Japanese clinical medicine最新文献_第2页

Histologic Chorioamnionitis, Amniotic Fluid Interleukin 6, Krebs von den Lungen 6, and Transforming Growth Factor β₁ for the Development of Neonatal Bronchopulmonary Dysplasia. 新生儿支气管肺发育不良的组织学羊膜炎、羊水白细胞介素6、肺克雷伯氏菌6和转化生长因子β1的发展

Japanese clinical medicine Pub Date : 2017-03-07 eCollection Date: 2017-01-01 DOI: 10.1177/1179066017696076

Hisako Matsumura, Hiroyuki Ichiba, Satoshi Ohnishi, Mika Saito, Haruo Shintaku

{"title":"Histologic Chorioamnionitis, Amniotic Fluid Interleukin 6, Krebs von den Lungen 6, and Transforming Growth Factor β1 for the Development of Neonatal Bronchopulmonary Dysplasia.","authors":"Hisako Matsumura, Hiroyuki Ichiba, Satoshi Ohnishi, Mika Saito, Haruo Shintaku","doi":"10.1177/1179066017696076","DOIUrl":"https://doi.org/10.1177/1179066017696076","url":null,"abstract":"Background: Chorioamnionitis (CAM) is an important risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants.Objectives: To evaluate the effects of CAM on the development of BPD using interleukin 6 (IL-6), Krebs von den Lungen 6 (KL-6), and transforming growth factor β1 (TGF-β1) in the amniotic fluid as markers for inflammation, lung injury, and fibrosis/remodeling, respectively.Methods: Amniotic fluid concentrations of IL-6, KL-6, and TGF-β1 were measured with enzyme-linked immunosorbent assay or electro-chemiluminescence immunoassay.Results: Of the 36 preterm infants, 18 were exposed to histologically confirmed CAM. Of these, 12 were later diagnosed as having BPD. The IL-6, KL-6, and TGF-β1 levels in the amniotic fluid significantly increased with increasing histologic severity of CAM. Moreover, these markers were higher in the BPD group with histologic CAM than those without.Conclusions: Our study suggests that CAM is likely to induce inflammatory, injury, and remodeling processes in the fetal lung.","PeriodicalId":89792,"journal":{"name":"Japanese clinical medicine","volume":"8 ","pages":"1179066017696076"},"PeriodicalIF":0.0,"publicationDate":"2017-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179066017696076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34964544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

KRAS Mutation as a Potential Prognostic Biomarker of Biliary Tract Cancers KRAS突变作为胆道癌的潜在预后生物标志物

Japanese clinical medicine Pub Date : 2016-12-13 DOI: 10.4137/JCM.S40549

M. Yokoyama, H. Ohnishi, K. Ohtsuka, S. Matsushima, Y. Ohkura, J. Furuse, Takashi Watanabe, Toshiyuki Mori, M. Sugiyama

{"title":"KRAS Mutation as a Potential Prognostic Biomarker of Biliary Tract Cancers","authors":"M. Yokoyama, H. Ohnishi, K. Ohtsuka, S. Matsushima, Y. Ohkura, J. Furuse, Takashi Watanabe, Toshiyuki Mori, M. Sugiyama","doi":"10.4137/JCM.S40549","DOIUrl":"https://doi.org/10.4137/JCM.S40549","url":null,"abstract":"BACKGROUND The aim of this study was to identify the unique molecular characteristics of biliary tract cancer (BTC) for the development of novel molecular-targeted therapies. MATERIALS AND METHODS We performed mutational analysis of KRAS, BRAF, PIK3CA, and FBXW7 and immunohistochemical analysis of EGFR and TP53 in 63 Japanese patients with BTC and retrospectively evaluated the association between the molecular characteristics and clinicopathological features of BTC. RESULTS KRAS mutations were identified in 9 (14%) of the 63 BTC patients; no mutations were detected within the analyzed regions of BRAF, PIK3CA, and FBXW7. EGFR overexpression was observed in 5 (8%) of the 63 tumors, while TP53 overexpression was observed in 48% (30/63) of the patients. Overall survival of patients with KRAS mutation was significantly shorter than that of patients with the wild-type KRAS gene (P = 0.005). By multivariate analysis incorporating molecular and clinicopathological features, KRAS mutations and lymph node metastasis were identified to be independently associated with shorter overall survival (KRAS, P = 0.004; lymph node metastasis, P = 0.015). CONCLUSIONS Our data suggest that KRAS mutation is a poor prognosis predictive biomarker for the survival in BTC patients.","PeriodicalId":89792,"journal":{"name":"Japanese clinical medicine","volume":"7 1","pages":"33 - 39"},"PeriodicalIF":0.0,"publicationDate":"2016-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/JCM.S40549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Linagliptin Has Wide-Ranging Anti-Inflammatory Points of Action in Human Umbilical Vein Endothelial Cells 利格列汀对人脐静脉内皮细胞具有广泛的抗炎作用点

