Translational medicine (Sunnyvale, Calif.)最新文献_第2页

St-elevation myocardial infarction in a healthy 16-year-old adolescent: a clinical case 健康16岁青少年St段抬高型心肌梗死一例临床分析

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-05-20 DOI: 10.18705/2311-4495-202310-2-105-115

A. Prokhorikhin, V. D. Peshkilev, D. D. Zubarev, A. Gorbatykh, M. A. Chernyavsky, A. Yakovlev

{"title":"St-elevation myocardial infarction in a healthy 16-year-old adolescent: a clinical case","authors":"A. Prokhorikhin, V. D. Peshkilev, D. D. Zubarev, A. Gorbatykh, M. A. Chernyavsky, A. Yakovlev","doi":"10.18705/2311-4495-202310-2-105-115","DOIUrl":"https://doi.org/10.18705/2311-4495-202310-2-105-115","url":null,"abstract":"Background. Diagnosis of acute myocardial infarction (AMI) in pubertal patients is a diagnostic challenge, as individuals of such a young age usually do not have traditional risk factors for coronary heart disease (CHD) and, as a result, are at increased risk of misdiagnosis.Objective. To describe a clinical case of AMI in a 16-yearold patient against the background of complete well-being.Design and methods. A 16-year-old patient, against the background of complete well-being, developed pressing pains in the chest, which stopped on their own after a few hours. During hospitalization, in addition to an increase in the level of troponin, the results of other laboratory and instrumental studies did not confirm the version of AMI, as a result of which other cardiac and non-cardiac causes of the development of chest pain formed the basis of the diagnostic search. This was the reason for the delayed diagnosis and endovascular treatment of thrombotic occlusion of the right coronary artery, and, as a result, the formation of an area of persistent hypokinesia of the lower parts of the left ventricle. Further search for possible causes of AMI, including the analysis of genetically associated conditions, did not yield results.Results. This publication describes a case of acute inferior myocardial infarction with ST segment elevation and thrombotic occlusion of the right coronary artery in a 16-year-old adolescent and the impact of an irrational diagnostic process on long-term prognosis.Conclusion. The presented clinical case demonstrates the importance of including the diagnosis of AMI in the process of differential diagnosis of acute chest pain, even in adolescent patients.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42450983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of 11C-choline PET/CT in parathyroid adenomas’ localization in patients with primary hyperparathyroidism 11C-胆碱PET/CT在原发性甲状旁腺功能亢进患者甲状旁腺腺瘤定位中的作用

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-05-20 DOI: 10.18705/2311-4495-2023-10-2-88-95

K. Pogosian, T. L. Karonova, D. Ryzhkova, L. Yanevskaya, U. Tsoy, O. V. Yudina, E. V. Ivanikha, E. Grineva

{"title":"Role of 11C-choline PET/CT in parathyroid adenomas’ localization in patients with primary hyperparathyroidism","authors":"K. Pogosian, T. L. Karonova, D. Ryzhkova, L. Yanevskaya, U. Tsoy, O. V. Yudina, E. V. Ivanikha, E. Grineva","doi":"10.18705/2311-4495-2023-10-2-88-95","DOIUrl":"https://doi.org/10.18705/2311-4495-2023-10-2-88-95","url":null,"abstract":"Background. Topical diagnosis of primary hyperparathyroidism (PHPT) remains an urgent problem due to the high incidence of persistence and recurrence after surgical treatment. At the preoperative stage, a search for the parathyroid hormone hyperproduction source is performed using instrumental methods: ultrasound, scintigraphy of the parathyroid glands (PTG) and multislice computed tomography (MSCT). The cause of PHPT persistence and recurrence after parathyroidectomy may be the multiple nature of PTG lesions or their ectopic location. Additional methods of visualization of PTG adenomas can be used to improve diagnosis (PET/CT).Objective. To compare the sensitivity and specificity of PET/CT with 11C-choline with the traditional visualization techniques.Design and methods. 16 PHPT patients were analyzed. All patients underwent US, subtraction scintigraphy with 99mTc-technetril/99mTc-pertechnitate and CT were performed in 12 and 16 patients, respectively. 11C-choline PET/CT was used for all patients. Imaging results’ coincidence of two methods were labeled as the true one.Results. The sensitivity of PET/CT with 11C-choline was 94 %, CT, subtraction scintigraphy with 99mTc-technetril/99mTc-pertechnitate and US — 75 %, 69 % and 63 %, respectively. The specificity of PET/CT with 11C-choline, CT, scintigraphy with 99mTc-technetril/99mTc-pertechnitate, and US was 100 %, 84 %, 76 %, and 68 %, respectively.Conclusion. PET/CT with 11C-choline demonstrated best sensitivity and specificity among all methods and can become an alternative in PHPT diagnostics in case of negative or inconvclusive results of previous visualization.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46175872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosis in patients with cardiorenal syndrome depending on the clinical form of atrial fibrillation 心肾综合征患者的预后取决于心房颤动的临床形式

