ISRN Pain Pub Date : 2014-03-10 eCollection Date: 2014-01-01 DOI: 10.1155/2014/853826

Evmorfia Stavropoulou, Erifili Argyra, Panagiotis Zis, Athina Vadalouca, Ioanna Siafaka

{"title":"The Effect of Intravenous Lidocaine on Trigeminal Neuralgia: A Randomized Double Blind Placebo Controlled Trial.","authors":"Evmorfia Stavropoulou, Erifili Argyra, Panagiotis Zis, Athina Vadalouca, Ioanna Siafaka","doi":"10.1155/2014/853826","DOIUrl":"https://doi.org/10.1155/2014/853826","url":null,"abstract":"Trigeminal neuralgia is the most common neuralgia. Its therapeutic approach is challenging as the first line treatment often does not help, or even causes intolerable side effects. The aim of our randomized double blind, placebo controlled, crossover study was to investigate in a prospective way the effect of lidocaine in patients with trigeminal neuralgia. Twenty patients met our inclusion criteria and completed the study. Each patient underwent four weekly sessions, two of which were with lidocaine (5 mgs/kg) and two with placebo infusions administered over 60 minutes. Intravenous lidocaine was superior regarding the reduction of the intensity of pain, the allodynia, and the hyperalgesia compared to placebo. Moreover, contrary to placebo, lidocaine managed to maintain its therapeutic results for the first 24 hours after intravenous infusion. Although, intravenous lidocaine is not a first line treatment, when first line medications fail to help, pain specialists may try it as an add-on treatment. This trial is registered with NCT01955967. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2014 ","pages":"853826"},"PeriodicalIF":0.0,"publicationDate":"2014-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/853826","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34669735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Antinociceptive Effects of the Serotonin and Noradrenaline Reuptake Inhibitors Milnacipran and Duloxetine on Vincristine-Induced Neuropathic Pain Model in Mice. 羟色胺和去甲肾上腺素再摄取抑制剂米那西普兰和度洛西汀对长春新碱诱导的小鼠神经病理性疼痛模型的抗痛觉作用

ISRN Pain Pub Date : 2014-02-23 eCollection Date: 2014-01-01 DOI: 10.1155/2014/915464

Soh Katsuyama, Hiromu Aso, Akira Otowa, Tomomi Yagi, Yukinaga Kishikawa, Takaaki Komatsu, Tsukasa Sakurada, Hitoshi Nakamura

{"title":"Antinociceptive Effects of the Serotonin and Noradrenaline Reuptake Inhibitors Milnacipran and Duloxetine on Vincristine-Induced Neuropathic Pain Model in Mice.","authors":"Soh Katsuyama, Hiromu Aso, Akira Otowa, Tomomi Yagi, Yukinaga Kishikawa, Takaaki Komatsu, Tsukasa Sakurada, Hitoshi Nakamura","doi":"10.1155/2014/915464","DOIUrl":"10.1155/2014/915464","url":null,"abstract":"Vincristine is an anticancer drug used to treat a variety of cancer types, but it frequently causes peripheral neuropathy. Neuropathic pain is often associated with the appearance of abnormal sensory signs, such as allodynia. Milnacipran and duloxetine, serotonin/noradrenaline reuptake inhibitors, have shown efficacy against several chronic pain syndromes. In this study, we investigated the attenuation of vincristine-induced mechanical allodynia in mice by milnacipran and duloxetine. To induce peripheral neuropathy, vincristine was administered once per day (0.1 mg/kg, intraperitoneally (i.p.)) for 7 days. Mechanical allodynia was evaluated by measuring the withdrawal response to stimulation with a von Frey filament. In vincristine-treated mice, mechanical allodynia was observed on days 3-28 of vincristine administration. A single administration of milnacipran (40 mg/kg, i.p.) or duloxetine (20 mg/kg, i.p.) had no effect on vincristine-induced mechanical allodynia. However, repeated administration of milnacipran (20 or 40 mg/kg, once per day, i.p.) or duloxetine (5, 10, or 20 mg/kg, once per day, i.p.) for 7 days significantly reduced vincristine-induced mechanical allodynia. These results suggest that chronic vincristine administration induces mechanical allodynia, and that repeated milnacipran and duloxetine administration may be an effective approach for the treatment of neuropathic pain caused by vincristine treatment for cancer. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2014 ","pages":"915464"},"PeriodicalIF":0.0,"publicationDate":"2014-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34669736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution of Spinal Sensitization Evoked by Inflammatory Pain Using Local Spinal Cord Glucose Utilization Combined with (3) H-Phorbol 12,13-Dibutyrate Binding in Rats. 大鼠局部脊髓葡萄糖利用联合(3)H-Phorbol 12,13-二丁酸盐结合诱发炎性疼痛的脊髓致敏分布

