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International journal of biomedical nanoscience and nanotechnology最新文献

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Thermometry on the nanometre-scale for biomedical applications using NMR spectroscopy 利用核磁共振波谱在纳米尺度上进行生物医学应用的测温
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-06-29 DOI: 10.1504/IJBNN.2011.040996
A. Wolter, R. Klingeler, B. Büchner
{"title":"Thermometry on the nanometre-scale for biomedical applications using NMR spectroscopy","authors":"A. Wolter, R. Klingeler, B. Büchner","doi":"10.1504/IJBNN.2011.040996","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.040996","url":null,"abstract":"Accurate temperature control with high spatial resolution is a challenging research topic in nano- and biotechnology. Due to their extraordinary physical and chemical properties carbon nanotubes reveal a promising potential as biomedical agents for temperature sensoring on the cellular level. Filling carbon nanotubes with tailored materials realises nanoscaled containers in which the active content is encapsulated by a protecting carbon shell. In particular, the filling with NMR active substances allows the usage as markers and temperature sensors. Their potential for biomedical applications is highlighted by temperature dependent NMR studies giving a proof-of-concept for a non-invasive temperature control on the cellular level.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"2 1","pages":"99"},"PeriodicalIF":0.0,"publicationDate":"2011-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.040996","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Gold-carbon nanotube nanocomposites: synthesis and applications 金-碳纳米管纳米复合材料:合成与应用
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-06-29 DOI: 10.1504/IJBNN.2011.040997
Renyun Zhang, Håkan Olin
{"title":"Gold-carbon nanotube nanocomposites: synthesis and applications","authors":"Renyun Zhang, Håkan Olin","doi":"10.1504/IJBNN.2011.040997","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.040997","url":null,"abstract":"Nanocomposites are combinations of nanomaterials with other molecules or nanoscaled materials, such as nanoparticles or nanotubes. In general, these novel nanocomposites have different physical and chemical properties from the constituent particles or wires, and will thus allow new kinds of applications. Among these nanocomposites, gold-carbon nanotube (Au-CNT) composites are of particular interests, due to their easy fabrication protocols and broad potential applications. Au-CNT nanocomposites commonly refer to gold nanoparticles deposited on carbon nanotubes. To obtain Au-CNT nanocomposites, different methods have been developed, including direct and linked deposition of gold nanoparticles on CNT. Au-CNT nanocomposites combine the excellent physical and chemical properties of both gold nanoparticles and carbon nanotubes. The easy modification surface of gold nanoparticle and the excellent conductivity of carbon nanotube as well the high surface area, point towards a broad range of applications, such as biosensing, gas sensing, and electrochemistry. This paper reviews the recent progress of different kinds of Au-CNT nanocomposites and their synthesis and applications.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"2 1","pages":"112-135"},"PeriodicalIF":0.0,"publicationDate":"2011-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.040997","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Oligonucleotide-based signal amplification for ultrasensitive electrochemical biosensor 基于寡核苷酸的超灵敏电化学生物传感器信号放大
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-06-29 DOI: 10.1504/IJBNN.2011.041001
A. Kawde
{"title":"Oligonucleotide-based signal amplification for ultrasensitive electrochemical biosensor","authors":"A. Kawde","doi":"10.1504/IJBNN.2011.041001","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.041001","url":null,"abstract":"There is a need for an inexpensive, non-invasive and quick investigation with high sensitivity and specificity for early and accurate diagnosis of cancers. The present amplified bioassay takes advantage of the state-of-the-art electrical DNA detection methods, including the highly sensitive stripping response based on the intrinsic electroactivity of guanine and adenine nucleobases, and the amplification potential of latex microspheres carrying numerous oligonucleotide tags. The dramatic signal amplification advantage of this type of detection has been combined with efficient magnetic removal of non-complementary DNA for maximum selectivity, use of microlitre sample volumes and disposable transducers. The advantages of this procedure were demonstrated by its application in the detection of DNA segments related to the BRCA1 breast cancer gene.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"2 1","pages":"177"},"PeriodicalIF":0.0,"publicationDate":"2011-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.041001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of electric cell-substrate impedance sensing for the detection of nanomaterial toxicity 评价电池-衬底阻抗传感在纳米材料毒性检测中的应用
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-06-29 DOI: 10.1504/IJBNN.2011.040998
Erin M McAuley, B. Mohanraj, T. Phamduy, G. Plopper, D. Corr, D. Chrisey
