Chenguang Wang, Suhaib Abdelrahman, Xiangrong Geng, Alyssa Burgess, Ying S. Hu, Mohd Ahmar Rauf, Nermin Kady, Yao Fu, Tara A. Reilly, Ira P. Maine, Phillip Boonstra, Kirill Sabitov, Carlos Murga-Zamalloa, Ryan A. Wilcox
{"title":"CDK9 is a dependency in GATA-3 driven and MCL-1 independent T-cell Lymphomas","authors":"Chenguang Wang, Suhaib Abdelrahman, Xiangrong Geng, Alyssa Burgess, Ying S. Hu, Mohd Ahmar Rauf, Nermin Kady, Yao Fu, Tara A. Reilly, Ira P. Maine, Phillip Boonstra, Kirill Sabitov, Carlos Murga-Zamalloa, Ryan A. Wilcox","doi":"10.1038/s41408-025-01427-1","DOIUrl":"https://doi.org/10.1038/s41408-025-01427-1","url":null,"abstract":"The transcription factor GATA-binding protein 3 (GATA-3) regulates oncogenic transcriptional programs across diverse T-cell lymphomas, including subsets of both peripheral and primary cutaneous T-cell lymphomas. These GATA-3 dependent transcriptional programs, in collaboration with the genetic landscape, promote cell growth and survival, and confer resistance to conventional chemotherapeutic agents. We observed that transcriptional cyclin dependent kinase 9 (CDK9) activation regulates diverse oncogenic transcriptional programs in these aggressive T-cell lymphomas and is thus a novel therapeutic vulnerability. Using complementary and orthogonal approaches, we identified multiple independent mechanisms by which CDK9 promotes T-cell lymphomagenesis, including a mechanism by which GATA-3 promotes CDK9 activation at GATA-3 dependent loci. We also identify novel mechanisms by which GATA-3 and CDK9 regulate rRNA transcription and processing, respectively, collaboratively promoting ribosome biogenesis. Therefore, CDK9 is a therapeutic vulnerability across genetically and transcriptionally diverse T-cell lymphomas, including those for which GATA-3 is oncogenic.","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"206 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145611323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utilization of real-world evidence in regulatory approvals for multiple myeloma therapies","authors":"Lockwood Taylor, Angela Chen, Amy Pierre","doi":"10.1038/s41408-025-01420-8","DOIUrl":"https://doi.org/10.1038/s41408-025-01420-8","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"119 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paula Rodríguez-Otero, Surbhi Sidana, Mathilde Kouwenhoven, Jordan M. Schecter, Nikoletta Lendvai, Kevin C. De Braganca, Ana Slaughter, Carolina Lonardi, Philip Vlummens, Helen Varsos, Christina Corsale, Deepu Madduri, Hao Zhao, Katherine Li, Erin Lee, Loreta Marquez, Man Zhao, Tzu-min Yeh, Diana Chen, Vicki Plaks, Rocio Montes de Oca, Erika Florendo, Nitin Patel, Muhammad Akram, Mythili Koneru, Bianca D. Santomasso, Jaime Gállego Perez-Larraya, Niels WCJ van de Donk
{"title":"Clinical experience with cranial nerve palsy in patients infused with ciltacabtagene autoleucel for the treatment of relapsed/refractory MM in CARTITUDE-1, -2, and -4","authors":"Paula Rodríguez-Otero, Surbhi Sidana, Mathilde Kouwenhoven, Jordan M. Schecter, Nikoletta Lendvai, Kevin C. De Braganca, Ana Slaughter, Carolina Lonardi, Philip Vlummens, Helen Varsos, Christina Corsale, Deepu Madduri, Hao Zhao, Katherine Li, Erin Lee, Loreta Marquez, Man Zhao, Tzu-min Yeh, Diana Chen, Vicki Plaks, Rocio Montes de Oca, Erika Florendo, Nitin Patel, Muhammad Akram, Mythili Koneru, Bianca D. Santomasso, Jaime Gállego Perez-Larraya, Niels WCJ van de Donk","doi":"10.1038/s41408-025-01410-w","DOIUrl":"https://doi.org/10.1038/s41408-025-01410-w","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"145 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shlomo Elias, Samantha Brown, Ogechukwu Egini, Moneeza Walji, Sylvester Homsy, Arash Velayati, Sean Devlin, Doris M. Ponce, Vanessa Kennedy, Sushma Bharadwaj, Parveen Shiraz, Ann A. Jakubowski, Esperanza B. Papadopoulos, Lori Muffly, Miguel-Angel Perales, Sergio A. Giralt, Melody Smith, Boglarka Gyurkocza
{"title":"Allogeneic hematopoietic cell transplantation in acute myeloid leukemia not in complete remission: outcomes and prognostic factors in a contemporary cohort","authors":"Shlomo Elias, Samantha Brown, Ogechukwu Egini, Moneeza Walji, Sylvester Homsy, Arash Velayati, Sean Devlin, Doris M. Ponce, Vanessa Kennedy, Sushma Bharadwaj, Parveen Shiraz, Ann A. Jakubowski, Esperanza B. Papadopoulos, Lori Muffly, Miguel-Angel Perales, Sergio A. Giralt, Melody Smith, Boglarka Gyurkocza","doi":"10.1038/s41408-025-01418-2","DOIUrl":"https://doi.org/10.1038/s41408-025-01418-2","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"12 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145593614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wei-Ying Jen, Curtis A. Lachowiez, Jennifer Marvin-Peek, Jessica K. Altman, Musa Yilmaz, Jacqueline S. Garcia, Yasmin Abaza, Nicholas J. Short, Joshua F. Zeidner, Naval G. Daver, Andrew H. Wei, Ghayas C. Issa, Courtney D. DiNardo
