Clinical medicine insights. Women's health最新文献

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Shaping the Conversation: A Secondary Analysis of Reproductive Decision-Making Among Black Mothers with HIV. 塑造对话:感染艾滋病毒的黑人母亲生育决策的二次分析。
Clinical medicine insights. Women's health Pub Date : 2016-05-02 eCollection Date: 2016-01-01 DOI: 10.4137/CMWH.S34671
Ndidiamaka N Amutah, Jacqueline Gifuni, Yvonne Wesley
{"title":"Shaping the Conversation: A Secondary Analysis of Reproductive Decision-Making Among Black Mothers with HIV.","authors":"Ndidiamaka N Amutah,&nbsp;Jacqueline Gifuni,&nbsp;Yvonne Wesley","doi":"10.4137/CMWH.S34671","DOIUrl":"https://doi.org/10.4137/CMWH.S34671","url":null,"abstract":"<p><p>The purpose of this qualitative secondary data analysis is to examine the major influencers on mothers with HIV in their childbearing decisions, as well as how those influencers shape conversations with clinicians and health-care providers regarding HIV treatment and prevention. The original study gained insight into the reproductive decision-making of mothers with HIV. By analyzing a subsample of 15 interviews from an original cohort of 25 participants in the earlier study, three major themes were identified as follows: (1) family members, not health-care providers, influence reproductive decisions; (2) negative attitudes toward subsequent pregnancies are mainly due to HIV transmission; and (3) birth control decisions were predominately supported by family members, while health-care providers were not consulted. </p>","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"9 Suppl 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMWH.S34671","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34466398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Radical Surgery for Endometriosis: Analysis of Quality of Life and Surgical Procedure 子宫内膜异位症的根治性手术:生活质量和手术方法的分析
Clinical medicine insights. Women's health Pub Date : 2016-03-07 DOI: 10.4137/CMWH.S38170
Cristina de la Hera-Lázaro, José l Muñoz-gonzález, Reyes Pérez, Rocío Vellido-Cotelo, Alvaro Díez-Álvarez, Leticia Muñoz-Hernando, C. Alvarez-Conejo, J. Jiménez-López
{"title":"Radical Surgery for Endometriosis: Analysis of Quality of Life and Surgical Procedure","authors":"Cristina de la Hera-Lázaro, José l Muñoz-gonzález, Reyes Pérez, Rocío Vellido-Cotelo, Alvaro Díez-Álvarez, Leticia Muñoz-Hernando, C. Alvarez-Conejo, J. Jiménez-López","doi":"10.4137/CMWH.S38170","DOIUrl":"https://doi.org/10.4137/CMWH.S38170","url":null,"abstract":"OBJECTIVE The main aim of this study is to determine the improvement in quality of life in patients who have undergone radical surgery because of severe endometriosis. PATIENTS AND METHODS This nonrandomized interventional study (quasi experimental) was carried out between January 2009 and September 2014. A total of 46 patients with diagnosis of severe endometriosis were included. Radical surgery, including hysterectomy, was performed. Acting as their own control group, the patients were asked to fill in a validated questionnaire of quality of life [Endometriosis Health Profile-5 (EHP-5)] and a visual analog scale of pain at the moment of the preoperative visit (one month prior to surgery) and six months after the surgery. RESULTS Radical surgery for endometriosis was performed in 46 patients at our center over the period of six years. Among the patients, 73.9% of them had undergone previous surgery for endometriosis. In 82.6% of cases, a complete laparoscopic resection was carried out. Gastrointestinal tract resection was performed in 21.7%, and urinary tract resection was necessary in 8.7%. The mean age of the patients was 38.6 years. The rate of complications was 30.4%. Six months after the surgery, all items of the EHP-5 questionnaire had a lower score, which means an improvement in all aspects of quality of life related to endometriosis. The difference obtained between the scores before and after the surgery was statistically significant. The mean visual analog scale score before