Blood vessels最新文献_第3页

Vascular neuroeffector mechanisms. Proceedings of the 7th International Symposium on Vascular Neuroeffector Mechanisms held in Bonn, FRG, July 8 - 11, 1990. 血管神经效应机制。1990年7月8日至11日在德国波恩举行的第七届血管神经效应机制国际研讨会论文集。

Blood vessels Pub Date : 1991-01-01

引用次数: 0

Effects of buflomedil on microvascular disorders in diabetic patients. 丁咯地尔对糖尿病患者微血管病变的影响。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158919

C Le Dévéhat, M Vimeux, G Bondoux, T Khodabandehlou

{"title":"Effects of buflomedil on microvascular disorders in diabetic patients.","authors":"C Le Dévéhat, M Vimeux, G Bondoux, T Khodabandehlou","doi":"10.1159/000158919","DOIUrl":"https://doi.org/10.1159/000158919","url":null,"abstract":"The aim of this work was to evaluate the effect of buflomedil on hemorheologic, hemodynamic and microcirculatory properties in diabetic patients. Patients were 20 noninsulin-dependent diabetics with distal arteriopathy characterized by chronic hypoxia (transcutaneous oxygen pressure = 25.2 +/- 4.8 mm Hg). They were randomly assigned to two groups for a double-blind study versus placebo. The treatment consisted of a 4-hour intravenous perfusion of 400 mg of buflomedil or placebo as a daily dose during 7 days. Results showed significant improvements in hemodynamic parameters such as post-occlusive peak flow and time to peak flow at the end of buflomedil treatment. In the same manner, the transcutaneous oxygen pressure was found to be significantly increased after buflomedil treatment, whereas there was no modification by placebo. Indeed, red cell aggregation was significantly less important as a result of buflomedil treatment whilst red cell deformability was found to be significantly increased. These hemorheological improvements make the blood flow redistribution through the microcirculatory network easier and lead ultimately to better tissue oxygenation.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":"28 Suppl 1 ","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158919","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13091255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Two indices of functional damage of the artery wall parallel the time course of irreversible narrowing in experimental vasospasm in the rabbit. 兔实验性血管痉挛时动脉壁功能损伤的两项指标与不可逆收缩的时间过程平行。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158859

P Vorkapic, J A Bevan, R D Bevan

引用次数: 15

Hemorheological effects of buflomedil: action on shape and functions of the human neutrophils. 丁咯地尔对人体中性粒细胞形态和功能的血液流变学影响。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158915

M R Boisseau, G Freyburger, F Belloc, M Seigneur

{"title":"Hemorheological effects of buflomedil: action on shape and functions of the human neutrophils.","authors":"M R Boisseau, G Freyburger, F Belloc, M Seigneur","doi":"10.1159/000158915","DOIUrl":"https://doi.org/10.1159/000158915","url":null,"abstract":"In vitro studies on the action of buflomedil (BFL) and its derivative CRL 41034 on the polymorphonuclear cells (PMN) has been performed using functional tests and scanning electron microscopy. The two drugs exhibited the same effects. BFL does not change the in vitro chemotaxis of PMN, but exhibits a regulatory effect on ZMS-induced aggregation of these cells. BFL also appeared to decrease superoxide production of PMN, in a dose- and time-dependent way. The cytoskeleton F-actin polymerization, analyzed through the binding of rhodamin-phalloidin, was increased when the total F-actin of the cells was unchanged. When cell extensions were studied morphologically a change in the shape of the pseudopods as well as the general aspect of the PMN (cottonous aspect) was observed as compared to controls. These drug-induced modifications in the shape change may be efficient in adhesion processes. Finally this latter effect and the influence on oxygen metabolite production could be another means of BFL to protect the microvessels during ischemia, in addition to its vasomotion promoting properties.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":"28 Suppl 1 ","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158915","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12822867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Chronic captopril treatment reverses the enhanced vascular concentrations of 3-methylhistidine in the spontaneously hypertensive rat. 慢性卡托普利治疗可逆转自发性高血压大鼠血管中3-甲基组氨酸浓度的升高。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158889

