US neurologyPub Date : 2018-01-01DOI: 10.17925/USN.2018.14.1.31
Faan Mary R Rensel
{"title":"Wellness Journey with Multiple Sclerosis—Where to Start","authors":"Faan Mary R Rensel","doi":"10.17925/USN.2018.14.1.31","DOIUrl":"https://doi.org/10.17925/USN.2018.14.1.31","url":null,"abstract":"L ifestyle factors can increase one’s wellness or overall health for patients with multiple sclerosis (MS). This independent editorial clarifies the supporting literature behind the topics of discussion in a series of accompanying Bayer-supported videos filmed in partnership with the Multiple Sclerosis Association of America (MSAA).","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67611957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US neurologyPub Date : 2018-01-01DOI: 10.17925/USN.2018.14.2.66
G. Grossberg
{"title":"Highlights from the Alzheimer’s Association International Conference—AAIC 2018","authors":"G. Grossberg","doi":"10.17925/USN.2018.14.2.66","DOIUrl":"https://doi.org/10.17925/USN.2018.14.2.66","url":null,"abstract":"","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"66"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US neurologyPub Date : 2018-01-01DOI: 10.17925/USN.2018.14.2.80
J. Katz
{"title":"Latest Advances in the Treatment of Acute Stroke","authors":"J. Katz","doi":"10.17925/USN.2018.14.2.80","DOIUrl":"https://doi.org/10.17925/USN.2018.14.2.80","url":null,"abstract":"Support: No funding was received in the publication of this article. About 85% of strokes are ischemic, and the most severe ischemic strokes are caused by large vessel occlusion due to either artery-to-artery embolism or cardiac embolism. Early treatment is essential to rescue potentially salvageable tissue. Until recently, the only proven treatment for acute ischemic stroke was intravenous thrombolysis with recombinant tissue-type plasminogen activator (tPA). However, since December 2014, several randomized controlled trials have demonstrated the efficacy and safety of mechanical endovascular thrombectomy. The clinical benefit of endovascular thrombectomy when performed within 6 hours after the onset of stroke symptoms is now well established. Recently, two clinical trials found that this time window could be extended in patients selected based on computed tomography (CT) perfusion imaging analyzed with RAPID software [iSchemaView, Inc., Menlo Park, CA, US]. The DAWN study found that in people who have relatively small ischemic cores and occlusion of either the intracranial internal carotid or the proximal middle cerebral artery, endovascular therapy at 6–24 hours post-stroke onset plus medical therapy produced better functional outcomes at 90 days compared with medical therapy alone. In DEFUSE-3, patients with large vessel strokes with favorable ischemic core to penumbra ratios, endovascular therapy at 6–16 hours post stroke onset, in addition to medical therapy, improved functional neurological outcome at 90 days, compared with medical therapy alone. In an expert interview, Jeffrey M Katz discusses these advances in stroke treatment.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"80"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US neurologyPub Date : 2018-01-01DOI: 10.17925/USN.2018.14.2.71
S. Tepper
{"title":"Update on Current Treatments for Migraine","authors":"S. Tepper","doi":"10.17925/USN.2018.14.2.71","DOIUrl":"https://doi.org/10.17925/USN.2018.14.2.71","url":null,"abstract":"","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"71"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US neurologyPub Date : 2017-01-01DOI: 10.17925/USN.2017.13.01.18
S. Beydoun, T. Brannagan, P. Donofrio, C. Koski, E. Lancaster
