International journal of cardiovascular research最新文献

Patent Foramen Ovale and Inherited Thrombophilia in the Pathogenesis of Arterial Thrombosis in a Young Patient: A Case Report and Literature Review 一名年轻患者动脉血栓形成的发病机制中的卵圆孔未闭和遗传性血栓倾向:1例报告和文献复习

International journal of cardiovascular research Pub Date : 2021-01-30 DOI: 10.37532/ICRJ.2021.10(1).429

El Abasse Zeine, B. Rime, Ghali Benani, L. Azzouzi, Habbal Rachida

{"title":"Patent Foramen Ovale and Inherited Thrombophilia in the Pathogenesis of Arterial Thrombosis in a Young Patient: A Case Report and Literature Review","authors":"El Abasse Zeine, B. Rime, Ghali Benani, L. Azzouzi, Habbal Rachida","doi":"10.37532/ICRJ.2021.10(1).429","DOIUrl":"https://doi.org/10.37532/ICRJ.2021.10(1).429","url":null,"abstract":"Background: A Patent Foramen Ovale (PFO) is frequently associated with cryptogenic stroke in young patients with paradoxical embolism as the presumed mechanism. Moreover, hypercoagulable states that are known in the pathogenesis of venous thrombosis, can sometimes be found in patients with stroke, which can be explained by the PFO, that provides the missing link. The association between PFO and prothrombotic state may hence increase the risk for paradoxical embolism. Yet, the cause-and-effect relationship between these pathologies is not clearly established and the best therapeutic and preventive strategy are unelucidated. Case Report: We report a case associating ischemic stroke, left internal carotid occlusion, and pulmonary embolism with the discovery of a PFO and inherited thrombophilic disorders, in a young woman under combined contraceptives. Conclusion: We believe that this case is important since it shows the importance of searching for a PFO in young patients with arterial events and thrombophilia and also the interest of systematic screening for procoagulant disorders in those with stroke and PFO, and highlights the challenge in the multidisciplinary management of such patients.","PeriodicalId":89940,"journal":{"name":"International journal of cardiovascular research","volume":"2021 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46482151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Cardiovascular Risk Research in Alzheimer’s Disease and Other Neurodegenerative Diseases 阿尔茨海默病和其他神经退行性疾病的心血管风险研究

International journal of cardiovascular research Pub Date : 2021-01-30 DOI: 10.37532/ICRJ.2021.10(1).430

T. L. Sampaio, E. A. D. Siqueira

{"title":"The Cardiovascular Risk Research in Alzheimer’s Disease and Other Neurodegenerative Diseases","authors":"T. L. Sampaio, E. A. D. Siqueira","doi":"10.37532/ICRJ.2021.10(1).430","DOIUrl":"https://doi.org/10.37532/ICRJ.2021.10(1).430","url":null,"abstract":"The occurrence of chronic and neurodegenerative diseases is epidemiologically important in elderly population, including Alzheimer’s Disease (AD). Risk factors such as diabetes, obesity, hypertension, Cardiovascular Diseases (CVD), hyperlipidemia, hyperhomocysteinemia, and smoking can lead to Cerebrovascular Diseases (CBVD). The neurodegeneration is consequence of cumulative macro and microcirculatory damage, corroborating to increase in systolic pressure, neuroinflammation, oxidative stress, and excitotoxicity. There are some intersections between AD and CVD. For example, e4 allele of the Apolipoprotein E (APOE) gene is a risk; low plasma levels of ApoE protein favor the risk of AD, regardless of the APOE genotype. Furthermore, the insulin resistance causes atrophy of the white matter with loss of myelinated fibrils. These phenomena modify the function of the Blood-Brain Barrier (BBB), causing injury to pericytes and activation of the Cell Adhesion Molecule-1 (VCAM-1), Intercellular Adhesion Molecule-1 (ICAM-1) and E-selectin. In consequence, it is observed excitotoxicity, predisposing to ischemic stroke, activation of neuroinflammation, excessive production of Beta-Amyloid Protein (Aβ42) and aberrantly phosphorylated tau, activation of astrocytes evidenced by overexpression of Glial Fibrillar Acid Protein (GFAP), inhibition of neurotransmitter uptake, excessive depolarization of neurons efferent and decrease on expression of Brain-Derived Neurotrophic Factor (BDNF). Thus, future experimental and population-based studies are encouraged.","PeriodicalId":89940,"journal":{"name":"International journal of cardiovascular research","volume":"2021 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43456730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary supportive therapy for symptomatic patients with left ventricular dilatation and reduced ejection fraction 左室扩张和射血分数降低患者的辅助支持治疗

