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Targeted therapeutics in pancreatic cancer for precision medicine 胰腺癌精准医学的靶向治疗
Pancreatic disorders & therapy Pub Date : 2017-10-07 DOI: 10.4172/2165-7092-C1-005
Sorah Yoon
{"title":"Targeted therapeutics in pancreatic cancer for precision medicine","authors":"Sorah Yoon","doi":"10.4172/2165-7092-C1-005","DOIUrl":"https://doi.org/10.4172/2165-7092-C1-005","url":null,"abstract":"","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85112082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Developing therapy-responsive prognostic biomarkers, and conquering undruggable oncogenic k-ras-driven pancreatic cancer by attacking its major k-ras vulnerability and the k-ras signaling gatekeeper - the siah proteolysis machinery 开发治疗反应性预后生物标志物，通过攻击其主要的k-ras易损和k-ras信号看门人- siah蛋白水解机制，征服不可药物的癌性k-ras驱动的胰腺癌
Pancreatic disorders & therapy Pub Date : 2017-10-07 DOI: 10.4172/2165-7092-C1-004
Amy H Tang
{"title":"Developing therapy-responsive prognostic biomarkers, and conquering undruggable oncogenic k-ras-driven pancreatic cancer by attacking its major k-ras vulnerability and the k-ras signaling gatekeeper - the siah proteolysis machinery","authors":"Amy H Tang","doi":"10.4172/2165-7092-C1-004","DOIUrl":"https://doi.org/10.4172/2165-7092-C1-004","url":null,"abstract":"","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"490 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77797209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations in Cancer-related Genes Associated with Grading of Well Differentiated Pancreatic Neuroendocrine Neoplasms 与分化良好的胰腺神经内分泌肿瘤分级相关的癌症相关基因的改变
Pancreatic disorders & therapy Pub Date : 2017-09-11 DOI: 10.4172/2165-7092.1000189
Yudai Yokota, M. Fukasawa, S. Takano, Hiroko Shindo, Ei Takahashi, Makoto Kadokura, Kunio Mochizuki, S. Maekawa, J. Itakura, H. Fujii, Tadashi Sato, N. Enomoto
{"title":"Alterations in Cancer-related Genes Associated with Grading of Well Differentiated Pancreatic Neuroendocrine Neoplasms","authors":"Yudai Yokota, M. Fukasawa, S. Takano, Hiroko Shindo, Ei Takahashi, Makoto Kadokura, Kunio Mochizuki, S. Maekawa, J. Itakura, H. Fujii, Tadashi Sato, N. Enomoto","doi":"10.4172/2165-7092.1000189","DOIUrl":"https://doi.org/10.4172/2165-7092.1000189","url":null,"abstract":"Objectives: Although recent advances in next-generation sequencing (NGS) have revealed some genetic alterations in various tumors, including pancreatic neuroendocrine tumors (PanNETs), their clinical significance is not fully understood. To investigate the clinical significance of gene alteration in PanNETs, we performed genetic analysis of well differentiated PanNETs using NGS. \u0000Methods: Twenty-nine resected primary PanNET tissue samples and three samples of metastatic liver tissues, obtained from 29 PanNET patients, were analyzed. DNA was extracted from laser-captured formalin-fixed paraffinembedded tissues, and 50 cancer-associated genes, including approximately 2,800 hotspots, were amplified by multiplex PCR. Amplified libraries were sequenced using NGS, and the results were analyzed in conjunction with respective clinicopathological features. \u0000Results: Among 50 investigated genes, somatic mutations were observed in four of 29 PanNET cases. We identified APC mutations in three cases, PTEN in two, and VHL and STK11 in one. The identified mutations were observed only in NET G2 tumors. All liver metastases contained at least one mutation, such as PTEN or TP53, which was not observed in the primary tumor. \u0000Conclusion: The cancer-related gene mutations observed in PanNETs were associated with G2 grade tumors. The mutations were more frequent in PanNET liver metastasis than in the primary tumors. Our analysis of liver metastasis cases suggested that cancer-related gene mutations might raise the tumor grade and promote liver metastasis. Further studies of associations between genetic alterations and clinicopathological features should help in the cancer diagnosis and prediction of therapeutic effects of molecular-target drugs.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"74 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75668658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postoperative Duodenal Obstruction: Etiology, Pathogenesis, Clinical Features and Problem Resolving 术后十二指肠梗阻:病因、发病机制、临床特征及解决方法