the surgery was 8.5, whereas it decreased to 1.4 after the surgery (P < 0.001). CONCLUSION Performing a radical surgery is a difficult decision to make; however, it can provide optimal results in terms of improvement of quality of life and, therefore, should be considered when conservative therapy fails.","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"48 1","pages":"7 - 11"},"PeriodicalIF":0.0,"publicationDate":"2016-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82612215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Secondary Advanced Abdominal Pregnancy after Suspected Ruptured Cornual Pregnancy with Good Maternal Outcome: A Case with Unusual Gangrenous Fetal Toes and Ultrasound Diagnoses Managed by Hysterectomy 怀疑角角妊娠破裂后继发晚期腹部妊娠,产妇结局良好:异常胎趾坏疽1例,超声诊断经子宫切除术处理
Clinical medicine insights. Women's health Pub Date : 2016-02-04 DOI: 10.4137/CMWH.S36311
A. El-Agwany, El-Sayeda H. M. El-Badawy, A. El-habashy, Hesham El-gammal, M. Abdelnaby
{"title":"Secondary Advanced Abdominal Pregnancy after Suspected Ruptured Cornual Pregnancy with Good Maternal Outcome: A Case with Unusual Gangrenous Fetal Toes and Ultrasound Diagnoses Managed by Hysterectomy","authors":"A. El-Agwany, El-Sayeda H. M. El-Badawy, A. El-habashy, Hesham El-gammal, M. Abdelnaby","doi":"10.4137/CMWH.S36311","DOIUrl":"https://doi.org/10.4137/CMWH.S36311","url":null,"abstract":"Incidence of abdominal pregnancy is accounting for 1.4% of all ectopic pregnancies. This is a rare case report of a 35-year-old multigravida who was presented to our hospital at 24 weeks of gestation with advanced live intraabdominal pregnancy diagnosed by ultrasound. The patient was followed up till 28 weeks in hospital for medicolegal viability in Egypt. Midline laparotomy was done, a live baby was delivered, and hysterectomy was done for attached placenta. Mother was discharged in good health, and baby was admitted in neonatal intensive care unit with no congenital anomalies and died after three weeks of sepsis. The management of advanced abdominal pregnancy remains controversial. Diagnosis and management of advanced abdominal pregnancy is still a challenge to today’s medical world. But high index of suspicion aided with imaging studies can help in timely diagnosis, thereby preventing the associated life-threatening complications.","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"8 1","pages":"1 - 5"},"PeriodicalIF":0.0,"publicationDate":"2016-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73964503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Prediction of Fetal Hypertrophic Cardiomyopathy in Diabetic Pregnancies Compared with Postnatal Outcome 糖尿病妊娠与产后预后比较胎儿肥厚性心肌病的预测
Clinical medicine insights. Women's health Pub Date : 2015-12-01 DOI: 10.4137/CMWH.S32825
S. Elmekkawi, G. Mansour, Mohammed S E Elsafty, Alaa S. Hassanin, M. Laban, Heba M. Elsayed
{"title":"Prediction of Fetal Hypertrophic Cardiomyopathy in Diabetic Pregnancies Compared with Postnatal Outcome","authors":"S. Elmekkawi, G. Mansour, Mohammed S E Elsafty, Alaa S. Hassanin, M. Laban, Heba M. Elsayed","doi":"10.4137/CMWH.S32825","DOIUrl":"https://doi.org/10.4137/CMWH.S32825","url":null,"abstract":"OBJECTIVE The aim of this study was to estimate the accuracy of prenatal assessment of interventricular septum (IVS) thickness, right myocardial wall thickness (RMWT), and left myocardial wall thickness (LMWT) by two-dimensional (2D) ultrasound for the prediction of perinatal mortality and postnatal diagnosis of hypertrophic cardiomyopathy (HCM) among diabetic pregnant women. SUBJECTS AND METHODS A total of 120 diabetic pregnant women at 35 weeks or more were enrolled in this study from January 1, 2012, to June 30, 2014, at Ain Shams Maternity Hospital, Cairo, Egypt. The 2D ultrasound was done once for all the participants at the time of recruitment; IVS thickness, RMWT, and LMWT were measured. The glycosylated hemoglobin (HbA1c) levels of the participants were recorded. Neonatal assessment including postnatal echocardiography was done