{"title":"Evaluation of electric cell-substrate impedance sensing for the detection of nanomaterial toxicity","authors":"Erin M McAuley, B. Mohanraj, T. Phamduy, G. Plopper, D. Corr, D. Chrisey","doi":"10.1504/IJBNN.2011.040998","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.040998","url":null,"abstract":"Electric cell-substrate impedance sensing (ECIS) is an in situ and real-time monitoring system used to detect toxic agents by monitoring changes in impedance of a confluent cell monolayer. When toxic agents are introduced to cells, they can cause a change in the cell barrier function, a direct measure of the resistance to current flow caused by tight junction formation between cells. This exposure results in an immediate, quantitative change in the measured resistance between the electrodes, thus, continuously monitoring cell behaviour and by extension, toxic exposure. We have developed an ECIS-based protocol to functionally characterise epithelial cell response when challenged by different toxicants, particularly silver and copper nanoparticles. We verified our impedance changes with observed structural changes by fluorescent staining of zonula occludens-1 (ZO-1) protein in the tight junctions of a model epithelial cell line.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"2 1","pages":"136"},"PeriodicalIF":0.0,"publicationDate":"2011-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.040998","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
PCR-based detection of Bacillus anthracis using an integrated microfluidic platform 基于聚合酶链反应的集成微流控平台检测炭疽芽孢杆菌
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-06-29 DOI: 10.1504/IJBNN.2011.040999
N. Cady, S. Stelick, C. Batt
{"title":"PCR-based detection of Bacillus anthracis using an integrated microfluidic platform","authors":"N. Cady, S. Stelick, C. Batt","doi":"10.1504/IJBNN.2011.040999","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.040999","url":null,"abstract":"A highly-integrated PCR-based detection system has been developed for the rapid identification of pathogenic bacteria. Nanofabricated fluidic cartridges were used to carry out SYBR Green-based fluorogenic PCR assays for the detection of Bacillus anthracis which incorporated the chromosomal BA813 locus as the target for amplification. Real-time PCR assay conditions and operating parameters were optimised to increase detection sensitivity. Optimisation of the system resulted in the detection of as few as 40 B. anthracis colony forming units (CFU) with an average time to detection of 60 min, inclusive of DNA purification and PCR amplification, and a dynamic range of 40 to 400,000 CFU. Real-time fluorescence curves were analysed using a simplified mathematical method to determine threshold cycle (Ct) values with comparable results to a statistically-based analysis algorithm. These results support the utility of the system for rapid, sensitive detection of B. anthracis as well as potential for quantitative determination of target cell concentration.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"2 1","pages":"152"},"PeriodicalIF":0.0,"publicationDate":"2011-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.040999","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The impact of protein disulfide bonds on the amyloid fibril morphology. 蛋白质二硫键对淀粉样纤维形态的影响。
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-04-01 DOI: 10.1504/IJBNN.2011.041000
Dmitry Kurouski, Igor K Lednev
{"title":"The impact of protein disulfide bonds on the amyloid fibril morphology.","authors":"Dmitry Kurouski,&nbsp;Igor K Lednev","doi":"10.1504/IJBNN.2011.041000","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.041000","url":null,"abstract":"<p><p>Amyloid fibrils are associated with many neurodegenerative diseases. Being formed from more than 20 different proteins that are functionally or structurally unrelated, amyloid fibrils share a common cross-β core structure. It is a well-accepted hypothesis that fibril biological activity and the associated toxicity vary with their morphology. Partial denaturation of a native protein usually precedes the initial stage of fibrillation, namely the nucleation process. Low pH and elevated temperature, typical conditions of amyloid fibril formation in vitro, resulted in partial denaturation of the proteins. Cleavage of disulfide bonds results typically in significant disruption of protein native structure and in the formation of the molten global state. Herein we report on a comparative investigation of fibril formation by apo-α-lactalbumin and its analog that contains only one of the four original disulfide bonds using deep UV resonance and non-resonance Raman spectroscopy and atomic force microscopy. Significant differences in the aggregation mechanism and the resulting fibril morphology were found.</p>","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"2 2","pages":"167-176"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.041000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32230725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
In vitro and in vivo intracellular delivery of quantum dots by maurocalcine 量子点在体内外细胞内的传递
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-02-08 DOI: 10.1504/IJBNN.2011.038464
Narendra Ram, I. Texier-Nogues, K. Pernet-Gallay, Cathy Poillot, F. Pirollet, M. Ronjat, A. Andrieux, C. Arnoult, T. Daou, M. Waard