Pancreatic disorders & therapy Pub Date : 2017-08-05 DOI: 10.4172/2165-7092.1000188
Jie Zhan, Chaojun Kong, Z. Jia
{"title":"Postoperative Duodenal Obstruction: Etiology, Pathogenesis, Clinical Features and Problem Resolving","authors":"Jie Zhan, Chaojun Kong, Z. Jia","doi":"10.4172/2165-7092.1000188","DOIUrl":"https://doi.org/10.4172/2165-7092.1000188","url":null,"abstract":"As we all well known, the pancreatic cystic neoplasm is very common in clinical practice, which sometimes is recognised as an indication of limited local surgery due to its convenience and safety as well [1,2]. Generally, if the size in diameter of pancreatic cystic neoplasm less than 3.0 cm, major of them should be recognized as benign and supervenience for them is accessible. As a matter of fact, the neoplasma carcinomalization judged only by size of cyst is not completely correct. Active surgery intervention may be more helpful. However, postoperative ischemia-origin duodenum obstruction was rarely reported except for Wan et al. reported last year [3]. Although the hospital mortality is less than 1% [4], ischemia duodenal obstruction after surgery is very interesting for some surgeons and to be worthy of discussing once again. Herein, authors would like to share their experience of limited case.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"69 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82667392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inmedate Feeding Tolerance in Patients with Mild Acute Biliary Pancreatitis 轻度急性胆源性胰腺炎患者的直接喂养耐受
Pancreatic disorders & therapy Pub Date : 2017-07-16 DOI: 10.4172/2165-7092.1000187
Esmer David, Rivera Manuel, Sánchez Martín, Hern, ez Juan Francisco, V. Liliana
{"title":"Inmedate Feeding Tolerance in Patients with Mild Acute Biliary Pancreatitis","authors":"Esmer David, Rivera Manuel, Sánchez Martín, Hern, ez Juan Francisco, V. Liliana","doi":"10.4172/2165-7092.1000187","DOIUrl":"https://doi.org/10.4172/2165-7092.1000187","url":null,"abstract":"There is a large body of literature that describes the short-term complications (e.g., pancreatic or biliary anastomotic leaks) that occur after PD, but little has been published regarding long-term anastomotic complications. Stenosis of the anastomosis is often asymptomatic but symptomatic and painful presentations are difficult to treat, and the optimal treatment is not currently defined. The aim of this work is to report case of pancreatojejunostomy stenosis. The Pancreatic enteric anastomosis stenosis was diagnosed following presentation with pancreatitis that developed following pancreatoduodenectomy. The patient was treated surgically by fashioning side to side pancreatogastrostomy.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"23 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86523870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis 胰腺糖尿病和酗酒是酒精性慢性胰腺炎发生肝纤维化的危险因素
Pancreatic disorders & therapy Pub Date : 2017-07-15 DOI: 10.4172/2165-7092.1000186
Gábor Zsóri, M. Czepán, D. Illés, A. Pálvölgyi, I. Nagy, L. Czakó
{"title":"Pancreatic Diabetes Mellitus and Heavy Drinking are Risk Factors for the Development of Liver Fibrosis in Alcoholic Chronic Pancreatitis","authors":"Gábor Zsóri, M. Czepán, D. Illés, A. Pálvölgyi, I. Nagy, L. Czakó","doi":"10.4172/2165-7092.1000186","DOIUrl":"https://doi.org/10.4172/2165-7092.1000186","url":null,"abstract":"Objective: The coincidence of chronic pancreatitis and liver cirrhosis in alcoholic patients is comparatively rare. Our aim was to assess liver fibrosis in patients with alcoholic chronic pancreatitis (ACP) by measuring noninvasive fibrosis scores and liver stiffness. \u0000Methods: Fifty-five patients with ACP were enrolled in the study. Eight healthy