after 48 hours. Postnatal results were compared with the prenatal predictive results. RESULTS Higher thickness values for IVS, RMW, and LMW were obtained in the uncontrolled diabetic cases (HbA1c > 6.5%) than in the controlled diabetic cases (HbA1c < 6.5%; P < 0.01). Of the included 120 neonates, 10 (8.3%) were stillborn, 99 (82.5%) had a five-minute Apgar score ≥7, and 4 (3.3%) had a five-minute Apgar score ≤3. The four neonates with severe neonatal distress died after admission to neonatal intensive care unit within one week after delivery. Out of 110 live-born neonates, 4 (3.6%) neonates had a low ejection fraction (EF) (<50%) due to HCM; of them 2 (1.8%) died within one week after delivery, while 2 (1.8%) survived. Another two (1.8%) neonates died from severe respiratory distress syndrome. A cutoff value of ≥4.5 mm for prenatal IVS thickness was predictive of neonatal distress due to HCM with a sensitivity of 82%, specificity of 68%, and diagnostic accuracy of 72%. A cutoff value of <1.18 for the ratio of IVS thickness to LMWT had a sensitivity of 82%, specificity of 72%, and diagnostic accuracy of 74% for the prediction of neonatal distress due to HCM. In this study, 8 of the 10 fetuses with intrauterine demise and the 2 neonates who died within one week after delivery due to heart failure had a prenatal IVS thickness of ≥4.5 mm, while 7 of the 10 fetuses with intrauterine demise and the 2 neonates who died postnatal from heart failure had a prenatal IVS thickness to LMWT ratio of ≤1.18. CONCLUSION A prenatal IVS thickness of ≥4.5 mm or an IVS/LMWT ratio of ≤1.18 seems to be predictive of HCM and is associated with almost twofold higher risk of intrauterine fetal death and almost threefold higher risk of possibly relevant perinatal mortality.","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"61 1","pages":"39 - 43"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80084558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Impact of Advertising on Tampon Wear-time Practices 广告对卫生棉条使用时间的影响
Clinical medicine insights. Women's health Pub Date : 2015-11-29 DOI: 10.4137/CMWH.S25123
Kara E. Woeller, K. W. Miller, Amy L Robertson-Smith, Lisa C. Bohman
{"title":"Impact of Advertising on Tampon Wear-time Practices","authors":"Kara E. Woeller, K. W. Miller, Amy L Robertson-Smith, Lisa C. Bohman","doi":"10.4137/CMWH.S25123","DOIUrl":"https://doi.org/10.4137/CMWH.S25123","url":null,"abstract":"OBJECTIVES (1) To determine whether advertising nighttime tampon use for up to eight hours was understood to be consistent with label recommendations and (2) to determine whether television and print advertising with this message affected tampon wear times in adults and teens. METHODS (1) A comprehension study (online advertising and follow-up questionnaire) among women aged 14–49 years (300 per group) who viewed either the test or a control advertising message; (2) Diary-based surveys of tampon wear times performed prior to (n = 292 adults, 18–49 years, 74 teens, 12–17 years) and after (n = 287 adults, 104 teens) the launch of national advertising. RESULTS Significantly more test message viewers than controls stated tampons should be worn less than or equal to eight hours (93.6% vs. 88.6%, respectively, P = 0.049). A directionally higher percentage of test message viewers said they would use a pad if sleeping longer than eight hours (52% vs. 42% of controls). Among the women who used tampons longer than eight hours when sleeping, 52% reported they would wake up and change compared with 45% of controls. No significant difference between baseline and follow-up diary surveys was found among teens or adults in various measures of tampon wear time (mean wear times; usage intervals from less than two hours to more than 10 hours; percentage of tampons used for more than or equal to eight hours; frequency of wearing at least one tampon more than eight hours). CONCLUSIONS Advertising nighttime tampon wear for up to eight hours effectively communicated label recommendations but did not alter tampon wear times. The informational intervention had limited impact on established habits.","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"12 1","pages":"29 - 38"},"PeriodicalIF":0.0,"publicationDate":"2015-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87859634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Predictive Risk Factors in the Treatment of Gestational Diabetes Mellitus. 治疗妊娠糖尿病的预测性风险因素。