Japanese clinical medicine Pub Date : 2016-12-05 DOI: 10.4137/JCM.S39317

Yuya Nakamura, M. Inagaki, Mayumi Tsuji, Toshihiko Gocho, Kazuaki Handa, H. Hasegawa, A. Yura, T. Kawakami, I. Ohsawa, Yoshikazu Goto, Hiromichi Gotoh, Y. Kiuchi

{"title":"Linagliptin Has Wide-Ranging Anti-Inflammatory Points of Action in Human Umbilical Vein Endothelial Cells","authors":"Yuya Nakamura, M. Inagaki, Mayumi Tsuji, Toshihiko Gocho, Kazuaki Handa, H. Hasegawa, A. Yura, T. Kawakami, I. Ohsawa, Yoshikazu Goto, Hiromichi Gotoh, Y. Kiuchi","doi":"10.4137/JCM.S39317","DOIUrl":"https://doi.org/10.4137/JCM.S39317","url":null,"abstract":"BACKGROUND Because of the potential anti-inflammatory effects, linagliptin, a therapeutic dipeptidyl peptidase-4 inhibitor, is used as an effective drug for diabetic patients for whom inflammation is a prognosis-related factor. We investigated the anti-inflammatory mechanism of linagliptin using seven markers. METHODS We pretreated human umbilical vein endothelial cells (HUVECs), with linagliptin and lipopolysaccharide (LPS). The cytosolic fractions were evaluated for protein kinase A (PKA), protein kinase B (PKB), protein kinase C (PKC), ratio of reactive oxygen species (ROS) and Cu/Zn superoxide dismutase (SOD), activator protein 1 (AP-1), and adenosine 3′,5′-cyclic monophosphate (cAMP). RESULTS Linagliptin increased the PKA and PKC activities and the cAMP levels in LPS-treated cells. However, it inhibited LPS-induced PKB phosphorylation, ratio of ROS and Cu/Zn SOD, and LPS-stimulated AP-1 nuclear translocation. CONCLUSION We reaffirmed the anti-inflammatory and antioxidant effects of linagliptin. These effects might be related to the three protein kinases. Our findings suggest that linagliptin has a wide range of anti-inflammatory effects.","PeriodicalId":89792,"journal":{"name":"Japanese clinical medicine","volume":"7 1","pages":"27 - 32"},"PeriodicalIF":0.0,"publicationDate":"2016-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/JCM.S39317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Predominant Corticospinal Tract Involvement in a Late Infant with Krabbe Disease 晚期婴儿克拉布病的主要皮质脊髓束受累

