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Current trends in endocrinology最新文献

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Growth hormone and omic systems immunology: the prominent role of interferon signaling 生长激素与经济系统免疫学：干扰素信号传导的重要作用
Current trends in endocrinology Pub Date : 2022-12-31 DOI: 10.31300/ctendo.13.2022.59-76
L. Lili, Jasmine Gujral, E. Golden, M. Yau, C. Becker, B. Kidd, J. Dudley, R. Rapaport
{"title":"Growth hormone and omic systems immunology: the prominent role of interferon signaling","authors":"L. Lili, Jasmine Gujral, E. Golden, M. Yau, C. Becker, B. Kidd, J. Dudley, R. Rapaport","doi":"10.31300/ctendo.13.2022.59-76","DOIUrl":"https://doi.org/10.31300/ctendo.13.2022.59-76","url":null,"abstract":"Growth hormone (GH) imposes pleiotropic effects on human tissues by coordinating growth, facilitating metabolic, cardiovascular, immune, and neuroendocrine systems, and governing the aging process. Growth hormone deficiency (GHD) is estimated to occur in 2.5% of children and may present with age-dependent symptoms: hypoglycemia, jaundice in infancy, and poor growth in childhood. This study attempts to define the GH-immune landscape and its complex molecular drivers at the systems level. Integrative statistical analysis of multi-omic data from blood of 52 children with short stature before and after a GH stimulation test showed significant, concordant changes imposed by GH across the whole genome, metabolome, and inflammatory proteome. These changes involved signaling molecules along the GH/IGF axis, the JAK-STAT pathway, cytokines, and GH-induced nitrogen metabolism. Interferon signaling network drivers were correlated significantly with GHD demonstrating the prominent role of interferon at the nexus of the endocrine, immune and metabolic systems.","PeriodicalId":89913,"journal":{"name":"Current trends in endocrinology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48618533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estrogen receptor subtype ratio change protects against podocyte damage. 雌激素受体亚型比例变化对足细胞损伤有保护作用。
Current trends in endocrinology Pub Date : 2017-01-01
Paola Catanuto, Xiaomei Xia, Simone Pereira-Simon, Sharon Elliot
{"title":"Estrogen receptor subtype ratio change protects against podocyte damage.","authors":"Paola Catanuto,&nbsp;Xiaomei Xia,&nbsp;Simone Pereira-Simon,&nbsp;Sharon Elliot","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Women are relatively protected against the development and progression of glomerulosclerosis (GS) prior to menopause. However, the \"female advantage\" is lost in women who are either diabetic, post-menopausal or both. We showed that 17β-estradiol (E<sub>2</sub>) was effective in prevention of diabetic GS development in part through the stabilization of podocyte cytoskeleton and a change in estrogen receptor (ER) subtype ratio. The objective of this study was to examine whether resveratrol (RSV), reported to have estrogen-like action and renoprotective activity against diabetic GS, would affect similar pathways. After <i>in vitro</i> treatment with RSV we found a change in the ERα and ERβ expression ratio in favor of ERβ, suppression of heat shock protein 25 (Hsp25) expression and increase in β1-integrin expression, important for maintaining podocyte cytoskeleton. We noted a reduction of insulin-like growth factor 1 receptor (IGFR1) expression, decrease in extracellular signal-regulated kinase (ERK) activation, decrease in reactive oxygen species (ROS), and decrease in cleaved-caspase 3 expression. We found an increase in [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) and an increase in matrix metalloproteinases (MMP-2 and MMP-9) activity. Using cre-loxP strategy we developed podocyte-specific ERα knockout mice to show the importance of ERβ. In isolated podocytes, we confirmed reduction of ERα expression in conjunction with a decrease in IGFR1 expression, ERK and increase of MMP-2 similar to that of our <i>in vitro</i> treatment with RSV. Taken together these data suggest an important role for ERβ and ER subtype ratio in podocyte stabilization. Therefore RSV or other regulators of ER pathways could offer protection against diabetic and age-related podocyte changes.</p>","PeriodicalId":89913,"journal":{"name":"Current trends in endocrinology","volume":"9 ","pages":"19-29"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777622/pdf/nihms934101.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35765637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Familiar and novel reproductive endocrine disruptors: xenoestrogens, dioxins and nanoparticles. 熟悉的和新的生殖内分泌干扰物:异种雌激素，二恶英和纳米颗粒。
Current trends in endocrinology Pub Date : 2014-01-01
R J Hutz, M J Carvan, J K Larson, Q Liu, R V Stelzer, T C King-Heiden, M G Baldridge, N Shahnoor, K Julien
{"title":"Familiar and novel reproductive endocrine disruptors: xenoestrogens, dioxins and nanoparticles.","authors":"R J Hutz,&nbsp;M J Carvan,&nbsp;J K Larson,&nbsp;Q Liu,&nbsp;R V Stelzer,&nbsp;T C King-Heiden,&nbsp;M G Baldridge,&nbsp;N Shahnoor,&nbsp;K Julien","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Environmental contaminants are known to exert endocrine-disrupting effects on the reproductive axis of animals. Many of these molecules can affect steroid biosynthesis or estrogen-receptor signaling by behaving as estrogen-like molecules (\"xenoestrogens\"), or by exerting estrogenmodulatory effects. Exposure to some compounds has been correlated with the skewing of sex ratios in aquatic species, feminization and demasculinization of male animals, declines in human sperm counts, and overall diminution in fertility of birds, fish, and mammals. We herein devote space to several classes of endocrine-disrupting compounds (EDCs), including estrogenic substances such as bisphenol A (BPA), molecules that can behave at times anti-estrogenically while activating the aromatic hydrocarbon receptor (AHR), such as dioxins (a known human carcinogen), and novel, ubiquitous molecules such as nanoparticles, particularly gold nanoparticles (GNPs), that appear to alter the sexsteroid biosynthetic pathway.</p>","PeriodicalId":89913,"journal":{"name":"Current trends in endocrinology","volume":"7 ","pages":"111-122"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364387/pdf/nihms-667878.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33032292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatty acid metabolism and thyroid hormones. 脂肪酸代谢与甲状腺激素
Current trends in endocrinology Pub Date : 2012-01-01
Naomi L Sayre, James D Lechleiter
{"title":"Fatty acid metabolism and thyroid hormones.","authors":"Naomi L Sayre, James D Lechleiter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The importance of thyroid hormone signaling in the acute regulation of metabolic activity has been recognized for decades. Slowly, the underlying mechanisms responsible for this activity are being elucidated. A prominent characteristic of thyroid signaling is rapid increases in oxygen consumption and ATP production. This discovery implicated a non-genomic regulation of mitochondrial metabolism by thyroid hormones. Another important clue came from the discovery that thyroid hormones stimulated fatty acid oxidation (FAO) in a variety of tissues in a receptor-dependent, but transcriptional-independent manner. Recently, key linkages between thyroid hormone signaling and specific mitochondrial-targeted pathways have been discovered. This review focuses on the molecular mechanisms by which mitochondrial FAO can be increased through thyroid hormone signaling. The roles of both the full-length and shortened mitochondrial isoforms of thyroid hormone receptor will be discussed. Additionally, the impact of thyroid hormone signaling on dyslipidemias such as obesity, type II diabetes, and fatty liver disease will be considered.</p>","PeriodicalId":89913,"journal":{"name":"Current trends in endocrinology","volume":"6 ","pages":"65-76"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891511/pdf/nihms507888.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32039842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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