Clinical medicine. Case reports最新文献

A case of protruding eyeballs and diminishing vision. 眼球突出，视力下降。

Clinical medicine. Case reports Pub Date : 2010-01-20 eCollection Date: 2010-01-01 DOI: 10.4137/ccrep.s3752

Rakesh Biswas, Saroj Gupta, Sumit Dahiya, Shashi Kiran, B V Girish, A S Kasthuri

引用次数: 0

Common variable immunodeficiency associated with inflammatory bowel disease and type I diabetes. 与炎症性肠病和I型糖尿病相关的常见可变免疫缺陷。

Clinical medicine. Case reports Pub Date : 2009-11-27 eCollection Date: 2009-01-01 DOI: 10.4137/ccrep.s3432

Branka Filipović, Zorica Sporčić, Tomislav Randjelović, Goran Nikolić

{"title":"Common variable immunodeficiency associated with inflammatory bowel disease and type I diabetes.","authors":"Branka Filipović, Zorica Sporčić, Tomislav Randjelović, Goran Nikolić","doi":"10.4137/ccrep.s3432","DOIUrl":"https://doi.org/10.4137/ccrep.s3432","url":null,"abstract":"Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency disorders characterized by defective antibody production, low levels of serum immunoglobulins and increased susceptibility to infection. The patient was a 39-year-old male who was admitted to the gastroenterology department with a two week history of diarrhea, blunt abdominal pain below the umbilicus, prolonged febrile state, loss of appetite and loss of body weight of 18 kg during the previous six months. Screening tests of serum immunoglobulins showed decreased concentrations of three types of immunoglobulins: IgA < 0.24 g/L, IgM < 0.18 g/L and IgG < 1.55 g/L. Lymphocytes immunophenotypisation revealed inversed CD4(+)/8(+) T cells ratio, 0.31 and absence of plasma cells (CD138 negative). Colonoscopy showed a rectal mucosa like cobblestones with multiple longitudinal and serpentinous ulceration, without involvement of other segments of the colon and the small intestine. Histopathology revealed aphtous ulcerative lesions, transmural inflammation with multiple lymphoid aggregates and benign lymphoid nodular hyperplasia of the small intestine. Plasma cells were absent from the lamina propria. Magnetic resonance imaging of a perianal fistula demonstrated a trans-sphicteric type. This case is specific because of the three illnesses associated and only one case of an association of diabetes mellitus type I and immunodeficiency reported thus far. ","PeriodicalId":89909,"journal":{"name":"Clinical medicine. Case reports","volume":"2 ","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2009-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ccrep.s3432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31823832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A Case of Fahr's Disease Presenting as Chorea Successfully Treated by the Use of Quetiapine. 奎硫平成功治疗以舞蹈病为表现的Fahr病1例。

Clinical medicine. Case reports Pub Date : 2009-10-22 eCollection Date: 2009-01-01 DOI: 10.4137/ccrep.s3423

Syoichiro Kono, Yasuhiro Manabe, Tomotaka Tanaka, Daiki Fujii, Yasuko Sakai, Hisashi Narai, Nobuhiko Omori, Koji Abe

引用次数: 11

Dysfunction of Corticomotoneurons in Guillain-Barré Syndrome (GBS)? 吉兰-巴罗综合征(GBS)患者的皮质运动神经元功能障碍?

Clinical medicine. Case reports Pub Date : 2009-10-01 eCollection Date: 2009-01-01

Steve Vucic

引用次数: 0

Dysfunction of Corticomotoneurons in Guillain-Barré Syndrome (GBS)? 吉兰-巴罗综合征(GBS)患者的皮质运动神经元功能障碍?

Clinical medicine. Case reports Pub Date : 2009-10-01 DOI: 10.4137/CCREP.S3553

Steve Vucic

引用次数: 0

Metabolic complications of bypass surgery for morbid obesity. 旁路手术治疗病态肥胖的代谢并发症。

Clinical medicine. Case reports Pub Date : 2009-09-18 eCollection Date: 2009-01-01 DOI: 10.4137/ccrep.s3226

S Richard-Devantoy, J B Garré, B Gohier

引用次数: 7

Asymmetrical weakness associated with central nervous system involvement in a patient with guillain-barrè syndrome. guillain-barrè综合征患者中枢神经系统受累的不对称无力。

Clinical medicine. Case reports Pub Date : 2009-09-03 eCollection Date: 2009-01-01 DOI: 10.4137/ccrep.s3180

Takao Kiriyama, Makito Hirano, Susumu Kusunoki, Daiji Morita, Minako Hirakawa, Yasuyo Tonomura, Takanori Kitauchi, Satoshi Ueno

引用次数: 7

Methotrexate-induced acute leukemia: report of three cases and review of the literature. 甲氨蝶呤致急性白血病3例报告并文献复习。

Clinical medicine. Case reports Pub Date : 2009-07-31 eCollection Date: 2009-01-01 DOI: 10.4137/ccrep.s3078