Japanese clinical medicine Pub Date : 2016-09-18 DOI: 10.4137/JCM.S40470

Ayumi Yoshimura, T. Kibe, K. Irahara, N. Sakai, K. Yokochi

{"title":"Predominant Corticospinal Tract Involvement in a Late Infant with Krabbe Disease","authors":"Ayumi Yoshimura, T. Kibe, K. Irahara, N. Sakai, K. Yokochi","doi":"10.4137/JCM.S40470","DOIUrl":"https://doi.org/10.4137/JCM.S40470","url":null,"abstract":"A case of late-infantile Krabbe disease in a patient who presented with developmental regression and spastic quadriplegia in late infancy is reported. Brain magnetic resonance imaging (MRI) at 11 months of age showed predominant corticospinal tract involvement, which usually appears in adult Krabbe disease. Galactocerebrosidase activity in lymphocytes and skin fibroblasts was very low. Genetic testing revealed compound heterozygous mutations of the galactocerebrosidase (GALC) gene, c.635_646 delinsCTC and c.1901T>C [p.L618S], both of which are known pathogenic mutations. It has been reported that the c.1901T>C [p.L618S] mutation is associated with the late-onset phenotype and, in a past case, a homozygous mutation at this location showed predominant corticospinal tract involvement on MRI. Although further analysis is needed to identify the pathophysiological mechanism, this combination of mutations is likely to be associated with this unusual MRI finding in late-infantile Krabbe disease. Because these types of mutations are common for Japanese patients, it is possible that there are more undiagnosed and late-diagnosed patients of late-infantile Krabbe disease who display limited lesions on MRI. Pediatricians should be aware that patients with late-infantile Krabbe disease can present with predominant corticospinal tract involvement on MRI.","PeriodicalId":89792,"journal":{"name":"Japanese clinical medicine","volume":"7 1","pages":"23 - 26"},"PeriodicalIF":0.0,"publicationDate":"2016-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/JCM.S40470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

A Patient-Held Medical Record Integrating Depression Care into Diabetes Care. 将抑郁症护理纳入糖尿病护理的患者病历。

Japanese clinical medicine Pub Date : 2016-07-18 eCollection Date: 2016-01-01 DOI: 10.4137/JCM.S39766

Noriko Satoh-Asahara, Hiroto Ito, Tomoyuki Akashi, Hajime Yamakage, Kazuhiko Kotani, Daisuke Nagata, Kazuyuki Nakagome, Mitsuhiko Noda

{"title":"A Patient-Held Medical Record Integrating Depression Care into Diabetes Care.","authors":"Noriko Satoh-Asahara, Hiroto Ito, Tomoyuki Akashi, Hajime Yamakage, Kazuhiko Kotani, Daisuke Nagata, Kazuyuki Nakagome, Mitsuhiko Noda","doi":"10.4137/JCM.S39766","DOIUrl":"https://doi.org/10.4137/JCM.S39766","url":null,"abstract":"Purpose: Depression is frequently observed in people with diabetes. The purpose of this study is to develop a tool for individuals with diabetes and depression to communicate their comorbid conditions to health-care providers.Method: We searched the Internet to review patient-held medical records (PHRs) of patients with diabetes and examine current levels of integration of diabetes and depression care in Japan.Results: Eight sets of PHRs were found for people with diabetes. All PHRs included clinical follow-up of diabetes and multidisciplinary clinical pathways for diabetes care. No PHRs included depression monitoring and/or treatment. In terms of an integrated PHR for a patient comorbid with diabetes and depression, necessary components include hopes/preferences, educational information on diabetes complications and treatment, medical history, stress and coping, resources, and monitoring diabetes and depression.Conclusion: A new PHR may be suitable for comorbid patients with diabetes and depression.","PeriodicalId":89792,"journal":{"name":"Japanese clinical medicine","volume":"7 ","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"2016-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/JCM.S39766","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34721845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Perinatal Outcomes of Monochorionic-Diamniotic Twin Pregnancies Uncomplicated at 28 Weeks of Gestation. 单绒毛膜-双羊膜双胎妊娠28周无并发症的围产期结局。

Japanese clinical medicine Pub Date : 2016-05-22 eCollection Date: 2016-01-01 DOI: 10.4137/JCM.S38895

Shunji Suzuki

引用次数: 8

Familial Dysalbuminemic Hyperthyroxinemia in a Japanese Man Caused by a Point Albumin Gene Mutation (R218P). 由白蛋白点突变(R218P)引起的日本男性家族性白蛋白异常血症高甲状腺素血症。

