Sina A. Beer,David A. Cairns,Molly Went,Philip Law,Amy Holroyd,Elsa Ferris,Charlotte Pawlyn,Gordon Cook,Mark Drayson,Kevin Boyd,Faith E. Davies,Matthew Jenner,Gareth J. Morgan,Graham Jackson,Richard Houlston,Martin F. Kaiser
{"title":"Clinical, cytogenetic, and germline genetic determinants of arterial thromboembolism in IMiD-treated multiple myeloma","authors":"Sina A. Beer,David A. Cairns,Molly Went,Philip Law,Amy Holroyd,Elsa Ferris,Charlotte Pawlyn,Gordon Cook,Mark Drayson,Kevin Boyd,Faith E. Davies,Matthew Jenner,Gareth J. Morgan,Graham Jackson,Richard Houlston,Martin F. Kaiser","doi":"10.1038/s41408-026-01635-3","DOIUrl":"https://doi.org/10.1038/s41408-026-01635-3","url":null,"abstract":"Abstract Immunomodulatory drugs (IMiDs) are associated with an increased risk of arterial thromboembolism (ATE) in multiple myeloma (MM), but determinants and mechanisms remain poorly defined. We evaluated incidence, timing, and clinical risk factors in 4287 patients with newly diagnosed MM from the Myeloma-XI-trial; all received IMiD-based induction and 1412 were randomised to Lenalidomide (Len) maintenance. Associations with tumour and inherited genetics, the latter through a genome-wide association study (GWAS), were interrogated in subsets of 1800 patients each. ATE occurred in 92 patients (2.1%), predominantly as ischaemic stroke (>80%). At MM diagnosis, higher leucocyte count, lower serum albumin, and Len-based-induction in elderly were independent risk factors. Older age was the predominant determinant for maintenance-related ATE. Among tumour genetics, del(17p) (HR 3.5, P = 0.001) was strongly associated with ATE risk. Finally, GWAS identified a germline locus at 6q15 independently linked to ATE risk (OR 4.8, P = 3.9 × 10 −8 ). Functional annotation implicates vascular enhancer activity and regulation of MAP3K7 and BACH2 . Together, these findings demonstrate distinct temporal patterns of IMiD-associated ATE risk across treatment phases. In addition to clinical risk factors, inherited variation at 6q15 may contribute to individual susceptibility. These results are hypothesis-generating and require validation in independent cohorts but may ultimately inform individualised prevention strategies.","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"10 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Wang,Justin Desroches,Fang Yang,Dongni Yi,Yajuan Gao,Robin R. Klebig,Jonas Paludo,Ivana N. Micallef,Muhamad Alhaj Moustafa,Madiha Iqbal,Julio C. Chavez,Javier L. Munoz,Yi Lin,Yucai Wang,Jithma P. Abeykoon
{"title":"Comparative efficacy and safety of CD19 chimeric antigen receptor T-cell therapy versus CD3/CD20 bispecific antibodies in relapsed/refractory mantle cell lymphoma: a meta-analysis of clinical trials and real-world studies","authors":"Julia Wang,Justin Desroches,Fang Yang,Dongni Yi,Yajuan Gao,Robin R. Klebig,Jonas Paludo,Ivana N. Micallef,Muhamad Alhaj Moustafa,Madiha Iqbal,Julio C. Chavez,Javier L. Munoz,Yi Lin,Yucai Wang,Jithma P. Abeykoon","doi":"10.1038/s41408-026-01624-6","DOIUrl":"https://doi.org/10.1038/s41408-026-01624-6","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"5 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149022240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miguel Bastos-Boente,María García-Álvarez,Cristina Jiménez,Alicia Antón,Ana Balanzategui,María Eugenia Sarasquete,Alejandro Medina,Rebeca Maldonado,David Alonso-Castronuño,María J. Vidal,Erik de Cabo,Beatriz González-Mena,José María Alonso-Alonso,Emilia Pardal,Francisco Javier Díaz-Gálvez,Luis García,José A. Queizán,María Jesús Peñarrubia,Abelardo Bárez,Carlos Aguilar,Cristina de Ramon,Norma C. Gutiérrez,Ramón García-Sanz,Marcos González,Almudena Navarro-Bailón,Miguel Alcoceba
