ISRN Pain最新文献_第2页

Evidence of Physiotherapy Interventions for Patients with Chronic Neck Pain: A Systematic Review of Randomised Controlled Trials. 慢性颈部疼痛患者物理治疗干预的证据:随机对照试验的系统回顾。

ISRN Pain Pub Date : 2013-04-15 eCollection Date: 2013-01-01 DOI: 10.1155/2013/567175

Pia Damgaard, Else Marie Bartels, Inge Ris, Robin Christensen, Birgit Juul-Kristensen

{"title":"Evidence of Physiotherapy Interventions for Patients with Chronic Neck Pain: A Systematic Review of Randomised Controlled Trials.","authors":"Pia Damgaard, Else Marie Bartels, Inge Ris, Robin Christensen, Birgit Juul-Kristensen","doi":"10.1155/2013/567175","DOIUrl":"10.1155/2013/567175","url":null,"abstract":"Chronic neck pain (CNP) is common and costly, and the effect of physiotherapeutic interventions on the condition is unclear. We reviewed the literature for evidence of effect of physiotherapy interventions on patients with CNP. Five bibliographic databases (MEDLINE, EMBASE, CINAHL, Cochrane Library, and PEDro) were systematically searched. Randomised, placebo and active-treatment-controlled trials including physiotherapy interventions for adults with CNP were selected. Data were extracted primary outcome was pain. Risk of bias was appraised. Effect of an intervention was assessed, weighted to risk of bias. 42 trials reporting on randomised comparisons of various physiotherapy interventions and control conditions were eligible for inclusion involving 3919 patients with CNP. Out of these, 23 were unclear or at high risk of bias, and their results were considered moderate- or low-quality evidence. Nineteen were at low risk of bias, and here eight trials found effect on pain of a physiotherapy intervention. Only exercise therapy, focusing on strength and endurance training, and multimodal physiotherapy, cognitive-behavioural interventions, massage, manipulations, laser therapy, and to some extent also TNS appear to have an effect on CNP. However, sufficient evidence for application of a specific physiotherapy modality or aiming at a specific patient subgroup is not available. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"567175"},"PeriodicalIF":0.0,"publicationDate":"2013-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/567175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34506628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Duration of Analgesia Induced by Acupuncture-Like TENS on Experimental Heat Pain. 针刺样TENS对实验性热痛镇痛时间的影响。

ISRN Pain Pub Date : 2013-04-07 eCollection Date: 2013-01-01 DOI: 10.1155/2013/792383

Yannick Tousignant-Laflamme, Marilyne Brochu, Cynthia Dupuis-Michaud, Catherine Pagé, Draga Popovic, Marie-Eve Simard

{"title":"Duration of Analgesia Induced by Acupuncture-Like TENS on Experimental Heat Pain.","authors":"Yannick Tousignant-Laflamme, Marilyne Brochu, Cynthia Dupuis-Michaud, Catherine Pagé, Draga Popovic, Marie-Eve Simard","doi":"10.1155/2013/792383","DOIUrl":"https://doi.org/10.1155/2013/792383","url":null,"abstract":"Background. Acupuncture-like TENS (AL-TENS) is a treatment modality that can be used to temporarily reduce pain. However, there is no clear data in the literature regarding the specific duration of analgesia induced by AL-TENS. Objectives. To describe and quantify the duration and magnitude of AL-TENS analgesia on experimental heat pain in healthy subjects and verify if the duration or magnitude of analgesia induced by the AL-TENS was influenced by the duration of the application of the AL-TENS (15 versus 30 minutes). Methods. A repeated-measures, intrasubject randomized experimental design was used, where each participant was his/her own control. 22 healthy volunteers underwent heat pain stimulations with a contact thermode before (pretest) and after (posttest) AL-TENS application (15 and 30 minutes). Outcome measures included subjective pain during AL-TENS, duration, and magnitude of AL-TENS-induced analgesia. Results. Survival analysis showed that the median duration of AL-TENS analgesia was 10 minutes following the application of either 15 or 30 minutes of AL-TENS. The magnitude of analgesia following either application was comparable at all points in time (P values > 0.05) and ranged between -20% and -36% pain reduction. Conclusion. Only half of the participants still had heat-pain analgesia induced by the AL-TENS at 15 minutes postapplication. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"792383"},"PeriodicalIF":0.0,"publicationDate":"2013-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/792383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34506633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Electrophysiological Study of the Antinociception Produced by the Coapplication of (±)-CPP and Propentofylline in Monoarthritic Rats. (±)-CPP与丙烯茶碱共同作用对单关节炎大鼠抗痛作用的电生理研究。