Japanese clinical medicine Pub Date : 2016-04-04 eCollection Date: 2016-01-01 DOI: 10.4137/JCM.S38990

Yoshinori Osaki, Yoshitaka Hayashi, Yoshinori Nakagawa, Katsumi Yoshida, Hiroshi Ozaki, Hiroshi Fukazawa

引用次数: 6

Sustained Decrease of Early-Phase Insulin Secretion in Japanese Women with Gestational Diabetes Mellitus Who Developed Impaired Glucose Tolerance and Impaired Fasting Glucose Postpartum 日本妊娠期糖尿病患者糖耐量受损和产后空腹血糖受损的早期胰岛素分泌持续下降

Japanese clinical medicine Pub Date : 2015-12-09 DOI: 10.4137/JCM.S32743

Hiroko Katayama, D. Tachibana, A. Hamuro, T. Misugi, K. Motoyama, T. Morioka, S. Fukumoto, M. Emoto, M. Inaba, M. Koyama

{"title":"Sustained Decrease of Early-Phase Insulin Secretion in Japanese Women with Gestational Diabetes Mellitus Who Developed Impaired Glucose Tolerance and Impaired Fasting Glucose Postpartum","authors":"Hiroko Katayama, D. Tachibana, A. Hamuro, T. Misugi, K. Motoyama, T. Morioka, S. Fukumoto, M. Emoto, M. Inaba, M. Koyama","doi":"10.4137/JCM.S32743","DOIUrl":"https://doi.org/10.4137/JCM.S32743","url":null,"abstract":"OBJECTIVE The aim of this study was to compare glucose intolerance in the antenatal and the postpartum periods using a 75-g oral glucose tolerance test (OGTT) in the Japanese women with gestational diabetes mellitus (GDM) using a retrospective design. PATIENTS AND METHODS Data were obtained from 85 Japanese women with GDM who delivered from April 2011 through April 2015 and who underwent an OGTT 6–14 weeks postpartum. The women were divided into two groups based on the results of the postpartum OGTT: one group with normal glucose tolerance (NGT) and the other with impaired glucose tolerance (IGT) as well as impaired fasting glucose (IFG). We analyzed the associations between postpartum IGT–IFG and various factors. RESULTS Antenatally, a significant difference was observed between the groups only in the 1-hour plasma glucose level of the 75-g OGTT. Postpartum results of plasma glucose level were significantly higher at 0.5, 1, and 2 hours in the IGT–IFG group than those in the NGT group. Moreover, a significant decrease in the levels of 0.5-hour immunoreactive insulin and insulinogenic index was observed in the IGT–IFG group compared to those in the NGT group. Homeostasis model assessment-insulin resistance and homeostasis model assessment β-cell function of both groups were found to significantly decrease in the postpartum period; however, there was no significant change in the insulinogenic index of either group. CONCLUSIONS Our study clearly showed that the postpartum IGT and IFG levels of Japanese women with GDM are affected by impaired early-phase insulin secretion; however, insulin resistance promptly improves.","PeriodicalId":89792,"journal":{"name":"Japanese clinical medicine","volume":"38 1","pages":"35 - 39"},"PeriodicalIF":0.0,"publicationDate":"2015-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/JCM.S32743","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Serum Biopterin and Neopterin Levels as Predictors of Empty Follicles 血清生物蝶呤和新蝶呤水平作为空卵泡的预测指标

