Biological and Clinical Sciences Research Journal最新文献

{"title":"EFFECTS OF TYPE 2 DIABETES AND ITS IMPACT ON THE RISK OF DEVELOPING ARDS IN PATIENTS WITH LUNG CANCER POSTOPERATIVELY AND ITS PROGNOSIS","authors":"AJ Chaudhary, S. Iqbal, N. Iqbal, S. Kumar, .. Aroona, MS Nadeem","doi":"10.54112/bcsrj.v2024i1.875","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.875","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) and lung cancer are two prevalent health issues worldwide, each carrying significant morbidity and mortality burdens. Objective: The main objective of the study is to find the effects of type 2 diabetes Type 2 diabetes and its impact on the risk of developing ARDS in patients with lung cancer postoperatively and its prognosis. Methods: This retrospective study was conducted at CMH Lahore from 2021 to 2022. Data were collected from 320 patients diagnosed with lung cancer. Patients diagnosed with lung cancer who underwent surgery were included in the study. Patients with a history of any other malignancies and suffering from COPD were excluded from the study. Electronic medical records were reviewed to collect demographic information, including age, sex, body mass index (BMI), smoking history, comorbidities (including T2DM), tumour characteristics, surgical procedures performed, and postoperative outcomes. Results: Data were collected from 320 diagnosed patients with lung cancer according to inclusion and exclusion criteria. The mean age of the patients was 58.98±5.67 years. There were 60% male and 40% female patients. The prevalence of T2DM was 25%, and 50% followed the lobectomy surgical procedure. 40% of the patients were from stage I, 30% from stage II, 20% from stage III and 10% at stage IV. Forced Expiratory Volume in 1 Second (FEV1) had a mean value of 2.5 litres with a standard deviation of 0.8 litres. Forced Vital Capacity (FVC) showed a mean of 3.0 litres with a standard deviation of 1.0. The FEV1/FVC ratio was approximately 0.83, with a standard deviation of 0.05. Total Lung Capacity (TLC) exhibited a mean value of 5.0 litres with a standard deviation of 1.2 litres. Residual Volume (RV) had a mean of 1.2 litres with a standard deviation of 0.4. Conclusion: It is concluded that type 2 diabetes mellitus (T2DM) is associated with a higher incidence of acute respiratory distress syndrome (ARDS) in lung cancer surgery. T2DM independently predicts lesser prognosis and survival outcomes in patients who develop ARDS postoperatively.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USE OF ANTIBIOTICS AND THE FARMERS' AWARENESS LEVEL OF ANTIBIOTICS RESISTANCE OF BROILER FARMS","authors":"M. Usman, GA Khan, F. Khan, M. Javed, H ALI, M. Ahmad","doi":"10.54112/bcsrj.v2024i1.856","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.856","url":null,"abstract":"The ever-existent measures of antibiotic application in the broiler industry remain a controversial tool for improving livestock health and accelerating growth. The main objective of the study is to find the use of antibiotics and the farmers' awareness level of antibiotic resistance in broiler farms. This study is designed to investigate antibiotic usage practices and assess the awareness levels of broiler farmers regarding antibiotic resistance. A total of 280 participants from various broiler farms across the region were recruited from February 2023 to August 2023.  Eligible participants included farm owners, managers, and workers directly involved in broiler farming activities.  Data were collected from 280 participants through a designed survey. The study revealed a predominance of medium-sized farms, housing between 5,000 to 20,000 broilers, accounting for 60% of participants, followed by large farms with over 20,000 broilers at 25%. Basic biosecurity protocols were the most commonly implemented management practice among participants, reported by 50% of respondents, while 35% reported moderate implementation, and 15% reported advanced biosecurity measures. Tetracycline emerged as the most commonly used antibiotic (45%), often administered orally (60%) for disease prevention (40%). Enrofloxacin (30%) and Amoxicillin (25%) were also prevalent, with oral administration being the preferred route. Despite the predominance of seeking veterinary advice (70%), a notable proportion reported self-medication (20%) or seeking advice from fellow farmers (10%). It is concluded that antibiotic usage remains prevalent in commercial poultry farming, with tetracyclines, fluoroquinolones, and beta-lactams being commonly employed. While seeking veterinary advice predominates, there's a need to address gaps in access to veterinary services and promote responsible antibiotic stewardship among farmers.