volunteers served as controls. Noninvasive fibrosis scoring systems, including the aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 score (FIB-4), were determined and transient elastography (TE) was performed. \u0000Results: Mild (F1 or F2) and severe (F3 or F4) fibrosis was revealed by TE in 15 and 6 patients (38.2%), respectively. However, the levels of the liver enzymes were elevated in only 12 patients. The APRI and FIB-4 scores jointly revealed fibrosis of the liver in two patient. ACP patients with liver fibrosis drank significantly more amount of alcohol and had diabetes more frequently than ACP patients without liver fibrosis. \u0000Conclusion: Liver fibrosis was revealed by TE in one-fourth of the ACP patients. Liver enzymes are not reliable parameters with which to diagnose liver fibrosis. The quantity of consumed alcohol and the presence of DM are risk factors for the development of liver fibrosis in ACP.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"51 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90681575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Zollinger-Ellison Syndrome In Men1 Patients: Medical Or Surgical Treatment? 男性佐林格-埃里森综合征患者:药物治疗还是手术治疗?
Pancreatic disorders & therapy Pub Date : 2017-05-31 DOI: 10.4172/2165-7092.1000E149
F. Tonelli
{"title":"Zollinger-Ellison Syndrome In Men1 Patients: Medical Or Surgical Treatment?","authors":"F. Tonelli","doi":"10.4172/2165-7092.1000E149","DOIUrl":"https://doi.org/10.4172/2165-7092.1000E149","url":null,"abstract":"Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of tumors in different endocrine organs mainly parathyroid glands, pancreatic islets and anterior pituitary glands. The pancreatoduodenal neuroendocrine tumors (NET) have a high penetrance with a prevalence of 9%, 53% and 84% at 20, 50 and 80 years of age, respectively [1]. Pancreato-duodenal NETs may secrete hormones that provoke a clinical syndrome of hormonal excess or not secrete hormones (non-functioning NETs). Gastrinomas are the most frequent functioning pancreato-duodenal NET which can cause gastric acid hypersecretion with the manifestation of the Zollinger-Ellison syndrome (ZES). The hypergastrinemia has a throphic effect both on gastric mucosa and on gastric enterochromaffin cells (ECL). It is diagnosed in at least 50% of MEN1 patients at an age of 50 years ca, with prevalence in men [2,3]. At the moment of the diagnosis, pancreatic non-functioning NETs are usually detectable in all patients [2]. The great majority of the MEN1-gastrinomas (>90%) are found in the deep layer of the duodenal mucosa within the Brunner’s glands or in the duodenal submucosa. This aspect is in contrast to the sporadic gastrinoma that is found prevalently in the pancreas [4]. MEN1 associated duodenal gastrinomas are usually multiple, less than 5 mm in diameter, and well differentiated with a low K1 67 (less than 2%) [5]. The metastatic potential of most duodenal gastrinomas is restricted to the peripancreatic lymph nodes which are positive in 34% to 85%. These lymph node metastases do not adversely affect survival [2,5-8] There is general agreement that duodenal gastrinomas have exceptionally fast growth or metastatisation to the liver.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"12 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85660088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Pancreatojejunostomy for Intrahepatic Pseudocyst: A Unique Approach 胰空肠吻合术治疗肝内假性囊肿:一个独特的方法
Pancreatic disorders & therapy Pub Date : 2017-05-15 DOI: 10.4172/2165-7092.1000183
M. Kulkarni
