EFFECTS OF TYPE 2 DIABETES AND ITS IMPACT ON THE RISK OF DEVELOPING ARDS IN PATIENTS WITH LUNG CANCER POSTOPERATIVELY AND ITS PROGNOSIS

Abstract

Type 2 diabetes mellitus (T2DM) and lung cancer are two prevalent health issues worldwide, each carrying significant morbidity and mortality burdens. Objective: The main objective of the study is to find the effects of type 2 diabetes Type 2 diabetes and its impact on the risk of developing ARDS in patients with lung cancer postoperatively and its prognosis. Methods: This retrospective study was conducted at CMH Lahore from 2021 to 2022. Data were collected from 320 patients diagnosed with lung cancer. Patients diagnosed with lung cancer who underwent surgery were included in the study. Patients with a history of any other malignancies and suffering from COPD were excluded from the study. Electronic medical records were reviewed to collect demographic information, including age, sex, body mass index (BMI), smoking history, comorbidities (including T2DM), tumour characteristics, surgical procedures performed, and postoperative outcomes. Results: Data were collected from 320 diagnosed patients with lung cancer according to inclusion and exclusion criteria. The mean age of the patients was 58.98±5.67 years. There were 60% male and 40% female patients. The prevalence of T2DM was 25%, and 50% followed the lobectomy surgical procedure. 40% of the patients were from stage I, 30% from stage II, 20% from stage III and 10% at stage IV. Forced Expiratory Volume in 1 Second (FEV1) had a mean value of 2.5 litres with a standard deviation of 0.8 litres. Forced Vital Capacity (FVC) showed a mean of 3.0 litres with a standard deviation of 1.0. The FEV1/FVC ratio was approximately 0.83, with a standard deviation of 0.05. Total Lung Capacity (TLC) exhibited a mean value of 5.0 litres with a standard deviation of 1.2 litres. Residual Volume (RV) had a mean of 1.2 litres with a standard deviation of 0.4. Conclusion: It is concluded that type 2 diabetes mellitus (T2DM) is associated with a higher incidence of acute respiratory distress syndrome (ARDS) in lung cancer surgery. T2DM independently predicts lesser prognosis and survival outcomes in patients who develop ARDS postoperatively.