ISRN Pain Pub Date : 2013-04-04 eCollection Date: 2013-01-01 DOI: 10.1155/2013/315626

Claudio Laurido, José L Martínez, Francisco Morales

引用次数: 1

Flexion Relaxation Ratio Not Responsive to Acutely Induced Low Back Pain from a Delayed Onset Muscle Soreness Protocol. 迟发性肌肉酸痛方案的屈曲松弛比对急性引起的腰痛没有反应。

ISRN Pain Pub Date : 2013-02-25 eCollection Date: 2013-01-01 DOI: 10.1155/2013/617698

Maggie E Horn, Mark D Bishop

{"title":"Flexion Relaxation Ratio Not Responsive to Acutely Induced Low Back Pain from a Delayed Onset Muscle Soreness Protocol.","authors":"Maggie E Horn, Mark D Bishop","doi":"10.1155/2013/617698","DOIUrl":"https://doi.org/10.1155/2013/617698","url":null,"abstract":"Background. The flexion relaxation ratio (FRR) has been suggested as a measure of muscular performance in patients with low back pain (LBP). The purpose of this study was to investigate whether the FRR was responsive to acute LBP produced from a delayed onset muscle soreness (DOMS) protocol. Methods. Fifty-one pain-free volunteers performed DOMS to induce LBP. Current pain intensity, trunk flexion range of motion (ROM), and passive straight leg raise (SLR) were measured at baseline, 24 and 48 hours after DOMS. Participants were categorized into pain groups based on reported current pain intensity. Changes in FRR, trunk flexion ROM, and SLR ROM were examined using two-way repeated measures analysis of variance. Results. Pain group was not found to have a significant effect on FRR (F 1,29 = 0.054, P = 0.818), nor were there any two-way interactions for changes in FRR. The pain group had decreased trunk flexion ROM compared to the minimal pain group (F 1,38 = 7.21, P = 0.011), but no decreases in SLR ROM (F 1,38 = 3.51, P = 0.057) over time. Interpretation. There were no differences in FRR based on reported pain intensity of LBP from a DOMS protocol. The responsiveness of FRR might be limited in patients with acute onset LBP of muscular origin. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"617698"},"PeriodicalIF":0.0,"publicationDate":"2013-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/617698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34506630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Double-blind acupuncture needle: a potential tool to investigate the nature of pain and pleasure. 双盲针灸针:研究痛苦和快乐本质的潜在工具。

ISRN Pain Pub Date : 2013-01-01 DOI: 10.1155/2013/825751

Nobuari Takakura, Miho Takayama, Akiko Kawase, Ted J Kaptchuk, Hiroyoshi Yajima

{"title":"Double-blind acupuncture needle: a potential tool to investigate the nature of pain and pleasure.","authors":"Nobuari Takakura, Miho Takayama, Akiko Kawase, Ted J Kaptchuk, Hiroyoshi Yajima","doi":"10.1155/2013/825751","DOIUrl":"https://doi.org/10.1155/2013/825751","url":null,"abstract":"Background: Most of our knowledge about similarities in the neural processing of painful and pleasant sensations in the brain derives from studying each phenomenon separately. Patients often feel pain induced by acupuncture, which is noxious stimulation having the symbolic message of the cure, as pleasant.Objectives: We investigated whether the double-blind acupuncture needles are potential tool to investigate coinciding pain and pleasant events.Methods: Participants were 109 healthy acupuncture students. An acupuncturist applied the double-blind placebo and the matching penetrating needle at bilateral forearm of each subject, one needle on each side of the arm. We asked the subjects to rate the pain associated with needle application and its unpleasantness or pleasantness on a visual analogue scale.Results: Of 65 penetrating needle applications that elicited pain, 29 (45%) subjects did not describe the pain as being unpleasant, and interestingly, 18 (28%) subjects described the needle insertion as pleasant. There was no significant difference in reported pain intensity between penetrating needles elicited pain that elicited a pleasant sensation and those that elicited an unpleasant sensation (P = 0.34).Conclusions: The double-blind acupuncture needles can be a potential tool for investigating the concomitant hedonic (pleasure) experience of pain.","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/825751","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31913862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Characterization of the Visceral Antinociceptive Effect of Glial Glutamate Transporter GLT-1 Upregulation by Ceftriaxone. 头孢曲松上调胶质谷氨酸转运体GLT-1对内脏抗感觉性的影响。