Khalid A Al-Anazi, Khalid I Eltayeb, Mohammed Bakr, Fahad I Al-Mohareb

{"title":"Methotrexate-induced acute leukemia: report of three cases and review of the literature.","authors":"Khalid A Al-Anazi, Khalid I Eltayeb, Mohammed Bakr, Fahad I Al-Mohareb","doi":"10.4137/ccrep.s3078","DOIUrl":"https://doi.org/10.4137/ccrep.s3078","url":null,"abstract":"For many years, methotrexate has been used in the treatment of certain chronic medical disorders e.g. rheumatoid arthritis and psoriasis as well as a number of malignant disorders e.g. acute lymphoblastic leukemia, certain types of lymphoma and breast carcinoma. Its use has been associated with various systemic toxicities and complications. The association between methotrexate therapy and the development of lymphoma and pseudolymphoma is well established. In patients treated with methotrexate, the development of leukemia has been attributed to either the primary disorder e.g. rheumatoid arthritis or to other drugs used concomitantly e.g. cyclophosphamide. Reported here are two patients with rheumatoid arthritis and one patient with psoriasis treated with low dose methotrexate for variable periods of time. Two of these patients developed acute myeloid leukemia on myelodysplastic syndrome background, while the third patient developed pre-B acute lymphoblastic leukemia that expressed few myeloid markers and had a positive philadelphia chromosome. To our knowledge, these are the first reported cases of methotrexate-induced acute leukemia. ","PeriodicalId":89909,"journal":{"name":"Clinical medicine. Case reports","volume":"2 ","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"2009-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ccrep.s3078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31823827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Sarcomatoid carcinoma of the urinary bladder treated with adjuvant radiotherapy: a case report. 辅助放疗治疗膀胱肉瘤样癌1例。

Clinical medicine. Case reports Pub Date : 2009-07-30 eCollection Date: 2009-01-01 DOI: 10.4137/ccrep.s3126

Cem Onal, Berrin Pehlivan, Nebil Bal, Erkan Topkan, Ferhat Kilinc, Savas Topuk

{"title":"Sarcomatoid carcinoma of the urinary bladder treated with adjuvant radiotherapy: a case report.","authors":"Cem Onal, Berrin Pehlivan, Nebil Bal, Erkan Topkan, Ferhat Kilinc, Savas Topuk","doi":"10.4137/ccrep.s3126","DOIUrl":"https://doi.org/10.4137/ccrep.s3126","url":null,"abstract":"Sarcomatoid carcinoma is a rare tumor of the urinary bladder accounting for less than 0.5% of all primary urinary bladder tumors. Since the patients were presented with large tumor with extended stages, outcome was found to be poor. In order to improve local control, adjuvant local treatment may be practical. We report a rare case with sarcomatoid carcinoma of the urinary bladder diagnosed with immunuhistochemical (IHC) study and treated with 3D-conformal radiotherapy (3DCRT) post-operatively. A 55-year old female patient complained about painless hematuria for 2 months. Computed tomography of the pelvic region revealed tumor and wall thickening at the left posterolateral side of the bladder. Total cystectomy with lymph node dissection and total abdominal hysterectomy and bilateral salphingo-oopherectomy was performed and histopathological and immunohistochemical findings strongly correlate with sarcomatoid carcinoma. The patient was treated with 3D conformal radiotherapy (3DCRT) with a total dose of 59.4 Gy with 1.8 Gy fractional daily doses. Patient was alive without any local recurrence and distant metastasis 10 months after surgery. ","PeriodicalId":89909,"journal":{"name":"Clinical medicine. Case reports","volume":"2 ","pages":"39-42"},"PeriodicalIF":0.0,"publicationDate":"2009-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ccrep.s3126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31823826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Exophthalmos as a presenting manifestation of limited Wegener's granulomatosis in a patient with prior graves' disease. 有既往格雷夫斯病的病人，局限性韦格纳肉芽肿的表现为眼球突出。

Clinical medicine. Case reports Pub Date : 2009-06-30 eCollection Date: 2009-01-01 DOI: 10.4137/ccrep.s731

Brian Bowers, Deepak Gupta, Hirenkumar Patel, Naureen Mirza

{"title":"Exophthalmos as a presenting manifestation of limited Wegener's granulomatosis in a patient with prior graves' disease.","authors":"Brian Bowers, Deepak Gupta, Hirenkumar Patel, Naureen Mirza","doi":"10.4137/ccrep.s731","DOIUrl":"https://doi.org/10.4137/ccrep.s731","url":null,"abstract":"Wegener's granulomatosis is a granulomatous necrotizing vasculitis characterized by its predilection to affect the upper and lower respiratory tracts and kidneys. Ocular manifestations such as keratitis, conjunctivitis, scleritis, episcleritis, nasolacrimal duct obstruction, uveitis, retroorbital pseudotumor with proptosis retinal vessel occlusion, and optic neuritis have all been described. We present a case of limited Wegener's granulomatosis presenting with proptosis. A 57 year old woman with a history of Graves' disease 20 yrs ago, presented to her ophthalmologist with new onset of exophthalmos of right eye. An MRI of the brain and orbits revealed a soft tissue mass behind the right orbit. The biopsy of the mass revealed transmural inflammation with fibrinoid necrosis consistent with necrotizing vasculitis. She was diagnosed with Wegener's granulomatosis limited to the eye and was treated with oral cyclophosphamide and prednisone followed by weekly methotrexate with good response. Though ocular manifestations of Wegener's granulomatosis are well described, a review of the literature revealed that exophthalmos as the lone presenting manifestation is quite rare. Only two cases have been reported in the English literature since 1977. This case illustrates the importance of considering a diagnosis of limited Wegener's granulomatosis presenting with proptosis of the orbit. ","PeriodicalId":89909,"journal":{"name":"Clinical medicine. Case reports","volume":"2 ","pages":"35-7"},"PeriodicalIF":0.0,"publicationDate":"2009-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/ccrep.s731","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31823825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3