Clinical medicine insights. Women's health Pub Date : 2015-10-14 eCollection Date: 2015-01-01 DOI: 10.4137/CMWH.S31564
Lebriz Hale Aktun, Betul Yorgunlar, Nilay Karaca, Yaşam Kemal Akpak
{"title":"Predictive Risk Factors in the Treatment of Gestational Diabetes Mellitus.","authors":"Lebriz Hale Aktun, Betul Yorgunlar, Nilay Karaca, Yaşam Kemal Akpak","doi":"10.4137/CMWH.S31564","DOIUrl":"10.4137/CMWH.S31564","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate predictive risk factors in the treatment of gestational diabetes mellitus (GDM).</p><p><strong>Patients and methods: </strong>A total of 256 pregnant women who underwent 75 g oral glucose tolerance test (OGTT) during 24-28 weeks of pregnancy were included according to the World Health Organization criteria. Demographic characteristics of the patients, including age, parity, family history of diabetes, body weight before pregnancy, and body weight at the diagnosis of GDM, were recorded. Fasting insulin and hemoglobin A1c (HbA1c) values at the time of diagnosis were evaluated. The patients were divided into two groups: those requiring insulin treatment (insulin group, n = 89) and those receiving diet therapy (diet group, n = 167) during pregnancy according to the American Diabetes Association recommendations.</p><p><strong>Results: </strong>A total of 34.76% of the pregnant women with GDM required insulin treatment. The mean age of these patients was significantly higher compared to the diet group (34.9 ± 0.6 years vs. 31.9 ± 0.6 years; P = 0.004). Body mass index before pregnancy was also significantly higher in the insulin group than that in the diet group (32 ± 0.9 kg/m(2) vs. 29 ± 0.7 kg/m(2); P = 0.004). Fasting blood glucose (FBG) during OGTT was 105.6 ± 2.1 mg/dL and 96.7 ± 1.1 mg/dL in the insulin group and diet group, respectively (P < 0.001). There was no significant difference in fasting plasma glucose during OGTT between the groups (P = 0.069), while plasma glucose at two hours was 161.1 ± 6.8 mg/dL in the insulin group and 145.1 ± 3.7 mg/dL in the diet group (P = 0.027). At the time of diagnosis, HbA1c values were significantly higher in the insulin group compared to the diet group (5.3 ± 0.1 vs. 4.9 ± 0.1; P = 0.001). There was no significant difference in FBG and homeostasis model assessment-insulin resistance values between the groups (P = 0.908, P = 0.073).</p><p><strong>Conclusion: </strong>Our study results suggest that age, family history of diabetes, body weight before pregnancy, FBG, and HbA1c values are predictors for the necessity of insulin treatment.</p>","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"8 ","pages":"25-8"},"PeriodicalIF":0.0,"publicationDate":"2015-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34191342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Now I Can Do Better": A Study of Obese Women's Experiences Following a Nonprescriptive Nutritional Intervention. “现在我可以做得更好”:一项关于肥胖妇女在非规定性营养干预后经历的研究。
Clinical medicine insights. Women's health Pub Date : 2015-09-13 eCollection Date: 2015-01-01 DOI: 10.4137/CMWH.S23163
Mariana D Ulian, Bruno Gualano, Fabiana B Benatti, Patricia L de Campos-Ferraz, Odilon J Roble, Bruno T Modesto, Bruna C Brito, Karina A Murakawa, Mariana D Torre, Aline Cc Tritto, Ramiro F Unsain, Priscila de M Sato, Fernanda B Scagliusi
