European journal of nanomedicine最新文献

One-pot synthesis of biologically important xanthene derivatives using [(Et3 N)2 SO][HSO4 ]2 as a novel and green IL-based catalyst under solvent-free conditions 以[(Et3 N)2 SO][HSO4]2为新型绿色il基催化剂，在无溶剂条件下一锅合成具有重要生物学意义的杂蒽衍生物

European journal of nanomedicine Pub Date : 2020-05-05 DOI: 10.33582/2578-8760/1020

F. Nikfarjam, M. Hashemi, A. Ezabadi

引用次数: 0

Rodent models of complement activation-related pseudoallergy: Inducers, symptoms, inhibitors and reaction mechanisms 补体激活相关的假性过敏啮齿动物模型:诱导剂、症状、抑制剂和反应机制

European journal of nanomedicine Pub Date : 2019-01-15 DOI: 10.1515/ejnm-2015-0002

L. Dézsi, L. Rosivall, P. Hamar, J. Szebeni, G. Szénási

{"title":"Rodent models of complement activation-related pseudoallergy: Inducers, symptoms, inhibitors and reaction mechanisms","authors":"L. Dézsi, L. Rosivall, P. Hamar, J. Szebeni, G. Szénási","doi":"10.1515/ejnm-2015-0002","DOIUrl":"https://doi.org/10.1515/ejnm-2015-0002","url":null,"abstract":"Abstract Complement activation-related pseudoallergy (CARPA) is a hypersensitivity reaction to intravenous administration of nanoparticle-containing medicines (nanomedicines). This review focuses on CARPA in rodent models: rats, mice, guinea pigs and rabbits. Information on all aspects of hypersensitivity reactions caused by known complement activators (zymosan, cobra venom factor) and different nanomedicines (liposomes, other drug carrier nanocarriers) in these species has been compiled and analyzed, trying to highlight the similarities and differences. What is most common in all species’ reactions to i.v. complement activators, liposomes and other nanoparticles is a dose-dependent hemodynamic and cardiopulmonary disturbance manifested in acute, reversible rise or fall of blood pressure and respiratory distress that can lead to shock. Other symptoms include heart rate changes, leukopenia followed by leukocytosis, thrombocytopenia, hemoconcentration due to fluid extravasation (rise of hematocrit) and rise of plasma thromboxane B2. The results of a recent rat study are detailed, which show that rats are 2–3 orders of magnitude less sensitive to liposome-induced CARPA than pigs or hypersensitive humans. It is concluded that CARPA can be studied in rodent models, but they do not necessarily mimic the human reactions in terms of symptom spectrum and sensitivity.","PeriodicalId":89921,"journal":{"name":"European journal of nanomedicine","volume":"51 1","pages":"15 - 25"},"PeriodicalIF":0.0,"publicationDate":"2019-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84770966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

CAR-T cell immunotherapy and nanotechnology: An integrated approach for cancer care CAR-T细胞免疫疗法和纳米技术:癌症治疗的综合方法

European journal of nanomedicine Pub Date : 2018-11-06 DOI: 10.33582/2578-8760/1012

Sachin Kumar Deshmukh

引用次数: 0

Simultaneous determination of the ratio of live, dead and adherent bacteria in the presence of various single-walled carbon nanotubes 同时测定各种单壁碳纳米管存在下的活菌、死菌和附着菌的比例

European journal of nanomedicine Pub Date : 2018-10-31 DOI: 10.33582/2578-8760/1011

J. Fent, S. Lakatos

引用次数: 0

Influence of a single nucleotide polymorphism (SNP) and DNA hybridization on the drying patterns of micro droplets 单核苷酸多态性(SNP)和DNA杂交对微滴干燥模式的影响

European journal of nanomedicine Pub Date : 2018-06-04 DOI: 10.33582/2578-8760/1010

