生长激素与经济系统免疫学:干扰素信号传导的重要作用

L. Lili, Jasmine Gujral, E. Golden, M. Yau, C. Becker, B. Kidd, J. Dudley, R. Rapaport
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引用次数: 0

摘要

生长激素(GH)通过协调生长、促进代谢、心血管、免疫和神经内分泌系统以及控制衰老过程,对人体组织产生多效性作用。生长激素缺乏症(GHD)估计发生在2.5%的儿童中,并可能表现出年龄依赖性症状:低血糖、婴儿期黄疸和儿童期生长不良。本研究试图在系统水平上定义GH免疫景观及其复杂的分子驱动因素。对52名身材矮小儿童在GH刺激试验前后血液中的多组数据进行综合统计分析,结果显示GH在整个基因组、代谢组和炎症蛋白质组中产生了显著、一致的变化。这些变化涉及GH/IGF轴上的信号分子、JAK-STAT途径、细胞因子和GH诱导的氮代谢。干扰素信号网络驱动因素与GHD显著相关,表明干扰素在内分泌、免疫和代谢系统中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Growth hormone and omic systems immunology: the prominent role of interferon signaling
Growth hormone (GH) imposes pleiotropic effects on human tissues by coordinating growth, facilitating metabolic, cardiovascular, immune, and neuroendocrine systems, and governing the aging process. Growth hormone deficiency (GHD) is estimated to occur in 2.5% of children and may present with age-dependent symptoms: hypoglycemia, jaundice in infancy, and poor growth in childhood. This study attempts to define the GH-immune landscape and its complex molecular drivers at the systems level. Integrative statistical analysis of multi-omic data from blood of 52 children with short stature before and after a GH stimulation test showed significant, concordant changes imposed by GH across the whole genome, metabolome, and inflammatory proteome. These changes involved signaling molecules along the GH/IGF axis, the JAK-STAT pathway, cytokines, and GH-induced nitrogen metabolism. Interferon signaling network drivers were correlated significantly with GHD demonstrating the prominent role of interferon at the nexus of the endocrine, immune and metabolic systems.
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