courses offer great optimism for the applicability of emerging cancer immunotherapy to prospective treatment of cold tumours. This review comprehensively analyses and discusses notable current research directions in the field and underscores future directions for continued scientific progress alongside relevant clinical applications. Vitiligo is an autoimmune disorder characterised by white depigmented cutaneous macules. Although vitiligo may generally be considered a cosmetic disease, literature has associated broader systemic comorbidities, including a higher risk for atherosclerotic events, dyslipidaemia, and cardiovascular risk. To the authors’ knowledge, this is the first systematic review that assesses the association between vitiligo and cardiovascular disease (CVD)/CVD-associated factors. Utilising the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the authors searched PubMed and Scopus databases to identify studies available as of 30th June 2022, examining CVD and CVD-associated risk factors in patients with vitiligo. Of 2,553 articles, seven studies (four cross-sectional and three case-control), totalling 611 patients diagnosed with vitiligo (56.3% female), met the inclusion criteria for the authors’ review. Six studies suggested a significant association between patients with vitiligo and an increased risk for CVD via increased atherosclerotic events, constraint-induced movement therapy, plaque presence, dyslipidaemia, high-sensitivity C-reactive protein, oxidative stress, as well as decreased levels of vitamin D, calcium, zinc, and antioxidants. However, one study found that patients with vitiligo presented with fewer cardiovascular risk factors and increased levels of high-density lipoprotein. Although few studies indicated an increase in atherosclerotic risk due to elevated low-density lipoprotein-cholesterol and total cholesterol, contradictory high-density lipoprotein and total cholesterol levels in additional studies indicate the need for further investigation. Lastly, the association between vitiligo severity and CVD risk also indicated conflicting results. The authors’ small sample size restrained their ability to compare populations and incorporate racial and ethnic diversity to generalise their conclusions. Additional studies are required to comprehensively understand the association between vitiligo and the risk of CVD.","PeriodicalId":90162,"journal":{"name":"European medical Journal. Urology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85255994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health-Economic Determinants of COVID-19 Pandemic and Countries’ Efficiency","authors":"R. Ahangar, V. Prybutok","doi":"10.33590/emj/10301710","DOIUrl":"https://doi.org/10.33590/emj/10301710","url":null,"abstract":"This study examines the relationship between vaccination and inflation in battling the COVID-19 pandemic across nations. Data from 85 countries worldwide were collected from the Trading Economics (New York City, USA) website during the COVID-19 pandemic. First, a new theoretical model was proposed based on the economic and healthcare literature; then, a binary variable, inflation/vaccination% was developed according to the proposed theoretical model. The relationship between inflation/vaccination% and macroeconomic factors was examined using logistic regression. After that, the countries were ranked by minimising the inflation/vaccination% rate that measures a country’s efficiency in fighting the COVID-19 pandemic, thereby permitting governments to compare the performance of different countries. The findings show that a country with a higher gross domestic product growth rate and competitiveness index during the COVID-19 pandemic has a lower inflation/vaccination% ratio. The results of this study provide strong evidence that countries should mitigate a pandemic’s economic impact by managing vaccination programmes to control global inflation.","PeriodicalId":90162,"journal":{"name":"European medical Journal. Urology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79018268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Introducing Mavacamten for the Treatment of NYHA Class II and III Symptomatic Obstructive HCM in Adult Patients","authors":"None EMJ","doi":"10.33590/emjcardiol/10303519","DOIUrl":"https://doi.org/10.33590/emjcardiol/10303519","url":null,"abstract":"","PeriodicalId":90162,"journal":{"name":"European medical Journal. Urology","volume":"252 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135621546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensitivity And Specificity of FEF25–75/Forced Vital Capacity for Diagnosing Restrictive Lung Disease","authors":"Mohamad Reza Tarkhorani, Fateme Ziamanesh, Hosein Kazemi Zadeh, Maryam Edalatifard, B. Rahimi","doi":"10.33590/10.33590/emj/10306372","DOIUrl":"https://doi.org/10.33590/10.33590/emj/10306372","url":null,"abstract":"Introduction and objective: The role of spirometry in the diagnosis of restrictive lung diseases is unclear. This study investigated the sensitivity and specificity of the forced expiratory flow 25–75 (FEF25–75)/forced vital capacity (FVC) parameter in diagnosing restrictive lung disease.\u0000\u0000Methods: In this study, the records of all restrictive patients who were referred to the pulmonary centre of Imam Khomeini Hospital, Tehran, Iran, from March 2021–March 2022 have been reviewed, and the indexes in the body box and spirometry have been recorded.\u0000\u0000Results: A total of 527 people were included in the study. Among them, 134 people (25.4%) had restrictive lung disease. The average area under the graph of the FEF25–75/FVC index is 0.648±0.028. It can be said that the area under the graph for the FEF25–75/FVC index is between 0.594–0.703. The FEF25–75/FVC index at values above 79.90 has a sensitivity of 70.9% and a false positive rate (1- specificity) of 53.2%.\u0000\u0000Conclusions: According to the result of this study, the ratio of FEF25–75/FVC index in spirometry at above 79.90 has a sensitivity of 70.9% and a false positive rate (1- specificity) of 53.2%. Therefore, it can be used as a screening test for restrictive lung diseases.","PeriodicalId":90162,"journal":{"name":"European medical Journal. Urology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84976623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosis of Tuberculosis in Low-Resource Settings: Overcoming Challenges Within Laboratory Practice","authors":"Chavini K Shaozae, Debjani Das, M. Kumar","doi":"10.33590/emj/10302558","DOIUrl":"https://doi.org/10.33590/emj/10302558","url":null,"abstract":"Tuberculosis (TB), rightly referred to as an ancient disease, has affected humans for thousands of years, the first drafted reference of which came from India and China around 3,300 and 2,300 years ago, respectively. TB, caused by a bacillus called Mycobacterium tuberculosis, is a deadly infectious disease that is transmitted through aerosol droplets, and is estimated to have infected one-quarter of the global population. It has a mortality rate of 50% if treatment is not provided; however, with timely detection and interventions, which include currently recommended anti-TB drugs, 85% of people can be cured. India, being a resource-poor country, has one of the highest burdens of TB in the world, with an incidence of 210/100,000 in 2021, according to the World Health Organization (WHO) Global TB report of 2022.","PeriodicalId":90162,"journal":{"name":"European medical Journal. Urology","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74671702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ERA 2023 Abstract Highlights","authors":"None EMJ","doi":"10.33590/emjnephrol/10309372","DOIUrl":"https://doi.org/10.33590/emjnephrol/10309372","url":null,"abstract":"The following selected highlights explore several fascinating abstracts that were presented at the 60th European Renal Association (ERA) Congress 2023. Topics covered include vascular access in haemodialysis, renal transplantation, acute kidney injury, IgA nephropathy, and cardiovascular risk in chronic kidney disease.","PeriodicalId":90162,"journal":{"name":"European medical Journal. Urology","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135702348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interview: Kelly Hirko","authors":"Kelly A. Hirko","doi":"10.33590/emj/10305342","DOIUrl":"https://doi.org/10.33590/emj/10305342","url":null,"abstract":"","PeriodicalId":90162,"journal":{"name":"European medical Journal. Urology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77348411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}