{"title":"The mutational landscape of resistance to BTK and BCL2 inhibitors in CLL: a real-world multicentric study","authors":"Miguel Bastos-Boente,María García-Álvarez,Cristina Jiménez,Alicia Antón,Ana Balanzategui,María Eugenia Sarasquete,Alejandro Medina,Rebeca Maldonado,David Alonso-Castronuño,María J. Vidal,Erik de Cabo,Beatriz González-Mena,José María Alonso-Alonso,Emilia Pardal,Francisco Javier Díaz-Gálvez,Luis García,José A. Queizán,María Jesús Peñarrubia,Abelardo Bárez,Carlos Aguilar,Cristina de Ramon,Norma C. Gutiérrez,Ramón García-Sanz,Marcos González,Almudena Navarro-Bailón,Miguel Alcoceba","doi":"10.1038/s41408-026-01619-3","DOIUrl":"https://doi.org/10.1038/s41408-026-01619-3","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"1 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yucai Wang,Melissa C. Larson,Umar Farooq,Sara Ekberg,Karin E. Smedby,Mikkel R. Simonsen,Peter de Nully Brown,Carsten U. Niemann,Eric J. Zhao,Alina S. Gerrie,Jeffrey M. Switchenko,David A. Bond,Veronika Bachanova,Stefan K. Barta,Brian T. Hill,Peter Martin,Alexey V. Danilov,Natalie S. Grover,Reem Karmali,Nilanjan Ghosh,Timothy S. Fenske,Brad S. Kahl,Alexandra Albertsson-Lindblad,Ingrid Glimelius,Ahmed Ludvigsen Al-Mashhadi,Thomas S. Larsen,Kami J. Maddocks,Eric Mou,Jonas Paludo,Grzegorz S. Nowakowski,Thomas M. Habermann,Matthew J. Maurer,Diego Villa,Jonathon B. Cohen,Tarec C. El-Galaly,Mats Jerkeman,James R. Cerhan
{"title":"Long-term survival and cause-specific mortality after event-free survival at 24 months (EFS24) in mantle cell lymphoma: an international multicohort study","authors":"Yucai Wang,Melissa C. Larson,Umar Farooq,Sara Ekberg,Karin E. Smedby,Mikkel R. Simonsen,Peter de Nully Brown,Carsten U. Niemann,Eric J. Zhao,Alina S. Gerrie,Jeffrey M. Switchenko,David A. Bond,Veronika Bachanova,Stefan K. Barta,Brian T. Hill,Peter Martin,Alexey V. Danilov,Natalie S. Grover,Reem Karmali,Nilanjan Ghosh,Timothy S. Fenske,Brad S. Kahl,Alexandra Albertsson-Lindblad,Ingrid Glimelius,Ahmed Ludvigsen Al-Mashhadi,Thomas S. Larsen,Kami J. Maddocks,Eric Mou,Jonas Paludo,Grzegorz S. Nowakowski,Thomas M. Habermann,Matthew J. Maurer,Diego Villa,Jonathon B. Cohen,Tarec C. El-Galaly,Mats Jerkeman,James R. Cerhan","doi":"10.1038/s41408-026-01625-5","DOIUrl":"https://doi.org/10.1038/s41408-026-01625-5","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"21 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noriko Nishimura,Samantha Brown,Sarah Samorodnitsky,Sean M. Devlin,Mohammad Alhomoud,Parastoo Dahi,Charlotte Hughes,Eric Jergens,Heather J. Landau,Oscar B. Lahoud,Michael Scordo,Gunjan L. Shah,Ross Firestone,Hamza Hashmi,Hani Hassoun,Malin Hultcrantz,Neha Korde,Alexander M. Lesokhin,Kylee Maclachlan,Sham Mailankody,Francesco Maura,Maximilian Merz,Sridevi Rajeeve,Urvi A. Shah,Carlyn R. Tan,Gaurav K. Gupta,Elena Maryamchik,Evangelos Ntrivalas,Qi Gao,Mikhail Roshal,Saad Z. Usmani,Sergio A. Giralt,David J. Chung