J R Jonsson, D B Frewin, R J Head

{"title":"Chronic captopril treatment reverses the enhanced vascular concentrations of 3-methylhistidine in the spontaneously hypertensive rat.","authors":"J R Jonsson, D B Frewin, R J Head","doi":"10.1159/000158889","DOIUrl":"https://doi.org/10.1159/000158889","url":null,"abstract":"Morphometric studies conducted on the blood vessels of the spontaneously hypertensive rat have provided evidence that medial hypertrophy is a key characteristic of the vascular change which occurs in hypertension. In the present study, we determined whether 3-methylhistidine (3MH), a post-translationally modified amino acid which is found uniquely in the actin and myosin of muscle, could provide a biochemical marker of such change. Our results indicated that the concentrations of 3MH were selectively elevated in the blood vessels from the spontaneously hypertensive rat, when compared with concentrations in vascular tissues from the Wistar-Kyoto rat. The concentrations of 3MH in non-vascular tissues were similar in the two strains. Chronic captopril treatment prevented the development of hypertension in the spontaneously hypertensive rat and was associated with a reduction of the vascular concentrations of 3MH. We therefore conclude that blood vessel concentrations of 3MH are a useful biochemical index of the changes in vascular smooth muscle contractile protein which occur during the development of hypertension in the spontaneously hypertensive rat.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":"28 6","pages":"413-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158889","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12945866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In vitro methodology for resistance arteries. 抗阻动脉的体外方法学。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158869

W Halpern, M Kelley

引用次数: 64

Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation. 探讨环AMP和环GMP在平滑肌松弛中的作用机制。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158852

T M Lincoln, T L Cornwell

引用次数: 206

Molecular biology of the vascular renin-angiotensin system. 血管肾素-血管紧张素系统的分子生物学。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158864

N J Samani, J D Swales

引用次数: 17

Cell biology of atrial natriuretic peptide. 房利钠肽的细胞生物学。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158847

C Huot, J Tremblay, P Hamet

引用次数: 6

Effect of papaverine on endothelial cell harvest from canine external jugular veins. 罂粟碱对犬颈外静脉内皮细胞收获的影响。

Blood vessels Pub Date : 1991-01-01 DOI: 10.1159/000158895

T J Ranval, L E Townsend, R Fietsam, P J Bendick, D M Reitz-Vick, J L Glover

{"title":"Effect of papaverine on endothelial cell harvest from canine external jugular veins.","authors":"T J Ranval, L E Townsend, R Fietsam, P J Bendick, D M Reitz-Vick, J L Glover","doi":"10.1159/000158895","DOIUrl":"https://doi.org/10.1159/000158895","url":null,"abstract":"Endothelial cell seeding procedures have been developed to line prosthetic bypass grafts used in peripheral vascular disease; however, because of current inefficient cell harvest techniques a high ratio of vein-to-graft area is necessary. This study was done to determine if the use of papaverine, a smooth muscle cell relaxant, would affect the number or viability of endothelial cells harvested from canine external jugular veins. Using a 0.12 mg/ml solution of papaverine in tissue culture medium to bathe the veins during dissection and excision, the viable cell yield was 2.20 +/- 1.16 (cells x 10(4)/cm2). A control group of veins using standard dissection technique gave a yield of 0.97 +/- 0.40 (p = 0.025). A second group of veins dissected while bathed in tissue culture medium alone gave a yield of 1.82 +/- 0.75, compared to a yield of 2.73 +/- 0.45 for papaverine harvested veins (p = 0.009). Percent cell viability was not significantly different for any of the groups: 73, 70, and 76% for papaverine, control and media only veins, respectively. The papaverine-harvested cells and those harvested with medium alone grew to 95% confluence in tissue culture in 9.8 +/- 1.1 and 9.9 +/- 0.9 days, respectively. Compared to conventional surgical techniques, use of papaverine more than doubled the endothelial cell yield from excised vein segments without adversely affecting viability or rate of growth in cell culture.","PeriodicalId":9009,"journal":{"name":"Blood vessels","volume":"28 6","pages":"490-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000158895","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12944475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3