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Towards a Greater Understanding of Epilepsy—The Human Epilepsy Project 迈向对癫痫更深入的了解——人类癫痫计划
US neurology Pub Date : 2019-01-01 DOI: 10.17925/usn.2019.15.2.60
R. Kuzniecky
{"title":"Towards a Greater Understanding of Epilepsy—The Human Epilepsy Project","authors":"R. Kuzniecky","doi":"10.17925/usn.2019.15.2.60","DOIUrl":"https://doi.org/10.17925/usn.2019.15.2.60","url":null,"abstract":"<p />","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Role of the Microbiome in Multiple Sclerosis 探索微生物组在多发性硬化症中的作用
US neurology Pub Date : 2019-01-01 DOI: 10.17925/usn.2019.15.2.82
L. Kasper, T. Chitnis, M. Avila, Nicole Sconzo, R. Ashton, M. Rametta, Salfords Surrey Uk Ashton MediCom
{"title":"Exploring the Role of the Microbiome in Multiple Sclerosis","authors":"L. Kasper, T. Chitnis, M. Avila, Nicole Sconzo, R. Ashton, M. Rametta, Salfords Surrey Uk Ashton MediCom","doi":"10.17925/usn.2019.15.2.82","DOIUrl":"https://doi.org/10.17925/usn.2019.15.2.82","url":null,"abstract":"<p />","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Alzheimer’s disease—failure of drainage of fluid from the brain 阿尔茨海默病——大脑液体排出失败
US neurology Pub Date : 2018-03-01 DOI: 10.17925/USN.2018.14.1.21
R. Carare
{"title":"Alzheimer’s disease—failure of drainage of fluid from the brain","authors":"R. Carare","doi":"10.17925/USN.2018.14.1.21","DOIUrl":"https://doi.org/10.17925/USN.2018.14.1.21","url":null,"abstract":"The annual Alzheimer’s Association International Conference (AAIC) took place in London, UK in July 2017. In an expert interview, Roxana Carare recaps on the topic of her presentation during the ‘Emerging Concepts in Basic Science’ session, clearance of interstitial fluid of the brain and pathogenesis of dementia.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"21"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49643232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Descriptive Characteristics of Males with Duchenne Muscular Dystrophy in Those Covered by Government (Medicaid) and Non-government (Private) Health Plans 政府(医疗补助)和非政府(私人)健康计划涵盖的男性杜氏肌萎缩症患者的描述性特征
US neurology Pub Date : 2018-01-01 DOI: 10.17925/USN.2018.14.2.88
O. Mayer, J. Karafilidis, K. Higgins, B. Griffin, Burlington Ma Us Santhera Pharmaceuticals
{"title":"Descriptive Characteristics of Males with Duchenne Muscular Dystrophy in Those Covered by Government (Medicaid) and Non-government (Private) Health Plans","authors":"O. Mayer, J. Karafilidis, K. Higgins, B. Griffin, Burlington Ma Us Santhera Pharmaceuticals","doi":"10.17925/USN.2018.14.2.88","DOIUrl":"https://doi.org/10.17925/USN.2018.14.2.88","url":null,"abstract":"Duchenne muscular dystrophy (DMD) is a rare, inherited neuromuscular disorder. Methods: To describe the clinical characteristics and healthcare resource utilization (HCRU) of male patients with DMD in commercial and Medicaid cohorts, this retrospective study identified male patients in the Truven Health MarketScan Commercial and Medicaid databases diagnosed with hereditary progressive muscular dystrophy (HPMD) presumed to have DMD between 2011–2014. Patients with ≥2 medical claims with a diagnosis for HPMD (International Classification of Diseases, 9th revision, Clinical Modification: 359.1) were included. Patients were followed for 12 months after diagnosis date, during which clinical characteristics and HCRU were assessed. Results: In total, 2,285 patients met the selection criteria. In these patients, corticosteroid and anti-infective agents were commonly utilized. Physician office visits were extremely common, with over 70% of all patients having at least one visit. Wheelchairs were commonly used, with the incidence of use increasing with age. Mechanical ventilators and airway clearance devices were underrepresented in the data. Conclusion: Patients with DMD had higher annual HCRU costs when compared with a non-DMD age-matched cohort, with patients in commercial cohorts having a higher annual average cost than those in Medicaid cohorts.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"88"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
New Models of Care and Innovation in Alzheimer’s Disease and Related Dementias 阿尔茨海默病和相关痴呆的护理新模式和创新
US neurology Pub Date : 2018-01-01 DOI: 10.17925/USN.2018.14.1.19
Anitha Rao
{"title":"New Models of Care and Innovation in Alzheimer’s Disease and Related Dementias","authors":"Anitha Rao","doi":"10.17925/USN.2018.14.1.19","DOIUrl":"https://doi.org/10.17925/USN.2018.14.1.19","url":null,"abstract":"Support: No funding was received in the publication of this article. Dr. Anitha Rao delivered several presentations at the Alzheimer's Association International Conference (AAIC) in London, UK, July 2017. In an expert interview following AAIC 2017, Dr. Rao discusses the current limitations of standard care for patients with Alzheimer’s disease and related dementias (ADRD), and puts into perspective the potential positive impact of important new technologies such as Neurocern.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67611874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brainstem Network Disruption in Focal Epilepsy and Sudden Unexplained Death in Epilepsy (SUDEP) 局灶性癫痫脑干网络中断与癫痫猝死(SUDEP)
US neurology Pub Date : 2018-01-01 DOI: 10.17925/USN.2018.14.1.27
S. Mueller