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-05-20 DOI: 10.18705/2311-4495-2023-10-2-116-122

E. Polyanskaya

{"title":"Prognosis in patients with cardiorenal syndrome depending on the clinical form of atrial fibrillation","authors":"E. Polyanskaya","doi":"10.18705/2311-4495-2023-10-2-116-122","DOIUrl":"https://doi.org/10.18705/2311-4495-2023-10-2-116-122","url":null,"abstract":"Background. Atrial fibrillation (AF) is the most common stable arrhythmia in the population. The interaction of AF and cardiorenal syndrome is poorly understood, despite the fact that the proportion of such patients with combined heart and kidney damage reaches 60% among people with chronic heart failure (CHF). Data on the long-term prognosis in patients with cardiorenal syndrome depending on the form of AF is not enough.Objective. To assess the prognosis in patients with cardiorenal syndrome depending on the clinical form of AF.Design and methods. 126 patients with verified cardiorenal syndrome and various forms of AF were included. An observational study was performed with the fixation of hospitalizations for CHF and other cardiovascular events, including deaths.Results. The rate of onset of the first end point is higher in patients with permanent AF (8.5 [3.0; 18.5] months and 15.0 [5.0; 24.0] months, p < 0.001). Analysis of survival curves shows a worse prognosis in patients with permanent AF.Conclusion. In patients with cardiorenal syndrome in combination with AF, its clinical form has a significant impact on the long-term prognosis. Permanent AF, to a greater extent than paroxysmal/persistent AF, in conditions of cardiorenal syndrome is associated with faster and more frequent development of new cardiovascular events, including hospitalizations for decompensated CHF and deaths.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45170048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using of supersaturated oxygen delivery (SSO2 therapy) in patients with acute myocardial ischemia 超饱和氧输送（SSO2治疗）在急性心肌缺血患者中的应用

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-05-20 DOI: 10.18705/2311-4495-2023-10-2-96-104

A. M. Radovskiy, A. Bautin, A. Yakovlev, E. V. Shlyakhto

{"title":"Using of supersaturated oxygen delivery (SSO2 therapy) in patients with acute myocardial ischemia","authors":"A. M. Radovskiy, A. Bautin, A. Yakovlev, E. V. Shlyakhto","doi":"10.18705/2311-4495-2023-10-2-96-104","DOIUrl":"https://doi.org/10.18705/2311-4495-2023-10-2-96-104","url":null,"abstract":"Oxygen is the main participant in redox reactions in the body and its deficiency can lead to organ dysfunction. Thus, a decrease in blood flow in a certain region of the myocardium in patients with coronary heart disease can cause a heart attack. According to experimental studies, early reperfusion reduces infarct size, and clinical studies have shown that early effective reperfusion of the affected artery and prevention of re-occlusion is the basis for minimizing infarct size and mortality.Timely performed percutaneous intervention in patients with acute myocardial infarction significantly reduced the mortality rate and the risk of heart failure. Despite the endovascular treatment effectiveness, there is still a need for additional methods of cardioprotection, reducing the area of myocardial infarction and preventing the development of heart failure and adverse left ventricular remodeling. Blood oxygen supersaturation (SSO2 therapy) is one of the adjuvant methods of cardioprotection in the treatment of patients with acute myocardial ischemia.This review describes possible mechanisms for implementing the cardioprotective effects of SSO2 therapy, technology and equipment necessary for the application of this technique. In addition, the results of experimental and clinical studies on SSO2 therapy are consecrated. Of note, only one multicentre prospective randomized controlled trial with uniform randomization was performed. Thus, the use of this technology is limited by the use a commercial equipment.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44615469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D metabolism parameters in hospitalized COVID-19 patients COVID-19住院患者维生素D代谢参数