C. Hurth, T. Contente-Cuomo, M. Murtaza, F. Zenhausern

{"title":"Influence of a single nucleotide polymorphism (SNP) and DNA hybridization on the drying patterns of micro droplets","authors":"C. Hurth, T. Contente-Cuomo, M. Murtaza, F. Zenhausern","doi":"10.33582/2578-8760/1010","DOIUrl":"https://doi.org/10.33582/2578-8760/1010","url":null,"abstract":"We have recently reported an original observation of how a specific molecular recognition between coated Polystyrene (PS) beads dispersed in solution and a solid surface can drastically change the process by which micro droplets of fluids dry. This observation simply relies on the analysis of the final dried residue on the surface, therefore involving minimal intervention by trained individuals and a minimum investment in sophisticated readout equipment. For instance, a smart phone CCD camera would suffice to provide the data required for the analysis. These recent results naturally open the possibility of developing an inexpensive point-of-care diagnostics method for diseases with a known genome recognition sequence – or a monoclonal antibody signature – using biomedical approaches at the molecular or sub-nanometric level. The present results constitute a model to study the feasibility and sensitivity of the exposed method for the characterization of a known SNP (single Nucleotide Polymorphism) in the Epidermal Growth Factor Receptor (EGFR) gene (dbSNP ID: rs1050171) identified as an early biomarker for several cancers.","PeriodicalId":89921,"journal":{"name":"European journal of nanomedicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73243404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tailor-made mucoadhesive lipid nanogel improves oromucosal antimycotic activity of encapsulated miconazole nitrate 量身定制的黏附脂质纳米凝胶提高了包封硝酸咪康唑的粘膜抗真菌活性

European journal of nanomedicine Pub Date : 2017-10-26 DOI: 10.1515/ejnm-2017-0010

F. Kenechukwu, A. Attama, E. Ibezim, P. Nnamani, C. Umeyor, E. Uronnachi, M. A. Momoh, P. Akpa

{"title":"Tailor-made mucoadhesive lipid nanogel improves oromucosal antimycotic activity of encapsulated miconazole nitrate","authors":"F. Kenechukwu, A. Attama, E. Ibezim, P. Nnamani, C. Umeyor, E. Uronnachi, M. A. Momoh, P. Akpa","doi":"10.1515/ejnm-2017-0010","DOIUrl":"https://doi.org/10.1515/ejnm-2017-0010","url":null,"abstract":"Abstract The use of miconazole nitrate (MN) in the treatment of oropharyngeal candidiasis (OPC) is limited by low drug bioavailability, frequent administration, fungal resistance and toxicity concerns. Lipid nanogel comprising solid lipid nanoparticles (SLNs) incorporated into a gel base could be employed to prolong and target MN to the oromucosal layers, minimizing its associated side effects while enhancing its lethality against resistant Candida albicans. In this study, novel tailor-made oropharyngeal lipid nanogels encapsulating MN were developed and evaluated for improved treatment of OPC. Wide angle X-ray diffractogram analysis revealed the amorphous nature of the lipid matrix, containing beeswax and Phospholipon® 90H, used in preparing the SLNs. The SLNs had varied polydispersity indices, good encapsulation efficiency (EE) and mean droplet size of 204.0±2.9–263.0±7.1 nm. The developed lipid nanogels were pseudoplastic and possessed suitable mucoadhesive strengths on ‘cow-everted’ oromucosal tissue, with greater anticandidal properties regarding fungal inhibition than marketed MN formulation (Daktarin® oral gel) at equivalent concentration. This study has shown that the activity of MN against oral thrush swab (OTS) of C. albicans was improved by formulation as tailor-made mucoadhesive lipid nanogel, and hence could be exploited as an alternative therapeutic carrier for the effective treatment of OPC.","PeriodicalId":89921,"journal":{"name":"European journal of nanomedicine","volume":"45 1","pages":"115 - 126"},"PeriodicalIF":0.0,"publicationDate":"2017-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76489241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Endoscopic imaging using surface-enhanced Raman scattering 使用表面增强拉曼散射的内窥镜成像

European journal of nanomedicine Pub Date : 2017-10-26 DOI: 10.1515/ejnm-2017-0005

Yong-il Kim, Sinyoung Jeong, Bong-Hyun Jun, Yun-Sang Lee, Yoon-Sik Lee, D. Jeong, D. S. Lee