Japanese clinical medicine Pub Date : 2015-11-02 DOI: 10.4137/JCM.S32018

A. Hamuro, D. Tachibana, T. Misugi, Hiroko Katayama, K. Ozaki, Y. Fujino, Nakamura Yoshihiro, H. Shintaku, M. Koyama

{"title":"Serum Biopterin and Neopterin Levels as Predictors of Empty Follicles","authors":"A. Hamuro, D. Tachibana, T. Misugi, Hiroko Katayama, K. Ozaki, Y. Fujino, Nakamura Yoshihiro, H. Shintaku, M. Koyama","doi":"10.4137/JCM.S32018","DOIUrl":"https://doi.org/10.4137/JCM.S32018","url":null,"abstract":"OBJECTIVE This study measured serum and follicular fluid (FF) levels of biopterin, neopterin, vascular endothelial growth factor (VEGF), and macrophage colony-stimulating factor (M-CSF) in patients receiving mild ovarian stimulation for oocyte retrieval. PATIENTS AND METHODS Infertile patients who underwent ovarian stimulation were divided into the following: Group 1, no oocyte retrieval (n = 12), and Group 2, retrieval of more than four oocytes (n = 13). Median total gonadotropin dose in both groups was 150 IU. Biopterin and neopterin levels were measured using high-performance liquid chromatography. VEGF and M-CSF levels were measured by enzyme-linked immunosorbent assay. RESULTS Compared to Group 2, serum and FF levels of neopterin and VEGF and serum levels of M-CSF were significantly increased, and serum and FF levels of biopterin were significantly decreased in Group 1 (P < 0.05 each). CONCLUSION Biopterin and neopterin levels showed similar differences in FF and serum of patients with empty follicles. Decreased biopterin and increased neopterin in serum could predict poor oocyte retrieval.","PeriodicalId":89792,"journal":{"name":"Japanese clinical medicine","volume":"6 1","pages":"29 - 34"},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/JCM.S32018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70708313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Beta-Adrenergic Blockade Therapy for Autonomic Dysfunction is Less Effective for Elderly Patients with Heart Failure and Reduced Left Ventricular Ejection Fraction. 肾上腺素能阻断治疗自主神经功能障碍对老年心力衰竭和左心室射血分数降低患者效果较差。

Japanese clinical medicine Pub Date : 2015-10-11 eCollection Date: 2015-01-01 DOI: 10.4137/JCM.S30488

Ken Shimamoto, Masatoshi Kawana

{"title":"Beta-Adrenergic Blockade Therapy for Autonomic Dysfunction is Less Effective for Elderly Patients with Heart Failure and Reduced Left Ventricular Ejection Fraction.","authors":"Ken Shimamoto, Masatoshi Kawana","doi":"10.4137/JCM.S30488","DOIUrl":"https://doi.org/10.4137/JCM.S30488","url":null,"abstract":"Objective: Heart rate variability (HRV) has been reported to be an independent predictor of all-cause and sudden cardiac death in patients with heart failure. In the aging heart, however, both autonomic and cardiac functions appear to be altered. We assessed the relationship between aging and responsiveness of HRV and ventricular remodeling to beta-adrenergic blockade therapy in patients with heart failure and reduced ejection fraction (HFREF).Methods: Twenty-eight clinically stable patients with chronic heart failure, sinus rhythm, and left ventricular ejection fraction <50% as confirmed by echocardiography were included. At baseline and after carvedilol treatment, 24-hour ambulatory Holter monitor recording was used to analyze HRV indices by the maximum entropy method. Changes in these parameters were compared among three age groups.Results: HR decreased in all groups after carvedilol treatment, but was still highest in the youngest group despite the same treatment doses. Time and frequency domain variables improved. The response of time domain variables (the standard deviation of all normal sinus to normal sinus [NN] intervals and the standard deviation of the averages of NN intervals in all 5-minute or 30-minute segments) to carvedilol therapy significantly decreased with increasing age. Ventricular reverse remodeling induced by carvedilol therapy significantly decreased with increasing age. Increases in time domain variables and a low-frequency domain moderately correlated with left ventricular reverse remodeling.Conclusion: Beta-adrenergic blockade therapy improved HRV variables and ventricular remodeling in HFREF patients; however, the response tended to be milder in the elderly. HRV improvement was associated with ventricular reverse remodeling.","PeriodicalId":89792,"journal":{"name":"Japanese clinical medicine","volume":"6 ","pages":"21-7"},"PeriodicalIF":0.0,"publicationDate":"2015-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/JCM.S30488","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34101861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1