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-05-20 DOI: 10.18705/2311-4495-202310-2-69-76

A. Mikhailova, K. A. Golovatyuk, D. Lagutina, A. Chernikova, E. Vasilieva, E. Bykova, T. L. Karonova

{"title":"Vitamin D metabolism parameters in hospitalized COVID-19 patients","authors":"A. Mikhailova, K. A. Golovatyuk, D. Lagutina, A. Chernikova, E. Vasilieva, E. Bykova, T. L. Karonova","doi":"10.18705/2311-4495-202310-2-69-76","DOIUrl":"https://doi.org/10.18705/2311-4495-202310-2-69-76","url":null,"abstract":"Background. Recently, clinical benefits among COVID-19 patients, received vitamin D were demonstrated. Features of vitamin D metabolism in the acute period of COVID-19 remain unclear.Objective. To assess the level of 25(OH)D and 1,25(OH)2D in hospitalized COVID-19 patients and cholecalciferol effect on the vitamin D metabolites dynamic.Materials and methods. Group 1 (n = 22) patients received cholecalciferol bolus therapy at a total dose of 100,000 IU. Group 2 patients (n = 22) did not receive cholecalciferol supplementation. Serum 25(OH)D and 1,25(OH)2D levels were estimated for each group on the first and the ninth day of hospitalization.Results. On the ninth day of hospitalization 25(OH)D serum level demonstrated the 45.8 % rise in the Group 1, while in the Group 2 there was a decrease in the 25(OH)D level by 17.9%. At the same time, dynamic evaluation of the 1.25(OH)2D level did not show any differences between the groups, while pairwise comparison on the first and on the ninth days of hospitalization revealed an increase in the active metabolite concentration (p < 0.001) in both groups.Conclusion. Such vitamin D metabolism parameters in the acute period of COVID-19 may be associated with a 1α-hydroxylase activity alteration. Thus, 1.25(OH)2D serum level increase regardless of vitamin D status during the hospitalization could be explained by the COVID-19 course or concomitant corticosteroid medication.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41635511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in growth factors in polycystic ovarian syndrome 多囊卵巢综合征生长因子的变化

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-05-20 DOI: 10.18705/2311-44952023-10-2-77-87

E. Vasukova, E. Zaikova, O. V. Kalinina, I. Gorelova, I. Pyanova, E. Bogatyreva, E. Vasilyeva, M. Kokina, E. Grineva, P. Popova

{"title":"Changes in growth factors in polycystic ovarian syndrome","authors":"E. Vasukova, E. Zaikova, O. V. Kalinina, I. Gorelova, I. Pyanova, E. Bogatyreva, E. Vasilyeva, M. Kokina, E. Grineva, P. Popova","doi":"10.18705/2311-44952023-10-2-77-87","DOIUrl":"https://doi.org/10.18705/2311-44952023-10-2-77-87","url":null,"abstract":"Background. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 10-15% of women of reproductive age. PCOS is often associated with metabolic disorders, type 2 diabetes, cardiovascular disease, and other complications. In recent years, angiogenesis has been widely discussed as an important factor in the pathogenesis of PCOS.Objective. To identify growth factors in women with PCOS compared with healthy women in normal and overweight subgroups.Design and methods. This case-control study carried out at the Almazov National Medical Research Centre (ANMRC) included 45 patients with PCOS (22 women with a body mass index (BMI) < 25 kg/m2 and 23 women with a BMI > 25 kg/m2) and 45 women with normal ovulation (22 women with a BMI < 25 kg/m2 and 23 women with a BMI > 25 kg/m2). Seven growth factors were analyzed in the plasma of patients.Results. Compared to the control group, normal weight women with PCOS had higher plasma levels of EGF (medians were 5.57 and 0 pg/ml, p = 0.040) and FLT3L (medians were 5.0 and 2.25 pg/ml, p = 0.018). Growth factors FGF 2 and TGF alpha were increased in women with PCOS both in overweight and normal weight subgroups (p<0.001).Conclusion. In both overweight and non-overweight groups, women with PCOS show an increase in growth factors.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42890546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time three dimensional tte in quantification of left ventricular dyssynchrony 实时三维tte在左心室不同步性定量中的应用