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"22 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141111388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARISON OF EFFICACY BETWEEN DEXMEDETOMIDINE AND PROPOFOL AFTER CORONARY ARTERY BYPASS GRAFT SURGERY","authors":"R. Bangash, I. Ahmad, U. Naz, MU Islam, A. Zeb, NA SHAH, A. Shabir, MW Sajjad","doi":"10.54112/bcsrj.v2024i1.849","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.849","url":null,"abstract":"Postoperative management following coronary artery bypass graft (CABG) surgery is crucial for patient outcomes. Sedation plays a key role in recovery, with dexmedetomidine and propofol being commonly used agents. Evaluating the efficacy of these sedatives can help optimise postoperative care. Objective: To compare the effectiveness of dexmedetomidine and propofol in terms of pulmonary complications, mean mechanical ventilation time, and postoperative ICU and hospital stay in patients undergoing CABG surgery. Methods: A randomised controlled trial was conducted from October 1, 2023, to December 31, 2023, at a tertiary care hospital. Eighty patients scheduled for CABG surgery were randomised into two groups: Group A received dexmedetomidine, and Group B received propofol. Outcomes were assessed by measuring the incidence of pulmonary complications, mean mechanical ventilation time, length of postoperative ICU stay, and total hospital stay. Statistical analysis was performed using appropriate tests to compare the outcomes between the two groups, with significance set at P < 0.05. Results: Pulmonary complications occurred in 5% of patients in Group A, significantly lower than the 20% observed in Group B (P = 0.04). Group A's mean mechanical ventilation time was 17.03 ± 3.46 hours, considerably shorter than Group B's 23.20 ± 5.55 hours (P = 0.0001). Group A's average postoperative ICU stay was 62.53 ± 15.10 hours, notably less than the 71.10 ± 14.06 hours for Group B (P = 0.01). Additionally, the mean hospital stay in Group A was 20.60 ± 1.99 days, significantly shorter than the 21.85 ± 3.11 days in Group B (P = 0.03). Conclusion: Dexmedetomidine demonstrates superior efficacy to propofol for patients undergoing CABG surgery, as evidenced by reduced pulmonary complications, shorter mechanical ventilation duration, and decreased postoperative ICU and hospital stays.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"54 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141111494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN METABOLIC AND RENAL SYSTEM AFTER HCV CLEARANCE IN CHRONIC VIRAL HEPATITIS PATIENTS TREATED WITH DIRECT-ACTING ANTIVIRALS","authors":"H PASHA, AT Tariq, A BANGASH, M. Salim, T MOHIUDIN","doi":"10.54112/bcsrj.v2024i1.837","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.837","url":null,"abstract":"Chronic hepatitis C infection is associated with metabolic and renal abnormalities, with direct antiviral agents (DAAs) offering a promising treatment approach. However, the influence of hepatitis C virus (HCV) clearance on metabolic and renal parameters in these patients remains underexplored. Objective: This study aimed to assess the impact of HCV clearance on the metabolic and renal system of chronic hepatitis C patients treated with direct antiviral agents. Methods: A prospective study was conducted at the Department of Medicine, Shifa Hospital, Islamabad, from January 2022 to January 2024. A total of 323 patients with chronic hepatitis C treated with DAAs were included. Hepatic and renal function tests were recorded before treatment, post-treatment, and 6-month follow-up. Insulin resistance (IR) and B-cell function were evaluated using the homeostatic model assessment (HOMA). All patients received DAAs treatment, with or without ribavirin. Statistical analysis was performed using appropriate methods. Results: Following HCV clearance, both groups exhibited a significant decrease in fasting glucose and insulin levels and improvements in HOMA-IR values. Additionally, decreased creatinine levels and increased glomerular filtration rate (GFR) indicated enhanced renal function. Sustained virologic response (SVR) emerged as an independent predictor of improvement in GFR and HOMA-IR. Conclusion: HCV clearance in chronic hepatitis C infection, achieved through treatment with direct antiviral agents, leads to notable improvements in renal and metabolic parameters. These findings underscore the importance of achieving SVR in managing chronic hepatitis C.