{"title":"Chronic Inflammatory Demyelinating Polyradiculoneuropathy 101—Pitfalls and Pearls of Diagnosis and Treatment","authors":"S. Beydoun, T. Brannagan, P. Donofrio, C. Koski, E. Lancaster","doi":"10.17925/USN.2017.13.01.18","DOIUrl":"https://doi.org/10.17925/USN.2017.13.01.18","url":null,"abstract":"C hronic inflammatory demyelinating polyradiculoneuropathy (CIDP), which is caused by demyelination of the peripheral nerves, is characterized by progressive weakness and impaired sensory function in the arms and legs. CIDP is a treatable condition in which early diagnosis is crucial to limit chronic disability. CIDP can mimic other neuropathies and it is important to identify these in order to ensure prompt treatment. Patients with other causes of neuropathy should be suspected of having CIDP if there is rapid progress or proximal weakness. Intravenous immunoglobulin (IVIG), corticosteroids, and plasma exchange are first-line therapies. The IVIG CIDP Efficacy (ICE) trial, the largest trial reported of any CIDP treatment, demonstrated that IVIG therapy reduced disability and functional impairment, as well as improved quality of life. Autoantibodies against membrane proteins of the peripheral nerve axons or the myelin sheath have been reported recently, and an improved understanding of antibody responses in CIDP may enable the development of future targeted therapeutic interventions.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"13 1","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US neurologyPub Date : 2017-01-01DOI: 10.17925/USN.2017.13.01.42
A. Yeshokumar, B. Banwell
{"title":"Management of Children with Multiple Sclerosis","authors":"A. Yeshokumar, B. Banwell","doi":"10.17925/USN.2017.13.01.42","DOIUrl":"https://doi.org/10.17925/USN.2017.13.01.42","url":null,"abstract":"","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"13 1","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67611753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US neurologyPub Date : 2017-01-01DOI: 10.17925/USN.2017.13.01.16
S. Silberstein
{"title":"Interneuronal Transfer and Distal Action of Tetanus Toxin and Botulinum Neurotoxins A and D in Central Neurons","authors":"S. Silberstein","doi":"10.17925/USN.2017.13.01.16","DOIUrl":"https://doi.org/10.17925/USN.2017.13.01.16","url":null,"abstract":"Disclosure: As a consultant and/or advisory panel member, Stephen Silberstein receives, or has received, honoraria from Alder Biopharmaceuticals; Allergan, Inc.; Amgen; Avanir Pharmaceuticals, Inc.; Curelator, Inc.; Depomed; Dr Reddy’s Laboratories; eNeura Inc.; electroCore Medical, LLC; INSYS Therapeutics; Labrys Biologics; Lilly USA, LLC; Medscape, LLC.; Medtronic, Inc.; Neuralieve; NINDS; Pfizer, Inc.; Supernus Pharmaceuticals, Inc.; Teva Pharmaceuticals; Theranica; and Trigemina, Inc. No funding was received for the publication of this article. This article is a short opinion piece and has not been submitted to external peer reviewers.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"13 1","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US neurologyPub Date : 2017-01-01DOI: 10.17925/USN.2017.13.01.13
M. Sperling
{"title":"New Definition and Classifications of Epilepsy Among Highlights of the American Epilepsy Society Annual Meeting","authors":"M. Sperling","doi":"10.17925/USN.2017.13.01.13","DOIUrl":"https://doi.org/10.17925/USN.2017.13.01.13","url":null,"abstract":"M ore than 5 million children and adults suffer from epilepsy, but diagnosis and treatment remains challenging. A new classification system rolled out at the recent American Epilepsy Society annual meeting should help make diagnosis easier, ensuring earlier identification of epilepsy and more timely treatment. Other cutting-edge research, insights and best practices presented at the meeting focused on surgical and minimally invasive treatment options, the use of anti-epileptic drugs in pregnant women, the potential benefits of cannabidiol oil in patients refractory to standard treatment and the underdiagnosis of infantile spasms.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"13 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
US neurologyPub Date : 2017-01-01DOI: 10.17925/USN.2017.13.01.47
B. Gross, B. Jankowitz, R. Friedlander
{"title":"Cerebral Dural Arteriovenous Fistulas—an Update on Pathophysiology, Natural History and Treatment","authors":"B. Gross, B. Jankowitz, R. Friedlander","doi":"10.17925/USN.2017.13.01.47","DOIUrl":"https://doi.org/10.17925/USN.2017.13.01.47","url":null,"abstract":"","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"13 1","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67611759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}