{"title":"Optimizing lower intensity triplet therapy in acute myeloid leukemia: a practical guide","authors":"Wei-Ying Jen, Curtis A. Lachowiez, Jennifer Marvin-Peek, Jessica K. Altman, Musa Yilmaz, Jacqueline S. Garcia, Yasmin Abaza, Nicholas J. Short, Joshua F. Zeidner, Naval G. Daver, Andrew H. Wei, Ghayas C. Issa, Courtney D. DiNardo","doi":"10.1038/s41408-025-01429-z","DOIUrl":"https://doi.org/10.1038/s41408-025-01429-z","url":null,"abstract":"Venetoclax-based doublets with azacitidine or low dose cytarabine are the standard of care for the treatment of acute myeloid leukemia (AML) in older patients or those unfit for intensive chemotherapy. However, some patients do not attain complete remission, and over time, most patients relapse. Frontline triplet therapy incorporating a targeted therapy (FLT3, IDH or menin inhibitor) is an emerging treatment concept under investigation for this population. Initial triplet regimens have yielded encouraging composite complete remission and measurable residual disease negativity rates, enabling the transition to allogeneic stem cell transplantation for eligible patients. While effective, triplets are associated with myelosuppression and cytopenia-related toxicities, which can affect treatment tolerability and quality of life. In this review, we summarize the available evidence for triplet therapy in AML and offer our recommendations on the practical application of triplets in clinical practice, with particular focus on adjustments to dosing schedules in induction and continuation cycles. We also outline drug-specific adverse effects and interactions based on emerging clinical data to help guide the clinician, given the increasing use of novel combination therapies.","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"171 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145599078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanne J. J. P. M. Metsemakers, Geneviève I. C. G. Ector, Avinash G. Dinmohamed, Rosella P. M. G. Hermens, Nicole M. A. Blijlevens
{"title":"Real-world decline in survival with poor guideline adherence in chronic myeloid leukemia care","authors":"Sanne J. J. P. M. Metsemakers, Geneviève I. C. G. Ector, Avinash G. Dinmohamed, Rosella P. M. G. Hermens, Nicole M. A. Blijlevens","doi":"10.1038/s41408-025-01423-5","DOIUrl":"https://doi.org/10.1038/s41408-025-01423-5","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"113 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145583107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monia Marchetti, Alessandro Maria Vannucchi, John O. Mascarenhas, Alberto Alvarez-Larran, Prithviraj Bose, Robert Peter Gale, Claire Harrison, Rűdiger Hehlmann, Jean-Jacques Kiladjian, Steffen Koschmieder, Ruben Mesa, Francesco Passamonti, Alessandro Rambaldi, Ayalew Tefferi, Tiziano Barbui
{"title":"European LeukemiaNet criteria for safety and efficacy evaluation of new drugs for myelofibrosis","authors":"Monia Marchetti, Alessandro Maria Vannucchi, John O. Mascarenhas, Alberto Alvarez-Larran, Prithviraj Bose, Robert Peter Gale, Claire Harrison, Rűdiger Hehlmann, Jean-Jacques Kiladjian, Steffen Koschmieder, Ruben Mesa, Francesco Passamonti, Alessandro Rambaldi, Ayalew Tefferi, Tiziano Barbui","doi":"10.1038/s41408-025-01381-y","DOIUrl":"https://doi.org/10.1038/s41408-025-01381-y","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"1 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145593615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadine Wolgast, Eric Amelunxen, Lars Fransecky, Philipp Altrock, Thomas Beder, Julian Ronnacker, Frederik Peters, Soo-Zin Kim-Wanner, Monika Brüggemann, Christiane Pott, Alexander Katalinic, Claudia D. Baldus, David Baden
{"title":"Epidemiology and survival of patients with T-cell prolymphocytic leukemia","authors":"Nadine Wolgast, Eric Amelunxen, Lars Fransecky, Philipp Altrock, Thomas Beder, Julian Ronnacker, Frederik Peters, Soo-Zin Kim-Wanner, Monika Brüggemann, Christiane Pott, Alexander Katalinic, Claudia D. Baldus, David Baden","doi":"10.1038/s41408-025-01428-0","DOIUrl":"https://doi.org/10.1038/s41408-025-01428-0","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"27 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145583106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Dingli, Paul Rothweiler, Stephen M. Ansell, N. Nora Bennani, Urshila Durani, Patrick B. Johnston, Arushi Khurana, Jonas Paludo, J. C. Villasboas Bisneto, Yucai Wang, Yi Lin, Jason R. Young, Stephen M. Broski, Arthur G. Erdman, David Dingli
{"title":"The ratio of brain to liver glucose activity and prognosis with CAR-T in non-Hodgkin lymphoma","authors":"Sarah Dingli, Paul Rothweiler, Stephen M. Ansell, N. Nora Bennani, Urshila Durani, Patrick B. Johnston, Arushi Khurana, Jonas Paludo, J. C. Villasboas Bisneto, Yucai Wang, Yi Lin, Jason R. Young, Stephen M. Broski, Arthur G. Erdman, David Dingli","doi":"10.1038/s41408-025-01425-3","DOIUrl":"https://doi.org/10.1038/s41408-025-01425-3","url":null,"abstract":"","PeriodicalId":8989,"journal":{"name":"Blood Cancer Journal","volume":"96 1","pages":""},"PeriodicalIF":12.8,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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