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"35 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141117484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHALLENGES AND OPPORTUNITIES TO DESIGN FUTURE CROPS: GATEWAY TO SUSTAINABLE AGRICULTURE IN 21ST CENTURY","authors":"Hab Amin, S. Ullah, Sah Mahdi, HU Rehman, R. Kausar, F. Shamim, S. Ali, SA Kohli, A. Latif, N. Shahzadi, A. Alvi","doi":"10.54112/bcsrj.v2024i1.847","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.847","url":null,"abstract":"The global food production system is facing numerous challenges due to factors such as population growth, climate change, limited resources, and environmental preservation. To address these challenges, various strategies can be employed to develop future crops that are more productive, nutritious, and resilient. One strategy is to improve the yield potential of existing crops by developing new high-yielding cultivars. This can be achieved through the development of new varieties that can produce more grain under optimal conditions. Additionally, improving the nutritional quality of crops is important to address nutrient deficiencies. Synthetic biology and metabolic engineering methods can be used to develop crops with enhanced nutritional value. Efficient utilization of agricultural resources is another important aspect of crop improvement. This includes developing crops that use water and nutrients more efficiently, reducing the need for irrigation and fertilizers, and minimizing environmental impacts. Increasing the resistance of crops to pests, diseases, and extreme weather events can also help reduce the use of pesticides and minimize crop losses. The domestication of wild or semi-wild plants through genetic manipulation offers new opportunities for crop design. These plants may have high nutritional value, stress tolerance, and specialized metabolites that can be incorporated into cultivated crops. Similarly, the domestication of orphan or neglected plants can contribute to crop improvement by incorporating unique traits. Genetic improvement through the transfer of genes from wild relatives or other species can also enhance crop productivity. Advancements in genomics and genetic technologies can aid in the identification and transfer of beneficial alleles. Agronomic improvements, such as maximizing the effectiveness of crop protection agents and fertilizers while minimizing their environmental impact, can also contribute to crop performance. The emerging field of synthetic biology offers opportunities for developing novel biological devices and systems that can further enhance crop productivity and resilience. Overall, these strategies can help address the challenges faced by the global food production system.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"123 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GENETIC STUDIES FOR SOME YIELD-RELATED TRAITS IN OKRA (ABELMOSCHUS ESCULENTUS L.)","authors":"F. Khan, A. Kaynat, A. Saeed, T. Javaid, RA Iqbal, A. Latif, M. Nawaz, GM Siddiqui, A. Hassan, HM Javed","doi":"10.54112/bcsrj.v2024i1.848","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.848","url":null,"abstract":"Okra is a traditional vegetable famous for its nutritional value. It is a perfect villager's vegetable due to its robust nature, dietary fiber, and seed protein balance of both tryptophan and lysine. The research was carried out in the research area of the Department of Plant Breeding and Genetics, University of Agriculture Faisalabad. Cross combinations among 3 lines (Patel, Selection Super Green, and 19234) and 3 testers (IQRA-III, Perbhani Karanti, and Sabz Pari) were developed by using line × tester design. Crossed seeds along with parents were grown in the field under Randomized Complete Block Design (RCBD) with three replications. Data for various morphological traits was collected and analyzed statistically through analysis of variance and used to assess GCA, SCA, and gene action. Genotype 19234 exhibited maximum significant GCA (-11.4) for plant height in the negative direction and genotype Selection super Green proved a good general combiner for fruit weight, fruit diameter, and first flowering node, exhibiting values of 3.21, 1.191, and -0.89. IQRA-III (3.00), Patel (2.00), and Perbhani Karanti (1.11) exhibited significant GCA for number of fruits per plant. Line 19234 observed a good general combiner for crude fat (0.28), ash (5.43), and protein (0.39). Cross combination Patel × Perbhani exhibited the highest SCA for the number of fruits (7.78) followed by Selection Super Green × Sabz Pari (4.78) hence can be exploited for heterosis breeding. Cross combination Selection Super Green × Perbhani Karanti exhibited the highest significant SCA for plant height (-7.60) and Selection Super Green × IQRA-III displayed the maximum significant SCA value (2.26) for crude fat. Line Patel proved a good general combiner for most of the yield-related traits. Based on GCA and SCA, line 19234 can be used to enhance quality traits and cross combination Patel × Perbhani Karanti can be used to increase the number of fruits per plant.