{"title":"\"Now I Can Do Better\": A Study of Obese Women's Experiences Following a Nonprescriptive Nutritional Intervention.","authors":"Mariana D Ulian,&nbsp;Bruno Gualano,&nbsp;Fabiana B Benatti,&nbsp;Patricia L de Campos-Ferraz,&nbsp;Odilon J Roble,&nbsp;Bruno T Modesto,&nbsp;Bruna C Brito,&nbsp;Karina A Murakawa,&nbsp;Mariana D Torre,&nbsp;Aline Cc Tritto,&nbsp;Ramiro F Unsain,&nbsp;Priscila de M Sato,&nbsp;Fernanda B Scagliusi","doi":"10.4137/CMWH.S23163","DOIUrl":"https://doi.org/10.4137/CMWH.S23163","url":null,"abstract":"<p><p>The present study analyzed obese women's experiences following a nonprescriptive nutritional intervention, implemented through a 1-year program based on the Health at Every Size(®) philosophy. We employed an action research method and conducted three focus groups during the intervention. We identified five interpretative axes across the focus groups, as follows: conflicts and perceptions; gaining motivation, perspective, and positioning; becoming autonomous eaters; acquiring tools; and the meetings between the nutritional therapist and participant. Our findings revealed varying levels of readiness among participants in adapting to the intervention and varying valuations of achievements related to eating and health, independent of body-weight changes. Participants reported benefiting from and expressed approval of the intervention. Participants reported positive behavioral and attitudinal changes to their diet and improvements to diet quality, diet structure, and consumption. Finally, participants seemed to show increased autonomy concerning diet and indicated increased confidence, comfort, flexibility, and positivity of attitude regarding eating. </p>","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"8 ","pages":"13-24"},"PeriodicalIF":0.0,"publicationDate":"2015-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMWH.S23163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34112510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Knowledge and Attitude of Patients, and Practice of the Arrest of Breast Cancer in Outpatient Consultations in Mastology at the General Hospital of Huambo, Angola. 安哥拉万博总医院乳腺门诊患者的知识、态度和乳腺癌防治实践
Clinical medicine insights. Women's health Pub Date : 2015-08-25 eCollection Date: 2015-01-01 DOI: 10.4137/CMWH.S21320
Hamilton Dos Prazeres Tavares, Suelma Beatriz Marques Prata Tavares, Felizardo Abraão Natanel, Daniel Pires Capingana
{"title":"Knowledge and Attitude of Patients, and Practice of the Arrest of Breast Cancer in Outpatient Consultations in Mastology at the General Hospital of Huambo, Angola.","authors":"Hamilton Dos Prazeres Tavares,&nbsp;Suelma Beatriz Marques Prata Tavares,&nbsp;Felizardo Abraão Natanel,&nbsp;Daniel Pires Capingana","doi":"10.4137/CMWH.S21320","DOIUrl":"https://doi.org/10.4137/CMWH.S21320","url":null,"abstract":"<p><p>This work aims to understand the knowledge and perceptions of women aged over 40 years with breast cancer seen in mastology outpatients at the Maternity Hospital of Huambo, central Angola, from February to August 2010. It also examines the clinical practice of prevention and detection of breast cancer. The research consisted of a collection of descriptive, cross-sectional data through a questionnaire. Statistical analysis of the data was performed using Epi Info, version 6.04b. In our sample, half of the women were single, all had history of breast cancer in the family, and most had heard of breast self-examination, with the primary source of information being the mass media. Almost all women reported that it was important to perform self-examination and that they were aware of the seriousness of breast cancer, and although most of them had not been taught how to do breast self-examination, almost all knew the basics of how to do it. Some 17.6% had heard of mammography, but none had ever had a mammogram. </p>","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"8 ","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2015-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMWH.S21320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34183104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do premenopausal hypothyroid women on levothyroxine therapy need bone status monitoring? 接受左甲状腺素治疗的绝经前甲状腺功能减退症女性是否需要进行骨状况监测?
