Current neurobiology最新文献

Vision Neurobiology: How we know it the Moment When we see it 视觉神经生物学:我们如何在看到它的那一刻就知道它

Current neurobiology Pub Date : 2021-01-01 DOI: 10.36648/JCNB.21.1.03

Mizna Javaria

引用次数: 0

An Overview of Behavioral Effects and Neurobiological Mechanisms: Individual Choices 行为效应和神经生物学机制综述:个体选择

Current neurobiology Pub Date : 2021-01-01 DOI: 10.36648/JCNB.21.1.04

Namrata Das

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Neural damage and neuroprotection with glaucoma development in aniridia. 神经损伤和神经保护与青光眼在无毛细血管畸形中的发展。

Current neurobiology Pub Date : 2021-01-01

James D Cole, Carlos Rodriguez, Pedro Norat, Jingyi Gao, Ignacio Provencio, Peter A Netland, Xiaorong Liu

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Herbal Medicine Effectiveness on Neurological Disorders 草药治疗神经系统疾病的疗效

Current neurobiology Pub Date : 2021-01-01 DOI: 10.36648/JCNB.21.1.05

Javaria Usef

引用次数: 0

Why do People have Seizures and Epilepsy: What is the Cause? 人们为什么会癫痫发作:原因是什么?

Current neurobiology Pub Date : 2021-01-01 DOI: 10.36648/JCNB.21.1.01

Shivarani Manthena

引用次数: 0

Deep learning-based classification of multi-categorical Alzheimer's disease data. 基于深度学习的多类别阿尔茨海默病数据分类。

Current neurobiology Pub Date : 2019-10-01

David S Cohen, Kristy A Carpenter, Juliet T Jarrell, Xudong Huang

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The role of the immune system in brain metastasis. 免疫系统在脑转移中的作用。

Current neurobiology Pub Date : 2019-07-01

Adam T Leibold, Gina N Monaco, Mahua Dey

{"title":"The role of the immune system in brain metastasis.","authors":"Adam T Leibold, Gina N Monaco, Mahua Dey","doi":"","DOIUrl":"","url":null,"abstract":"Metastatic brain tumors are the most common brain tumors in adults. With numerous successful advancements in systemic treatment of most common cancer types, brain metastasis is becoming increasingly important in the overall prognosis of cancer patients. Brain metastasis of peripheral tumor is the result of complex interplay of primary tumor, immune system and central nervous system microenvironment. Once formed, brain metastases hide behind the blood brain barrier and become inaccessible to chemotherapies that are otherwise successful in targeting systemic cancer. The approval of immune checkpoint inhibitors for several common cancers such as advanced melanoma and lung cancers brings with it the opportunity and obligation to further understand the mechanisms of immunosuppression by tumors that spread to the brain as well as the interaction between the brain environment and tumor microenvironment. In this review paper we define the central role of the immune system in the development of brain metastases. We performed a comprehensive review of the literature to outline the molecular mechanisms of immunosuppression used by tumors and how the immune system interacts with the central nervous system to facilitate brain metastasis. In particular we discuss the tumor-type-specific mechanisms of metastasis of cancers that preferentially metastasize to the brain as well as the therapies that effectively modulate the immune response, such as immune checkpoint inhibitors and vaccines.","PeriodicalId":89670,"journal":{"name":"Current neurobiology","volume":"10 2","pages":"33-48"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513348/pdf/nihms-1024558.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37411478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep disturbances precede depressive symptomatology following traumatic brain injury. 创伤性脑损伤后的抑郁症状出现睡眠障碍。

Current neurobiology Pub Date : 2019-07-01

Emerson M Wickwire, Jennifer S Albrecht, Nicholas R Griffin, David M Schnyer, John K Yue, Amy J Markowitz, David O Okonkwo, Alex B Valadka, Neeraj Badjatia, Geoffrey T Manley

引用次数: 0

Levels of α-2 Macroglobulin in cognitively normal Mexican- Americans with Subjective Cognitive Decline: A HABLE Study. 认知正常的墨西哥裔美国人主观认知能力下降的α-2巨球蛋白水平:一项HABLE研究。

