Journal of caffeine research最新文献

{"title":"Caffeine Content Labeling: A Missed Opportunity for Promoting Personal and Public Health.","authors":"Jon Kole,&nbsp;Anne Barnhill","doi":"10.1089/jcr.2013.0017","DOIUrl":"10.1089/jcr.2013.0017","url":null,"abstract":"<p><p>Current regulation of caffeine-containing products is incoherent, fails to protect consumers' interests, and should be modified in multiple ways. We make the case for one of the regulatory reforms that are needed: all consumable products containing added caffeine should be required by the Food and Drug Administration (FDA) to include caffeine quantity on their labels. Currently, no foods or beverages that contain caffeine are required to include caffeine content on their labels. Strengthening these lax labeling requirements could prevent direct caffeine-induced harm, protect those most vulnerable to caffeine-related side effects, and enhance consumer autonomy and effective caffeine use. Consumers have an interest in regulating their intake of caffeine and thus, ought to know how much caffeine their foods and beverages contain.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"3 3","pages":"108-113"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jcr.2013.0017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32288447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Caffeinated Soft Drinks on Salivary Flow.","authors":"Gary H Hildebrandt,&nbsp;Daranee Tantbirojn,&nbsp;David G Augustson,&nbsp;Hongfei Guo","doi":"10.1089/jcr.2013.0012","DOIUrl":"https://doi.org/10.1089/jcr.2013.0012","url":null,"abstract":"<p><strong>Background: </strong>Soft drinks containing caffeine have been associated with more aggressive forms of dental decay. Cariogenicity of caffeinated soft drinks may be attributed to the effect of caffeine on salivary flow. This study assessed whether caffeinated soft drinks produced short-term oral dryness in healthy adults.</p><p><strong>Methods: </strong>The authors collected saliva on two separate days from 35 participants before and one hour after drinking a soft drink. On one of the days the soft drink was caffeinated and on the other day it was not. Saliva collection involved 15 minutes unstimulated whole saliva, 5 minutes paraffin-stimulated whole saliva, and 10 seconds labial minor salivary gland output.</p><p><strong>Results: </strong>Unstimulated and stimulated flow rates slightly increased and minor gland output slightly decreased one hour after the soft drink consumption regardless of caffeine content. These changes were not statistically significant (two-period two-treatment crossover trial using two-stage Grizzle model, <i>p</i>>0.05). A linear mixed model statistic did not show the caffeine effect on salivary flow rate.</p><p><strong>Conclusions: </strong>Caffeinated soft drink consumption had no significant effect on salivary flow rate after one hour by any of the three measures employed in this study. Caffeine's contribution to the cariogenicity of soft drinks is likely by centrally-mediated effects on consumption patterns.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"3 3","pages":"138-142"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jcr.2013.0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32287909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine Use Disorder: A Comprehensive Review and Research Agenda.","authors":"Steven E Meredith,&nbsp;Laura M Juliano,&nbsp;John R Hughes,&nbsp;Roland R Griffiths","doi":"10.1089/jcr.2013.0016","DOIUrl":"https://doi.org/10.1089/jcr.2013.0016","url":null,"abstract":"<p><p>Caffeine is the most commonly used drug in the world. Although consumption of low to moderate doses of caffeine is generally safe, an increasing number of clinical studies are showing that some caffeine users become dependent on the drug and are unable to reduce consumption despite knowledge of recurrent health problems associated with continued use. Thus, the World Health Organization and some health care professionals recognize caffeine dependence as a clinical disorder. In this comprehensive literature review, we summarize published research on the biological evidence for caffeine dependence; we provide a systematic review of the prevalence of caffeine dependence and rates of endorsement of clinically meaningful indicators of distress and functional impairment among habitual caffeine users; we discuss the diagnostic criteria for Caffeine Use Disorder-a condition for further study included in the <i>Diagnostic and Statistical Manual of Mental Disorders</i> (<i>5^th ed</i>.); and we outline a research agenda to help guide future clinical, epidemiological, and genetic investigations of caffeine dependence. Numerous controlled laboratory investigations reviewed in this article show that caffeine produces behavioral and physiological effects similar to other drugs of dependence. Moreover, several recent clinical studies indicate that caffeine dependence is a clinically meaningful disorder that affects a nontrivial proportion of caffeine users. Nevertheless, more research is needed to determine the reliability, validity, and prevalence of this clinically important health problem.