{"title":"Endoscopic imaging using surface-enhanced Raman scattering","authors":"Yong-il Kim, Sinyoung Jeong, Bong-Hyun Jun, Yun-Sang Lee, Yoon-Sik Lee, D. Jeong, D. S. Lee","doi":"10.1515/ejnm-2017-0005","DOIUrl":"https://doi.org/10.1515/ejnm-2017-0005","url":null,"abstract":"Abstract In this review, we assessed endoscopic imaging using surface-enhanced Raman scattering (SERS). As white-light endoscopy, the current standard for gastrointestinal endoscopy, is limited to morphology, Raman endoscopy using surface-enhanced Raman scattering nanoparticles (SERS endoscopy) was introduced as one of the novel functional modalities. SERS endoscopy has multiplex capability and high sensitivity with low autofluorescence and photobleaching. As a result, multiple molecular characteristics of the lesion can be accurately evaluated in real time while performing endoscopy using SERS probes and appropriate instrumentation. Especially, recently developed dual modality of fluorescence and SERS endoscopy offers easy localization with identification of multiple target molecules. For clinical use of SERS endoscopy in the future, problems of limited field of view and cytotoxicity should be addressed by fusion imaging, topical administration, and non-toxic coating of nanoparticles. We expect SERS endoscopic imaging would be an essential endoscopic technique for diagnosis of cancerous lesions, assessment of resection margins and evaluation of therapeutic responses.","PeriodicalId":89921,"journal":{"name":"European journal of nanomedicine","volume":"41 1","pages":"104 - 91"},"PeriodicalIF":0.0,"publicationDate":"2017-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76864389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Disulfiram and disulfiram-loaded poly-[lactide-co-glycolic acid] nanoparticles modulate metastatic markers and proteasomal activity in hepatocarcinoma Hep3b cell line 双硫仑和负载双硫仑的聚[乳酸-羟基乙酸]纳米颗粒调节肝癌Hep3b细胞系的转移标志物和蛋白酶体活性

European journal of nanomedicine Pub Date : 2017-10-26 DOI: 10.1515/ejnm-2017-0013

M. Hoda, B. Cavuturu, Saleem Iqbal, Garima Shakya, Rukkumani Rajagopalan

{"title":"Disulfiram and disulfiram-loaded poly-[lactide-co-glycolic acid] nanoparticles modulate metastatic markers and proteasomal activity in hepatocarcinoma Hep3b cell line","authors":"M. Hoda, B. Cavuturu, Saleem Iqbal, Garima Shakya, Rukkumani Rajagopalan","doi":"10.1515/ejnm-2017-0013","DOIUrl":"https://doi.org/10.1515/ejnm-2017-0013","url":null,"abstract":"Abstract Hepatocellular carcinoma (HCC) results in significantly high mortality rates due to its subtle metastatic expressions. Exorbitant costs of anticancer drugs have lead to the concept of repositioning standard drugs for their anticancer potential. One such antialcoholic drug, disulfiram (DSF), has been reported to show significant cytotoxicity (IC50 6 μM) against hepatocarcinoma cells. Hence, we studied its antimetastatic and proteasome-inhibiting potential to ascertain its efficacy against metastatic hepatocarcinoma. In addition, we also studied the influence of the components of polysorbate 80-stabilised poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) on metastastatic markers and proteasome complexes. A significant reduction in antimigratory assays (0.1 μM) and gelatin zymography (0.5 μM) was observed. A Western blot analysis furthermore confirmed the modulation of metastatic markers. Chymotrypsin-like activity was significantly inhibited at 2 μM of DSF, and in silico docking studies show comparable gliding scores of DSF against standard antimetastatic drugs. Our experiments suggest a significant antimetastatic and proteasome-inhibiting potential of DSF and its loaded NPs. We also infer that polysorbate 80 and PLGA neither show interference with drug behaviour nor inhibit metastasis and proteasome activity, thus behaving as components of a neutral vector. However, they may potentially manipulate the pharmacokinetics of DSF for achieving maximum therapeutic efficacy, in addition to targeted drug delivery.","PeriodicalId":89921,"journal":{"name":"European journal of nanomedicine","volume":"73 1","pages":"127 - 138"},"PeriodicalIF":0.0,"publicationDate":"2017-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89932319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sodium alginate nanoparticles as a new transdermal vehicle of glucosamine sulfate for treatment of osteoarthritis 海藻酸钠纳米颗粒作为新型硫酸氨基葡萄糖透皮载体治疗骨关节炎

European journal of nanomedicine Pub Date : 2017-10-26 DOI: 10.1515/ejnm-2017-0008