ISRN Pain Pub Date : 2013-12-26 eCollection Date: 2013-01-01 DOI: 10.1155/2013/340167

Yasuda Seiko, Ishikawa Kozo, Matsumoto Yoshihiro, Ariyoshi Toru, Sasaki Hironori, Ida Yuika, Iwanaga Yasutake, Kim Hae-Kyu, Nakanishi Osamu, Ishikawa Toshizo

{"title":"Distribution of Spinal Sensitization Evoked by Inflammatory Pain Using Local Spinal Cord Glucose Utilization Combined with (3) H-Phorbol 12,13-Dibutyrate Binding in Rats.","authors":"Yasuda Seiko, Ishikawa Kozo, Matsumoto Yoshihiro, Ariyoshi Toru, Sasaki Hironori, Ida Yuika, Iwanaga Yasutake, Kim Hae-Kyu, Nakanishi Osamu, Ishikawa Toshizo","doi":"10.1155/2013/340167","DOIUrl":"https://doi.org/10.1155/2013/340167","url":null,"abstract":"Aims. Hyperalgesia following tissue injury is induced by plasticity in neurotransmission. Few investigators have considered the ascending input which activates the superficial of spinal cord. The aim was to examine neurotransmission and nociceptive processing in the spinal cord after mustard-oil (MO) injection. Both in vitro and in vivo autoradiographs were employed for neuronal activity and transmission in discrete spinal cord regions using the (14)C-2-deoxyglucose method and (3)H-phorbol 12,13-dibutyrate ((3)H-PDBu) binding sites. Methods. To quantify the hyperalgesia evoked by MO, the flinching was counted for 60 min after MO (20%, 50 μL) injection in Wistar rats. Simultaneous determination of (14)C-2-deoxyglucose and (3)H-PDBu binding was used for a direct observation of neuronal/metabolic changes and intracellular signaling in the spinal cord. Results. MO injection evoked an increase in flinching for 60 min. LSCGU significantly increased in the Rexed I-II with (3)H-PDBu binding in the ipsilateral side of spinal cord. Discussion. We clearly demonstrated that the hyperalgesia is primarily relevant to increased neuronal activation with PKC activation in the Rexed I-II of the spinal cord. In addition, functional changes such as \"neuronal plasticity\" may result in increased neuronal excitability and a central sensitization. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"340167"},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/340167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34494017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary and Alternative Medicine in the Treatment of Chronic Pelvic Pain in Women: What Is the Evidence? 补充和替代医学治疗女性慢性盆腔疼痛:证据是什么?

ISRN Pain Pub Date : 2013-11-28 eCollection Date: 2013-01-01 DOI: 10.1155/2013/469575

Sara Paiva, Márcia Mendonça Carneiro

{"title":"Complementary and Alternative Medicine in the Treatment of Chronic Pelvic Pain in Women: What Is the Evidence?","authors":"Sara Paiva, Márcia Mendonça Carneiro","doi":"10.1155/2013/469575","DOIUrl":"10.1155/2013/469575","url":null,"abstract":"Chronic pelvic pain (CPP) is defined as pain of at least 6 months' duration that occurs in the lower abdomen or below the umbilicus and has resulted in functional or psychological disability or required intervention and treatment. Therapeutic interventions center around the treatment of CPP as a diagnosis in and of itself, and treatment of specific disorders that may be related to CPP. A multidisciplinary approach for diagnosis and treatment seems to be most effective for symptomatic relief. This paper reviews the evidence for such interventions as psychological treatments including the use of complementary and alternative medicine techniques for CPP in women. Unfortunately, finding the best evidence in this setting is difficult as only very few randomized controlled trials are available. A combination of treatments is usually required over time for the treatment of refractory CPP. The multifactorial nature of CPP needs to be discussed with the patient and a good rapport as well as a partnership needs to be developed to plan a management program with regular followup. Promotion of a multidisciplinary approach which includes complementary and alternative medicine techniques in managing CPP in women seems to yield the best results. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"469575"},"PeriodicalIF":0.0,"publicationDate":"2013-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/469575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34506626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A Health- and Resource-Oriented Perspective on NSLBP. 以健康和资源为导向的NSLBP研究。

ISRN Pain Pub Date : 2013-09-11 eCollection Date: 2013-01-01 DOI: 10.1155/2013/640690