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"3 3","pages":"114-130"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jcr.2013.0016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32287908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeinated Alcohol, Sensation Seeking, and Injury Risk.","authors":"Mary Claire O'Brien, Thomas P McCoy, Kathleen L Egan, Shoshanna Goldin, Scott D Rhodes, Mark Wolfson","doi":"10.1089/jcr.2013.0004","DOIUrl":"10.1089/jcr.2013.0004","url":null,"abstract":"<p><strong>Background: </strong>College students who consume caffeinated alcoholic beverages (CaffAlc) are at increased injury risk. This study examines the extent to which a sensation-seeking personality accounts for the relationship between consumption of CaffAlc and negative outcomes.</p><p><strong>Methods: </strong>A Web-based survey was administered to stratified random samples of 4907 college students from eight North Carolina universities in Fall 2009. Sensation seeking was assessed using the Brief Sensation-Seeking Scale (BSSS) (α=0.81). Data were analyzed using linear and logistic regression.</p><p><strong>Results: </strong>3390 students (71.2%) reported past 30-day drinking, of whom 786 (23.2%) consumed CaffAlc. CaffAlc past 30-day drinkers had higher BSSS scores (3.8 vs. 3.4; <i>p</i><0.001), compared to non-CaffAlc drinkers. Consumption of CaffAlc was associated with more frequent binge drinking (<i>p</i><0.001) and drunken days in a typical week (<i>p</i><0.001), even after adjusting for the BSSS score. CaffAlc students were more likely to be taken advantage of sexually (adjusted odds ratio [AOR]=1.70, <i>p</i>=0.012), drive under the influence of alcohol (AOR=2.00, <i>p</i><0.001), and ride with a driver under the influence of alcohol (AOR=1.87, <i>p</i><0.001). Injury requiring medical treatment was more prevalent among CaffAlc students with higher BSSS-8 scores (interaction <i>p</i>=0.024), even after adjustment for drinking levels and student characteristics.</p><p><strong>Conclusions: </strong>Sensation seeking does not fully account for the increase in risky drinking among college students who consume CaffAlc, nor does it moderate the relationship between CaffAlc and drinking behaviors. Sensation seeking moderates the risk of alcohol-associated injury requiring medical treatment among college students who consume CaffAlc. Those with strong sensation-seeking dispositions are at the highest risk of alcohol-associated injury requiring medical treatment.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"3 2","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680975/pdf/jcr.2013.0004.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32288444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine and Substance Use Disorders.","authors":"Sergi Ferré","doi":"10.1089/jcr.2013.0015","DOIUrl":"https://doi.org/10.1089/jcr.2013.0015","url":null,"abstract":"","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"3 2","pages":"57-58"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jcr.2013.0015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32288442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine Withdrawal and Dependence: A Convenience Survey Among Addiction Professionals.","authors":"Alan J Budney,&nbsp;Pamela C Brown,&nbsp;Roland R Griffiths,&nbsp;John R Hughes,&nbsp;Laura M Juliano","doi":"10.1089/jcr.2013.0005","DOIUrl":"https://doi.org/10.1089/jcr.2013.0005","url":null,"abstract":"<p><strong>Aims: </strong>Caffeine withdrawal was included in the research appendix of the DSM-IV to encourage additional research to assist with determining its status for the next version of the manual. Caffeine dependence was not included because of a lack of empirical research at the time of publication. This study assessed the beliefs of addiction professionals about the clinical importance of caffeine withdrawal and dependence.</p><p><strong>Methods: </strong>A 6-item survey was developed and delivered electronically to the members of six professional organizations that focus on addiction. Open-ended comments were also solicited. Five hundred members responded.