{"title":"In vitro and in vivo intracellular delivery of quantum dots by maurocalcine","authors":"Narendra Ram, I. Texier-Nogues, K. Pernet-Gallay, Cathy Poillot, F. Pirollet, M. Ronjat, A. Andrieux, C. Arnoult, T. Daou, M. Waard","doi":"10.1504/IJBNN.2011.038464","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.038464","url":null,"abstract":"Maurocalcine is a new member of the increasing family of cell penetrating peptides. We report for the first time that this peptide is able to deliver quantum dots inside a variety of cells, both in vitro and in vivo. In vivo, maurocalcine produces intracellular delivery of the nanoparticles without affecting the relative distribution of quantum dots within organs. The data stress out that maurocalcine can be used for intracellular delivery of functionalised nanoparticles in vivo.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"2 1","pages":"12-32"},"PeriodicalIF":0.0,"publicationDate":"2011-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.038464","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Quantum dots and their potential applications in cancer detection and therapy 量子点及其在癌症检测和治疗中的潜在应用
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-02-08 DOI: 10.1504/IJBNN.2011.038465
H. Banerjee, M. Verma
{"title":"Quantum dots and their potential applications in cancer detection and therapy","authors":"H. Banerjee, M. Verma","doi":"10.1504/IJBNN.2011.038465","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.038465","url":null,"abstract":"Tools are needed which can distinguish healthy from high risk populations for the early diagnosis of cancer and development of cancer control strategies. Imaging tools which may analyse the cellular profiles are non-invasive tools suitable for epidemiologic screening purposes. Quantum dots (QDs) technology fulfils the requirements of non-invasive technologies and high-throughput. Optical properties of normal cells and cancer cells are different. QDs help identify cancerous tissues and cells and follow-up of the efficacy of treatment based on the optical properties of cells. Although QD technology is still in a formative phase, it is maturing at an extremely rapid pace. Semiconductor quantum dots and nanoparticles composed of metals, lipids or polymers have emerged with promising applications for early detection and therapy of cancer. Implications of QDs in the biomedical field, especially cancer, are discussed in this article.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"2 1","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2011-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.038465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of environmental microorganisms with a bead-based assay and quantum dots 用微球法和量子点法检测环境微生物
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-02-08 DOI: 10.1504/IJBNN.2011.038468
R. Ibáñez-Peral, B. Ferrari, P. Bergquist
{"title":"Detection of environmental microorganisms with a bead-based assay and quantum dots","authors":"R. Ibáñez-Peral, B. Ferrari, P. Bergquist","doi":"10.1504/IJBNN.2011.038468","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.038468","url":null,"abstract":"Quantum dots (QDs) promise significant advantages in environmental and bead-based applications where the target cells need to be discriminated above background fluorescence. We examined the possible applications of QDs as markers for flow cytometric measurements. Paramagnetic beads were labelled with either QDs or some commonly-used fluorochromes and their fluorescence intensity was studied by flow cytometry after DNA capture or amplification. PCR amplicons were detected successfully when using a blue light excitation source for the QDs. Despite the low fluorescent signal of QDs compared to organic dyes found in this study, it is anticipated that the use of a UV laser instead of a blue laser would magnify the signal intensity significantly. We describe a bead-based method for identifying bacteria and archaea based on beads with an inherent fluorescent dye but applications of QDs may be reduced due to their large size relative to current fluorophores.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"71 1","pages":"75"},"PeriodicalIF":0.0,"publicationDate":"2011-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.038468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of zinc in aqueous solution using CdSe/ZnS quantum dots functionalised with [carboxymethyl-(4-mercapto-phenyl)-amino]-acetate 用[羧甲基-(4-巯基苯基)氨基]乙酸功能化的CdSe/ZnS量子点测定水溶液中的锌
International journal of biomedical nanoscience and nanotechnology Pub Date : 2011-02-08 DOI: 10.1504/IJBNN.2011.038463
John F. Callan, Bridgeen McCaughan, R. Mulrooney, S. Kamila
{"title":"Determination of zinc in aqueous solution using CdSe/ZnS quantum dots functionalised with [carboxymethyl-(4-mercapto-phenyl)-amino]-acetate","authors":"John F. Callan, Bridgeen McCaughan, R. Mulrooney, S. Kamila","doi":"10.1504/IJBNN.2011.038463","DOIUrl":"https://doi.org/10.1504/IJBNN.2011.038463","url":null,"abstract":"CdSe/ZnS quantum dots functionalised with [Carboxymethyl-(4-mercapto-phenyl)-amino]-acetate displayed selectivity for Zn2+ ion when tested against a range of other commonly available metal ions in buffered aqueous solution (pH 7.0 ± 0.1). The probe displayed an enhancement in its fluorescence intensity upon addition of Zn2+ attributed to a cancellation of a photoinduced electron transfer process from the bound receptor to the excited quantum dot that otherwise led to non-radiative decay. Good linearity was established for Zn2+ in the 0.2 to 5.0 mM range.","PeriodicalId":89939,"journal":{"name":"International journal of biomedical nanoscience and nanotechnology","volume":"2 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2011-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1504/IJBNN.2011.038463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66691409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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