International journal of cardiovascular research Pub Date : 2021-01-01 DOI: 10.4172/2324-8602-C3-011

Mila Jakovljević

引用次数: 1

Pulmonary Disorder in A Patient Recovering from Coronavirus Disease 2019 In Cardiac Surgery: Case Report and Review 2019年心脏手术中冠状病毒病恢复期患者肺部疾病:病例报告与回顾

International journal of cardiovascular research Pub Date : 2020-10-14 DOI: 10.37532/ICRJ.2020.9(6).419

M. Ghodrati, A. Amini, Omid Imani

引用次数: 0

Evaluation of Extracardiac Intrathoracic Vascular Anomalies on CT Angiography In 254 Patients being Evaluated for Congenital Heart Disease and Comparison with Echocardiography 254例先天性心脏病患者心外-胸内血管异常的CT血管造影评价及与超声心动图的比较

International journal of cardiovascular research Pub Date : 2020-10-09 DOI: 10.37532/ICRJ.2020.9(6).418

Reena An, N. Awasthy, K. S. Dagar, B. Aggarwal

{"title":"Evaluation of Extracardiac Intrathoracic Vascular Anomalies on CT Angiography In 254 Patients being Evaluated for Congenital Heart Disease and Comparison with Echocardiography","authors":"Reena An, N. Awasthy, K. S. Dagar, B. Aggarwal","doi":"10.37532/ICRJ.2020.9(6).418","DOIUrl":"https://doi.org/10.37532/ICRJ.2020.9(6).418","url":null,"abstract":"Background: To evaluate the advantage of CT Angiography (CTA) in diagnosis of extra cardiac vascular and non-vascular abnormalities in patients of congenital heart disease. Patients and Methods: This is a retrospective study wherein two hundred fifty four consecutive patients from January 2017 to December 2019 with known congenital heart disease who were referred for CTA as a part of their regular clinical work up were included. Findings of Echocardiography (ECHO) were also recorded. Results: The vascular anomalies on CTA were found in 191 patients giving an incidence of 75.1% with MAPCAs showed the highest incidence (34.61%). On ECHO vascular anomalies were found in 97 patients giving an incidence of 38.18%. Incidence of associated non-cardiovascular anomalies detected on CTA came out to be 16.4% The most common detected congenital heart disease was TOF on both CTA and ECHO. Although ASD and VSD are diagnosed on Echo, CTA was performed in these cases as a part of the comprehensive workup. CTA significantly outperformed ECHO in the detection of vascular anomalies eg. PDA and COA. Rests of the CHD detection were equal in CTA and ECHO. Conclusion: As patients of congenital heart diseases also present with a wide range of associated extra cardiac vascular findings which range from non-significant to those affecting the clinical outcome of patients. Assessment of extra-cardiac vessels is mandatory at the time of performing these studies since these findings are important for giving a complete diagnosis and for treatment planning in some cases. CTA also detects incidental non-cardiovascular anomalies which can affect the treatment planning of that patient.","PeriodicalId":89940,"journal":{"name":"International journal of cardiovascular research","volume":"2020 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48032662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Short Note on Arrhythmia 关于心律失常的简短说明

International journal of cardiovascular research Pub Date : 2020-08-29 DOI: 10.37532/ICRJ.2020.9(5).413

Ashwini Mattapalli

引用次数: 0

Cardiovascular Research at COVID-19 新冠肺炎的心血管研究

International journal of cardiovascular research Pub Date : 2020-08-29 DOI: 10.37532/ICRJ.2020.9(5).412

