Vanessa Torrecillas, Chelsea M Allen, Tom Greene, Albert Park, Winnie Chung, Tatiana M Lanzieri, Gail Demmler-Harrison
{"title":"Should You Follow the Better-Hearing Ear for Congenital Cytomegalovirus Infection and Isolated Sensorineural Hearing Loss?","authors":"Vanessa Torrecillas, Chelsea M Allen, Tom Greene, Albert Park, Winnie Chung, Tatiana M Lanzieri, Gail Demmler-Harrison","doi":"10.1177/0194599819880348","DOIUrl":"10.1177/0194599819880348","url":null,"abstract":"<p><strong>Objective: </strong>To describe the progression of sensorineural hearing loss (SNHL) in the better- and poorer-hearing ears in children with asymptomatic congenital cytomegalovirus (CMV) infection with isolated SNHL.</p><p><strong>Study design: </strong>Longitudinal prospective cohort study.</p><p><strong>Setting: </strong>Tertiary medical center.</p><p><strong>Subjects and methods: </strong>We analyzed hearing thresholds of the better- and poorer-hearing ears of 16 CMV-infected patients with isolated congenital/early-onset or delayed-onset SNHL identified through hospital-based CMV screening of >30,000 newborns from 1982 to 1992.</p><p><strong>Results: </strong>By 12 months of age, 4 of 7 patients with congenital/early-onset SNHL developed worsening thresholds in the poorer-hearing ear, and 1 had an improvement in the better-hearing ear. By 18 years of age, all 7 patients had worsening thresholds in the poorer-hearing ear and 3 patients had worsening thresholds in the better-hearing ear. Hearing loss first worsened at a mean age of 2 and 6 years in the poorer- and better-hearing ears, respectively. Nine patients were diagnosed with delayed-onset SNHL (mean age of 9 years vs 12 years for the poorer- and better-hearing ears), 6 of whom had worsening thresholds in the poorer-hearing ear and 1 in both ears.</p><p><strong>Conclusion: </strong>In most children with congenital CMV infection and isolated SNHL, the poorer-hearing ear worsened earlier and more precipitously than the better-hearing ear. This study suggests that monitoring individual hearing thresholds in both ears is important for appropriate interventions and future evaluation of efficacy of antiviral treatment.</p>","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"6 1","pages":"114-120"},"PeriodicalIF":2.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77701290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanan Kong, Lu Yang, Weidong Wei, Ning Lyu, Yutian Zou, Guanfeng Gao, Xueqi Ou, Xiaoming Xie, Hailin Tang
{"title":"CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression.","authors":"Yanan Kong, Lu Yang, Weidong Wei, Ning Lyu, Yutian Zou, Guanfeng Gao, Xueqi Ou, Xiaoming Xie, Hailin Tang","doi":"10.2217/epi-2019-0093","DOIUrl":"10.2217/epi-2019-0093","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the role of circRNAs in triple-negative breast cancer (TNBC) and the underlying mechanisms. <b>Materials & methods:</b> We performed circRNA microarrays to explore the expression profiles of TNBC cell lines. Experiments <i>in vitro</i> and <i>in vivo</i> were conducted to explore the effects of circPLK1 on tumor proliferation and metastasis as well as the interaction between circPLK1, miR-296-5p and <i>PLK1</i> in TNBC. <b>Results & conclusion:</b> CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. CircPLK1 knockdown inhibited cell growth and invasion <i>in vitro</i> as well as tumor occurrence and metastasis <i>in vivo</i>. CircPLK1-miR-296-5p-<i>PLK1</i> axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC.</p>","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"12 1","pages":"1163-1176"},"PeriodicalIF":3.8,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/epi-2019-0093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77743239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lexical expectations in sentence comprehension","authors":"Charles Clifton Jr., Lyn Frazier, Cynthia Connine","doi":"10.1016/S0022-5371(84)90426-2","DOIUrl":"10.1016/S0022-5371(84)90426-2","url":null,"abstract":"<div><p>Verbs, as a syntactic category, accept noun phrase complements (direct objects). Some specific verbs require such complements, others prohibit them, while still others differ in the likelihood that they will be used with direct objects. Two experiments demonstrated that readers use specific lexical information in comprehending sentences to anticipate and prepare for the appearance of lexical noun phrases and to postulate “gaps” that are associated with “fillers.” One experiment used an on-line secondary task to demonstrate the effects of violating a lexically based syntactic expectation, while a second experiment used an end-of-the-sentence grammaticality judgment task to demonstrate a similar effect on gap filling. The experiments demonstrated that lexically based expectations involve the use of information about appropriate syntactic or thematic categories, and provided evidence for the use of pragmatic information as well. The question of how lexical information interacts with other types of information in sentence processing was raised.