Current neurobiology Pub Date : 2019-04-01

James R Hall, April R Wiechmann, Leigh A Johnson, Melissa L Edwards, Sid E O'Bryant

{"title":"Levels of α-2 Macroglobulin in cognitively normal Mexican- Americans with Subjective Cognitive Decline: A HABLE Study.","authors":"James R Hall, April R Wiechmann, Leigh A Johnson, Melissa L Edwards, Sid E O'Bryant","doi":"","DOIUrl":"","url":null,"abstract":"Background: The presence of Subjective Cognitive Decline (SCD) in the absence of objective change and the inflammatory biomarker Alpha 2 Macroglobulin (A2M) have both been implicated in preclinical Alzheimer's disease. Mexican Americans are population with high rates of cardiovascular and inflammatory disorders.Objectives: The current study investigated the levels of A2M in cognitively normal Mexican Americans with and without complaints of cognitive decline.Method: 293 (243 females, 50 males) community-based cognitively normal older Mexican Americans from the ongoing Health and Aging Brain among Latino Elders (HABLE) study were grouped based on subjective cognitive decline and blood samples were assayed by electrochemiluminescence to determine levels of A2M.Results: Participants with SCD had significantly higher levels of A2M than those without SCD. Females with SCD had a significantly higher level of A2M.Conclusions: Results suggest that higher levels of A2M, a marker of neuronal injury, may be involved in subtle changes in cognitive functioning recognizable to persons reporting SCD but too subtle to be objectively measured. Longitudinal research is needed to assess the impact of SDC and A2M in progression to MCI and dementia in Mexican Americans.","PeriodicalId":89670,"journal":{"name":"Current neurobiology","volume":"10 1","pages":"22-25"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499402/pdf/nihms-1014310.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37219776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Restriction and Glycolytic Inhibition Reduce Proteotoxicity and Extend Lifespan via NHR-49. 饮食限制和糖酵解抑制通过NHR-49降低蛋白质毒性和延长寿命。

Current neurobiology Pub Date : 2018-04-01

Bridget K Marcellino, Nydia Ekasumara, Charles V Mobbs

{"title":"Dietary Restriction and Glycolytic Inhibition Reduce Proteotoxicity and Extend Lifespan via NHR-49.","authors":"Bridget K Marcellino, Nydia Ekasumara, Charles V Mobbs","doi":"","DOIUrl":"","url":null,"abstract":"Mechanisms mediating protective effects of dietary restriction during aging are of great interest since activating such mechanisms protect against a wide range of age-related diseases. In mammals key metabolic responses to nutritional deprivation are mediated by the transcription factor PPAR-alpha, which is activated by free fatty acids and promotes lipid metabolism while inhibiting glucose metabolism. The C. elegans gene nhr-49 appears to function similarly in C. elegans. Here we report that protective effects of dietary restriction and inhibition of glucose metabolism to increase lifespan wild-type C. elegans and reduce toxicity in a polyQ model of Huntington's disease in C. elegans are dependent on NHR-49 and its co-activator CREB-Binding Protein (CBP). We have previously demonstrated that inhibition of cbp blocks protective effects of dietary restriction and blocks the molecular switch from glucose metabolism to alternative substrates. Conversely, increased glucose concentration and inhibition of cbp reduce lifespan and increase proteotoxicity. Lactate and inhibition of ETC complex II mimicked toxic effects of glucose on proteotoxicity whereas pyruvate and inhibition of ETC complex I protected against glucose-enhanced proteotoxicity. These results support that PPAR-alpha-like activity mediates protective effects of dietary restriction by reducing glucose metabolism via reducing production of NADH, and corroborate and extend recent studies demonstrating that PPPAR-alpha agonists increase lifespan in C. elegans dependent on NHR-49.","PeriodicalId":89670,"journal":{"name":"Current neurobiology","volume":"9 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390974/pdf/nihms-981894.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37173135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0