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-04-07 DOI: 10.18705/2311-4495-2023-10-1-14-24

A. I. Mamedova, N. A. Prihod’ko, T. Lubimceva, A. Kozlenok, D. S. Lebedev

{"title":"Real-time three dimensional tte in quantification of left ventricular dyssynchrony","authors":"A. I. Mamedova, N. A. Prihod’ko, T. Lubimceva, A. Kozlenok, D. S. Lebedev","doi":"10.18705/2311-4495-2023-10-1-14-24","DOIUrl":"https://doi.org/10.18705/2311-4495-2023-10-1-14-24","url":null,"abstract":"Background. The main problem in the patient selection for cardiac resynchronization therapy (CRT) is the lack of unified approaches to the definition of mechanical dyssynchrony (MD) and selection criteria.Objective. To reveal the dependence of the criteria of dyssynchrony in patients on the method and point of stimulation and to reveal the correlation of these data with the width of the QRS complex and the percentage of global two-dimensional longitudinal deformation.Design and methods. The study involved 12 patients with drug-compensated CHF of class II-IV, LVEF< 35 % and a QRS duration >130 ms, having CRT indications. All patients were intraoperatively injected with a retrograde transaortically guided electrode. During stimulation of each point (88 points), transesophageal Echo-KG (PE Echo-KG) was performed. TomTec and Philips Qlab 3DQ Advanced software was used for data analysis.Results. The segmental excursion and myocardial contractility differed significantly depending on the stimulation point. A moderate inverse correlation was found between ExcAvg, LVEF and QRS duration. There were a direct correlation of the SDI-16 and the QRS duration was shown, and an inverse correlation of SDI-16 with ExcAvg and LVEF. 2D longitudinal global strain was inversely correlated with the EF.Conclusion. The technique is useful for regional LV myocardial contractility assessment and patient selection and comparison of alternative approaches to LV pacing to improve response to CRT.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48073124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic imaging for DeBakey type III aortic dissection complicated by aneurysm rupture with the formation of an aortoesophageal fistula: a case report DeBakey III型主动脉夹层并发动脉瘤破裂并主动脉食管瘘的影像学诊断1例报告

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-04-07 DOI: 10.18705/2311-4495-2023-10-1-36-45

L. E. Galyautdinova, I. V. Basek, D. V. Karpova, M. Chernyavskiy, V. S. Yegorova, A. A. Borshevetskaya

{"title":"Diagnostic imaging for DeBakey type III aortic dissection complicated by aneurysm rupture with the formation of an aortoesophageal fistula: a case report","authors":"L. E. Galyautdinova, I. V. Basek, D. V. Karpova, M. Chernyavskiy, V. S. Yegorova, A. A. Borshevetskaya","doi":"10.18705/2311-4495-2023-10-1-36-45","DOIUrl":"https://doi.org/10.18705/2311-4495-2023-10-1-36-45","url":null,"abstract":"Aortic dissection is a type of acute aortic syndrome characterized by a high mortality rate in the first 48 hours. The problem of early diagnosis of acute aortic dissection is still relevant and due to a high risk of severe complications, as well as a non-specific clinical features. If left untreated, aortic dissection can be complicated by the formation of an aortic aneurysm and its rupture. Sometimes, the rupture of an aortic aneurysm is accompanied by the fistula formation. The article discusses the use of computed tomography (CT) scans for visualization of DeBakey type III aortic dissection complicated by aortic rupture and the formation of an aorto-esophageal fistula.A 60 y.o. male diagnosed with aortic dissection was urgently transferred from the city hospital for surgical treatment. As part of the preoperative preparation, the patient underwent computed tomography angiography (CT angiography), that demonstrated not only an acute DeBakey type III dissection with a thoracic aortic aneurysm of the descending aorta, but also its complication in the form of aortic rupture with the formation of aorto-esophageal fistula.The patient underwent a successful endovascular thoracic aortic stent grafting with unmarkable postoperative period. Follow-up CT angiography showed complete isolation of the false lumen and closure of the aorto-esophageal fistula. The patient showed clinical improvement and was discharged home on 14 day.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43266522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction of multicenter design in the non-clinical phase to overcome translational barriers in clinical trials 在非临床阶段引入多中心设计以克服临床试验中的转化障碍

