Histologic Chorioamnionitis, Amniotic Fluid Interleukin 6, Krebs von den Lungen 6, and Transforming Growth Factor β1 for the Development of Neonatal Bronchopulmonary Dysplasia.
Hisako Matsumura, Hiroyuki Ichiba, Satoshi Ohnishi, Mika Saito, Haruo Shintaku
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引用次数: 8
Abstract
Background: Chorioamnionitis (CAM) is an important risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants.
Objectives: To evaluate the effects of CAM on the development of BPD using interleukin 6 (IL-6), Krebs von den Lungen 6 (KL-6), and transforming growth factor β1 (TGF-β1) in the amniotic fluid as markers for inflammation, lung injury, and fibrosis/remodeling, respectively.
Methods: Amniotic fluid concentrations of IL-6, KL-6, and TGF-β1 were measured with enzyme-linked immunosorbent assay or electro-chemiluminescence immunoassay.
Results: Of the 36 preterm infants, 18 were exposed to histologically confirmed CAM. Of these, 12 were later diagnosed as having BPD. The IL-6, KL-6, and TGF-β1 levels in the amniotic fluid significantly increased with increasing histologic severity of CAM. Moreover, these markers were higher in the BPD group with histologic CAM than those without.
Conclusions: Our study suggests that CAM is likely to induce inflammatory, injury, and remodeling processes in the fetal lung.
背景:绒毛膜羊膜炎(CAM)是早产儿发生支气管肺发育不良(BPD)的重要危险因素。目的:利用羊水中白细胞介素6 (IL-6)、肺Krebs von den Lungen 6 (KL-6)和转化生长因子β1 (TGF-β1)分别作为炎症、肺损伤和纤维化/重构的标志物，评价CAM对BPD发展的影响。方法:采用酶联免疫吸附法或电化学发光免疫分析法测定羊水中IL-6、KL-6、TGF-β1的浓度。结果:36例早产儿中，18例暴露于组织学证实的CAM。其中12人后来被诊断为BPD。羊水中IL-6、KL-6、TGF-β1水平随CAM组织学严重程度的增加而显著升高。此外，这些指标在有组织学CAM的BPD组高于没有CAM的BPD组。结论:我们的研究表明，CAM可能会诱发胎儿肺的炎症、损伤和重塑过程。
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