ISRN Pain Pub Date : 2012-12-25 eCollection Date: 2013-01-01 DOI: 10.1155/2013/726891

K Roman, M Yang, Robert L Stephens

{"title":"Characterization of the Visceral Antinociceptive Effect of Glial Glutamate Transporter GLT-1 Upregulation by Ceftriaxone.","authors":"K Roman, M Yang, Robert L Stephens","doi":"10.1155/2013/726891","DOIUrl":"https://doi.org/10.1155/2013/726891","url":null,"abstract":"Recent studies demonstrate that glial glutamate transporter-1 (GLT-1) upregulation attenuates visceral nociception. The present work further characterized the effect of ceftriaxone- (CTX-) mediated GLT-1 upregulation on visceral hyperalgesia. Intrathecal pretreatment with dihydrokainate, a selective GLT-1 antagonist, produced a reversal of the antinociceptive response to bladder distension produced by CTX. The hyperalgesic response to urinary bladder distension caused by intravesicular acrolein was also attenuated by CTX treatment as was the enhanced time spent licking of abdominal area due to intravesicular acrolein. Bladder inflammation via cyclophosphamide injections enhanced the nociceptive to bladder distension; cohorts administered CTX and concomitant cyclophosphamide showed reduced hyperalgesic response. Cyclophosphamide-induced bladder hyperalgesia correlated with a significant 22% increase in GluR1 AMPA receptor subunit expression in the membrane fraction of the lumbosacral spinal cord, which was attenuated by CTX coadministration. Finally, neonatal colon insult-induced hyperalgesia caused by intracolonic mustard oil (2%) administration at P9 and P11 was attenuated by CTX. These studies suggest that GLT-1 upregulation (1) attenuates the hyperalgesia caused by bladder irritation/inflammation or by neonatal colonic insult, (2) acts at a spinal site, and (3) may produce antinociceptive effects by attenuating GluR1 membrane trafficking. These findings support further consideration of this FDA-approved drug to treat chronic pelvic pain syndromes. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"726891"},"PeriodicalIF":0.0,"publicationDate":"2012-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/726891","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34494013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Depression, Depressive Somatic or Nonsomatic Symptoms, and Function in a Primarily Hispanic Chronic Pain Population. 西班牙裔慢性疼痛人群的抑郁、抑郁、躯体或非躯体症状和功能

ISRN Pain Pub Date : 2012-12-01 eCollection Date: 2013-01-01 DOI: 10.1155/2013/401732

Kristynia M Robinson, Jose J Monsivais

{"title":"Depression, Depressive Somatic or Nonsomatic Symptoms, and Function in a Primarily Hispanic Chronic Pain Population.","authors":"Kristynia M Robinson, Jose J Monsivais","doi":"10.1155/2013/401732","DOIUrl":"10.1155/2013/401732","url":null,"abstract":"Chronic pain and depression are two major causes of disability. Comorbidity decreases psychosocial and physical functioning while increasing economic burden. The prevailing belief that Hispanics somaticize depression may hinder the diagnostic process and, thus, may impact outcomes. The purpose of this study was to explore the relationships among depression and depressive symptoms (somatic or nonsomatic) and function in chronic pain sufferers residing along the USA-Mexico border. Like other studies, as level of depression increased, level of pain increased and level of functioning decreased. So much so that almost a quarter of the participants reported moderate-to-severe depression, and another quarter of the participants reported suicidal ideation independent of depression or treatment. Unlike other published reports, we used a sample of chronic pain patients who received individualized, multimodal pain treatment. Compared to our previous work in a similar population, pain intensity and suicidal ideation were lower in this study. A plausible explanation is the use of antidepressants as adjuvant treatment for pain. Regardless of gender or ethnicity, persons with chronic pain will disclose symptoms of depression when appropriate tools are used to collect the data. Implications for future research and clinical practice are discussed. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"401732"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/401732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34494011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Time Course of Placebo Effect of Acupuncture on Pain: A Systematic Review. 针刺对疼痛安慰剂效应的时间过程:一项系统综述。