Clinical medicine insights. Women's health Pub Date : 2015-03-15 eCollection Date: 2015-01-01 DOI: 10.4137/CMWH.S22114
Ruby P Babu, Alap Christy, Anupama Hegde, Poornima Manjrekar, Vivian D'Souza
{"title":"Do premenopausal hypothyroid women on levothyroxine therapy need bone status monitoring?","authors":"Ruby P Babu, Alap Christy, Anupama Hegde, Poornima Manjrekar, Vivian D'Souza","doi":"10.4137/CMWH.S22114","DOIUrl":"10.4137/CMWH.S22114","url":null,"abstract":"<p><strong>Background: </strong>Suppressive doses of levothyroxine therapy are reported to reduce bone mineral density (BMD) in women. Data on bone changes in premenopausal hypothyroid women with replacement therapy are limited. Hence, this study was undertaken to evaluate bone changes in this group using bone markers and BMD.</p><p><strong>Materials and methods: </strong>A hospital-based case-control study including 75 premenopausal women aged 30-45 years was conducted. The subjects were categorized based on their thyroid function and history into three groups of 25 euthyroid, 25 newly diagnosed hypothyroid, and 25 hypothyroid women on 100-200 μg of levothyroxine for a minimum of 5 years. The bone changes were evaluated and compared among the groups biochemically by estimating their plasma osteocalcin and serum calcium and phosphorus and radiologically by measuring their BMD by quantitative ultrasonography. Statistical analysis was conducted by using analysis of variance, Tukey's test, and Pearson's correlation using IBM SPSS Statistics 20.</p><p><strong>Results: </strong>Levels of plasma osteocalcin, serum calcium, and serum phosphorus in patients on long-term levothyroxine therapy were significantly higher than those in newly diagnosed hypothyroid women and in the euthyroid group. BMD showed definite features of osteopenia (T-score: -2.26 ± 0.5) among the women in the treatment group, while it was well within the normal range in the newly diagnosed and euthyroid women. A significant correlation was found between the osteocalcin levels and T-score.</p><p><strong>Conclusion: </strong>Hypothyroid women on long-term levothyroxine therapy showed signs of increased bone turnover and increased resorptive changes, though not frank osteoporosis. Hence, it may be important to evaluate the bone status of patients on levothyroxine for >5 years.</p>","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"8 ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2015-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33204994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction. 蒺藜提取物治疗女性性功能障碍的临床评价。
Clinical medicine insights. Women's health Pub Date : 2014-12-22 eCollection Date: 2014-01-01 DOI: 10.4137/CMWH.S17853
Carlos Rb Gama, Ricardo Lasmar, Gustavo F Gama, Camila S Abreu, Carlos P Nunes, Mauro Geller, Lisa Oliveira, Alessandra Santos
{"title":"Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction.","authors":"Carlos Rb Gama,&nbsp;Ricardo Lasmar,&nbsp;Gustavo F Gama,&nbsp;Camila S Abreu,&nbsp;Carlos P Nunes,&nbsp;Mauro Geller,&nbsp;Lisa Oliveira,&nbsp;Alessandra Santos","doi":"10.4137/CMWH.S17853","DOIUrl":"https://doi.org/10.4137/CMWH.S17853","url":null,"abstract":"<p><p>This is a qualitative-quantitative study based on hospital records of female patients of reproductive age, presenting sexual dysfunction, and treated with 250 mg Tribulus terrestris extract (1 tablet thrice daily for 90 days). Safety monitoring included vital signs, physical examination, laboratory tests, and occurrence of adverse events. Efficacy analysis included results of the Female Sexual Function Index (FSFI), dehydroepiandrosterone (DHEA) levels together with total and free testosterone, and the patient and physician assessments. There was a statistically significant improvement in total FSFI scores (P < 0.0001) post-treatment, with improvement among 106 (88.33%) subjects. There was a statistically significant (P < 0.0001) increase in the level of DHEA, while the levels of both serum testosterone (P = 0.284) and free testosterone decreased (P < 0.0001). Most adverse events recorded were related to the gastrointestinal tract. Physical examination showed no significant changes post-treatment. Based on the results, it is concluded that the T. terrestris extract is safe and effective in the treatment of female sexual dysfunction. </p>","PeriodicalId":90142,"journal":{"name":"Clinical medicine insights. Women's health","volume":"7 ","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2014-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/CMWH.S17853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32963199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
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