</p><p><strong>Results: </strong>The majority (95%) thought that cessation of caffeine could produce a withdrawal syndrome, and that caffeine withdrawal can have clinical importance (73%); however, only half (48%) thought that caffeine withdrawal should be included in the Diagnostic and Statistical Manual of Mental Disorders (DSM). A majority (58%) believed that some people develop caffeine dependence; however, only 44% indicated that it should be in the DSM. Comments suggested that trepidation about inclusion of caffeine diagnoses was due to the concerns about the field of psychiatry being criticized for including common disorders with a relatively low clinical severity. Others, however, expressed an urgent need to take caffeine-related problems more seriously.</p><p><strong>Conclusions: </strong>The majority of addiction professionals believe that caffeine withdrawal and dependence disorders exist and are clinically important; however, these professionals are divided in whether caffeine withdrawal and dependence should be included in DSM. Wider dissemination of the extant literature on caffeine withdrawal and additional research on caffeine dependence will be needed to provide additional guidance to policymakers and healthcare workers.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"3 2","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jcr.2013.0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32288445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraxanthine: Connecting Caffeine to Nitric Oxide Neurotransmission.","authors":"Sergi Ferré,&nbsp;Marco Orrú,&nbsp;Xavier Guitart","doi":"10.1089/jcr.2013.0006","DOIUrl":"https://doi.org/10.1089/jcr.2013.0006","url":null,"abstract":"<p><p>Recent results obtained in our laboratory indicate that paraxanthine, the main metabolite of caffeine in humans, produces a significantly stronger locomotor activation in rats than caffeine. Furthermore, paraxanthine also produced a very significant increase in striatal extracellular concentrations of dopamine. Searching for an additional mechanism other than adenosine antagonism responsible for these psychostimulant-like effects, it was found that paraxanthine, but not caffeine, inhibited cGMP-preferring phosphodiesterases. Furthermore, interrupting nitric oxide neurotransmision (inhibiting nitric oxide synthase) significantly decreased both the locomotor-activating and the dopamine-releasing effects of paraxanthine. These results open up some obvious questions about the role of paraxanthine in the pharmacological effects of caffeine.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"3 2","pages":"72-78"},"PeriodicalIF":0.0,"publicationDate":"2013-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jcr.2013.0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32288446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coffee Consumption Associated with Increased Mortality of Women with Breast Cancer.","authors":"Steven Lehrer,&nbsp;Sheryl Green,&nbsp;Kenneth E Rosenzweig","doi":"10.1089/jcr.2013.0001","DOIUrl":"https://doi.org/10.1089/jcr.2013.0001","url":null,"abstract":"<p><strong>Background: </strong>There has been some speculation that caffeine consumption may affect breast cancer. Most case-control studies have not documented evidence of a caffeine-breast cancer incidence link; however, there has been very little analysis of the possible effects of caffeine consumption on breast cancer survival.</p><p><strong>Methods: </strong>We examined overall a 20-year survival of 96 women treated for breast cancer between 1990 and 1994. As part of their health history, these women were asked about coffee drinking.</p><p><strong>Results: </strong>Fifty-three women drank one cup a day (79.2% survival), 22 women had two cups a day (72.7% survival), and 21 women drank three or more cups a day (42.9% survival). The effect of coffee consumption on survival was significant (<i>p</i>=0.006, the log rank test). To exclude the effects of lymph node involvement, age at diagnosis, and smoking history, Cox regression was performed. The effect of coffee was significant (<i>p</i>=0.001), independent of the effects of lymph node involvement (<i>p</i>=0.012) and age at diagnosis (<i>p</i>=0.014), and unrelated to a smoking history (<i>p</i>=0.721).</p><p><strong>Conclusion: </strong>Fatigued breast cancer survivors have an abnormal proinflammatory cytokine activity, an average of 5 years after diagnosis, as well as significant serum cortisol derangements compared to other survivors. One possible interpretation of our results suggests that there is an abnormal hypothalamic-pituitary-adrenal axis functioning in breast cancer patients with persistent fatigue, who might be using coffee to self-medicate. In other words, coffee consumption in the present study might be a surrogate marker for fatigue. Because of the paucity of data regarding caffeine intake, poor sleep, fatigue, and breast cancer survival, further studies could be worthwhile.