{"title":"Stem cell autograft minimal residual disease negativity and survival outcomes for multiple myeloma autotransplant","authors":"Noriko Nishimura,Samantha Brown,Sarah Samorodnitsky,Sean M. Devlin,Mohammad Alhomoud,Parastoo Dahi,Charlotte Hughes,Eric Jergens,Heather J. Landau,Oscar B. Lahoud,Michael Scordo,Gunjan L. Shah,Ross Firestone,Hamza Hashmi,Hani Hassoun,Malin Hultcrantz,Neha Korde,Alexander M. Lesokhin,Kylee Maclachlan,Sham Mailankody,Francesco Maura,Maximilian Merz,Sridevi Rajeeve,Urvi A. Shah,Carlyn R. Tan,Gaurav K. Gupta,Elena Maryamchik,Evangelos Ntrivalas,Qi Gao,Mikhail Roshal,Saad Z. Usmani,Sergio A. Giralt,David J. Chung","doi":"10.1038/s41408-026-01621-9","DOIUrl":"https://doi.org/10.1038/s41408-026-01621-9","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"63 4 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Faith E. Davies, Beth Faiman, Hayley Beer, Anne Quinn Young, Katie Joyner, Kate Morgan, Stephen Huo, J. Blake Bartlett, Yi Han, Georgia Attfield, Daniel Egbase, Joseph Mikhael
{"title":"REVEAL-MM: retrospective evaluation of variables in early assessment and landmark trends in multiple myeloma—a US claims-based case-control study","authors":"Faith E. Davies, Beth Faiman, Hayley Beer, Anne Quinn Young, Katie Joyner, Kate Morgan, Stephen Huo, J. Blake Bartlett, Yi Han, Georgia Attfield, Daniel Egbase, Joseph Mikhael","doi":"10.1038/s41408-026-01609-5","DOIUrl":"https://doi.org/10.1038/s41408-026-01609-5","url":null,"abstract":"Multiple myeloma (MM) frequently presents with non-specific symptoms that overlap other common conditions, often leading to diagnostic delays and poorer clinical outcomes. Although diagnostic delays in MM are well recognized, the healthcare utilization patterns that precede MM diagnosis are not well defined. This retrospective, 1:1 matched case-control study used US administrative claims data from 9466 patients to identify early signals of MM and evaluate whether such data could be used to predict individuals at risk of MM prior to their formal diagnosis. All diagnostic, procedural, prescription, and physician-visit claims were evaluated at 12, 9, and 6 months within the two years before diagnosis. Interpretable predictive models (LASSO and Random Forest) identified distinct encounter patterns associated with MM as early as 12-months before diagnosis. Predictive performance across all models increased as diagnosis approached, with the machine learning model reaching a peak area under the curve (AUC) of 0.826 at 6 months. Claims consistent with typical MM manifestations, including anemia-, musculoskeletal-, and M-protein–related testing, were more common prior to MM diagnosis. These findings suggest that routinely collected claims data could support earlier identification and evaluation of individuals at risk of MM, enabling more timely diagnosis and improved outcomes.","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"13 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricardo Ahrens, Kyra Ahrens, Maximilian Al-Bazaz, Lisa Leypoldt, Carsten Bokemeyer, Winfried Alsdorf, Katja Weisel
{"title":"A structural framework for mutation-guided immunotherapy sequencing of GPRC5D-targeted T cell engagers in multiple myeloma.","authors":"Ricardo Ahrens, Kyra Ahrens, Maximilian Al-Bazaz, Lisa Leypoldt, Carsten Bokemeyer, Winfried Alsdorf, Katja Weisel","doi":"10.1038/s41408-026-01616-6","DOIUrl":"10.1038/s41408-026-01616-6","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"16 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Doris K Hansen, Danai Dima, Hira Mian, Jakob Devos, Ruta Brazauskas, Temitope Oloyede, Aimaz Afrough, Nausheen Ahmed, Larry D Anderson, Rahul Banerjee, Jesus G Berdeja, Aram Bidikian, Binod Dhakal, Ajoy Dias, Yvonne Efebera, Muhammad Salman Faisal, Lohith Gowda, Hamza Hashmi, Abu-Sayeef Mirza, Meera Mohan, Ravi Narra, Ashley E Rosko, Mark Schroeder, Taiga Nishihori, Heather Landau, Saad Usmani, Marcelo C Pasquini, Othman S Akhtar, Surbhi Sidana, Krina K Patel