{"title":"Pancreatojejunostomy for Intrahepatic Pseudocyst: A Unique Approach","authors":"M. Kulkarni","doi":"10.4172/2165-7092.1000183","DOIUrl":"https://doi.org/10.4172/2165-7092.1000183","url":null,"abstract":"Intrahepatic pseudocyst of pancreas is a very rare entity and a significant diagnostic dilemma with less than 30 cases reported in the world literature. Demonstration of amylase rich fluid and a communication with pancreatic duct system establishes the diagnosis. There are no definite guidelines for the management. Here we describe a patient with alchohol related chronic pancreatitis with pseudocyst in head of pancreas developing intrahepatic dissection of pseudocyst resulting in a large intrahepatic multicystic lesion. The diagnosis was made by CT scan and Ultrasound guided aspiration of intrahepatic cyst contents showing amylase rich fluid. The patient had to be treated for both the pancreatic pain and intrahepatic pseudocyst. The patient underwent lateral pancreaticojejunostomy. The surgery resulted in resolution of intrahepatic pseudocyst by decompressing the main pancreatic duct and also resolved the pain of chronic pancreatitis.The lateral pancreato jejunostomy in this case is unique and not described before to treat intrahepatic pseudocyst.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"71 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73612377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lateral Pancreatogastrostomy for Stenotic Pancreatojejunostomy After Pancreatoduodenectomy: A Case Report 胰十二指肠切除术后狭窄胰空肠吻合行外侧胰胃吻合术1例
Pancreatic disorders & therapy Pub Date : 2017-05-15 DOI: 10.4172/2165-7092.1000184
D. Vaishnav, T. Lakhia
{"title":"Lateral Pancreatogastrostomy for Stenotic Pancreatojejunostomy After Pancreatoduodenectomy: A Case Report","authors":"D. Vaishnav, T. Lakhia","doi":"10.4172/2165-7092.1000184","DOIUrl":"https://doi.org/10.4172/2165-7092.1000184","url":null,"abstract":"There is a large body of literature that describes the short-term complications (e.g., pancreatic or biliary anastomotic leaks) that occur after PD, but little has been published regarding long-term anastomotic complications. Stenosis of the anastomosis is often asymptomatic but symptomatic and painful presentations are difficult to treat, and the optimal treatment is not currently defined. The aim of this work is to report case of pancreatojejunostomy stenosis. The Pancreatic enteric anastomosis stenosis was diagnosed following presentation with pancreatitis that developed following pancreatoduodenectomy. The patient was treated surgically by fashioning side to side pancreatogastrostomy.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"127 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80087083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreatic Ductal Adenocarcinoma Harboring Germline BRCA 2 Mutation, A Case Report and Review of The Literature 携带生殖系brca2突变的胰腺导管腺癌1例报告及文献复习
Pancreatic disorders & therapy Pub Date : 2017-05-08 DOI: 10.4172/2165-7092.1000182
Lemstrova Radmila, Melichar Bohuslav, Mohelnikova Duchonova Beatrice
{"title":"Pancreatic Ductal Adenocarcinoma Harboring Germline BRCA 2 Mutation, A Case Report and Review of The Literature","authors":"Lemstrova Radmila, Melichar Bohuslav, Mohelnikova Duchonova Beatrice","doi":"10.4172/2165-7092.1000182","DOIUrl":"https://doi.org/10.4172/2165-7092.1000182","url":null,"abstract":"Introduction: Despite recent advances in the diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC) the prognosis of this tumor remains dismal. It is estimated that 5-10% of all PDAC patients harbor a germline BRCA-1 or BRCA-2 mutation. There is some evidence that BRCA-mutated PDAC cases respond to chemotherapy regimens based on platinum derivate and cross linking agents. Case report: Here we present a case of metastatic PDAC in a 41-year-old BRCA2 germline mutation carrier. The patient had a favorable response to systemic treatment, including a partial response even to the third line cisplatin monotherapy administered with palliative intent. Discussion: PDAC associated with BRCA mutation represents a special disease entity. Platinum derivates and cross linking agents should be considered even in the advanced palliative setting in these patients.","PeriodicalId":89708,"journal":{"name":"Pancreatic disorders & therapy","volume":"36 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74454179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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