T. L. Sampaio, R. Menezes

{"title":"Cardiovascular Research at COVID-19","authors":"T. L. Sampaio, R. Menezes","doi":"10.37532/ICRJ.2020.9(5).412","DOIUrl":"https://doi.org/10.37532/ICRJ.2020.9(5).412","url":null,"abstract":"Year 2020 is a historic year for society and challenging for science. With the rise of COVID-19 pandemic, several research groups around the world have studied the structure of the causative virus, potential new drugs, drugs candidates for repurposing, vaccines, and methods of management of the main complications caused by the disease. The new coronavirus can cause several organic complications in respiratory, nervous, urinary, hepatobiliary tissues and bloodstream. Among these complications, it is important to highlight the cardiovascular disorders, since patients with heart disease, systemic arterial hypertension, congestive heart failure, metabolic syndrome and diabetes are some of the main risk groups. In a global alert scenario, the social importance of scientists in cardiovascular research is ratified. Therefore, several research groups have sought strategies aiming the early diagnosis of cardiovascular complications in patients with COVID-19. Additionally, different patient management protocols in intensive care have been designed and constantly revised, which could improve life quality of these patients and minimize mortality rates. Therefore, this editorial for the International Journal of Cardiovascular Research aims to reinforce the importance of research in the area, congratulate the scientists for their efforts in these turbulent times and encourage new studies on this topic, suggesting new experimental and clinical paths.","PeriodicalId":89940,"journal":{"name":"International journal of cardiovascular research","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42512739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapies in the Treatment of Heart Failure 心力衰竭的治疗方法

International journal of cardiovascular research Pub Date : 2020-08-29 DOI: 10.37532/ICRJ.2020.9(5).414

Mamatha Dereddy

引用次数: 0

Papillary Muscle Noncompaction: A Unique Mechanism for Mitral Regurgitation in Children 乳头肌不紧缩：儿童二尖瓣反流的独特机制

International journal of cardiovascular research Pub Date : 2020-08-26 DOI: 10.37532/ICRJ.2020.9(5).411

Sulafa K M Ali, Laila M Elmahdi

{"title":"Papillary Muscle Noncompaction: A Unique Mechanism for Mitral Regurgitation in Children","authors":"Sulafa K M Ali, Laila M Elmahdi","doi":"10.37532/ICRJ.2020.9(5).411","DOIUrl":"https://doi.org/10.37532/ICRJ.2020.9(5).411","url":null,"abstract":"Background: Noncompaction Cardiomyopathy (NCCM) is a primary genetic cardiomyopathy with variable clinical and Echocardiographic (echo) features. Association with Mitral Regurgitation (MR) was reported but the mechanism of this association has not been well described in pediatric patients. Aims: To describe clinical and echo features of MR in NCCM. Methods: All pediatric patients with NCCM associated with MR and preserved ventricle function seen in one center from January 2015 to March 2020 were included. Clinical and echo features were described. Results: Twelve patients were identified (66% females), 8 (66%) presented with heart failure due to severe MR , and 4 were asymptomatic with mild-moderate MR. Echo features in all patients showed Papillary Muscle Noncompaction (PMNC). The Papillary Muscle (PM) base was discontinuous with the endocardium in 5 patients (41%) and PM were not well differentiated from the noncompacted myocardium in 3 patients (25%)There were variable degrees of chordal elongation and malcoaptation of the leaflets in all patients. Five patients (41%) had associated congenital heart disease including ventricular septal defects in 4 and patent ductus arteriosus in one patient. Conclusion: PMNC causes MV chordal abnormalities that lead to malcoaptation of the mitral leaflets resulting in MR. NCCM needs to be considered when evaluating patients with MR.","PeriodicalId":89940,"journal":{"name":"International journal of cardiovascular research","volume":" ","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45044792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bronchial artery Aneurysm Diagnosis and Treatment 支气管动脉瘤的诊断与治疗

International journal of cardiovascular research Pub Date : 2020-08-26 DOI: 10.37532/ICRJ.2020.9(5).410

Mamatha Dereddy, A. Paladugu

引用次数: 0