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"3 1","pages":"38-40"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jcr.2013.0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32288441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Caffeine on the Behavioral Effects of Ethanol Related to Abuse and Addiction: A Review of Animal Studies.","authors":"Laura López-Cruz, John D Salamone, Mercè Correa","doi":"10.1089/jcr.2013.0003","DOIUrl":"10.1089/jcr.2013.0003","url":null,"abstract":"<p><p>The impact of caffeine on the behavioral effects of ethanol, including ethanol consumption and abuse, has become a topic of great interest due to the rise in popularity of the so-called energy drinks. Energy drinks high in caffeine are frequently taken in combination with ethanol under the popular belief that caffeine can offset some of the intoxicating effects of ethanol. However, scientific research has not universally supported the idea that caffeine can reduce the effects of ethanol in humans or in rodents, and the mechanisms mediating the caffeine-ethanol interactions are not well understood. Caffeine and ethanol have a common biological substrate; both act on neurochemical processes related to the neuromodulator adenosine. Caffeine acts as a nonselective adenosine A₁ and A_2A receptor antagonist, while ethanol has been demonstrated to increase the basal adenosinergic tone via multiple mechanisms. Since adenosine transmission modulates multiple behavioral processes, the interaction of both drugs can regulate a wide range of effects related to alcohol consumption and the development of ethanol addiction. In the present review, we discuss the relatively small number of animal studies that have assessed the interactions between caffeine and ethanol, as well as the interactions between ethanol and subtype-selective adenosine receptor antagonists, to understand the basic findings and determine the possible mechanisms of action underlying the caffeine-ethanol interactions.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"3 1","pages":"9-21"},"PeriodicalIF":0.0,"publicationDate":"2013-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643311/pdf/jcr.2013.0003.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32288443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Preliminary Study on the Effects of Self-Reported Dietary Caffeine on Pain Experience and Postoperative Analgesia.","authors":"Nirmani P Karunathilake,&nbsp;Reginald F Frye,&nbsp;Mary F Stavropoulos,&nbsp;Mary A Herman,&nbsp;Barbara A Hastie","doi":"10.1089/jcr.2012.0016","DOIUrl":"https://doi.org/10.1089/jcr.2012.0016","url":null,"abstract":"<p><strong>Background: </strong>Caffeine reduces the amount of analgesic medications necessary to provide postoperative pain (POP) relief and augments treatments for headaches and dental pain. Despite considerable evidence of its beneficial effects, little is understood about the role of dietary caffeine consumption on baseline pain sensitivity or POP following oral surgery.</p><p><strong>Method: </strong>Baseline experimental pain testing (quantitative sensory testing [QST]) using four stimulus modalities was conducted on 30 healthy adults (53% females) before surgical extraction of four third molars. Self-reported caffeine ingestion was reported before QST, and on the day of surgery, preoperative and postoperative caffeine plasma concentrations (CPC) were measured by mass spectrometry. POP ratings were obtained at timed intervals.</p><p><strong>Results: </strong>In QST, compared to subjects who self-reported no caffeine intake, those who self-reported caffeine ingestion demonstrated a higher pain sensitivity, particularly, on ramp and hold sustained heat at 44°C and 46°C, as well as a lower heat pain threshold and tolerance (<i>p</i>=0.05). Differences approached significance (<i>p</i>=0.06) in POP between subjects with CPC above 300 ng/mL and those with CPC below 300 ng/mL. Specifically, those with >300 ng/mL CPC had a slightly lower POP (mean 2.43, range 0-5) compared to those with <300 ng/mL CPC whose POP ratings were slightly higher (mean 2.89) with a greater variability (range 0-9.5).</p><p><strong>Conclusions: </strong>Self-reported, dietary caffeine intake was associated with higher QST ratings with lower threshold and tolerance particularly on heat pain modalities. External factors (i.e., analgesic dosage) may have played a role in the analgesic effects of caffeine on POP in oral surgery, especially in individuals with CPC exceeding 300 ng/mL who reported lower pain.</p>","PeriodicalId":89685,"journal":{"name":"Journal of caffeine research","volume":"2 4","pages":"159-166"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/jcr.2012.0016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32288440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}