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-04-07 DOI: 10.18705/2311-4495-2023-10-1-52-63

I. G. Murazov, M. Kovaleva, M. Makarova, V. Makarov

{"title":"Introduction of multicenter design in the non-clinical phase to overcome translational barriers in clinical trials","authors":"I. G. Murazov, M. Kovaleva, M. Makarova, V. Makarov","doi":"10.18705/2311-4495-2023-10-1-52-63","DOIUrl":"https://doi.org/10.18705/2311-4495-2023-10-1-52-63","url":null,"abstract":"Background. The translating of individual preclinical studies (PCTs) results into clinical practice is accompanied by a significant number of failures and is associated with significant time and financial costs. The unsatisfactory design of individual non-clinical studies and the reports submitted after having done in vivo experiments at one laboratories do not allow overcoming translational barriers and increasing the results reproducibility. To conduct multicenter non-clinical trials is relevant to to confirm the effectiveness of medicines and increase the chances of successful translation of non-clinical results into clinical practice.Objective. To analyze the scientific literature devoted to multicenter non-clinical studies in the research of the pharmacological activity of new drugs.Design and methods. The research was done using PubMed and Google Scholar databases. The review included available publications as of October 16, 2022.Results. It was discovered that single-center studies did not allow predicting the magnitude of the effect accurately, and large sample sizes made the estimation of the magnitude of the effect even less precise.Conclusions. The main purpose of multicenter non-clinical studies rather should be assessing the direction of the effect, including its “stability”, as well as to identify sources of heterogeneity between studies conducted in different laboratories (centers) than performing a quantitative assessment of the effect on several laboratories, as it tend to be in foreign non-clinical practice.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44005246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-day telemonitoring is the optimum control method in the medicational treatment of arrhythmias 多日远程监护是心律失常药物治疗的最佳控制方法

Translational medicine (Sunnyvale, Calif.) Pub Date : 2023-04-07 DOI: 10.18705/2311-4495-2023-10-1-5-13

T. É. Tulintseva, V. Tikhonenko, E. Zhabina, T. Treshkur

{"title":"Multi-day telemonitoring is the optimum control method in the medicational treatment of arrhythmias","authors":"T. É. Tulintseva, V. Tikhonenko, E. Zhabina, T. Treshkur","doi":"10.18705/2311-4495-2023-10-1-5-13","DOIUrl":"https://doi.org/10.18705/2311-4495-2023-10-1-5-13","url":null,"abstract":"Background. The use of antiarrhythmic (AA) drugs requires constant monitoring due to the risk of arrhythmic and side effects. It is impossible to quickly identify and respond to emerging adverse events using 24-hour monitoring of the electrocardiogram (ECG), due to the method technical features. The introduction into practice of multi-day telemonitoring (MTM) of ECG contributes to an increase in the detection of rare and asymptomatic arrhythmias, and improves control over the AA therapy effectiveness.Objective. To study the possibilities and advantages of MTM in the selection of AA therapy and the prevention of its complications in patients with ventricular arrhythmias (VA).Design and methods. The study included 73 patients with frequent symptomatic high-grade VA (44 women and 29 men) aged 28 to 86 years (56.6 ± 28.3 years), in whom MTM ECG was performed for the purpose of individual selection of AA therapy.Results. In 19 % patients using MTM, the psychogenic nature of VA and a necessity to avoid prescribing was suspected. In 63 % patients with VA the optimal AA therapy in the minimum effective doses was selected using MTM, in 18 % patients the futility of drug therapy was proven and radiofrequency ablation was recommended.Conclusion. MTM ECG is justified for the selecting AA therapy in patients with VA. MTM has undoubted advantages over daily monitoring and helps to reduce the time for AA agent choosing.","PeriodicalId":89863,"journal":{"name":"Translational medicine (Sunnyvale, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43964958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0