</p></div>","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"23 6","pages":"Pages 696-708"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0022-5371(84)90426-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55831649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of intention on what concepts are acquired","authors":"Deborah G. Kemler Nelson","doi":"10.1016/S0022-5371(84)90442-0","DOIUrl":"10.1016/S0022-5371(84)90442-0","url":null,"abstract":"<div><p>Categories that have a strong family-resemblance structure should be learned more easily than categories based on a selected criterial attribute under conditions that promote non-analytic processing (that is guided by overall similarity). Two studies of artificial category learning by adults test the hypothesis that incidental conditions, more than intentional learning conditions, favor the acquisition of family-resemblance categories as opposed to categories based on criterial attributes. A third experiment confirms that this relation is mediated by the increased use of holistic processing under incidental conditions: exemplar encoding and sensitivity to overall similarity relations. A final study shows a parallel effect of developmental status. Under intentional learning conditions, 5-year olds, but not 10-year olds, have more difficulty learning criterial-attribute-based categories than categories organized by family resemblances. Thus, both characteristics of the task and characteristics of the learner affect the structural nature of the concept that is learned, and both effects underline the importance of overall similarity relations under more “primitive” conditions. These findings have implications for the understanding of natural concepts and natural category learning, where the role of overall similarity may have been underestimated.</p></div>","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"23 6","pages":"Pages 734-759"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0022-5371(84)90442-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55831966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Decisions and memory: Differential retrievability of consistent and contradictory evidence","authors":"Denise Dellarosa, Lyle E. Bourne Jr.","doi":"10.1016/S0022-5371(84)90410-9","DOIUrl":"10.1016/S0022-5371(84)90410-9","url":null,"abstract":"<div><p>Three experiments are reported that investigate the effect of decision-making on memory. In Experiment 1, subjects were found to recall, following a delay, more facts that supported decisions they had made concerning three texts than facts that contradicted their decisions. Recognition of both types of facts was equivalent, however. The same results were obtained even when recall of both types of facts was equated prior to decision-making (Experiment 2) and when decisional processing was eliminated by simply informing the subject of the correct decision for each text (Experiment 3). On the basis of these results, we concluded that (1) decisions, whether internally generated or externally provided, produce a reorganization of memory traces, (2) this reorganization produces differential accessibility of supporting and contradictory facts, and (3) this differential accessibility produces biased memory performance that can be removed by the use of strong retrieval cues. Two models of memory performance following decision-making are proposed to account for these results.</p></div>","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"23 6","pages":"Pages 669-682"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0022-5371(84)90410-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55831476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Author index for volume 23","authors":"","doi":"10.1016/S0022-5371(84)90450-X","DOIUrl":"https://doi.org/10.1016/S0022-5371(84)90450-X","url":null,"abstract":"","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"23 6","pages":"Page 760"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0022-5371(84)90450-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71740224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prenominal adjectives and the disambiguation of anaphoric nouns","authors":"Albert T. Corbett","doi":"10.1016/S0022-5371(84)90418-3","DOIUrl":"10.1016/S0022-5371(84)90418-3","url":null,"abstract":"<div><p>Two experiments are described in which subjects read short passages containing an adjective-category noun reference (e.g., <em>wooden toy</em>) to an antecedent in the text (<em>wooden block</em>). In half the passages a nonantecedent example of the category also appeared in the text (<em>rubber ball</em>). The presence of this nonantecedent distractor generally slowed reading time for the anaphoric reference, but this interference effect interacted with the typicality of the examples. No interference effect was obtained when the antecedent was a typical example of the adjective-category phrase and the nonantecedent distractor was not typical. The results suggest that, while prenominal adjectives can be used to select the intended antecedent quickly, the adjectives do not actually prevent the nonantecedent distractors from being accessed.</p></div>","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"23 6","pages":"Pages 683-695"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0022-5371(84)90418-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55831507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Semantic priming without association: A second look","authors":"Stephen J. Lupker","doi":"10.1016/S0022-5371(84)90434-1","DOIUrl":"10.1016/S0022-5371(84)90434-1","url":null,"abstract":"<div><p>It has long been known that a word (e.g., BUTTER) presented shortly after a related word (e.g., BREAD) can be processed more rapidly than when presented shortly after an unrelated word (e.g., TABLE). This phenomenon has come to be referred to as “semantic” priming. To this date, however, only I. Fischler (1977, <em>Memory & Cognition</em>, <strong>5,</strong> 335–339) has provided any evidence that this phenomenon is semantically and not associatively based. In the present paper six studies were undertaken in an attempt to generalize Fischler's findings to tasks other than the simultaneous lexical decision task he used. In Experiments 1, 2, and 3 it was determined that semantic category relationships, in which the two words named members of the same semantic category (e.g., DOG-PIG) did little to facilitate naming of the second stimulus. In Experiments 4 and 6, it was determined that a semantic category relationship did nothing to augment the priming from associative relationships in naming and lexical decision tasks, respectively. However, in Experiment 5, in a replication of Fischler's results, semantic relatedness alone did produce priming in a lexical decision task. These results appear to indicate that the role of semantics in the priming process is somewhat limited. Further, these results also indicate that the amount of priming observed is somewhat task dependent. Implications for models of “semantic” priming are discussed.</p></div>","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"23 6","pages":"Pages 709-733"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0022-5371(84)90434-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55831716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Subject index volume 23","authors":"","doi":"10.1016/S0022-5371(84)90458-4","DOIUrl":"https://doi.org/10.1016/S0022-5371(84)90458-4","url":null,"abstract":"","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"23 6","pages":"Pages 761-763"},"PeriodicalIF":0.0,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0022-5371(84)90458-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71740225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prototypicality and deductive reasoning","authors":"Christopher Cherniak","doi":"10.1016/S0022-5371(84)90391-8","DOIUrl":"10.1016/S0022-5371(84)90391-8","url":null,"abstract":"<div><p>It is hypothesized that people use formally incorrect deductive procedures, and this is sometimes advisable. The particular “prototypicality heuristic” investigated is: to determine validity of a proof, (a) work out an example, and (b) pick a “good” rather than arbitrary example. An interaction was predicted between validity of inference and prototypicality of example. Experiment 1, although quite sensitive to “calibration” variables, does not reveal the interaction in reaction times. However, Experiment 2, in which subjects' time was limited, seems to elicit the interaction in subjects' first-trial confidence judgments; the explanation proposed is that subjects then decide they must shift to a “quick and dirty” heuristic. Experiment 3 provides some preliminary evidence that subjects' “metaheuristic” decision to use the heuristic does lower error rates.</p></div>","PeriodicalId":89821,"journal":{"name":"Journal of verbal learning and verbal behavior","volume":"23 5","pages":"Pages 625-642"},"PeriodicalIF":0.0,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0022-5371(84)90391-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55831313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}