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"104 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141124736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION FOR IMPACT OF CLIMATE CHANGE ON WHEAT (TRITICUM AESTIVUM L.) GRAIN QUALITY AND YIELD TRAITS","authors":"S. Shamim, M. Abdullah, H. Shair, J. Ahmad, M. Farooq, S. Ajmal","doi":"10.54112/bcsrj.v2024i1.842","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.842","url":null,"abstract":"Climate change is increasing stress on agricultural production, notably in developing nations where crop yields are critically impacted. Swift changes in climate conditions directly diminish wheat yields and adversely influence key grain constituents such as starch, fibre, protein, amino acids, and essential nutrients. The studies were conducted for six years, from 2017-18 to 2022-23, to understand the impact of changing climate on wheat grain composition and quality. The results indicated that November is the best month for sowing wheat. The post-anthesis drought or less water availability helps the plants accumulate more protein and gluten contents, and starch contents decrease. The quality of the grain, however, is more significantly influenced by the variety of wheat, the type of environmental stress, and the duration and severity of exposure. Faisalabad 08 had the highest protein and gluten contents, while Galaxy 13 had the highest starch contents in D2. Galaxy 13 indicated the highest value of test weight and 1000-grain weight in November.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"115 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141126347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENHANCING PRE AND POST VEGETATIVE HEAT RESILIENCE AND YIELD POTENTIAL IN THE NEWLY RELEASED MAIZE VARIETY \"SAHIWAL GOLD\" THROUGH MODIFIED SELECTION","authors":"HM Javed, W. Akbar, M. Abbas, IU Haq, W. Sabir, S. Saddam, GY Shaikh, S ALI, Z. Asif, A. Rehman, A. Razaq","doi":"10.54112/bcsrj.v2024i1.855","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.855","url":null,"abstract":"Maize is well-anchored crop across the globe due to its nutritional profile, multipurpose usage, and underlying financial benefits. Growing of open-pollinated maize varieties (OPVs) is a traditional trend and is still followed by a huge community of small farmers in most of the developing world. Improvement in yield potential is always inevitable and requires a purposeful and definite strategy. The current climate scenario loaded with heat escalation and extreme fluctuations is creating uncertainty and unsustainability through acute yield losses in domesticated crops. The breeding strategy of Sahiwal Gold (2008-2018) was comprised of four developmental phases i.e. enrichment phase, half-sib selection, pedigree selection, uniformity phase, and field evaluation at various agro-ecological zones of Pakistan. Each consecutive autumn and spring season was utilized to improve yield potential by exploiting pre and post-vegetative heat resilience. Half sib and pedigree selection improved plant features like height (12%), cob length (4.1%), seeds per cob (7.5%), grain (10%), and stalk yield (11.2%) from enrichment to uniformity phase. Sahiwal Gold maintained a high adaption profile across the tested locations and out-yielded the check variety (MMRI Yellow) by 18% and 26% on average in 6 stations and 16 national yield trials, respectively. National yield testing approved its suitability across provinces like Punjab, Khyber-Pakhtunkhwa (KPK), and Islamabad territory under a diverse range of temperatures. Analysis of variance revealed that highly significant interaction between season and genotypes work for plant height, grain, and stalk yield potential. Higher grain yield up to 95 mounds/acre was observed for spring season crop and batter stalk yield results (650 mounds/acre) were assessed during autumn plantation. Twelve (12) feet tall plants with 4 feet long leaves having 75-90% stay green ability provide a good opportunity fodder and grain yield potential at farmer’s field. This work will provide a better understanding to researchers for designing breeding programs for the development of heat resilience germplasm in crops.