A. S. El-Houssiny, A. Ward, D. Mostafa, S. Abd-El-Messieh, K. N. Abdel-Nour, M. M. Darwish, W. Khalil

{"title":"Sodium alginate nanoparticles as a new transdermal vehicle of glucosamine sulfate for treatment of osteoarthritis","authors":"A. S. El-Houssiny, A. Ward, D. Mostafa, S. Abd-El-Messieh, K. N. Abdel-Nour, M. M. Darwish, W. Khalil","doi":"10.1515/ejnm-2017-0008","DOIUrl":"https://doi.org/10.1515/ejnm-2017-0008","url":null,"abstract":"Abstract Glucosamine sulfate (GS) has been used orally for the treatment of osteoarthritis (OA). However, it may be susceptible to the liver first pass phenomenon, which greatly affects its bioavailability, in addition to its side effects on the gastrointestinal tract. Alginate nanoparticles (Alg NPs) were investigated as a new drug carrier for transdermal delivery of GS to improve its effectiveness and reduce side effects. GS-Alg NPs were characterized by encapsulation efficiency, NP yield, particle size and surface charge properties. The in vitro release studies of GS and the ex vivo permeability through rat skin were determined using a UV-Vis spectrophotometer. GS-Alg NPs are within the nanometer range of size. High negative surface charge values are obtained and indicate the high suspension stability of the prepared formulation. The in vitro release studies showed that GS is released from Alg NPs in a sustained and prolonged manner. The ex vivo permeability of GS through rat skin is enhanced significantly after encapsulation in the negatively charged Alg NPs. We successfully reported a highly stable nanoparticlulate system using Alg NPs that permits the encapsulation of GS for topical administration, overcoming the disadvantages of oral administration.","PeriodicalId":89921,"journal":{"name":"European journal of nanomedicine","volume":"122 1","pages":"105 - 114"},"PeriodicalIF":0.0,"publicationDate":"2017-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81707818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

A physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONs) accumulation in vivo 基于生理的药代动力学模型预测超顺磁性氧化铁纳米颗粒(SPIONs)在体内的积累

European journal of nanomedicine Pub Date : 2017-04-01 DOI: 10.1515/ejnm-2017-0001

Adny Henrique Silva, Enio Lima Jr., M. Vasquez Mansilla, R. Zysler, Mary Mojica-Pisciotti, Claudriana Locatelli, Rajith Kumar Reddy Rajoli, A. Owen, T. Creczynski‐Pasa, M. Siccardi

{"title":"A physiologically based pharmacokinetic model to predict the superparamagnetic iron oxide nanoparticles (SPIONs) accumulation in vivo","authors":"Adny Henrique Silva, Enio Lima Jr., M. Vasquez Mansilla, R. Zysler, Mary Mojica-Pisciotti, Claudriana Locatelli, Rajith Kumar Reddy Rajoli, A. Owen, T. Creczynski‐Pasa, M. Siccardi","doi":"10.1515/ejnm-2017-0001","DOIUrl":"https://doi.org/10.1515/ejnm-2017-0001","url":null,"abstract":"Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) have been identified as a promising material for biomedical applications. These include as contrast agents for medical imaging, drug delivery and/or cancer cell treatment. The nanotoxicological profile of SPIONs has been investigated in different studies and the distribution of SPIONs in the human body has not been fully characterized. The aim of this study was to develop a physiologically-based pharmacokinetic (PBPK) model to predict the pharmacokinetics of SPIONs. The distribution and accumulation of SPIONs in organs were simulated taking into consideration their penetration through capillary walls and their active uptake by specialized macrophages in the liver, spleen and lungs. To estimate the kinetics of SPION uptake, a novel experimental approach using primary macrophages was developed. The murine PBPK model was validated against in vivo pharmacokinetic data, and accurately described accumulation in liver, spleen and lungs. After validation of the murine model, a similar PBPK approach was developed to simulate the distribution of SPIONs in humans. These data demonstrate the utility of PBPK modeling for estimating biodistribution of inorganic nanoparticles and represents an initial platform to provide computational prediction of nanoparticle pharmacokinetics.","PeriodicalId":89921,"journal":{"name":"European journal of nanomedicine","volume":"18 1","pages":"79 - 90"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86808303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13