Cornelia Rolli Salathé, Achim Elfering

{"title":"A Health- and Resource-Oriented Perspective on NSLBP.","authors":"Cornelia Rolli Salathé, Achim Elfering","doi":"10.1155/2013/640690","DOIUrl":"https://doi.org/10.1155/2013/640690","url":null,"abstract":"Nonspecific low back pain (NSLBP) is an important health issue of our time. Personal as well as economic factors, like suffering pain and experiencing disability on the one hand and enormous and still increasing costs to the economy and society on the other hand, display the importance of the matter. Tremendous research has been conducted in the last few decades on NSLBP. A PubMed search (June 17, 2013) on \"low back pain\" provided 22,980 hits, and when specifying for \"low back pain, systematic review,\" 3,134 hits were still generated. Most research has been done examining the development, risk factors, or therapeutic measures of NSLBP, but hardly any literature exists on resources related to NSLBP. The aims of this review are twofold. In order to shade light on the salutogenetic approach of NSLBP, and thus to focus on health instead of illness, the first aim is to facilitate the understanding of which therapeutic measures enhance the ability to cope with chronic NSLBP and enable (more) normal functioning in life. The second aim is to stimulate the understanding of resources protecting against the onset of NSLBP or against the development of chronic NSLBP and its resulting work absence. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"640690"},"PeriodicalIF":0.0,"publicationDate":"2013-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/640690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34506632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Tramadol Extended-Release for the Management of Pain due to Osteoarthritis. 曲马多缓释治疗骨关节炎所致疼痛。

ISRN Pain Pub Date : 2013-09-04 eCollection Date: 2013-01-01 DOI: 10.1155/2013/245346

Chiara Angeletti, Cristiana Guetti, Antonella Paladini, Giustino Varrassi

{"title":"Tramadol Extended-Release for the Management of Pain due to Osteoarthritis.","authors":"Chiara Angeletti, Cristiana Guetti, Antonella Paladini, Giustino Varrassi","doi":"10.1155/2013/245346","DOIUrl":"https://doi.org/10.1155/2013/245346","url":null,"abstract":"Current knowledge on pathogenesis of osteoarticular pain, as well as the consequent several, especially on the gastrointestinal, renal, and cardiovascular systems, side effects of NSAIDs, makes it difficult to perform an optimal management of this mixed typology of pain. This is especially observable in elderly patients, the most frequently affected by osteoarthritis (OA). Tramadol is an analgesic drug, the action of which has a twofold action. It has a weak affinity to mu opioid receptors and, at the same time, can result in inhibition of the reuptake of noradrenaline and serotonin in nociceptorial descending inhibitory control system. These two mechanisms, \"opioidergic\" and \"nonopioidergic,\" are the grounds for contrasting certain types of pain that are generally less responsive to opioids, such as neuropathic pain or mixed OA pain. The extended-release formulation of tramadol has good efficacy and tolerability and acts through a dosing schedule that allows a high level of patients compliance to therapies with a good recovery outcome for the patients' functional status. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"245346"},"PeriodicalIF":0.0,"publicationDate":"2013-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/245346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34494015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

PKC-Dependent Signaling Pathways within PAG and Thalamus Contribute to the Nitric Oxide-Induced Nociceptive Behavior. PAG和丘脑内pkc依赖的信号通路参与一氧化氮诱导的伤害性行为。

ISRN Pain Pub Date : 2013-08-21 eCollection Date: 2013-01-01 DOI: 10.1155/2013/471378

Nicoletta Galeotti, Carla Ghelardini

{"title":"PKC-Dependent Signaling Pathways within PAG and Thalamus Contribute to the Nitric Oxide-Induced Nociceptive Behavior.","authors":"Nicoletta Galeotti, Carla Ghelardini","doi":"10.1155/2013/471378","DOIUrl":"https://doi.org/10.1155/2013/471378","url":null,"abstract":"Nitric oxide (NO) is an important molecule involved in nociceptive processing in the central nervous system. The release of NO within the spinal cord has long been implicated in the mechanisms underlying exaggerated pain sensitivity, and administration of NO donors can induce hyperalgesia. To elucidate the supraspinal mechanism responsible for NO-induced nociceptive hypersensitivity, we investigated the modulation of protein kinase C (PKC) and downstream effectors following treatment with the NO donors nitroglycerin and sodium nitroprusside. Both compounds induced a prolonged cold allodynia and heat hyperalgesia, increased levels of c-Fos and IL-1β, and activated NF-κB within periaqueductal grey matter and thalamus. Simultaneously, an increased expression and phosphorylation of PKC γ and ε were detected. To clarify the cellular mechanism involved in the NO-induced hypernociception, we examined the expression of transcription factors that act as PKC downstream effectors. A dramatic hyperphosphorylation of CREB and STAT1 was observed. The i.c.v. administration of the PKC blocker calphostin C prevented the NO-induced hypernociception, the hyperphosphorylation of CREB and STAT1, and partially reduced NF-κB activation. Conversely, the increase of IL-1β was unmodified by calphostin C. These results suggest the relevance of cerebral PKC-mediated CREB and STAT1 activation in the NO donor-induced nociceptive behavior. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"471378"},"PeriodicalIF":0.0,"publicationDate":"2013-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/471378","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34506627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Changes in the Bispectral Index in Response to Experimental Noxious Stimuli in Adults under General Anesthesia. 全身麻醉下成人对实验性有害刺激的双谱指数变化。