{"title":"Correction: Safety and efficacy of ciltacabtagene autoleucel for relapsed/refractory multiple myeloma: a CIBMTR study.","authors":"Doris K Hansen, Danai Dima, Hira Mian, Jakob Devos, Ruta Brazauskas, Temitope Oloyede, Aimaz Afrough, Nausheen Ahmed, Larry D Anderson, Rahul Banerjee, Jesus G Berdeja, Aram Bidikian, Binod Dhakal, Ajoy Dias, Yvonne Efebera, Muhammad Salman Faisal, Lohith Gowda, Hamza Hashmi, Abu-Sayeef Mirza, Meera Mohan, Ravi Narra, Ashley E Rosko, Mark Schroeder, Taiga Nishihori, Heather Landau, Saad Usmani, Marcelo C Pasquini, Othman S Akhtar, Surbhi Sidana, Krina K Patel","doi":"10.1038/s41408-026-01605-9","DOIUrl":"10.1038/s41408-026-01605-9","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"16 1","pages":""},"PeriodicalIF":13.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samer Al Hadidi, Eric Chinaeke, Jinghua He, Helen Pai, Agne Paner-Straseviciute, Ibrahim Saber, Jessica Fowler, Tonya Le Blanc, Niodita Gupta-Werner, Xinke Zhang, Shuchita Kaila
{"title":"Infection burden among patients with triple-class–exposed RRMM receiving non–T-cell–redirecting therapies: a US claims study","authors":"Samer Al Hadidi, Eric Chinaeke, Jinghua He, Helen Pai, Agne Paner-Straseviciute, Ibrahim Saber, Jessica Fowler, Tonya Le Blanc, Niodita Gupta-Werner, Xinke Zhang, Shuchita Kaila","doi":"10.1038/s41408-026-01614-8","DOIUrl":"https://doi.org/10.1038/s41408-026-01614-8","url":null,"abstract":"Triple-class–exposed (TCE) relapsed/refractory multiple myeloma (RRMM) is associated with cumulative immunosuppression and heightened infection risk. In this longitudinal, retrospective, observational study, US claims data from the Komodo Healthcare Map (KHM; n = 2702; median follow-up, 9.5 months) and the All-Payer Claims Data (APCD; n = 1755; median follow-up, 14.9 months) were used to assess infection burden in patients with TCE RRMM receiving non-bispecific antibody therapies after ≥4 prior lines of therapy (LOTs). The study period was from 1/1/2016 through 10/31/2024. Median (range) index LOT number was 5 (5–5; KHM) and 5 (5–6; APCD); median (interquartile range) age was 67.0 (60–75; KHM) and 71.0 (64–77; APCD) years. Across datasets, the weighted average rate for any infection was 63.5% (95% confidence interval [CI], 61.2–65.8), with the most common infection type being bacterial (58.2%), then viral (27.4%) and fungal (8.2%). Severe infections occurred in 46.1% of patients (95% CI, 44.1–48.1). Cumulative infection rates increased from 49.5 (26 weeks) to 66.4% (52 weeks); cumulative severe infection rates increased from 31.5 to 44.9%, respectively. These findings demonstrate substantial real-world infection burden in heavily pretreated patients with TCE RRMM receiving non-bispecific antibody and non–CAR-T therapies, underscoring the need for infection prophylaxis and supportive care.","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"38 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148853489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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