ISRN Pain Pub Date : 2012-11-28 eCollection Date: 2013-01-01 DOI: 10.1155/2013/204108

Yun Hyung Koog, Won Young Jung

{"title":"Time Course of Placebo Effect of Acupuncture on Pain: A Systematic Review.","authors":"Yun Hyung Koog, Won Young Jung","doi":"10.1155/2013/204108","DOIUrl":"https://doi.org/10.1155/2013/204108","url":null,"abstract":"Objectives. Our objective was to investigate the time course of the placebo effect of acupuncture on pain and the factors affecting the placebo effect. Methods. Previously we retrieved three-armed randomized acupuncture trials including sham and no-treatment groups which were published until October 2009. We searched electronic databases again to identify additional trials from October 2009 to December 2011. After a screening of trials, fifteen three-armed acupuncture trials for pain were included in the analysis. Standardized mean differences between the sham and no-treatment groups were calculated for placebo effect. We then plotted the magnitude of the placebo effect over time. Results. The placebo effect gradually has increased for 12 weeks with a standardized mean difference of 0.74 (95% CI: 0.54 to 0.94). Then it decreased after 12 weeks as time passed. When the placebo effects were compared for factors including methodological qualities, they were not affected by all factors, except patient blinding. Trials with sufficient patient blinding showed a larger placebo effect at 8 weeks than those with insufficient patient blinding (P = 0.0009). Conclusion. The placebo effect of acupuncture showed a unique pattern, which was affected by insufficient patient blinding. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"204108"},"PeriodicalIF":0.0,"publicationDate":"2012-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/204108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34605358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Intravenous Methadone for Severe Cancer Pain: A Presentation of 10 Cases. 静脉注射美沙酮治疗严重癌性疼痛10例报告。

ISRN Pain Pub Date : 2012-11-28 eCollection Date: 2013-01-01 DOI: 10.1155/2013/452957

D Lossignol, I Libert, B Michel, C Rousseau, M Obiols-Portis

{"title":"Intravenous Methadone for Severe Cancer Pain: A Presentation of 10 Cases.","authors":"D Lossignol, I Libert, B Michel, C Rousseau, M Obiols-Portis","doi":"10.1155/2013/452957","DOIUrl":"https://doi.org/10.1155/2013/452957","url":null,"abstract":"Purpose. Methadone, a synthetic opioid agonist, is an effective alternative to strong opioids (morphine, hydromorphone, oxycodone, and buprenorphine) and is widely available as an oral formulation. Few data have been published so far on the use of intravenous (i.v.) methadone for the management of severe or refractory cancer pain. Methods. We followed 10 consecutives cancer patients with severe pain, treated with IV methadone. All had advanced disease and had already received strong opioids, some in association with ketamine. Pain was assessed at T0, T24 hours, and at the end of the treatment. Results. All patients benefited from the switch to IV methadone with a reduction of pain on VAS after 24 hours (median: 4/10; range 0-5) until the end of the treatment (all cases <3/10). The median starting dose was 100 mg/day (range 20-400) and the final dose remained stable with a median of 100 mg/day (range 27-700). The median duration of IV methadone was 11 days (range 2-59). No cardiac toxicity had been observed. Conclusions. IV methadone is an effective pain relieving alternative for the treatment of severe cancer pain, especially in refractory pain syndrome. Moreover, we did not observe any toxicity (neurological or cardiac) or any other major side effects and the treatment was overall well tolerated. More extensive comparative studies should be planned. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"452957"},"PeriodicalIF":0.0,"publicationDate":"2012-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/452957","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34494012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4