{"title":"Brainstem Network Disruption in Focal Epilepsy and Sudden Unexplained Death in Epilepsy (SUDEP)","authors":"S. Mueller","doi":"10.17925/USN.2018.14.1.27","DOIUrl":"https://doi.org/10.17925/USN.2018.14.1.27","url":null,"abstract":"Q. What was previously known about brainstem network validation in focal epilepsy and sudden unexplained death in epilepsy (SUDEP)? The first line of evidence for an involvement of the brainstem had come from those rare cases in whom SUDEP was witnessed. The symptoms observed in those patients indicated a breakdown of central autonomic control. The brainstem is one of the brain structures that plays a critical role in autonomic control. The second line of evidence came from animal models of SUDEP that also pointed to the brainstem as a critical structure. These observations motivated us to investigate brainstem abnormalities in a small group of patients with temporal lobe epilepsy who had undergone magnetic resonance (MR) imaging for another project. Two patients of this cohort had later died of SUDEP. This study showed that temporal lobe epilepsy is associated with brainstem volume loss/network abnormalities. The two patients who later died of SUDEP had more severe and more extensive damage than the other patients. This observation led to this new study, which was presented at AES.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67611949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Importance of Cognitive Screening and Management in Multiple Sclerosis Care—Reflection on the Recent Recommendations 认知筛查和管理在多发性硬化症护理中的重要性——对近期建议的反思
US neurology Pub Date : 2018-01-01 DOI: 10.17925/USN.2018.14.2.73
R. Kalb
{"title":"Importance of Cognitive Screening and Management in Multiple Sclerosis Care—Reflection on the Recent Recommendations","authors":"R. Kalb","doi":"10.17925/USN.2018.14.2.73","DOIUrl":"https://doi.org/10.17925/USN.2018.14.2.73","url":null,"abstract":"Support: No funding was received in the publication of this article. The importance of recognizing and including cognition as a key factor to consider when ensuring comprehensive care for individuals with multiple sclerosis (MS) cannot be over emphasized. Unfortunately, despite it being accepted as a common symptom, cognitive function in MS is still not openly discussed, routinely assessed, or optimally treated. In an expert interview, Rosalind Kalb describes the background and crucial recent steps taken to tackle this issue, starting with a convening of the National MS Society’s National Medical Advisory Committee and leading to published recommendations for cognitive screening and management in MS care.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"47 22 1","pages":"73"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Vitamin D in Cognitive Disorders in Older Adults 维生素D在老年人认知障碍中的作用
US neurology Pub Date : 2018-01-01 DOI: 10.17925/USN.2018.14.1.41
J. Gold, A. Shoaib, Gopinath Gorthy, G. Grossberg
{"title":"The Role of Vitamin D in Cognitive Disorders in Older Adults","authors":"J. Gold, A. Shoaib, Gopinath Gorthy, G. Grossberg","doi":"10.17925/USN.2018.14.1.41","DOIUrl":"https://doi.org/10.17925/USN.2018.14.1.41","url":null,"abstract":"The physiological effects of vitamin D on calcium/phosphorus metabolism have been well studied since its discovery in the early 20th century. With recent advances in cellular and molecular biology, its role in maintaining normal brain functions and the protection of neurons via maintenance of cellular homeostasis, immune regulation, modulation of synaptic structure and function are more clearly known. Recently, its deficiency is increasingly implicated in major neurocognitive disorders including Alzheimer’s disease, Parkinson’s disease, and vascular dementia. Older adults are particularly vulnerable not only because vitamin D deficiency becomes more prevalent with aging, but they also are often complicated with other comorbid illnesses. This article reviews the role of vitamin D in maintaining normal brain functions, and implications for vitamin D deficiency in cognitive disorders.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Lifestyle and its Potential to Preserve Cognitive Function and Reduce the Risk of Dementia 生活方式及其保持认知功能和降低痴呆风险的潜力
US neurology Pub Date : 2018-01-01 DOI: 10.17925/USN.2018.14.1.11
M. Carrillo
{"title":"Lifestyle and its Potential to Preserve Cognitive Function and Reduce the Risk of Dementia","authors":"M. Carrillo","doi":"10.17925/USN.2018.14.1.11","DOIUrl":"https://doi.org/10.17925/USN.2018.14.1.11","url":null,"abstract":"Support: No funding was received in the publication of this article. The annual Alzheimer’s Association International Conference (AAIC) took place in London, UK in July 2017. In an expert interview, the Alzheimer’s Association’s very own Maria Carrillo, Chief Science Officer, Medical and Scientific Relations, shares her perspectives on one of the key themes of the meeting—lifestyle and its potential to reduce the risk of developing dementia.","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67611807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Data Sharing in Alzheimer’s Disease Research 阿尔茨海默病研究中的数据共享
US neurology Pub Date : 2018-01-01 DOI: 10.17925/USN.2018.14.2.68
A. Toga, Mary Stevens Neuroimaging
{"title":"Data Sharing in Alzheimer’s Disease Research","authors":"A. Toga, Mary Stevens Neuroimaging","doi":"10.17925/USN.2018.14.2.68","DOIUrl":"https://doi.org/10.17925/USN.2018.14.2.68","url":null,"abstract":"","PeriodicalId":90076,"journal":{"name":"US neurology","volume":"14 1","pages":"68"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67612298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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