ISRN Pain Pub Date : 2013-08-01 eCollection Date: 2013-01-01 DOI: 10.1155/2013/583920

Robin Marie Coleman, Yannick Tousignant-Laflamme, Céline Gélinas, Manon Choinière, Maya Atallah, Elizabeth Parenteau-Goudreault, Patricia Bourgault

{"title":"Changes in the Bispectral Index in Response to Experimental Noxious Stimuli in Adults under General Anesthesia.","authors":"Robin Marie Coleman, Yannick Tousignant-Laflamme, Céline Gélinas, Manon Choinière, Maya Atallah, Elizabeth Parenteau-Goudreault, Patricia Bourgault","doi":"10.1155/2013/583920","DOIUrl":"https://doi.org/10.1155/2013/583920","url":null,"abstract":"Objective. Pain assessment is a major challenge in nonverbal patients in the intensive care unit (ICU). Recent studies suggest a relationship between the Bispectral Index (BIS) and nociceptive stimuli. This study was designed to examine changes in BIS in response to experimental noxious stimuli. Methods. Thirty participants under general anesthesia were in this quasiexperimental, within subject, pre- and poststudy. In the operating room (OR), BIS was monitored during moderate and severe noxious stimuli, induced by a thermal probe on the participants' forearm, after induction of general anesthesia, prior to surgery. Results. Significant increases in BIS occurred during moderate (increase from 35.00 to 40.00, P = 0.003) and severe noxious stimuli (increase from 37.67 to 40.00, P = 0.007). ROC showed a sensitivity (Se) of 40.0% and a specificity (Sp) of 73.3% at a BIS value > 45, in distinguishing a moderate from a severe noxious stimuli. Conclusion. BIS increased in response to moderate and severe noxious stimuli. The Se and Sp of the BIS did not support the use of the BIS for distinction of different pain intensities in the context of deep sedation in the OR. However, the results justify further studies in more lightly sedated patients such as those in the ICU. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"583920"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/583920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34506629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Neural Mechanisms That Underlie Angina-Induced Referred Pain in the Trigeminal Nerve Territory: A c-Fos Study in Rats. 三叉神经区域心绞痛引起的牵涉性疼痛的神经机制:大鼠c-Fos研究。

ISRN Pain Pub Date : 2013-07-28 eCollection Date: 2013-01-01 DOI: 10.1155/2013/671503

Bunsho Hayashi, Masako Maeda, Masayoshi Tsuruoka, Tomio Inoue

引用次数: 6

Opioid Mechanism Involvement in the Synergism Produced by the Combination of Diclofenac and Caffeine in the Formalin Model. 在福尔马林模型中，阿片机制参与双氯芬酸和咖啡因联合产生的协同作用。

ISRN Pain Pub Date : 2013-05-09 eCollection Date: 2013-01-01 DOI: 10.1155/2013/196429

José María Flores-Ramos, M Irene Díaz-Reval

{"title":"Opioid Mechanism Involvement in the Synergism Produced by the Combination of Diclofenac and Caffeine in the Formalin Model.","authors":"José María Flores-Ramos, M Irene Díaz-Reval","doi":"10.1155/2013/196429","DOIUrl":"https://doi.org/10.1155/2013/196429","url":null,"abstract":"Analgesics can be administered in combination with caffeine for improved analgesic effectiveness in a process known as synergism. The mechanisms by which these combinations produce synergism are not yet fully understood. The aim of this study was to analyze whether the administration of diclofenac combined with caffeine produced antinociceptive synergism and whether opioid mechanisms played a role in this event. The formalin model was used to evaluate the antinociception produced by the oral administration of diclofenac, caffeine, or their combination. Opioid involvement was analyzed through intracerebroventricular (i.c.v.) administration of naloxone followed by the oral administration of the study drugs. Diclofenac presented a dose-dependent effect, with a mean effective dose (ED50) of 6.7 mg/kg. Caffeine presented an analgesic effect with a 17-36% range. The combination of subeffective doses of each of the two drugs presented the greatest synergism with an effect of 57.7 ± 5.6%. The maximal antinociceptive effect was obtained with the combination of 10.0 mg/kg diclofenac and 1.0 mg/kg of caffeine, with an effect of 76.7 ± 5.6%. The i.c.v. administration of naloxone inhibited the effect of diclofenac, both separately and combined. In conclusion, caffeine produces antinociceptive synergism when administered in combination with diclofenac, and this synergism is partially mediated by opioid mechanisms at the central level. ","PeriodicalId":89956,"journal":{"name":"ISRN Pain","volume":"2013 ","pages":"196429"},"PeriodicalIF":0.0,"publicationDate":"2013-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/196429","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34494014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

ISRN Pain最新文献