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141129758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF STAGED VERSUS INDEX PROCEDURE COMPLETE REVASCULARIZATION IN ST-ELEVATION MYOCARDIAL INFARCTION","authors":"SB Shah, S. Khan","doi":"10.54112/bcsrj.v2024i1.775","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.775","url":null,"abstract":"ST-elevation myocardial infarction (STEMI) is a critical condition that necessitates quick and efficient revascularization techniques. Recently, there has been a discussion on the best method for revascularization staged versus index procedure complete revascularization. The study compares the clinical outcomes of staged versus index procedure complete revascularization in ST-elevation myocardial infarction.  This study is a prospective comparative analysis conducted at Ayub Teaching Hospital, Abbottabad. The patients were divided into two groups, with 40 participants in each group. Demographic data that included Smoking history, Diabetes mellitus, Dyslipidemia, Previous MI, and (LVEF) was recorded. Intraoperative and postoperative outcomes at 72 hours and six months were recorded. The quality of life was also assessed using SF-36 16. Data was entered and analyzed using SPSS (Statistical Package for the Social Sciences) version 24. P-values of ≤0.05 will be considered statistically significant. These findings suggest that in Group A, the frequency of \"No reflow\" (1 case) and \"Abrupt closure\" (0 instances) p=0.02) compared to Group B, where \"No reflow\" was observed in 2 cases and \"Abrupt closure\" in 1 case, (and (p=0.01), the investigation into post-operative outcomes, revealed no statistically significant differences between the two groups. P values ranged from 0.31 to 0.45, indicating comparable outcomes. After six months post-surgery, Group A demonstrated significantly better outcomes across various health-related domains than Group B, as indicated by the SF-36 questionnaire. In conclusion, index complete vascularization holds a distinct advantage over staged procedures. The observed differences across various health indicators highlight the potential clinical significance of prioritizing complete revascularization during the initial intervention.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"48 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EARLY OUTCOME OF LEFT VENTRICULAR FUNCTION AFTER CORONARY ARTERY BYPASS SURGERY: A SINGLE-CENTER EXPERIENCE","authors":"Mai Qureshi, FS Roomi, SQ Abbas","doi":"10.54112/bcsrj.v2024i1.772","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.772","url":null,"abstract":" \u0000Patients with ischemic heart disease and low ejection fraction often exhibit improved outcomes following coronary artery bypass grafting (CABG). Our study aimed to assess the impact of CABG on left ventricular (LV) systolic function and identify predictors of adverse postoperative outcomes. We conducted a prospective cross-sectional study involving 110 CABG patients with a mean age of 56.1 ± 12.2 years and preoperative left ventricular ejection fraction (LVEF) below 50%. Patients were categorized into two groups: group I (n=76, LVEF > 35%) and group II (n=34, LVEF < 35%). In group II, there was a significantly higher prevalence of diabetes mellitus (DM) (p = 0.05) and Euro SCORE II compared to group I (p < 0.001). However, other clinical predictors showed no significant difference between the two groups. Both groups exhibited a significant improvement in LVEF post-surgery (p = 0.05), with comparable in-hospital mortality rates recorded. The study identified DM, significant diastolic dysfunction, and intra-aortic balloon pump (IABP) insertion as predictors of in-hospital mortality (p = 0.001, 0.03, and < 0.001, respectively). These findings suggest a noticeable enhancement in LV systolic function post-CABG, contributing to improved survival rates. However, patients with DM, significant diastolic dysfunction, and those requiring IABP insertion during the perioperative period are at higher risk of mortality. Therefore, targeted attention and specialized care are essential for optimizing outcomes in these high-risk patients.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"40 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140365319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}